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Journal Articles

CD74 Signaling Regulates Inflammatory Stress to Drive Defective Hematopoiesis and Fitness Advantage of Progenitors in RUNX1-Familial Platelet Disorder

Blood (2024) 144 (Supplement 1): 198.

https://doi.org/10.1182/blood-2024-211542

Published: 2024

Journal Articles

Interplay between Inflammatory Microenvironment and RUNX1-Mediated Transcriptomic Changes Drives Defective Hematopoiesis in Familial Platelet Disorder

Blood (2023) 142 (Supplement 1): 945.

https://doi.org/10.1182/blood-2023-187750

Published: 2023

Journal Articles

Germline Runx1 Mutations Induce Inflammation in Hematopoietic Stem and Progenitor Cells and Predispose to Hematologic Malignancies

Mohd Hafiz Ahmad, Mahesh Hegde, Waihay J. Wong, Andrew Dunbar, Anneliese Carrascoso, Lisa J Garrett, Nayara K Ferreira, Haibo Liu, Rui Li, Benjamin L. Ebert, Ross L. Levine, Julie Zhu, Scot A. Wolfe, Paul P Lui, Lucio H. Castilla

Blood (2021) 138 (Supplement 1): 2201.

https://doi.org/10.1182/blood-2021-153433

Published: 2021

Journal Articles

The CBFβ-SMMHC/NRP1 Axis Regulates FLT3 and TGF-Beta Pathways in Inv(16) Acute Myeloid Leukemia

Mahesh Hegde, Mohd Hafiz Ahmad, Rui Li, Anneliese Carrascoso, Roger Mulet-Lazaro, Ruud Delwel, John H. Bushweller, Monica L. Guzman, Scot A. Wolfe, Julie Zhu, Lucio H. Castilla

Blood (2021) 138 (Supplement 1): 3314.

https://doi.org/10.1182/blood-2021-153275

Published: 2021

Journal Articles

Core Binding Factor Leukemias Utilize a Physiologic Sense/Antisense Promoter Switch Employed By T-Cells

Blood (2020) 136 (Supplement 1): 40–41.

https://doi.org/10.1182/blood-2020-140776

Published: 2020

Journal Articles

NRAS palmitoylation and oncogenic fitness

Lucio H. Castilla

Blood (2020) 135 (20): 1725–1726.

https://doi.org/10.1182/blood.2020005720

Published: 2020

Journal Articles

CBFβ-SMMHC Inhibition Disrupts Enhancer Chromatin Dynamics and Represses MYC Transcriptional Program in Inv(16) Leukemia

John Anto Pulikkan, PhD, Mahesh Hegde, Houda Belaghzal, Anuradha Illendula, Jun Yu, Hafiz Ahmed, Kelsey O'Hagen, Jianhong Ou, Carsten Müller-Tidow, Scot A. Wolfe, Julie Zhu, Job Dekker, John H. Bushweller, Lucio H. Castilla

Blood (2017) 130 (Supplement 1): 784.

https://doi.org/10.1182/blood.V130.Suppl_1.784.784

Published: 2017

Journal Articles

RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia

AHyun Choi, Anuradha Illendula, John A. Pulikkan, Justine E. Roderick, Jessica Tesell, Jun Yu, Nicole Hermance, Lihua Julie Zhu, Lucio H. Castilla, John H. Bushweller, Michelle A. Kelliher

Blood (2017) 130 (15): 1722–1733.

https://doi.org/10.1182/blood-2017-03-775536

Published: 2017

Includes: Supplemental data

Journal Articles

HIF-1α Promotes Cbfbeta-SMMHC-Induced Acute Myeloid Leukemia Development

Benedikt W. Pelzer, Anita Hollenbeck, PhD, Stefanie Weber, Bertram Opalka, PhD, Lucio H. Castilla, PhD, Ulrich Dührsen, MD, Joachim R. Göthert, MD

Blood (2016) 128 (22): 1559.

https://doi.org/10.1182/blood.V128.22.1559.1559

Published: 2016

Journal Articles

Selective Inhibition of the Leukemia Fusion Protein CBFβ-SMMHC By Small Molecule AI-10-49 in the Treatment of Inv(16) AML

John Anto Pulikkan, PhD, Anuradha Illendula, PhD, Jolanta Grembecka, Liting Xue, Roger Rajewski, Monica L. Guzman, PhD, John H. Bushweller, PhD, Lucio H. Castilla, PhD

Blood (2014) 124 (21): 390.

https://doi.org/10.1182/blood.V124.21.390.390

Published: 2014

Journal Articles

Nras G12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfβ-SMMHC via activation of MEK/ERK axis

Liting Xue, John A. Pulikkan, Peter J. M. Valk, Lucio H. Castilla

Blood (2014) 124 (3): 426–436.

https://doi.org/10.1182/blood-2013-12-541730

Published: 2014

Includes: Supplemental data

Journal Articles

Deletion Of Core Binding Factors Runx1 and Runx2 Leads To Perturbed Hematopoiesis In Multiple Lineages

John Anto Pulikkan, PhD, Xue Liting, Rachel Gerstein, PhD, Merav Socolovsky, PhD, Lucio H. Castilla, PhD

Blood (2013) 122 (21): 46.

