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Journal Articles

Preclinical Evaluation of a Novel Orally Bioavailable Menin-MLL Interaction Inhibitor, DSP-5336, for the Treatment of Acute Leukemia Patients with MLL -Rearrangement or NPM1 Mutation

Ken Eguchi, Takafumi Shimizu, Daiki Kato, Yudai Furuta, Seiji Kamioka, Hitoshi Ban, Setsuko Ymamoto, Akihiko Yokoyama, Issay Kitabayashi

Blood (2021) 138 (Supplement 1): 3339.

https://doi.org/10.1182/blood-2021-152050

Published: 2021

Journal Articles

Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells

Haruko Shima, Emi Takamatsu-Ichihara, Mika Shino, Kazutsune Yamagata, Takuo Katsumoto, Yukiko Aikawa, Shuhei Fujita, Haruhiko Koseki, Issay Kitabayashi

Blood (2018) 131 (16): 1833–1845.

https://doi.org/10.1182/blood-2017-05-787226

Published: 2018

Includes: Supplemental data

Journal Articles

Novel Stem Cell-Targeted Therapy for Multiple Myeloma Based on Dual Inhibition of EZH1/2

Makoto Nakagawa, MD, Shuhei Fujita, MD BS, Daisuke Honma, PhD, Kazushi Araki, D.V.M., PhD, Tatsuya Inoue, Ayako Kato, Koichiro Inaki, PhD, Chisa Wada, Ono Yoshimasa, Yasuharu Nakashima, MDPhD, Issay Kitabayashi, PhD

Blood (2017) 130 (Supplement 1): 590.

https://doi.org/10.1182/blood.V130.Suppl_1.590.590

Published: 2017

Journal Articles

MLL Is Essential for NUP98-HOXA9-Induced Leukemia

Yutaka Shima, PhD, Minori Yumoto, Issay Kitabayashi, PhD

Blood (2015) 126 (23): 1223.

https://doi.org/10.1182/blood.V126.23.1223.1223

Published: 2015

Journal Articles

The Role of IDH Mutants, Which Are Promising Therapeutic Targets for Acute Myeloid Leukemia

Yoko Ogawara, PhD, Hironori Matsunaga, Takahiko Seki, PhD, Yukino Machida, Kazushi Araki, D.V.M., PhD, Issay Kitabayashi, PhD

Blood (2015) 126 (23): 3796.

https://doi.org/10.1182/blood.V126.23.3796.3796

Published: 2015

Journal Articles

Novel Leukemia Stem Cell-Targeted Therapy for Acute Myeloid Leukemia Based on Dual Inhibition of Ezh1/Ezh2

Shuhei Fujita, MD BS, Daisuke Honma, PhD, Nobuaki Adachi, PhD, Kazushi Araki, D.V.M., PhD, Emi Takamatsu, PhD, Kazumasa Aoyama, PhD, Atsushi Iwama, MD PhD, Issay Kitabayashi, PhD

Blood (2015) 126 (23): 457.

https://doi.org/10.1182/blood.V126.23.457.457

Published: 2015

Journal Articles

Leukemia-Associated MLL-AF10 Fusion Maintains an Active State of Chromatin on Its Target Genes By Recruiting Tip60

Kazutsune Yamagata, PhD, Yukiko Aikawa, Mika Shino, Issay Kitabayashi, PhD

Blood (2015) 126 (23): 304.

https://doi.org/10.1182/blood.V126.23.304.304

Published: 2015

Journal Articles

FASN Is Critical for Maintenance of NUP98 Fusion-Induced Leukemias

Yutaka Shima, PhD, Issay Kitabayashi, PhD

Blood (2014) 124 (21): 2377.

https://doi.org/10.1182/blood.V124.21.2377.2377

Published: 2014

Journal Articles

Essential Role of Endogenous MOZ in Aberrant HoxA9 and Meis1 Expressions Induced By MOZ Fusion Gene

Takuo Katsumoto, PhD, Kazutsune Yamagata, PhD, Yoko Ogawara, PhD, Takuro Nakamura, Issay Kitabayashi, PhD

Blood (2014) 124 (21): 2191.

https://doi.org/10.1182/blood.V124.21.2191.2191

Published: 2014

Journal Articles

Critical Roles Of The IDH2 Mutation In Development and Maintenance Of Acute Myeloid Leukemia

Yoko Ogawara, PhD, Takuo Katsumoto, PhD, Yukiko Aikawa, Yutaka Shima, PhD, Yuki Kagiyama, PhD, Hironori Matsunaga, Takahiko Seki, Ph.D., Issay Kitabayashi, PhD

Blood (2013) 122 (21): 225.

https://doi.org/10.1182/blood.V122.21.225.225

Published: 2013

Journal Articles

Roles of Ring1A/B on Stem Cell Potential of MOZ and Other Acute Myeloid Leukemias,

Haruko Shima, MD, PhD, Mika Shino, Kazutsune Yamagata, PhD, Yukiko Aikawa, Haruhiko Koseki, MD, PhD, Issay Kitabayashi, PhD

Blood (2011) 118 (21): 3998.

https://doi.org/10.1182/blood.V118.21.3998.3998

Published: 2011

Journal Articles

MOZ Is Critical for MOZ/MLL-Fusion-Induced HoxA9/Meis1 Expression and Leukemia Development,

Takuo Katsumoto, PhD, Issay Kitabayashi, PhD

Blood (2011) 118 (21): 3467.

