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Ernst Holler
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Journal Articles

Refinement of Day 28 Treatment Response Criteria for Acute GVHD: A Collaboration Study of the JSTCT and MAGIC

Yu Akahoshi, Yoshihiro Inamoto, Nikolaos Spyrou, Hideki Nakasone, Francis A. Ayuk, Hannah Choe, Noriko Doki, Tetsuya Eto, Aaron Etra, Elizabeth O. Hexner, Nobuhiro Hiramoto, William J. Hogan, Ernst Holler, Keisuke Kataoka, Masatsugu Tanaka, Takashi Tanaka, Naoyuki Uchida, Ingrid Vasova, Fumihiko Ishimaru, Takahiro Fukuda, Yi-Bin Chen, Junya Kanda, Ryotaro Nakamura, Yoshiko Atsuta, James L.M. Ferrara, Yoshinobu Kanda, John Levine, Takanori Teshima
Journal: Blood
Blood (2024) 144 (Supplement 1): 384.
https://doi.org/10.1182/blood-2024-203344
Published: 2024
Journal Articles

Serial Clinical and Biomarker Monitoring during Treatment Can Stratify Patients with Low Risk Gvhd

Nikolaos Katsivelos, Nikolaos Spyrou, Daniela Weber, Ingrid Vasova, Francis A. Ayuk, Hannah Choe, William J. Hogan, Zachariah Defilipp, Muna Qayed, Aaron Etra, Karamjeet S Sandhu, Sabrina Kraus, Timothy S. Olson, Elizabeth O. Hexner, Paibel Aguayo-Hiraldo, Ran Reshef, Evelyn Ullrich, Tal Schechter-Finkelstein, Carrie L. Kitko, Chantiya Chanswangphuwana, Pietro Merli, Yu Akahoshi, Janna Baez, Gilbert Eng, Rahnuma Beheshti, Steven Kowalyk, George Morales, Ioannis Evangelos Louloudis, Rachel Young, Ernst Holler, Ryotaro Nakamura, James L.M. Ferrara, John Levine
Journal: Blood
Blood (2024) 144 (Supplement 1): 380.
https://doi.org/10.1182/blood-2024-204010
Published: 2024
Journal Articles

Recovery of the Intestinal Microbiome in Patients at Day +100 after Allogeneic Stem Cell Transplantation Is Defined By Microbial Metabolite Profiles and Linked to Long-Term Outcomes

Alix Schwarz, Tina Eismann, Tingting Zheng, Sophia Goeldel, Mats Urban, Mohsen Pourjam, Klaus Neuhaus, Ilias Lagkouvardos, Daniel Wolff, Peter Herhaus, Mareike Verbeek, Ernst Holler, Wolfgang Herr, Karin Kleigrewe, Simon M Heidegger, Klaus-Peter Janssen, Florian Bassermann, Melanie Schirmer, Hendrik Poeck, Daniela Weber, Erik Thiele Orberg
Journal: Blood
Blood (2024) 144 (Supplement 1): 780.
https://doi.org/10.1182/blood-2024-199035
Published: 2024
Journal Articles

Immunomodulatory Microbial Metabolites Protect Against Graft-Vs-Host Disease and Enhance Anti-Leukemia Responses in Mice and Patients Receiving Stem Cell Transplantation

Sascha Göttert, Erik Thiele-Orberg, Kaiji Fan, Paul Heinrich, Daniel Wolff, Daniela Weber, Florian Bassermann, Petra Hoffmann, Matthias Edinger, Natalie Koehler, André Gessner, Wolfgang Herr, Simon M Heidegger, Ernst Holler, Hendrik Poeck
Journal: Blood
Blood (2024) 144 (Supplement 1): 264.
https://doi.org/10.1182/blood-2024-205921
Published: 2024
Journal Articles

CD47 Upregulation Inhibits Phagocytic Clearance of Alloreactive Donor T Cells after Allo-HCT

