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Raymone Pajarillo
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Journal Articles

CD5-Deleted Chimeric Antigen Receptor Cells (Senza5™ CART5) to Enhance Immunotherapy Against T-Cell Non-Hodgkin Lymphoma: A First-in-Human Phase I Clinical Trial

Stefan K. Barta, Marco Ruella, Stephen J. Schuster, Jakub Svoboda, Jordan Carter, Elise A. Chong, Daniel J. Landsburg, Sunita D. Nasta, Colin Thomas, Ruchi P. Patel, Guido Ghilardi, Patrizia Porazzi, Steven Yang, Dean Qian, Raymone Pajarillo, Yunlin Zhang, Aditya Nimmagadda, Trang Vu, Lavanya Peddada, Adam E. Snook, Nicholas A. Siciliano, Rosemary Mazanet
Journal: Blood
Blood (2024) 144 (Supplement 1): 7221.
https://doi.org/10.1182/blood-2024-201063
Published: 2024
Journal Articles

Efficacy and Safety of Anti-CD19 and Anti-BCMA Chimeric Antigen Receptor (CAR) T-Cell Therapies in Patients with Autoimmune Disease and Lymphoma or Myeloma

Luca Paruzzo, Riemke Bouvier, Guido Ghilardi, Eugenio Fardella, Bria Fulmer, Ivan J Cohen, Elise A. Chong, Jakub Svoboda, Sunita D. Nasta, Daniel J. Landsburg, Vrutti Patel, Li Ziyu, Raymone Pajarillo, Adam Waxman, Adam D. Cohen, Dan T. Vogl, Stefan K. Barta, Patrizia Porazzi, Joseph A. Fraietta, Vijay Bhoj, Alfred L. Garfall, Edward A. Stadtmauer, Stephen J. Schuster, Jordan S. Carter, Sokratis A. Apostolidis, Sandra Susanibar-Adaniya, Marco Ruella
Journal: Blood
Blood (2024) 144 (Supplement 1): 7243.
https://doi.org/10.1182/blood-2024-206608
Published: 2024
Journal Articles

Overcoming the Lack of CD2:CD58 Costimulation in Chimeric Antigen Receptor T-Cell Immunotherapies

Alberto Carturan, Mathew G. Angelos, Raymone Pajarillo, Jesse Rodriguez, Jaryse Harris, Yunlin Zhang, Ekta Singh, Andrew Lee, Ositadimma Ugwuanyi, Ruchi P. Patel, Puneeth Guruprasad, Jean Lemoine, Jong Hyun Cho, Patrizia Porazzi, Stephen J. Schuster, Marco Ruella
Journal: Blood
Blood (2024) 144 (Supplement 1): 504.
https://doi.org/10.1182/blood-2024-206061
Published: 2024
Journal Articles

Ketogenic Diet Enhances CAR T Cell Antitumor Function Via β-Hydroxybutyrate

Shan Liu, Puneeth Guruprasad, Kecheng Han, Luca Paruzzo, Alexander Shestov, Andre Kelly, Kevin R. Amses, Amichay Afriat, Bhoomi Madhu, Lev Litichevskiy, Ezra Dubowitz, Neil Tangal, Alana McSween, Melody Tan, Alberto Carturan, Andrew Lee, Yunlin Zhang, Giulia Gabrielli, Raymone Pajarillo, Ruchi P. Patel, Guido Ghilardi, Patrizia Porazzi, Stephen J. Schuster, Roddy S. O'Connor, Michael C. Milone, Joshua Rabinowitz, Maayan Levy, Marco Ruella
Journal: Blood
Blood (2024) 144 (Supplement 1): 4.
https://doi.org/10.1182/blood-2024-208913
Published: 2024
Journal Articles

Exploiting the CD200-CD200R immune checkpoint axis in multiple myeloma to enhance CAR T-cell therapy

