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Puneeth Guruprasad
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Journal Articles

Overcoming the Lack of CD2:CD58 Costimulation in Chimeric Antigen Receptor T-Cell Immunotherapies

Alberto Carturan, Mathew G. Angelos, Raymone Pajarillo, Jesse Rodriguez, Jaryse Harris, Yunlin Zhang, Ekta Singh, Andrew Lee, Ositadimma Ugwuanyi, Ruchi P. Patel, Puneeth Guruprasad, Jean Lemoine, Jong Hyun Cho, Patrizia Porazzi, Stephen J. Schuster, Marco Ruella
Journal: Blood
Blood (2024) 144 (Supplement 1): 504.
https://doi.org/10.1182/blood-2024-206061
Published: 2024
Journal Articles

Ketogenic Diet Enhances CAR T Cell Antitumor Function Via β-Hydroxybutyrate

Shan Liu, Puneeth Guruprasad, Kecheng Han, Luca Paruzzo, Alexander Shestov, Andre Kelly, Kevin R. Amses, Amichay Afriat, Bhoomi Madhu, Lev Litichevskiy, Ezra Dubowitz, Neil Tangal, Alana McSween, Melody Tan, Alberto Carturan, Andrew Lee, Yunlin Zhang, Giulia Gabrielli, Raymone Pajarillo, Ruchi P. Patel, Guido Ghilardi, Patrizia Porazzi, Stephen J. Schuster, Roddy S. O'Connor, Michael C. Milone, Joshua Rabinowitz, Maayan Levy, Marco Ruella
Journal: Blood
Blood (2024) 144 (Supplement 1): 4.
https://doi.org/10.1182/blood-2024-208913
Published: 2024
Journal Articles

EZH1/2 Inhibition Improves the Anti-Tumor Efficacy of CAR and TCR T-Cell Based Therapies Against Multiple Liquid and Solid Tumors

Siena Nason, Ziqi Yang, Guido Ghilardi, Luca Paruzzo, Alberto Carturan, Eugenio Fardella, Puneeth Guruprasad, Anushka Anant Padmanabhan, Tatiana Blanchard, Gerald Linette, Beatriz M. Carreno, Sandra Susanibar-Adaniya, Alfred L. Garfall, Marco Ruella, Patrizia Porazzi
Journal: Blood
Blood (2024) 144 (Supplement 1): 4792.
https://doi.org/10.1182/blood-2024-206011
Published: 2024
Journal Articles

A First-in-Human Phase I Study of AT101, a Novel Anti-CD19 Chimeric Antigen Receptor T Cell Product Targeting a Membrane-Proximal Domain of CD19 in Adults with Relapsed or Refractory B Cell Non-Hodgkin Lymphoma

Yunlin Zhang, Ruchi P. Patel, Ki Hyun Kim, Hyungwoo Cho, Jae-Cheol Cho, Seong Hyun Jeong, Sung Yong Oh, Yoon Seok Choi, Sung-Hyun Kim, Ji Hyun Lee, Mathew G. Angelos, Puneeth Guruprasad, Ivan J Cohen, Ositadimma Ugwuanyi, Yong Gu Lee, Raymone Pajarillo, Jong Hyun Cho, Alberto Carturan, Luca Paruzzo, Guido Ghilardi, Soohwan Kim, Sung Min Kim, Hyun Jong Lee, Ji Ho Park, Lei Guang Cui, Tae Bum Lee, Insik Hwang, Youngha Lee, Yong-Jun Lee, Patrizia Porazzi, Dongfang Liu, Yoon Lee, Jong Hoon Kim, Jong Seo Lee, Dok Hyun Yoon, Junho Chung, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 2096.
https://doi.org/10.1182/blood-2023-189369
Published: 2023
Journal Articles

Disinhibition of T Cell Activation Via CD5 Knockout Is a Universal Strategy to Enhance Adoptive T Cell Immunotherapies

