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Journal Articles

Transcription Factor Gata2 Regulates the Myeloid-Lymphoid Fate Decision in Multipotent Progenitors

Yuya Tanaka, Hiroki Kato, Sayaka Sano, Daigo Michimata, Kazuki Sakurai, Kazuki Hashimoto, Naoya Morota, Koichi Onodera, Shunsuke Hatta, Noriko Fukuhara, Yasushi Onishi, Tohru Fujiwara, Hideo Harigae

Blood (2024) 144 (Supplement 1): 4037.

https://doi.org/10.1182/blood-2024-207236

Published: 2024

Journal Articles

Pyridoxine: beyond a cofactor of ALAS

Tohru Fujiwara, Hideo Harigae

Blood (2024) 144 (13): 1358–1359.

https://doi.org/10.1182/blood.2024025575

Published: 2024

Journal Articles

Roles for Heme Synthesis in the Maintenance of Hematopoietic Stem and Progenitor Cells

Yan Yan, Hiroki Kato, Sayaka Sano, Eijiro Furukawa, Daigo Michimata, Yuya Tanaka, Kazuki Sakurai, Koichi Onodera, Satoshi Ichikawa, Tohru Fujiwara, Yasushi Onishi, Noriko Fukuhara, Hisayuki Yokoyama, Hideo Harigae

Blood (2023) 142 (Supplement 1): 2682.

https://doi.org/10.1182/blood-2023-174202

Published: 2023

Journal Articles

Hematopoietic Stem/Progenitor Cell Intrinsic SAM Synthesis Is Required to Prevent p53 Pathway Activation By Maintaining DNA Stability

Eijiro Furukawa, Hiroki Kato, Sayaka Sano, Yan Yan, Daigo Michimata, Yuya Tanaka, Kazuki Sakurai, Koichi Onodera, Satoshi Ichikawa, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Daisuke Saigusa, Tohru Fujiwara, Kazuhiko Igarashi, Hideo Harigae

Blood (2023) 142 (Supplement 1): 4049.

https://doi.org/10.1182/blood-2023-180384

Published: 2023

Journal Articles

Transcription Factor GATA2 Is Inevitable for the Survival and Proper Differentiation of Thymic Multipotent Progenitor Cells By Gene Expression Orchestration

Sayaka Sano, Hiroki Kato, Yan Yan, Eijiro Furukawa, Daigo Michimata, Yuya Tanaka, Kazuki Sakurai, Koichi Onodera, Satoshi Ichikawa, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Tohru Fujiwara, Hideo Harigae

Blood (2023) 142 (Supplement 1): 1182.

https://doi.org/10.1182/blood-2023-178454

Published: 2023

Journal Articles

Altered Transcription By GATA1 Impairs Autophagy and Prevents Ferroptosis in X-Linked Sideroblastic Anemia

Koya Ono, Tohru Fujiwara, Hiroki Shima, Hironari Nishizawa, Chie Suzuki, Noriyuki Takahashi, Hiroki Kato, Koichi Onodera, Satoshi Ichikawa, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Yukio Nakamura, Kazuhiko Igarashi, Hideo Harigae

Blood (2022) 140 (Supplement 1): 2467–2468.

https://doi.org/10.1182/blood-2022-163073

Published: 2022

Journal Articles

Inhibition of S-Adenosylmethionine Synthesis Promotes Erythropoiesis Via Epigenetic Modifications

Hiroki Kato, Nguyen Chi Long, Yusho Ishii, Mitsuyo Matsumoto, Catherine Rhee, Daisuke Saigusa, Ryo Funayama, Hiroaki Okae, Tohru Fujiwara, Akihiko Muto, Hideo Harigae, David T. Scadden, Kazuhiko Igarashi

Blood (2021) 138 (Supplement 1): 1991.

https://doi.org/10.1182/blood-2021-147065

Published: 2021

Journal Articles

Proteomic Analysis of Mitochondrial Membrane Protein FAM210B in Erythroid Cells

Chie Suzuki, Tohru Fujiwara, MD PhD, Hiroki Shima, Koya Ono, MD, Kei Saito, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Hisayuki Yokoyama, MD PhD, Shinichi Fujimaki, Yukio Nakamura, MD PhD, Hideo Harigae, MD PhD

Blood (2019) 134 (Supplement_1): 3523.

https://doi.org/10.1182/blood-2019-122618

Published: 2019

Journal Articles

Molecular Characterization and Novel Therapeutic Strategy for X-Linked Sideroblastic Anemia Associated with ALAS2 Missense Variants

Koya Ono, MD, Tohru Fujiwara, MD PhD, Kei Saito, MD PhD, Chie Suzuki, Noriyuki Takahashi, Koichi Onodera, MD PhD, Satoshi Ichikawa, MD PhD, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Hisayuki Yokoyama, MD PhD, Yukio Nakamura, MD PhD, Hideo Harigae, MD PhD

Blood (2019) 134 (Supplement_1): 3530.

https://doi.org/10.1182/blood-2019-124810

Published: 2019

Journal Articles

Characterization of Congenital Sideroblastic Anemia Model Due to ABCB7 Defects: How Do Defects in Iron-Sulfur Cluster Metabolism Lead to Ring Sideroblast Formation?

