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Vladimir Kirkin
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Journal Articles

MP0533 (CD33 x CD123 x CD70 x CD3), a Tetra-Specific CD3-Engaging Darpin for the Treatment of Patients with Relapsed/Refractory AML or MDS/AML: Results of an Ongoing Phase 1/2a Study

Mojca Jongen-Lavrencic, Thomas Pabst, Pierre Bories, Laimonas Griškevičius, Gerwin Huls, David C. de Leeuw, Steffen Boettcher, Arnaud Pigneux, Nicolas Boissel, Mariola Dymkowska, Christiane Andrieu, Oliver Schönborn-Kellenberger, Paul G. Baverel, Zita Arany, Elena Fernandez, Ana-Maria Florescu, Michael P. Sanderson, Anne Goubier, Vladimir Kirkin, Philippe Legenne, Marion Subklewe
Journal: Blood
Blood (2024) 144 (Supplement 1): 2881.
https://doi.org/10.1182/blood-2024-199211
Published: 2024
Journal Articles

MP0533, a CD3-Engaging Darpin Targeting CD33, CD123, and CD70 in Patients with Relapsed/Refractory AML or MDS/AML: Preliminary Results of a Phase 1/2a Study

Thomas Pabst, Mojca Jongen-Lavrencic, Steffen Boettcher, Geert A. Huls, David C. de Leeuw, Philippe Legenne, Mariola Dymkowska, Christiane Andrieu, Oliver Schönborn-Kellenberger, Paul G. Baverel, Zita Arany, Elena Fernandez, Anne Goubier, Vladimir Kirkin, Nicolas Leupin, Marion Subklewe
Journal: Blood
Blood (2023) 142 (Supplement 1): 2921.
https://doi.org/10.1182/blood-2023-173353
Published: 2023
Journal Articles

MP0533: A Multispecific Darpin CD3 Engager Targeting CD33, CD123, and CD70 for the Treatment of AML and MDS Designed to Selectively Target Leukemic Stem Cells

Matteo Bianchi, Christian Reichen, Stefanie Fischer, Yvonne Grübler, Aline Eggenschwiler, Rajlakshmi Marpakwar, Thamar Looser, Patricia Spitzli, Christel Herzog, Denis Villemagne, Yvonne Kaufmann, Alienor Auge, Martin Hänggi, Waleed Ali, Tamara Lekishvili, Teresa Frasconi, Stephan Wullschleger, Christof Zitt, Marco Franchini, Amelie Croset, Randall Watson, Vladimir Kirkin, Ursina Luethi, Adrian Ochsenbein, Carsten Riether, Daniel Steiner, Nicolas Leupin, Anne Goubier
Journal: Blood
Blood (2022) 140 (Supplement 1): 2251–2252.
https://doi.org/10.1182/blood-2022-163075
Published: 2022
Journal Articles

Avidity-Engineered CD3 Engaging DARPin ® Targeting Three Tumor Associated Antigens Induce Strong and Specific T Cell Dependent Killing of AML Cells with Potential for Improved Safety

Matteo Bianchi, Nina Reschke, Christian Reichen, Stefanie Fischer, Yvonne Grübler, Aline Eggenschwiler, Jennifer Krieg, Kyriaki Ioannou, Simone Ragusa, Thamar Looser, Patricia Spitzli, Christel Herzog, Denis Villemagne, Yvonne Kaufmann, Mirela Matzner, Alienor Auge, Martin Hänggi, Waleed Ali, Marco Franchini, Vladimir Kirkin, Bernd Schlereth, Ursina Luethi, Adrian Ochsenbein, Carsten Riether, Daniel Steiner, Anne Goubier
Journal: Blood
Blood (2021) 138 (Supplement 1): 1164.
https://doi.org/10.1182/blood-2021-152790
Published: 2021
Journal Articles

Immune modulation by Fas ligand reverse signaling: lymphocyte proliferation is attenuated by the intracellular Fas ligand domain

Katharina Lückerath, Vladimir Kirkin, Inga Maria Melzer, Frederic B. Thalheimer, Dagmar Siele, Wiebke Milani, Thure Adler, Antonio Aguilar-Pimentel, Marion Horsch, Geert Michel, Johannes Beckers, Dirk H. Busch, Markus Ollert, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabĕ de Angelis, Frank J. T. Staal, Krishnaraj Rajalingam, Anne-Odile Hueber, Lothar J. Strobl, Ursula Zimber-Strobl, Martin Zörnig
Journal: Blood
Blood (2011) 117 (2): 519–529.
https://doi.org/10.1182/blood-2010-07-292722
Published: 2011
Includes: Supplemental data
Journal Articles

Fas ligand is localized to membrane rafts, where it displays increased cell death–inducing activity

Nathalie Cahuzac, Wiebke Baum, Vladimir Kirkin, Fabien Conchonaud, Laure Wawrezinieck, Didier Marguet, Ottmar Janssen, Martin Zörnig, Anne-Odile Hueber
Journal: Blood
Blood (2006) 107 (6): 2384–2391.
https://doi.org/10.1182/blood-2005-07-2883
Published: 2006