Haroon Shaikh, Cindy Flamann, Carina Matos, Hla Ali, Michael AG Kern, Marina Kreutz, Maike Buettner-Herold, Christopher Lischer, Simon Voelkl, Christian Kellner, Katrin Bitterer, Domenica Saul, Ernst Holler, Alma Zernecke, Dimitrios Mougiakakos, Andreas Beilhack, Heiko Bruns
Journal: Blood
Blood (2024) 144 (Supplement 1): 2023.
https://doi.org/10.1182/blood-2024-205870
Published: 2024
Journal Articles

Bacterial and Bacteriophage Consortia Are Associated with Protective Intestinal Immuno-Modulatory Metabolites in Allogeneic Stem Cell Transplantation Patients

Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Paul Heinrich, Sakhila Ghimire, Oriana Miltiadous, Sarah Lindner, Alix Schwarz, Klaus-Peter Janssen, Peter Herhaus, Mareike Verbeek, Marcel R.M. van den Brink, Daniela Weber, Matthias Edinger, Daniel Wolff, Karin Kleigrewe, Wolfgang Herr, Florian Bassermann, André Gessner, Li Deng, Ernst Holler, Hendrik Poeck
Journal: Blood
Blood (2023) 142 (Supplement 1): 477.
https://doi.org/10.1182/blood-2023-172457
Published: 2023
Journal Articles

A Multicentre, Randomized, Double-Blinded, Phase 2b Study Evaluating the Efficacy and Safety of MaaT033, an Oral, Pooled Microbiome Ecosystem Therapy in Patients Undergoing Allogenic Hematopoietic Cell Transplantation to Improve Overall Survival: The Phoebus Trial

Florent Malard, Myriam Labopin, Ernst Holler, Joël Doré, Emilie Plantamura, Mohamad Mohty
Journal: Blood
Blood (2023) 142 (Supplement 1): 4947.
https://doi.org/10.1182/blood-2023-185639
Published: 2023
Journal Articles

A Day 14 Endpoint for Acute Gvhd Clinical Trials

Nikolaos Spyrou, Yu Akahoshi, Steven Kowalyk, George Morales, Rahnuma Beheshti, Paibel Aguayo-Hiraldo, MHD Monzr Al Malki, Francis Ayuketang Ayuk, Peter Bader, Janna Baez, Alexandra Capellini, Hannah Choe, Zachariah Defilipp, Matthias Eder, Gilbert Eng, Aaron Etra, Sigrun Gleich, Stephan Grupp, Elizabeth Hexner, Matthias Hoepting, William J. Hogan, Stelios Kasikis, Nikolaos Katsivelos, Carrie L. Kitko, Sabrina Kraus, Deukwoo Kwon, Pietro Merli, Joseph Portelli, Muna Qayed, Ran Reshef, Tal Schechter-Finkelstein, Ingrid Vasova, Matthias Woelfl, Kitsada Wudhikarn, Rachel Young, Ernst Holler, Yi-Bin Chen, Ryotaro Nakamura, John Levine, James L.M. Ferrara
Journal: Blood
Blood (2023) 142 (Supplement 1): 779.
https://doi.org/10.1182/blood-2023-172955
Published: 2023
Journal Articles

Harnessing the Expression of TNFR2 on Tregs to Prevent Agvhd

Juan Gamboa Vargas, Carla Kanzler, Lukas Scheller, Jennifer Kreckel, Haroon Shaikh, Isabell Lang, Juliane Medler, Mohamed Anany, Tim Steinfatt, Julia Hartweg, Stefanie Haack, Ernst Holler, Maike Büttner-Herold, Paula Tabares Gaviria, Harald Wajant, Andreas Beilhack, Hermann Einsele
Journal: Blood
Blood (2022) 140 (Supplement 1): 4465–4466.
https://doi.org/10.1182/blood-2022-168592
Published: 2022
Journal Articles

Immunomodulatory Microbial Metabolites Identified in Allo-SCT Patients Protect from GvHD By Sting Dependent Modulation of Intestinal Tissue Homeostasis

Sascha Göttert, Erik Thiele-Orberg, Kaiji Fan, Sakhila Ghimire, Paul Heinrich, Wolfgang Herr, Simon Heidegger, Ernst Holler, Hendrik Poeck
Journal: Blood
Blood (2022) 140 (Supplement 1): 7336–7337.
https://doi.org/10.1182/blood-2022-169118
Published: 2022
Journal Articles

