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Erik Thiele Orberg
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Journal Articles

Recovery of the Intestinal Microbiome in Patients at Day +100 after Allogeneic Stem Cell Transplantation Is Defined By Microbial Metabolite Profiles and Linked to Long-Term Outcomes

Alix Schwarz, Tina Eismann, Tingting Zheng, Sophia Goeldel, Mats Urban, Mohsen Pourjam, Klaus Neuhaus, Ilias Lagkouvardos, Daniel Wolff, Peter Herhaus, Mareike Verbeek, Ernst Holler, Wolfgang Herr, Karin Kleigrewe, Simon M Heidegger, Klaus-Peter Janssen, Florian Bassermann, Melanie Schirmer, Hendrik Poeck, Daniela Weber, Erik Thiele Orberg
Journal: Blood
Blood (2024) 144 (Supplement 1): 780.
https://doi.org/10.1182/blood-2024-199035
Published: 2024
Journal Articles

Immunomodulatory Microbial Metabolites Protect Against Graft-Vs-Host Disease and Enhance Anti-Leukemia Responses in Mice and Patients Receiving Stem Cell Transplantation

Sascha Göttert, Erik Thiele-Orberg, Kaiji Fan, Paul Heinrich, Daniel Wolff, Daniela Weber, Florian Bassermann, Petra Hoffmann, Matthias Edinger, Natalie Koehler, André Gessner, Wolfgang Herr, Simon M Heidegger, Ernst Holler, Hendrik Poeck
Journal: Blood
Blood (2024) 144 (Supplement 1): 264.
https://doi.org/10.1182/blood-2024-205921
Published: 2024
Journal Articles

Loss of Microbiota-Derived Metabolites Is Associated with Mucosal-Barrier-Injury Bloodstream Infection in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Sophia Göldel, Tingting Zheng, Tina Eismann, Melanie Tiefgraber, Mats Urban, Alix Schwarz, Klaus Neuhaus, Mohsen Pourjam, Ilias Lagkouvardos, Elisabeth Meedt, Karin Kleigrewe, Julia Frank, Michael Neuenhahn, Dirk H Busch, Peter Herhaus, Mareike Verbeek, Wolfgang Herr, Romana Gerner, Klaus-Peter Janssen, Simon M Heidegger, Florian Bassermann, Hendrik Poeck, Melanie Schirmer, Erik Thiele-Orberg
Journal: Blood
Blood (2024) 144 (Supplement 1): 4904.
https://doi.org/10.1182/blood-2024-193273
Published: 2024
Journal Articles

Bacterial and Bacteriophage Consortia Are Associated with Protective Intestinal Immuno-Modulatory Metabolites in Allogeneic Stem Cell Transplantation Patients

Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Paul Heinrich, Sakhila Ghimire, Oriana Miltiadous, Sarah Lindner, Alix Schwarz, Klaus-Peter Janssen, Peter Herhaus, Mareike Verbeek, Marcel R.M. van den Brink, Daniela Weber, Matthias Edinger, Daniel Wolff, Karin Kleigrewe, Wolfgang Herr, Florian Bassermann, André Gessner, Li Deng, Ernst Holler, Hendrik Poeck
Journal: Blood
Blood (2023) 142 (Supplement 1): 477.
https://doi.org/10.1182/blood-2023-172457
Published: 2023
Journal Articles

Immunomodulatory Microbial Metabolites Identified in Allo-SCT Patients Protect from GvHD By Sting Dependent Modulation of Intestinal Tissue Homeostasis

Sascha Göttert, Erik Thiele-Orberg, Kaiji Fan, Sakhila Ghimire, Paul Heinrich, Wolfgang Herr, Simon Heidegger, Ernst Holler, Hendrik Poeck
Journal: Blood
Blood (2022) 140 (Supplement 1): 7336–7337.
https://doi.org/10.1182/blood-2022-169118
Published: 2022
Journal Articles

IFN-Gamma Is Crucial for the Counterbalance of T Cell-Mediated Injury to the Intestinal Stem Cell Compartment By Regulatory T Cells in Mice and Humans