Yan Tang, Wei Liu, Siddhant Kadu, Omar Johnson, Zainul S. Hasanali, Andre Kelly, Alexander Shestov, Raymone Pajarillo, Eli Greenblatt, Matthew Holmes, Li-Ping Wang, Natalie Shih, Roddy S. O’Connor, Marco Ruella, Alfred L. Garfall, David Allman, Dan T. Vogl, Adam Cohen, Carl H. June, Neil C. Sheppard
Journal: Blood
Blood (2024) 143 (2): 139–151.
https://doi.org/10.1182/blood.2022018658
Published: 2024
Includes: Supplemental data
Journal Articles

A First-in-Human Phase I Study of AT101, a Novel Anti-CD19 Chimeric Antigen Receptor T Cell Product Targeting a Membrane-Proximal Domain of CD19 in Adults with Relapsed or Refractory B Cell Non-Hodgkin Lymphoma

Yunlin Zhang, Ruchi P. Patel, Ki Hyun Kim, Hyungwoo Cho, Jae-Cheol Cho, Seong Hyun Jeong, Sung Yong Oh, Yoon Seok Choi, Sung-Hyun Kim, Ji Hyun Lee, Mathew G. Angelos, Puneeth Guruprasad, Ivan J Cohen, Ositadimma Ugwuanyi, Yong Gu Lee, Raymone Pajarillo, Jong Hyun Cho, Alberto Carturan, Luca Paruzzo, Guido Ghilardi, Soohwan Kim, Sung Min Kim, Hyun Jong Lee, Ji Ho Park, Lei Guang Cui, Tae Bum Lee, Insik Hwang, Youngha Lee, Yong-Jun Lee, Patrizia Porazzi, Dongfang Liu, Yoon Lee, Jong Hoon Kim, Jong Seo Lee, Dok Hyun Yoon, Junho Chung, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 2096.
https://doi.org/10.1182/blood-2023-189369
Published: 2023
Journal Articles

Fratricide-Resistant Anti-CD2 Chimeric Antigen Receptor T-Cells with Endogenous CD2 Knockout Are Highly Effective Against T-Cell Neoplasms

Mathew G. Angelos, Ruchi P. Patel, Yi-Hao Chiang, Wei Xie, Raymone Pajarillo, Carolyn E. Shaw, Ekta Singh, Jason Xu, Avery D. Posey, Alain Rook, Antonia Rotolo, Vinodh Pillai, Stefano A. Pileri, David T. Teachey, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 885.
https://doi.org/10.1182/blood-2023-181282
Published: 2023
Journal Articles

Disinhibition of T Cell Activation Via CD5 Knockout Is a Universal Strategy to Enhance Adoptive T Cell Immunotherapies

Ruchi P. Patel, Guido Ghilardi, Yunlin Zhang, Puneeth Guruprasad, Mathew G. Angelos, Raymone Pajarillo, Khatuna Gabunia, Chong Xu, Tatiana Blanchard, John Scholler, Patrizia Porazzi, Gerald Linette, Beatriz M. Carreno, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 102.
https://doi.org/10.1182/blood-2023-186611
Published: 2023
Journal Articles

Bendamustine Is Less Toxic Than Fludarabine-Cyclophosphamide-Based Lymphodepletion before CD28-Costimulated CART19 through Reduced Inflammatory Cytokines

Guido Ghilardi, Luca Paruzzo, Jakub Svoboda, Elise A. Chong, Alexander Shestov, Linhui Chen, Ivan J Cohen, Giulia Gabrielli, Dwivedy S. Nasta, Patrizia Porazzi, Daniel J. Landsburg, James Gerson, Jordan Carter, Stefan K. Barta, Rebecca Yelton, Raymone Pajarillo, Griffin W White, Hatcher Ballard, Elizabeth Weber, Ellen B. Napier, Emeline R. Chong, Joseph A Fraietta, Alfred L. Garfall, David L. Porter, Michael C. Milone, Roderick O'Connor, Stephen J. Schuster, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 4483.
https://doi.org/10.1182/blood-2023-182234
Published: 2023
Journal Articles

Modulation of the Btla-HVEM Axis to Enhance CAR T Cell Immunotherapy Against Cancer

