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Nicolas Leupin
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Journal Articles

MP0533, a CD3-Engaging Darpin Targeting CD33, CD123, and CD70 in Patients with Relapsed/Refractory AML or MDS/AML: Preliminary Results of a Phase 1/2a Study

Thomas Pabst, Mojca Jongen-Lavrencic, Steffen Boettcher, Geert A. Huls, David C. de Leeuw, Philippe Legenne, Mariola Dymkowska, Christiane Andrieu, Oliver Schönborn-Kellenberger, Paul G. Baverel, Zita Arany, Elena Fernandez, Anne Goubier, Vladimir Kirkin, Nicolas Leupin, Marion Subklewe
Journal: Blood
Blood (2023) 142 (Supplement 1): 2921.
https://doi.org/10.1182/blood-2023-173353
Published: 2023
Journal Articles

MP0533: A Multispecific Darpin CD3 Engager Targeting CD33, CD123, and CD70 for the Treatment of AML and MDS Designed to Selectively Target Leukemic Stem Cells

Matteo Bianchi, Christian Reichen, Stefanie Fischer, Yvonne Grübler, Aline Eggenschwiler, Rajlakshmi Marpakwar, Thamar Looser, Patricia Spitzli, Christel Herzog, Denis Villemagne, Yvonne Kaufmann, Alienor Auge, Martin Hänggi, Waleed Ali, Tamara Lekishvili, Teresa Frasconi, Stephan Wullschleger, Christof Zitt, Marco Franchini, Amelie Croset, Randall Watson, Vladimir Kirkin, Ursina Luethi, Adrian Ochsenbein, Carsten Riether, Daniel Steiner, Nicolas Leupin, Anne Goubier
Journal: Blood
Blood (2022) 140 (Supplement 1): 2251–2252.
https://doi.org/10.1182/blood-2022-163075
Published: 2022
Journal Articles

Phase 2 Study of Efgartigimod, a Novel FcRn Antagonist, in Adult Patients with Primary Immune Thrombocytopenia

Adrian C. Newland, Blanca Sánchez-González, László Rejtő, Miklos Egyed, Nataliya Romanyuk, Marie Godar, Katrien Verschueren, Domenica Gandini, Peter Ulrichts, Jon Beauchamp, Torsten Dreier, E. Sally Ward, Marc Michel, Howard A. Liebman, Hans De Haard, Nicolas Leupin, David J. Kuter
Journal: Blood
Blood (2019) 134 (Supplement_1): 895.
https://doi.org/10.1182/blood-2019-128022
Published: 2019
Journal Articles

Targeting CD70 with Cusatuzumab Eliminates Acute Myeloid Leukemia Stem Cells in Humans

Adrian F Ochsenbein, MD, Thomas Pabst, MD, Sabine Höpner, PhD, Vera Ulrike Bacher, Magdalena Hinterbrandner, Msc, Yara Banz, Rouven Müller, MD, Markus G. Manz, Prof.Dr.MD, Walid Gharib, David Francisco, Rémy Bruggmann, PhD, Luc Van Rompaey, PhD, Mahan Moshir, MSc, Tim Delahaye, MSc, Domenica Gandini, Ellen Erzeel, Anna Hultberg, PhD, Samson Fung, MD, Hans De Haard, Nicolas Leupin, Carsten Riether, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 234.
https://doi.org/10.1182/blood-2019-129916
Published: 2019
Journal Articles

The Combination of the BCL-2 Antagonist Venetoclax with the CD70-Targeting Antibody Cusatuzumab Synergistically Eliminates Primary Human Leukemia Stem Cells

Carsten Riether, PhD, Tanja Chiorazzo, PhD, Amy J. Johnson, PhD, Christina Diane Drenberg, PhD, Khaja Waheeduddin Syed, BPharm, MS, Mahan Moshir, MSc, Anna Hultberg, PhD, Nicolas Leupin, Hans De Haard, Adrian F Ochsenbein, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3918.
https://doi.org/10.1182/blood-2019-127464
Published: 2019
Journal Articles

Argx-110 Targeting CD70, in Combination with Azacitidine, Shows Favorable Safety Profile and Promising Anti-Leukemia Activity in Newly Diagnosed AML Patients in an Ongoing Phase 1/2 Clinical Trial

Adrian F Ochsenbein, MD, Carsten Riether, PhD, Ulrike Bacher, Rouven Müller, MD, Sabine Höpner, PhD, Yara Banz, Magdalena Hinterbrandner, Msc, Mario Bargetzi, MD, Markus G. Manz, MD, Luc Van Rompaey, PhD, Mahan Moshir, MSc, Tim Delahaye, MSc, Domenica Gandini, MD PhD, Ellen Erzeel, Anna Hultberg, PhD, Samson Fung, MD, Hans De Haard, PhD, Nicolas Leupin, MD, Thomas Pabst, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2680.
https://doi.org/10.1182/blood-2018-99-118302
Published: 2018
Journal Articles