Ruchi P. Patel, Guido Ghilardi, Yunlin Zhang, Puneeth Guruprasad, Mathew G. Angelos, Raymone Pajarillo, Khatuna Gabunia, Chong Xu, Tatiana Blanchard, John Scholler, Patrizia Porazzi, Gerald Linette, Beatriz M. Carreno, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 102.
https://doi.org/10.1182/blood-2023-186611
Published: 2023
Journal Articles

Inhibition of EZH2 Improves CART19 Immunotherapy By Reprogramming Lymphoma Tumor Cells and Enhancing T-Cell Functionality

Patrizia Porazzi, Yusuke Isshiki, Guido Ghilardi, Siena Nason, Ziqi Yang, Alberto Carturan, Linhui Chen, Yunlin Zhang, Ruchi P. Patel, Puneeth Guruprasad, Ositadimma Ugwuanyi, Ivan J Cohen, Stephen J Schuster, Ari M Melnick, Wendy Béguelin, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 1018.
https://doi.org/10.1182/blood-2023-182440
Published: 2023
Journal Articles

Modulation of the Btla-HVEM Axis to Enhance CAR T Cell Immunotherapy Against Cancer

Puneeth Guruprasad, Alberto Carturan, Yunlin Zhang, Kingsley Gideon Kumashie, Ivan J Cohen, Guido Ghilardi, Ki-Hyun Kim, Jong-Seo Lee, Yoon Lee, Jong-Hoon Kim, Junho Chung, Maksim Shestov, Raymone Pajarillo, Jaryse Harris, Yong Gu Lee, Michael Wang, Hatcher Ballard, Aasha Gupta, Ositadimma Ugwuanyi, Seok Jae Hong, Linhui Chen, Luca Paruzzo, Shane Kammerman, Ruchi P. Patel, Olga Shestova, Laura Vella, Stephen J. Schuster, Jakub Svoboda, Patrizia Porazzi, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 768.
https://doi.org/10.1182/blood-2023-189633
Published: 2023
Journal Articles

Overcoming CD19-Negative Relapses in Patients with B-Cell Lymphomas Treated with Tisagenlecleucel

Guido Ghilardi, Yong Gu Lee, Patrizia Porazzi, Ivan Cohen, Luca Paruzzo, Ositadimma H Ugwuanyi, Raymone Pajarillo, Yunlin Zhang, Puneeth Guruprasad, Ruchi P. Patel, Elise A. Chong, Sunita Dwivedy Nasta, Stefan K. Barta, Alfred L. Garfall, Daniel J. Landsburg, Sam Sadigh, Mariusz Wasik, Jakub Svoboda, Siddharth Bhattacharyya, Stephen J. Schuster, Marco Ruella
Journal: Blood
Blood (2022) 140 (Supplement 1): 7371–7373.
https://doi.org/10.1182/blood-2022-167601
Published: 2022
Journal Articles

A Novel Anti-CD19 Chimeric Antigen Receptor T Cell Product Targeting a Membrane-Proximal Domain of CD19

Ruchi Patel, Ki-Hyun Kim, Yong Gu Lee, Puneeth Guruprasad, Soohwan Kim, Ji-Hyeon Choi, Sung-Min Kim, Gae-Baik Kim, Jong-Ho Lee, Hyun-Jong Lee, Ji-Ho Park, Guewha Lee, LeiGuang Cui, Min Yoon, Ki Hyun Kim, Soohyun Kim, In-Sik Hwang, Youngha Lee, Jong Seo Lee, Junho Chung, Marco Ruella
Journal: Blood
Blood (2021) 138 (Supplement 1): 2798.
https://doi.org/10.1182/blood-2021-154097
Published: 2021
Journal Articles

Integrated Microfluidic Automated Particle Tracking Enables High-Throughput Cell Deformability Cytometry for Red Cell Disorders

Christina Caruso, MD, Puneeth Guruprasad, Robert G Mannino, PhD, Hanqing Zhang, PhD, Cassandra D Josephson, MD, John D Roback, MD PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1033.
https://doi.org/10.1182/blood-2018-99-118830
Published: 2018