Puneeth Guruprasad, Alberto Carturan, Yunlin Zhang, Kingsley Gideon Kumashie, Ivan J Cohen, Guido Ghilardi, Ki-Hyun Kim, Jong-Seo Lee, Yoon Lee, Jong-Hoon Kim, Junho Chung, Maksim Shestov, Raymone Pajarillo, Jaryse Harris, Yong Gu Lee, Michael Wang, Hatcher Ballard, Aasha Gupta, Ositadimma Ugwuanyi, Seok Jae Hong, Linhui Chen, Luca Paruzzo, Shane Kammerman, Ruchi P. Patel, Olga Shestova, Laura Vella, Stephen J. Schuster, Jakub Svoboda, Patrizia Porazzi, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 768.
https://doi.org/10.1182/blood-2023-189633
Published: 2023
Journal Articles

Access and Outcomes of Minority Health Populations Receiving Commercial Anti-CD19 CART Therapy for Non-Hodgkin Lymphoma

Guido Ghilardi, Staci Williamson, Raymone Pajarillo, Luca Paruzzo, Linhui Chen, Connor Grady, Abigail Doucette, Eneida R Nemecek, Giulia Gabrielli, Stefan K. Barta, Jakub Svoboda, Elise A. Chong, Rebecca Yelton, Dwivedy S. Nasta, Daniel J. Landsburg, Ositadimma Ugwuanyi, Andy Chen, Levanto Schachter, Griffin W White, Hatcher Ballard, Elizabeth Weber, Cara Curley, David L. Porter, Alfred L. Garfall, Wei-Ting Hwang, Carmen E Guerra, Richard T Maziarz, Stephen J Schuster, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 2416.
https://doi.org/10.1182/blood-2023-187524
Published: 2023
Journal Articles

Precision Targeting of the Malignant Clone in Diffuse Large B Cell Lymphoma Using Chimeric Antigen Receptor T Cells Against the Clonotypic IGHV4-34 B Cell Receptor

Ivan J Cohen, Audrey C Bochi-Layec, Ki Hyun Kim, Scott Jenks, Ositadimma Ugwuanyi, Guido Ghilardi, Giulia Gabrielli, Jaryse Harris, Li-Ping Wang, Yunlin Zhang, Raymone Pajarillo, Elisavet Vlachonikola, Patrizia Porazzi, Ignacio Sanz, Paolo Ghia, Kostas Stamatopoulos, Stephen J Schuster, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 1020.
https://doi.org/10.1182/blood-2023-187618
Published: 2023
Journal Articles

Clinical Development of Senza5 TM CART5: a Novel Dual Population CD5 CRISPR-Cas9 Knocked out Anti-CD5 Chimeric Antigen Receptor T Cell Product for Relapsed and Refractory CD5+ Nodal T-Cell Lymphomas

Ruchi P. Patel, Guido Ghilardi, Patrizia Porazzi, Steven Yang, Dean Qian, Raymone Pajarillo, Michael Wang, Yunlin Zhang, Stephen J. Schuster, Stefan K. Barta, Aditya Nimmagadda, Adam Snook, Nicholas A. Siciliano, Marco Ruella
Journal: Blood
Blood (2022) 140 (Supplement 1): 1604–1605.
https://doi.org/10.1182/blood-2022-166605
Published: 2022
Journal Articles

Overcoming CD19-Negative Relapses in Patients with B-Cell Lymphomas Treated with Tisagenlecleucel

Guido Ghilardi, Yong Gu Lee, Patrizia Porazzi, Ivan Cohen, Luca Paruzzo, Ositadimma H Ugwuanyi, Raymone Pajarillo, Yunlin Zhang, Puneeth Guruprasad, Ruchi P. Patel, Elise A. Chong, Sunita Dwivedy Nasta, Stefan K. Barta, Alfred L. Garfall, Daniel J. Landsburg, Sam Sadigh, Mariusz Wasik, Jakub Svoboda, Siddharth Bhattacharyya, Stephen J. Schuster, Marco Ruella
Journal: Blood
Blood (2022) 140 (Supplement 1): 7371–7373.
https://doi.org/10.1182/blood-2022-167601
Published: 2022
Journal Articles