https://doi.org/10.1182/blood.V122.21.46.46

Published: 2013

Journal Articles

A Small Molecule Inhibitor of the CBFβ-SMMHC/RUNX Interaction Attenuates Inv(16) Leukemia in Vivo

John H. Bushweller, PhD, Anuradha Illendula, Ph.D., John Anto Pulikkan, Jolanta Grembecka, PhD, Paul Bradley, Yunpeng Zhou, Ph.D., Liting Xue, Yan Gao, Lucio H. Castilla, PhD

Blood (2012) 120 (21): 286.

https://doi.org/10.1182/blood.V120.21.286.286

Published: 2012

Journal Articles

Runx2 induces acute myeloid leukemia in cooperation with Cbfβ-SMMHC in mice

Ya-Huei Kuo, Sayyed K. Zaidi, Svetlana Gornostaeva, Toshihisa Komori, Gary S. Stein, Lucio H. Castilla

Blood (2009) 113 (14): 3323–3332.

https://doi.org/10.1182/blood-2008-06-162248

Published: 2009

Journal Articles

Cbfβ-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development

Ya-Huei Kuo, Rachel M. Gerstein, Lucio H. Castilla

Blood (2008) 111 (3): 1543–1551.

https://doi.org/10.1182/blood-2007-07-104422

Published: 2008

Journal Articles

CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus

Ling Zhao, Jennifer L. Cannons, Stacie Anderson, Martha Kirby, Liping Xu, Lucio H. Castilla, Pamela L. Schwartzberg, Rémy Bosselut, P. Paul Liu

Blood (2006) 109 (8): 3432–3440.

https://doi.org/10.1182/blood-2006-10-051508

Published: 2006

Includes: Supplemental data

Journal Articles

PLAGL2 Cooperates in Leukemia Development by Direcly Inducing c-Mpl Expression.

Sean F. Landrette, BS, Lucio H. Castilla, PhD

Blood (2005) 106 (11): 744.

https://doi.org/10.1182/blood.V106.11.744.744

Published: 2005

Journal Articles

Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11

Sean F. Landrette, Ya-Huei Kuo, Karen Hensen, Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Paola N. Perrat, Wim J. M. Van de Ven, Ruud Delwel, Lucio H. Castilla

Blood (2005) 105 (7): 2900–2907.

https://doi.org/10.1182/blood-2004-09-3630

Published: 2005

Journal Articles

The Role of CBFβ in T Cell Development.

Ling Zhao, MD, PhD, Jennifer L. Cannons, PhD, Lucio H. Castilla, PhD, Pamela L. Schwartzberg, MD, PhD, Pu Paul Liu, MD, PhD

Blood (2004) 104 (11): 3234.

https://doi.org/10.1182/blood.V104.11.3234.3234

Published: 2004

Journal Articles

Cbfb-MYH11 Induces Expansion of a Lin-Kit+Sca1- Abnormal Progenitor Compartment that Predisposes Acute Myeloid Leukemia in Mice.

Ya-Huei Kuo, Susan Heilman, Amy Chen, Pu P. Liu, Rachel Gernstein, Scott Kogan, Lucio H. Castilla

Blood (2004) 104 (11): 543.

https://doi.org/10.1182/blood.V104.11.543.543

Published: 2004

NARROW

CD74 Signaling Regulates Inflammatory Stress to Drive Defective Hematopoiesis and Fitness Advantage of Progenitors in RUNX1-Familial Platelet Disorder

Interplay between Inflammatory Microenvironment and RUNX1-Mediated Transcriptomic Changes Drives Defective Hematopoiesis in Familial Platelet Disorder

Germline Runx1 Mutations Induce Inflammation in Hematopoietic Stem and Progenitor Cells and Predispose to Hematologic Malignancies

The CBFβ-SMMHC/NRP1 Axis Regulates FLT3 and TGF-Beta Pathways in Inv(16) Acute Myeloid Leukemia

Core Binding Factor Leukemias Utilize a Physiologic Sense/Antisense Promoter Switch Employed By T-Cells

NRAS palmitoylation and oncogenic fitness

CBFβ-SMMHC Inhibition Disrupts Enhancer Chromatin Dynamics and Represses MYC Transcriptional Program in Inv(16) Leukemia

RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia

HIF-1α Promotes Cbfbeta-SMMHC-Induced Acute Myeloid Leukemia Development

Selective Inhibition of the Leukemia Fusion Protein CBFβ-SMMHC By Small Molecule AI-10-49 in the Treatment of Inv(16) AML

Nras G12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfβ-SMMHC via activation of MEK/ERK axis

Deletion Of Core Binding Factors Runx1 and Runx2 Leads To Perturbed Hematopoiesis In Multiple Lineages

A Small Molecule Inhibitor of the CBFβ-SMMHC/RUNX Interaction Attenuates Inv(16) Leukemia in Vivo

Runx2 induces acute myeloid leukemia in cooperation with Cbfβ-SMMHC in mice

Cbfβ-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development

CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus

PLAGL2 Cooperates in Leukemia Development by Direcly Inducing c-Mpl Expression.

Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11

The Role of CBFβ in T Cell Development.

Cbfb-MYH11 Induces Expansion of a Lin-Kit+Sca1- Abnormal Progenitor Compartment that Predisposes Acute Myeloid Leukemia in Mice.

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American Society of Hematology

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American Society of Hematology

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