Inhibition of the Receptor Interactive Protein Kinase 1 (RIP1) Pathway Prevents Acute Gvhd

James L.M. Ferrara, Mariano Prado Acosta, Seihwan Jeong, John E. Levine, Ernst Holler, Joshua Webster, George Morales, Domagoj Vucic
Journal: Blood
Blood (2022) 140 (Supplement 1): 7330–7331.
https://doi.org/10.1182/blood-2022-163730
Published: 2022
Journal Articles

IFN-Gamma Is Crucial for the Counterbalance of T Cell-Mediated Injury to the Intestinal Stem Cell Compartment By Regulatory T Cells in Mice and Humans

Sascha Göttert, Julius Clemens Fischer, Gabriel Eisenkolb, Erik Thiele Orberg, Sebastian Jarosch, Ernst Holler, Dirk Busch, Simon Heidegger, Hendrik Poeck
Journal: Blood
Blood (2022) 140 (Supplement 1): 10223–10224.
https://doi.org/10.1182/blood-2022-169303
Published: 2022
Journal Articles

Identification of Bacterial and Viral Consortia for the Production of Intestinal Microbiota-Derived Metabolites Associated with Protection in Allogeneic Stem Cell Transplantation Patients

Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Paul Heinrich, Sakhila Ghimire, Melanie Tiefgraber, Sophia Göldel, Tina Eismann, Alix Schwarz, Sebastian Jarosch, Katja Steiger, Karin Kleigrewe, Julius Clemens Fischer, Klaus-Peter Janssen, Michael Quante, Simon Heidegger, Peter Herhaus, Mareike Verbeek, Jürgen Ruland, Christian Schulz, Daniela Weber, Matthias Edinger, Daniel Wolff, Dirk Busch, Wolfgang Herr, Florian Bassermann, Li Deng, Andre Gessner, Ernst Holler, Hendrik Poeck
Journal: Blood
Blood (2022) 140 (Supplement 1): 7619–7621.
https://doi.org/10.1182/blood-2022-157423
Published: 2022
Journal Articles

IFN-Gamma Producing Regulatory T Cells Counterbalance T Cell-Mediated Injury to the Intestinal Stem Cell Compartment in Mice and Humans

Sascha Göttert, Julius Clemens Fischer, Gabriel Eisenkolb, Erik Thiele Orberg, Dirk Busch, Sebastian Jarosch, Ernst Holler, Thomas Engleitner, Lena Klostermeier, Caroline Walther, Laura Lansink Rotgerink, Sophie Nefzger, Marianne Reiser, Katja Steiger, Roland Rad, Stefanie E. Combs, Florian Bassermann, Simon Heidegger, Hendrik Poeck
Journal: Blood
Blood (2021) 138 (Supplement 1): 89.
https://doi.org/10.1182/blood-2021-152925
Published: 2021
Journal Articles

Microbial-Derived Metabolites Induce Epithelial Recovery Via the Sting Pathway in Mice and Men and Protect from Graft-Versus-Host Disease

Erik Thiele Orberg, Sascha Göttert, Andreas Hiergeist, Elisabeth Meedt, Karin Kleigrewe, Wolfgang Herr, Florian Bassermann, Andre Gessner, Ernst Holler, Simon Heidegger, Hendrik Poeck
Journal: Blood
Blood (2021) 138 (Supplement 1): 87.
https://doi.org/10.1182/blood-2021-147794
Published: 2021
Journal Articles

Pooled Allogenic Fecal Microbiotherapy MaaT013 for the Treatment of Steroid-Refractory Gastrointestinal Acute Graft-Versus-Host Disease: Results from the Phase IIa Heracles Study and Expanded Access Program

