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Journal Articles

Evaluating Efficacy and Safety of Rapid-Manufactured CD5KO CART5 Cells in Preclinical Models of T Cell Malignancies

Ruchi P. Patel, Trang Vu, Dean Qian, Yunlin Zhang, Guido Ghilardi, Steven Yang, Stefan K. Barta, Nicholas A. Siciliano, Adam E. Snook, Marco Ruella
Journal: Blood
Blood (2024) 144 (Supplement 1): 4848.
https://doi.org/10.1182/blood-2024-210255
Published: 2024
Journal Articles

CD5-Deleted Chimeric Antigen Receptor Cells (Senza5™ CART5) to Enhance Immunotherapy Against T-Cell Non-Hodgkin Lymphoma: A First-in-Human Phase I Clinical Trial

Stefan K. Barta, Marco Ruella, Stephen J. Schuster, Jakub Svoboda, Jordan Carter, Elise A. Chong, Daniel J. Landsburg, Sunita D. Nasta, Colin Thomas, Ruchi P. Patel, Guido Ghilardi, Patrizia Porazzi, Steven Yang, Dean Qian, Raymone Pajarillo, Yunlin Zhang, Aditya Nimmagadda, Trang Vu, Lavanya Peddada, Adam E. Snook, Nicholas A. Siciliano, Rosemary Mazanet
Journal: Blood
Blood (2024) 144 (Supplement 1): 7221.
https://doi.org/10.1182/blood-2024-201063
Published: 2024
Journal Articles

CD5 Elimination Enhances CART Cell Proliferation through JAK-STAT Activation

Trang Vu, Ruchi P. Patel, Steven Yang, Dean Qian, Stefan K. Barta, Nicholas A. Siciliano, Marco Ruella, Adam E. Snook
Journal: Blood
Blood (2024) 144 (Supplement 1): 500.
https://doi.org/10.1182/blood-2024-203590
Published: 2024
Journal Articles

Senza5 TM CART5 : An Autologous CD5-Deleted Anti-CD5 CART Product with Enhanced Anti-T-Cell Lymphoma Activity

Adam E. Snook, Ruchi P. Patel, Guido Ghilardi, Aditya Nimmagadda, Steven Yang, Dean Qian, Patrizia Porazzi, Rosemary Mazanet, Stephen J Schuster, Stefan K. Barta, Trang Vu, Marco Ruella, Nicholas A. Siciliano
Journal: Blood
Blood (2023) 142 (Supplement 1): 3462.
https://doi.org/10.1182/blood-2023-190386
Published: 2023
Journal Articles

Clinical Development of Senza5 TM CART5: a Novel Dual Population CD5 CRISPR-Cas9 Knocked out Anti-CD5 Chimeric Antigen Receptor T Cell Product for Relapsed and Refractory CD5+ Nodal T-Cell Lymphomas

Ruchi P. Patel, Guido Ghilardi, Patrizia Porazzi, Steven Yang, Dean Qian, Raymone Pajarillo, Michael Wang, Yunlin Zhang, Stephen J. Schuster, Stefan K. Barta, Aditya Nimmagadda, Adam Snook, Nicholas A. Siciliano, Marco Ruella
Journal: Blood
Blood (2022) 140 (Supplement 1): 1604–1605.
https://doi.org/10.1182/blood-2022-166605
Published: 2022