https://doi.org/10.1182/blood.V118.21.3467.3467

Published: 2011

Journal Articles

The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis

Yuta Mishima, Satoru Miyagi, Atsunori Saraya, Masamitsu Negishi, Mitsuhiro Endoh, Takaho A. Endo, Tetsuro Toyoda, Jun Shinga, Takuo Katsumoto, Tetsuhiro Chiba, Naoto Yamaguchi, Issay Kitabayashi, Haruhiko Koseki, Atsushi Iwama

Blood (2011) 118 (9): 2443–2453.

https://doi.org/10.1182/blood-2011-01-331892

Published: 2011

Includes: Supplemental data

Journal Articles

The Hbo1-Brd1/Brpf2 HAT Complex Is Required for Erythropoiesis In Fetal Liver

Yuta Mishima, Satoru Miyagi, Atsunori Saraya, Masamitsu Negishi, Mitsuhiro Endoh, Naoto Yamaguchi, Issay Kitabayashi, Haruhiko Koseki, Atsushi Iwama

Blood (2010) 116 (21): 3872.

https://doi.org/10.1182/blood.V116.21.3872.3872

Published: 2010

Journal Articles

A Critical Role of YB-1 In NPMc-Induced Acute Myeloid Leukemia

Yoko Ogawara, Takuo Katsumoto, Takeshi Uchiumi, Kimitoshi Kohno, Issay Kitabayashi

Blood (2010) 116 (21): 3149.

https://doi.org/10.1182/blood.V116.21.3149.3149

Published: 2010

Journal Articles

PU.1-Mediated Upregulation of M-CSFR Is Critical for MOZ-Leukemia Stem Cell Potential.

Yukiko Aikawa, Takuo Katsumoto, Daniel G. Tenen, MD, Issay Kitabayashi

Blood (2009) 114 (22): 216.

https://doi.org/10.1182/blood.V114.22.216.216

Published: 2009

Journal Articles

Roles of Histone Acetyltransferase MORF and MOZ in Hematopoiesis.

Takuo Katsumoto, Issay Kitabayashi, PhD

Blood (2009) 114 (22): 2525.

https://doi.org/10.1182/blood.V114.22.2525.2525

Published: 2009

Journal Articles

The Roles of MLL Holocomplex in Embryogenesis, Hematopoiesis and Tumor Suppression.

Akihiko Yokoyama, PhD, Francesca Ficara, PhD, Issay Kitabayashi, PhD, Michael L. Cleary, MD

Blood (2009) 114 (22): 2969.

https://doi.org/10.1182/blood.V114.22.2969.2969

Published: 2009

Journal Articles

PML Protects HIPK2 and p300 from SCF-Mediated Ubiquitin-Dependent Degradation To Activate Transcription.

Yutaka Shima, PhD, Takito Shima, Tomoki Chiba, Ph.D., Tatsuro Irimura, Ph.D., Issay Kitabayashi, Ph.D.

Blood (2007) 110 (11): 2653.

https://doi.org/10.1182/blood.V110.11.2653.2653

Published: 2007

Journal Articles

Functional Regulation of TEL through MOZ-Induced Acetylation.

Kazuhiro Maki, MD, Fumihiko Nakamura, M.D., Tetsuya Yamagata, M.D., Issay Kitabayashi, Ph.D., Kinuko Mitani, M.D.

Blood (2007) 110 (11): 2647.

https://doi.org/10.1182/blood.V110.11.2647.2647

Published: 2007

NARROW

Preclinical Evaluation of a Novel Orally Bioavailable Menin-MLL Interaction Inhibitor, DSP-5336, for the Treatment of Acute Leukemia Patients with MLL -Rearrangement or NPM1 Mutation

Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells

Novel Stem Cell-Targeted Therapy for Multiple Myeloma Based on Dual Inhibition of EZH1/2

MLL Is Essential for NUP98-HOXA9-Induced Leukemia

The Role of IDH Mutants, Which Are Promising Therapeutic Targets for Acute Myeloid Leukemia

Novel Leukemia Stem Cell-Targeted Therapy for Acute Myeloid Leukemia Based on Dual Inhibition of Ezh1/Ezh2

Leukemia-Associated MLL-AF10 Fusion Maintains an Active State of Chromatin on Its Target Genes By Recruiting Tip60

FASN Is Critical for Maintenance of NUP98 Fusion-Induced Leukemias

Essential Role of Endogenous MOZ in Aberrant HoxA9 and Meis1 Expressions Induced By MOZ Fusion Gene

Critical Roles Of The IDH2 Mutation In Development and Maintenance Of Acute Myeloid Leukemia

Roles of Ring1A/B on Stem Cell Potential of MOZ and Other Acute Myeloid Leukemias,

MOZ Is Critical for MOZ/MLL-Fusion-Induced HoxA9/Meis1 Expression and Leukemia Development,

The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis

The Hbo1-Brd1/Brpf2 HAT Complex Is Required for Erythropoiesis In Fetal Liver

A Critical Role of YB-1 In NPMc-Induced Acute Myeloid Leukemia

PU.1-Mediated Upregulation of M-CSFR Is Critical for MOZ-Leukemia Stem Cell Potential.

Roles of Histone Acetyltransferase MORF and MOZ in Hematopoiesis.

The Roles of MLL Holocomplex in Embryogenesis, Hematopoiesis and Tumor Suppression.

PML Protects HIPK2 and p300 from SCF-Mediated Ubiquitin-Dependent Degradation To Activate Transcription.

Functional Regulation of TEL through MOZ-Induced Acetylation.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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