Tohru Fujiwara, MD PhD, Chie Suzuki, Tetsuro Ochi, Koya Ono, MD, Kei Saito, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Hisayuki Yokoyama, MD PhD, Shinichi Fujimaki, Yukio Nakamura, MD PhD, Hideo Harigae, MD PhD

Blood (2019) 134 (Supplement_1): 2232.

https://doi.org/10.1182/blood-2019-123918

Published: 2019

Journal Articles

Generation and Molecular Characterization of Human Ring Sideroblasts

Kei Saito, Tohru Fujiwara, MD PhD, Shunsuke Hatta, Chie Suzuki, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Yukio Nakamura, MD PhD, Hideo Harigae, MD

Blood (2018) 132 (Supplement 1): 3613.

https://doi.org/10.1182/blood-2018-99-111066

Published: 2018

Journal Articles

Role of GATA2 in the Maintenance of the Bone Marrow Microenvironment

Shin Hasegawa, Tohru Fujiwara, MD PhD, Yoko Okitsu, MD PhD, Hiroki Kato, MD, PhD, Yuki Sato, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Kenichi Ishizawa, Ritsuko Shimizu, MD PhD, Masayuki Yamamoto, MD PhD, Hideo Harigae, MD

Blood (2017) 130 (Supplement 1): 3781.

https://doi.org/10.1182/blood.V130.Suppl_1.3781.3781

Published: 2017

Journal Articles

Establishment and Characterization of in Vitro Model of X-Linked Sideroblastic Anemia

Kei Saito, Tohru Fujiwara, MD PhD, Shunsuke Hatta, MD PhD, Yoko Okitsu, MD PhD, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Yukio Nakamura, MD PhD, Hideo Harigae, MD

Blood (2017) 130 (Supplement 1): 171.

https://doi.org/10.1182/blood.V130.Suppl_1.171.171

Published: 2017

Journal Articles

Generation of Induced Pluripotent Stem Cell-Derived Erythroblasts from a Patient with X-Linked Sideroblastic Anemia

Shunsuke Hatta, MD, PhD, Tohru Fujiwara, MD, PhD, Takako Yamamoto, Mayumi Kamata, MD, Yoshiko Tamai, Yukio Nakamura, MD, PhD, Shin Kawamata, Hideo Harigae, MD PhD

Blood (2016) 128 (22): 76.

https://doi.org/10.1182/blood.V128.22.76.76

Published: 2016

Journal Articles

Transcription Factor Bach1 and Bach2 Operate Erythro-Myeloid Competitive Differentiation By Responding to Environmental Changes

Hiroki Kato, MD, Ari Itoh-Nakadai, PhD, Mitsuyo Matsumoto, PhD, Risa Ebina-Shibuya, MD PhD, Yuki Sato, MD, Masahiro Kobayashi, MD PhD, Akihiko Muto, PhD, Tohru Fujiwara, MD PhD, Hideo Harigae, MD PhD, Kazuhiko Igarashi, MD PhD

Blood (2016) 128 (22): 2649.

https://doi.org/10.1182/blood.V128.22.2649.2649

Published: 2016

Journal Articles

GATA2 regulates dendritic cell differentiation

Koichi Onodera, Tohru Fujiwara, Yasushi Onishi, Ari Itoh-Nakadai, Yoko Okitsu, Noriko Fukuhara, Kenichi Ishizawa, Ritsuko Shimizu, Masayuki Yamamoto, Hideo Harigae

Blood (2016) 128 (4): 508–518.

https://doi.org/10.1182/blood-2016-02-698118

Published: 2016

Includes: Supplemental data

Journal Articles

GATA-2 Regulates Dendritic Cell Differentiation

Koichi Onodera, MD, PhD, Tohru Fujiwara, MD, PhD, Yasushi Onishi, MD, PhD, Ari Itoh-Nakadai, PhD, Yoko Okitsu, MD PhD, Noriko Fukuhara, MD PhD, Kenichi Ishizawa, MD, PhD, Ritsuko Shimizu, MD, PhD, Masayuki Yamamoto, MD, PhD, Hideo Harigae, MD, PhD

