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Matthew Bashton
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Journal Articles

Chromothripsis Orchestrates Leukemic Transformation in Blast Phase MPN through Targetable Amplification of DYRK1A

Charlotte K Brierley, Bon Ham Yip, Giulia Orlando, Harsh Goyal, Sean Wen, Jeremy Wen, Max F. Levine, Alba Rodriguez-Meira, Assunta Adamo, Matthew Bashton, Angela Hamblin, Sally-Ann Clark, Jennifer O Sullivan, Lauren Murphy, Aude-Anais Olijnik, Anitria Cotton, Shilpa Narina, Shondra Pruett-Miller, Amir Enshaei, Claire N Harrison, Mark W. Drummond, Steve Knapper, Ayalew Tefferi, Ileana antony-Debre, Supat Thongjuea, Stefan N Constantinescu, Elli Papaemmanuil, Bethan Psaila, John D. Crispino, Adam J Mead
Journal: Blood
Blood (2023) 142 (Supplement 1): 993.
https://doi.org/10.1182/blood-2023-178556
Published: 2023
Journal Articles

The genomic landscape of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21

Qingsong Gao, Sarra L. Ryan, Ilaria Iacobucci, Pankaj S. Ghate, Ruth E. Cranston, Claire Schwab, Abdelrahman H. Elsayed, Lei Shi, Stanley Pounds, Shaohua Lei, Pradyuamna Baviskar, Deqing Pei, Cheng Cheng, Matthew Bashton, Paul Sinclair, David R. Bentley, Mark T. Ross, Zoya Kingsbury, Terena James, Kathryn G. Roberts, Meenakshi Devidas, Yiping Fan, Wenan Chen, Ti-Cheng Chang, Gang Wu, Andrew Carroll, Nyla Heerema, Virginia Valentine, Marcus Valentine, Wenjian Yang, Jun J. Yang, Anthony V. Moorman, Christine J. Harrison, Charles G. Mullighan
Journal: Blood
Blood (2023) 142 (8): 711–723.
https://doi.org/10.1182/blood.2022019094
Published: 2023
Includes: Supplemental data
Journal Articles

Single-Cell Multi-Omics Reveals the Genetic, Cellular and Molecular Landscape of TP53 Mutated Leukemic Transformation in MPN

Alba Rodriguez-Meira, Haseeb Rahman, Ruggiero Norfo, Wei Wen, Agathe Chédeville, Jennifer O'Sullivan, Guanlin Wang, Aimee Paterson, Eleni Louka, Charlotte K Brierley, Warren W Kretzschmar, Francois Girodon, Zemin Ren, Matthew Bashton, Amir Enshaei, Mark W. Drummond, Florence Pasquier, Christophe Marzac, Claire N. Harrison, Isabelle Plo, Sten Eirik W Jacobsen, Supat Thongjuea, Bethan Psaila, Ileana Antony-Debre, Adam J. Mead
Journal: Blood
Blood (2021) 138 (Supplement 1): 3.
https://doi.org/10.1182/blood-2021-150191
Published: 2021
Journal Articles

Molecular Characterisation of Participants in the Phazar Trial Reveals Prognostic Impact of Mutations in Advanced-Phase-MPN

Charlotte K Brierley, MRCP, MD, Alba Rodriguez-Meira, PhD, Matthew Bashton, PhD, Angela Hamblin, MD PhD, Rachel S Fletcher, PhD, Sonia Fox, Charlotte Gaskell, BSc, MSc, Aimee Jackson, BSc, MSc, Jennifer O'Sullivan, MD, Lauren C Murphy, Nikolaos Sousos, MDMSc, Amir Enshaei, PhD, Claire Harrison, DM, FRCP, FRCPath, Mark W. Drummond, PhD FRCPath, Steve Knapper, BMBCh, MRCP, FRCPath, DM, Bethan Psaila, MD PhD, Adam J. Mead, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–41.
https://doi.org/10.1182/blood-2020-139520
Published: 2020
Journal Articles

A Genome-Wide CRISPR Screen Implicates MYC Dysregulation in TCF3 - PBX1 B-ALL

Ruth E Cranston, BSc, Paul B Sinclair, PhD, Matthew Bashton, PhD, Matthew P Selby, PhD, Christine J Harrison, PhD FRCPath
Journal: Blood
Blood (2018) 132 (Supplement 1): 3915.
https://doi.org/10.1182/blood-2018-99-110015
Published: 2018
Journal Articles

Constitutional Ring Chromosome 21 Predisposes to Acute Lymphoblastic Leukaemia (ALL) with iAMP21

Claire Schwab, Eigil Kjeldsen, MD DMSc, Nyla A. Heerema, PhD, Andrew Carroll, PhD, Matthew Bashton, PhD, Sarra Ryan, PhD, Anthony V. Moorman, PhD, Stephen P. Hunger, MD, Mignon L. Loh, MD, Henrik Hasle, MD PhD, Christine J Harrison, PhD FRCPath
Journal: Blood
Blood (2017) 130 (Supplement 1): 3978.
https://doi.org/10.1182/blood.V130.Suppl_1.3978.3978
Published: 2017
Journal Articles

A Whole Genome In Vivo Crispr Screen in Primary ALL Predicts Leukaemic Relapse

Katherine Dormon, MSci, Elda S Latif, PhD, Matthew Bashton, PhD, Deepali Pal, PhD, Matthew Selby, MSci, Helen Blair, PhD, Vikki Rand, PhD, Andrew G Hall, PhD, Josef Vormoor, MD FRCPCH, Olaf Heidenreich, PhD
Journal: Blood
Blood (2015) 126 (23): 2619.
https://doi.org/10.1182/blood.V126.23.2619.2619
Published: 2015