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Jeremy Wen
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Journal Articles

Chromothripsis Orchestrates Leukemic Transformation in Blast Phase MPN through Targetable Amplification of DYRK1A

Charlotte K Brierley, Bon Ham Yip, Giulia Orlando, Harsh Goyal, Sean Wen, Jeremy Wen, Max F. Levine, Alba Rodriguez-Meira, Assunta Adamo, Matthew Bashton, Angela Hamblin, Sally-Ann Clark, Jennifer O Sullivan, Lauren Murphy, Aude-Anais Olijnik, Anitria Cotton, Shilpa Narina, Shondra Pruett-Miller, Amir Enshaei, Claire N Harrison, Mark W. Drummond, Steve Knapper, Ayalew Tefferi, Ileana antony-Debre, Supat Thongjuea, Stefan N Constantinescu, Elli Papaemmanuil, Bethan Psaila, John D. Crispino, Adam J Mead
Journal: Blood
Blood (2023) 142 (Supplement 1): 993.
https://doi.org/10.1182/blood-2023-178556
Published: 2023
Journal Articles

Regulation of Alternative Splicing in B-Cell ALL By DYRK1A

Qi Jin, Ethan Harris, Jacquelyn A. Myers, Anitria Cotton, Jeremy Wen, Johanna Melo-Cardenas, Akihide Yoshimi, Omar Abdel-Wahab, Esther A. Obeng, John D. Crispino
Journal: Blood
Blood (2023) 142 (Supplement 1): 39.
https://doi.org/10.1182/blood-2023-174923
Published: 2023
Journal Articles

Activation of JAK/STAT Signaling in Megakaryocytes Is Necessary and Sufficient for Myeloproliferation In Vivo

Q. Jeremy Wen, Brittany Woods, PhD, Qiong Yang, MD, Chiu Sophia, Gu Lillu, Franck Rapaport, PhD, Ross L. Levine, MD, John Crispino, PhD MBA
Journal: Blood
Blood (2016) 128 (22): 949.
https://doi.org/10.1182/blood.V128.22.949.949
Published: 2016
Journal Articles

Aurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation

Benjamin Goldenson, Gina Kirsammer, Monika J. Stankiewicz, Qiang Jeremy Wen, John D. Crispino
Journal: Blood
Blood (2015) 125 (13): 2141–2150.
https://doi.org/10.1182/blood-2014-12-615401
Published: 2015
Includes: Supplemental data
Journal Articles

Tyrosine 599 Plays an Essential Role and Cooperates with Tyrosine 604 in MPL W515L-Indiced Myeloproliferative Neoplasms

Zan Huang, Chunjie Yu, PhDcandidate, Qiang Jeremy Wen, PhD MD, Qiong Yang, John Crispino, PhD, Demin Wang, PhD, Yuhong Chen
Journal: Blood
Blood (2014) 124 (21): 4580.
https://doi.org/10.1182/blood.V124.21.4580.4580
Published: 2014
Journal Articles

Aurora A Kinase Is Required For Hematopoiesis and Couples Polyploidization With Terminal Differentiation In Megakaryocytes Through Phosphorylation Of NF-E2

Benjamin Goldenson, BS, Qiang Jeremy Wen, PhD, MD, John D Crispino, PhD
Journal: Blood
Blood (2013) 122 (21): 219.
https://doi.org/10.1182/blood.V122.21.219.219
Published: 2013
Journal Articles

Aurora A Kinase Is a Novel Therapeutic Target In The Myeloproliferative Neoplasms

Qiang Jeremy Wen, PhD, MD, Benjamin Goldenson, Sebastien Malinge, PhD, Brady L Stein, MD MHS, Terra L Lasho, MT, (ASCP), Lawrence Breyfogle, Rachael Schultz, Qiong Yang, Laure gilles-Gendre, Priya Koppikar, Omar Abdel-Wahab, MD, Benjamin L. Ebert, MD, PhD, Animesh Pardanani, MBBS, PhD, Sandeep Gurbuxani, MBBS, PhD, Ross L. Levine, MD, Ann Mullally, MD, Ayalew Tefferi, MD, John D Crispino, PhD
Journal: Blood
Blood (2013) 122 (21): 109.
https://doi.org/10.1182/blood.V122.21.109.109
Published: 2013
Journal Articles

Aryl Hydrocarbon Receptor (AhR) Antagonist Stemregenin 1 (SR1) Enhances in Vitro- and in Vivo-Derived Platelets (PLTs) From Human Megakaryocytes (MKs)

Yuhuan Wang, PhD, Vincent M. Hayes, Lin Lu, Ph.D, Xiaoji Chen, Rudy Fuentes, PhD, Qiang Jeremy Wen, MD, PhD, Stella T Chou, MD, John Crispino, PhD, Patrick Paddison, PhD, Deborah L. French, PhD, Beverly Torok-Storb, PhD, Mortimer Poncz, MD
Journal: Blood
Blood (2012) 120 (21): 3450.
https://doi.org/10.1182/blood.V120.21.3450.3450
Published: 2012
Journal Articles

Dysregulation of PSTPIP2 Due to Loss of GATA-1 Contributes to Aberrant Megakaryopoiesis

Lu Liu, Shangqin Liu, Sr., Qiang Jeremy Wen, MD, PhD, John Crispino, PhD, Zan Huang
Journal: Blood
Blood (2012) 120 (21): 854.
https://doi.org/10.1182/blood.V120.21.854.854
Published: 2012
Journal Articles

Inhibition of AKT Signaling Potently Inhibits the Growth of JAK and MPL-Mutant Cells in the Myeloproliferative Neoplasms In Vitro and In Vivo,

Irum Khan, MBBS, Zan Huang, PhD, Qiang Jeremy Wen, MD, PhD, Priya Koppikar, Ross L Levine, MD, Ayalew Tefferi, MD, John Crispino, PhD
Journal: Blood
Blood (2011) 118 (21): 3862.
https://doi.org/10.1182/blood.V118.21.3862.3862
Published: 2011
Journal Articles

Induction of Megakaryocyte Polyploidization in Combination with JAK Inhibition As a Novel Therapeutic Strategy for Myeloproliferative Neoplasms

Qiang Jeremy Wen, MD, PhD, Benjamin Goldenson, Sebastien Malinge, PhD, Priya Koppikar, Ross L Levine, MD, Ayalew Tefferi, MD, John Crispino, PhD
Journal: Blood
Blood (2011) 118 (21): 64.
https://doi.org/10.1182/blood.V118.21.64.64
Published: 2011
Journal Articles

A Kinome shRNA Screen to Identify Pathways That Regulate Megakaryocyte Polyploidization and New Targets for Differentiation Therapy

Qiang Jeremy Wen, MD, PhD, Serena Silver, PhD, Tim Lewis, PhD, Sridevi Ponduru, MBBS, PhD, Vlado Dancik, phd, Ben Goldenson, Mark Bray, Anne Carpenter, PhD, Paul Clemons, PhD, David Root, phd, Andrew Stern, phd, Robert Gould, phd, John Crispino, PhD
Journal: Blood
Blood (2010) 116 (21): 89.
https://doi.org/10.1182/blood.V116.21.89.89
Published: 2010