Blood (2015) 126 (23): 2382.

https://doi.org/10.1182/blood.V126.23.2382.2382

Published: 2015

Journal Articles

Transcription Factor Bach1 and Bach2 Control Common Myeloid Progenitor Cell Differentiation Under Infectious Stimuli

Hiroki Kato, MD, Ari Itoh-Nakadai, PhD, Risa Ebina-Shibuya, MD, Masahiro Kobayashi, MD PhD, Mitsuyo Matsumoto, PhD, Akihiko Muto, PhD, Tohru Fujiwara, MD PhD, Hideo Harigae, MD PhD, Kazuhiko Igarashi, MD PhD

Blood (2015) 126 (23): 1164.

https://doi.org/10.1182/blood.V126.23.1164.1164

Published: 2015

Journal Articles

Impaired Lysophosphatidic Acid Receptor 3 Signaling in Mesenchymal Stromal Cells Promotes Multiple Myeloma Progression through Cellular Senescence and Transdifferentiation into Tumor-Associated Fibroblasts

Masahiko Kanehira, DVM, PhD, Tohru Fujiwara, MD PhD, Shinji Nakajima, MD PhD, Yoko Okitsu, MD PhD, Yasushi Ohnishi, MD PhD, Noriko Fukuhara, MD PhD, Ryo Ichinohasama, MD PhD, Hideo Harigae, MD PhD

Blood (2015) 126 (23): 1764.

https://doi.org/10.1182/blood.V126.23.1764.1764

Published: 2015

Journal Articles

Impact of TET2 Deficiency on Iron Metabolism in Erythroblasts: A Potential Link to Ring Sideroblast Formation

Kyoko Inokura, MD, Tohru Fujiwara, MD PhD, Yoko Okitsu, MD PhD, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Kenichi Ishizawa, MD PhD, Kazuya Shimoda, MD PhD, Hideo Harigae, MD PhD

Blood (2014) 124 (21): 750.

https://doi.org/10.1182/blood.V124.21.750.750

Published: 2014

NARROW

Transcription Factor Gata2 Regulates the Myeloid-Lymphoid Fate Decision in Multipotent Progenitors

Pyridoxine: beyond a cofactor of ALAS

Roles for Heme Synthesis in the Maintenance of Hematopoietic Stem and Progenitor Cells

Hematopoietic Stem/Progenitor Cell Intrinsic SAM Synthesis Is Required to Prevent p53 Pathway Activation By Maintaining DNA Stability

Transcription Factor GATA2 Is Inevitable for the Survival and Proper Differentiation of Thymic Multipotent Progenitor Cells By Gene Expression Orchestration

Altered Transcription By GATA1 Impairs Autophagy and Prevents Ferroptosis in X-Linked Sideroblastic Anemia

Inhibition of S-Adenosylmethionine Synthesis Promotes Erythropoiesis Via Epigenetic Modifications

Proteomic Analysis of Mitochondrial Membrane Protein FAM210B in Erythroid Cells

Molecular Characterization and Novel Therapeutic Strategy for X-Linked Sideroblastic Anemia Associated with ALAS2 Missense Variants

Characterization of Congenital Sideroblastic Anemia Model Due to ABCB7 Defects: How Do Defects in Iron-Sulfur Cluster Metabolism Lead to Ring Sideroblast Formation?

Generation and Molecular Characterization of Human Ring Sideroblasts

Role of GATA2 in the Maintenance of the Bone Marrow Microenvironment

Establishment and Characterization of in Vitro Model of X-Linked Sideroblastic Anemia

Generation of Induced Pluripotent Stem Cell-Derived Erythroblasts from a Patient with X-Linked Sideroblastic Anemia

Transcription Factor Bach1 and Bach2 Operate Erythro-Myeloid Competitive Differentiation By Responding to Environmental Changes

GATA2 regulates dendritic cell differentiation

GATA-2 Regulates Dendritic Cell Differentiation

Transcription Factor Bach1 and Bach2 Control Common Myeloid Progenitor Cell Differentiation Under Infectious Stimuli

Impaired Lysophosphatidic Acid Receptor 3 Signaling in Mesenchymal Stromal Cells Promotes Multiple Myeloma Progression through Cellular Senescence and Transdifferentiation into Tumor-Associated Fibroblasts

Impact of TET2 Deficiency on Iron Metabolism in Erythroblasts: A Potential Link to Ring Sideroblast Formation

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American Society of Hematology

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ASH Publications

American Society of Hematology

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