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Journal Articles

Harnessing the CD2 axis to broaden and enhance the efficacy of CAR T-cell therapies

Available to Purchase
Alberto Carturan, Mathew G. Angelos, Puneeth Guruprasad, Ruchi P Patel, Raymone Pajarillo, Andrew Evan Lee, David Espie, Yunlin Zhang, Yi-Hao Chiang, Wei Xie, Jesse L Rodriguez, Jaryse Harris, Pooja Devi, Olabisi I. Afolayan-Oloye, Jason Xu, Jonathan H. Sussman, Omar Elghawy, Austin G Yang, Adam Barsouk, Jong Hyun Cho, Carolyn E Shaw, Ekta Brijesh Singh, Ositadimma Ugwuanyi, Luca Paruzzo, Federico Stella, MD, Shan Liu, Siena Nason, Antonio Imparato, Antonia Rotolo, Jean Lemoine, David M Barrett, Avery D Posey, Jr., Alain H Rook, Vinodh Pillai, Adam Bagg, Stefano Aldo Pileri, Dongfang Liu, Kai Tan, Stephen J. Schuster, David Trent Teachey, Patrizia Porazzi, Marco Ruella
Journal: Blood
Blood blood.2025031409.
https://doi.org/10.1182/blood.2025031409
Published: 2026
Includes: Supplemental data
Journal Articles

A newly identified role for IL-5 in regulating CART-associated toxicity and efficacy

Free
Alberto Carturan, Carli Stewart, Andrew Lee, Sophia Goldberg, Luca Paruzzo, Grace DeFranco, Raymone Pajarillo, Brooke Kimball, Puneeth Guruprasad, Elizabeth Siegler, Yunlin Zhang, Ruchi Patel, Federico Stella, Melody Tan, Shan Liu, Siena Nason, Patrizia Porazzi, Stephen J. Schuster, Marco Ruella, Saad Kenderian
Journal: Blood
Blood (2025) 146 (Supplement 1): 808.
https://doi.org/10.1182/blood-2025-808
Published: 2025
Journal Articles

Epigenetic reprogramming via EZH1/2 inhibition enhances T cell-mediated immunotherapies against multiple myeloma

Free
Patrizia Porazzi, Martina Pucillo, Anushka Anant Padmanabhan, Siena Nason, Zhixuan Zheng, Luca Paruzzo, Matthew Ho, Peter Michener, Federico Stella, Antonio Imparato, Sandra Susanibar-Adaniya, Alfred Garfall, Joseph Fraietta, Marco Ruella
Journal: Blood
Blood (2025) 146 (Supplement 1): 2160.
https://doi.org/10.1182/blood-2025-2160
Published: 2025
Journal Articles

EZH1/2 Inhibition Improves the Anti-Tumor Efficacy of CAR and TCR T-Cell Based Therapies Against Multiple Liquid and Solid Tumors

Free
Siena Nason, Ziqi Yang, Guido Ghilardi, Luca Paruzzo, Alberto Carturan, Eugenio Fardella, Puneeth Guruprasad, Anushka Anant Padmanabhan, Tatiana Blanchard, Gerald Linette, Beatriz M. Carreno, Sandra Susanibar-Adaniya, Alfred L. Garfall, Marco Ruella, Patrizia Porazzi
Journal: Blood
Blood (2024) 144 (Supplement 1): 4792.
https://doi.org/10.1182/blood-2024-206011
Published: 2024
Journal Articles

Inhibition of EZH2 Improves CART19 Immunotherapy By Reprogramming Lymphoma Tumor Cells and Enhancing T-Cell Functionality

Free
Patrizia Porazzi, Yusuke Isshiki, Guido Ghilardi, Siena Nason, Ziqi Yang, Alberto Carturan, Linhui Chen, Yunlin Zhang, Ruchi P. Patel, Puneeth Guruprasad, Ositadimma Ugwuanyi, Ivan J Cohen, Stephen J Schuster, Ari M Melnick, Wendy Béguelin, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 1018.
https://doi.org/10.1182/blood-2023-182440
Published: 2023