Sascha Göttert, Julius Clemens Fischer, Gabriel Eisenkolb, Erik Thiele Orberg, Sebastian Jarosch, Ernst Holler, Dirk Busch, Simon Heidegger, Hendrik Poeck
Journal: Blood
Blood (2022) 140 (Supplement 1): 10223–10224.
https://doi.org/10.1182/blood-2022-169303
Published: 2022
Journal Articles

Identification of Bacterial and Viral Consortia for the Production of Intestinal Microbiota-Derived Metabolites Associated with Protection in Allogeneic Stem Cell Transplantation Patients

Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Paul Heinrich, Sakhila Ghimire, Melanie Tiefgraber, Sophia Göldel, Tina Eismann, Alix Schwarz, Sebastian Jarosch, Katja Steiger, Karin Kleigrewe, Julius Clemens Fischer, Klaus-Peter Janssen, Michael Quante, Simon Heidegger, Peter Herhaus, Mareike Verbeek, Jürgen Ruland, Christian Schulz, Daniela Weber, Matthias Edinger, Daniel Wolff, Dirk Busch, Wolfgang Herr, Florian Bassermann, Li Deng, Andre Gessner, Ernst Holler, Hendrik Poeck
Journal: Blood
Blood (2022) 140 (Supplement 1): 7619–7621.
https://doi.org/10.1182/blood-2022-157423
Published: 2022
Journal Articles

IFN-Gamma Producing Regulatory T Cells Counterbalance T Cell-Mediated Injury to the Intestinal Stem Cell Compartment in Mice and Humans

Sascha Göttert, Julius Clemens Fischer, Gabriel Eisenkolb, Erik Thiele Orberg, Dirk Busch, Sebastian Jarosch, Ernst Holler, Thomas Engleitner, Lena Klostermeier, Caroline Walther, Laura Lansink Rotgerink, Sophie Nefzger, Marianne Reiser, Katja Steiger, Roland Rad, Stefanie E. Combs, Florian Bassermann, Simon Heidegger, Hendrik Poeck
Journal: Blood
Blood (2021) 138 (Supplement 1): 89.
https://doi.org/10.1182/blood-2021-152925
Published: 2021
Journal Articles

Microbial-Derived Metabolites Induce Epithelial Recovery Via the Sting Pathway in Mice and Men and Protect from Graft-Versus-Host Disease

Erik Thiele Orberg, Sascha Göttert, Andreas Hiergeist, Elisabeth Meedt, Karin Kleigrewe, Wolfgang Herr, Florian Bassermann, Andre Gessner, Ernst Holler, Simon Heidegger, Hendrik Poeck
Journal: Blood
Blood (2021) 138 (Supplement 1): 87.
https://doi.org/10.1182/blood-2021-147794
Published: 2021
Journal Articles

Longitudinal Analysis of Gut Bacteriome, Mycobiome, Virome and Metabolome in Allogeneic Stem Cell Transplantation Reveals Susceptibility for Acute Graft-Versus-Host Disease

Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Sakhila Ghimire, Melanie Tiefgraber, Tina Eismann, Sophia Göldel, Peter Herhaus, Mareike Verbeek, Florian Bassermann, Michael Quante, Daniela Weber, Matthias Edinger, Daniel Wolff, Wolfgang Herr, Li Deng, André Gessner, Ernst Holler, Hendrik Poeck
Journal: Blood
Blood (2021) 138 (Supplement 1): 332.
https://doi.org/10.1182/blood-2021-153026
Published: 2021
Journal Articles

Type I Interferon Signaling before Hematopoietic Stem Cell Transplantation Lowers Donor T Cell Activation Via Reduced Allogenicity of Recipient Cells

Erik Thiele Orberg, MD PhD, Julius Clemens Fischer, Sascha Göttert, Florian Bassermann, MD PhD, Hendrik Poeck, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4431.
https://doi.org/10.1182/blood-2019-128784
Published: 2019
Journal Articles

Microbial-Derived Metabolites Drive Protective Type-I Interferon Responses in Models of Gut Epithelial Damage and Limit Graft-Versus-Host Disease

Erik Thiele Orberg, MD PhD, Sascha Göttert, Hendrik Poeck, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3207.
https://doi.org/10.1182/blood-2019-125850
Published: 2019