Florent Malard, Michael Loschi, Thomas Cluzeau, Anne Huynh, Sarah Guenounou, Cecile Borel, Faezeh Legrand, Angela Granata, Raynier Devillier, Valerio Maisano, Leonardo Magro, Corentin Orvain, Amandine Charbonnier, Marta Panz-Klapuch, Miroslaw Markiewicz, Deborah Desmier, Niels Moya, Jean-Baptiste Mear, Faustine Lhomme, Caroline Le Jeune, Jérôme Cornillon, Christine Robin, Ernst Holler, Etienne Daguindau, Karin Bilger, Maria Vehreschild, Amandine Le Bourgeois, Patrice Chevallier, Hélène Labussière-Wallet, Delphine Martineau, Marie-Anne Couturier, Claude-Eric Bulabois, Helene Lanic, Vincent Camus, Sylvain Chantepie, Patrice Ceballos, Cyrielle Gasc, Emilie Plantamura, Mohamad Mohty
Journal: Blood
Blood (2021) 138 (Supplement 1): 262.
https://doi.org/10.1182/blood-2021-147709
Published: 2021
Journal Articles

Longitudinal Analysis of Gut Bacteriome, Mycobiome, Virome and Metabolome in Allogeneic Stem Cell Transplantation Reveals Susceptibility for Acute Graft-Versus-Host Disease

Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Sakhila Ghimire, Melanie Tiefgraber, Tina Eismann, Sophia Göldel, Peter Herhaus, Mareike Verbeek, Florian Bassermann, Michael Quante, Daniela Weber, Matthias Edinger, Daniel Wolff, Wolfgang Herr, Li Deng, André Gessner, Ernst Holler, Hendrik Poeck
Journal: Blood
Blood (2021) 138 (Supplement 1): 332.
https://doi.org/10.1182/blood-2021-153026
Published: 2021
Journal Articles

Refractory acute graft-versus-host disease: a new working definition beyond corticosteroid refractoriness

Mohamad Mohty, Ernst Holler, Madan Jagasia, Robert Jenq, Florent Malard, Paul Martin, Gérard Socié, Robert Zeiser
Journal: Blood
Blood (2020) 136 (17): 1903–1906.
https://doi.org/10.1182/blood.2020007336
Published: 2020
Journal Articles

The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD

Clinical Trials & Observations Brief Report
Kate A. Markey, Jonas Schluter, Antonio L. C. Gomes, Eric R. Littmann, Amanda J. Pickard, Bradford P. Taylor, Paul A. Giardina, Daniela Weber, Anqi Dai, Melissa D. Docampo, Gabriel K. Armijo, Ann E. Slingerland, John B. Slingerland, Katherine B. Nichols, Daniel G. Brereton, Annelie G. Clurman, Ruben J. Ramos, Arka Rao, Amy Bush, Lauren Bohannon, Megan Covington, Meagan V. Lew, David A. Rizzieri, Nelson Chao, Molly Maloy, Christina Cho, Ioannis Politikos, Sergio Giralt, Ying Taur, Eric G. Pamer, Ernst Holler, Miguel-Angel Perales, Doris M. Ponce, Sean M. Devlin, Joao Xavier, Anthony D. Sung, Jonathan U. Peled, Justin R. Cross, Marcel R. M. van den Brink
Journal: Blood
Blood (2020) 136 (1): 130–136.
https://doi.org/10.1182/blood.2019003369
Published: 2020
Includes: Supplemental data
Journal Articles

Outcome of Allogeneic Haematopoietic Stem Cell Transplantation in Myeloproliferative Neoplasms-Unclassifiable: A Retrospective Study By the Chronic Malignancies Working Party of EBMT

Donal P. McLornan, MB, BCh (Hons), MRCP, PhD FRCPath, Vittoria Malpassuti, Simona Iacobelli, Anne Lippinkhof-Kozijn, Linda Koster, Marie Robin, MD, Yves Chalandon, Donald Bunjes, MD, Dietrich W. Beelen, Victoria Potter, MD PhD, Henrik Sengeloev, MD DMSc, Aleksandar Radujkovic, MD, Jakob R. Passweg, MDMS, Nicolaus Kröger, MD, Gerald Wulf, MD, Jan Erik Johansson, MD, Fabio Ciceri, MD, Martin Bornhäuser, MD, Ernst Holler, MD PhD, Yves Beguin, MD PhD, Bruno Lioure, MD, Sonja Martin, MD, Dragana Milojkovic, MBBS, MD, Patrick Hayden, Juan Carlos Hernandez Boluda, Tomasz Czerw, MD PhD, Ibrahim yakoub-Agha, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3335.
https://doi.org/10.1182/blood-2019-121820
Published: 2019