Gut Microbiota Tuning Promotes Tumor-Associated Antigen Cross Presentation and Enhances CAR T Antitumor Effects

Marco Ruella, Mireia Uribe-Herranz, Silvia Beghi, Kalpana Parvathaneni, Nektarios Kostopoulos, Guido Ghilardi, Kimberly Amelsberg, Yong Gu Gu Lee, Raymone Pajarillo, Noelle V Frey, Simon F Lacey, Khatuna Gabunia, John Scholler, Elise A Chong, Carl H June, David L. Porter, Stephen J. Schuster, Vijay Bhoj, Andrea Facciabene
Journal: Blood
Blood (2021) 138 (Supplement 1): 163.
https://doi.org/10.1182/blood-2021-151093
Published: 2021
Journal Articles

Bendamustine Is a Safe and Effective Regimen for Lymphodepletion before Tisagenlecleucel in Patients with Large B-Cell Lymphomas

Guido Ghilardi, Elise A Chong, Jakub Svoboda, Philipp Wohlfarth, Sunita Dwivedy Nasta, Staci Williamson, Daniel J Landsburg, James N Gerson, Stefan K. Barta, Raymone Pajarillo, Jessie Myers, Rebecca Yelton, Hatcher J. Ballard, Shannon H Gier, Danielle Victoriano, Elizabeth Weber, Ellen Napier, Simon F Lacey, Alfred L. Garfall, David L Porter, Ulrich Jaeger, Richard T. Maziarz, Marco Ruella, Stephen J Schuster
Journal: Blood
Blood (2021) 138 (Supplement 1): 1438.
https://doi.org/10.1182/blood-2021-151766
Published: 2021
Journal Articles

The Intestinal Microbiota Correlates with Response and Toxicity after CAR T Cell Therapy in Patients with B-Cell Malignancies

Melody Smith, Anqi Dai, Guido Ghilardi, Kimberly Amelsberg, Sean M Devlin, Raymone Pajarillo, John B Slingerland, Silvia Beghi, Pamela S Herrera, Paul A Giardina, Annelie Clurman, Emmanuel A Dwomoh, Gabriel K Armijo, Antonio L.C. Gomes, Eric R Littmann, Jonas Schluter, Emily Fontana, Ying Taur, Jae H Park, Maria Lia Palomba, Elizabeth Halton, Josel D Ruiz, Tania Jain, Martina Pennisi, Aishat Olaide Afuye, Miguel-Angel Perales, Craig W. Freyer, Alfred L Garfall, Shannon H Gier, Sunita Nasta, Daniel J Landsburg, James N Gerson, Jakub Svoboda, Justin Cross, Elise A Chong, Sergio A Giralt, Saar Gill, Isabelle Rivière, David L Porter, Stephen J Schuster, Michel Sadelain, Noelle V Frey, Renier J Brentjens, Carl H June, Eric G Pamer, Jonathan U Peled, Marco Ruella, Marcel van den Brink, Andrea Facciabene
Journal: Blood
Blood (2021) 138 (Supplement 1): 253.
https://doi.org/10.1182/blood-2021-153945
Published: 2021
Journal Articles

CRISPR-Cas9 Knock out of CD5 Enhances the Anti-Tumor Activity of Chimeric Antigen Receptor T Cells

Inkook Chun, MS, Ki Hyun Kim, PhD, Yi-Hao Chiang, MD, Wei Xie, MD, Yong Gu Gu Lee, PhD, Raymone Pajarillo, MS, Antonia Rotolo, MD PhD, Olga Shestova, PhD, Seok Jae Hong, MS, Mohamed Abdel-Mohsen, PhD, Maria Wysocka, PhD, Hatcher J. Ballard, BS, David M. Barrett, Avery D. Posey, PhD, Daniel Powell, Jr., PhD, Saar I. Gill, MDPhD, Stephen J. Schuster, MD, Stefan K. Barta, MDMRCP,MS, Alain H Rook, MD, Carl H June, MD, Marco Ruella, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 51–52.
https://doi.org/10.1182/blood-2020-136860
Published: 2020