Argx-110 for Treatment of CD70-Positive Advanced Cutaneous T-Cell Lymphoma in a Phase 1/2 Clinical Trial

Martine Bagot, MD PhD, Marie Maerevoet, MD, Pier Luigi Zinzani, MD, Fritz Offner, MD, Franck Morschhauser, MD, Jean-Marie Michot, MD, Vincent Ribrag, MD, Maxime Battistella, MD PhD, Helene Moins, Angelica Calleri, PhD, Stéphane Dalle, MD PhD, Marie Beylot-Barry, MD PhD, Karen Zwaenepoel, PhD, Koen De Winnie, PhD, Anne Marie-Cardine, PhD, Jean-Michel Cayuela, PhD, Valentina Tabanelli, MD, Giovanna Motta, PhD, Federica Melle, PhD, Anna Hultberg, PhD, Domenica Gandini, MD PhD, Teresa Marafioti, MD, Mahan Moshir, MSc, Tim Delahaye, MSc, Piotr Zabrocki, PhD, Karen Silence, PhD, Luc Van Rompaey, PhD, Armand Bensussan, MD PhD, Hans De Haard, PhD, Patrick Pauwels, MD PhD, Nicolas Leupin, MD, Stefano A. Pileri, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1627.
https://doi.org/10.1182/blood-2018-99-118204
Published: 2018
Journal Articles

Blocking CD70/CD27 Signaling in Combination with Hypomethylating Agents Eradicates Human CD34 + AML Stem and Progenitor Cells in Vitro and In Vivo

Magdalena Hinterbrandner, Msc, Nils Maria Kallen, Ursina Lüthi, Thomas Pabst, MD, Luc Van Rompaey, PhD, Nicolas Leupin, MD, Hans De Haard, PhD, Adrian F Ochsenbein, MD, Carsten Riether, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2652.
https://doi.org/10.1182/blood.V130.Suppl_1.2652.2652
Published: 2017
Journal Articles

Argx-113, a Novel Fc-Based Approach for Antibody-Induced Pathologies Such As Primary Immune Thrombocytopenia

Peter Ulrichts, PhD, Thierry Cousin, MD, Torsten Dreier, PhD, Hans de Haard, PhD, Nicolas Leupin, MD
Journal: Blood
Blood (2016) 128 (22): 4919.
https://doi.org/10.1182/blood.V128.22.4919.4919
Published: 2016
Journal Articles

Impact of Response Quality on Survival Outcomes in Transplant-Ineligible Newly Diagnosed Multiple Myeloma (NDMM) Patients (Pts): Results from the First Trial

Nizar J Bahlis, MD, Alessandro Corso, Lars-Olof Mugge, Zhi-Xiang Shen, Pierre Desjardins, Anne-Marie Stoppa, MD, Olivier Decaux, Thierry De Revel, Miquel Granell, Gerald Marit, Hareth Nahi, Hilde Demuynck, Shang-Yi Huang, Supratik Basu, Troy H. Guthrie, Annette Ervin-Haynes, Nicolas Leupin, Jennifer Marek, Guang Chen, Thierry Facon
Journal: Blood
Blood (2014) 124 (21): 3458.
https://doi.org/10.1182/blood.V124.21.3458.3458
Published: 2014
Journal Articles

A Randomized Study of Daily Versus Weekly Administration of 2-Chlorodeoxyadenosine in Patients with Hairy Cell Leukemia.

Reinhard Zenhausern, MD, Nicolas Leupin, Shu-Fang Hsu Schmitz, Max Solenthaler, Andre Tichelli, Dominik Heim, Urs Hess, Leda Leoncini, Mario Bargetzi, Andreas Tobler
Journal: Blood
Blood (2007) 110 (11): 1352.
https://doi.org/10.1182/blood.V110.11.1352.1352
Published: 2007
Journal Articles

The Combination of 2-CDA and Rituximab in Patients with Chronic Lymphocytic Leukemia (CLL): A Prospective Multicenter Phase II Trial (SAKK 34/02).

Nicolas Leupin, MD, Jan C. Schuller, PhD, Max Solenthaler, MD, Andre Tichelli, MD, Alois Gratwohl, MD, Kurt Beretta, MD, Mario J. Bargetzi, MD, Andreas Himmelmann, MD, Susanne Hanselmann, PhD, Reinhard Zenhausern, MD
Journal: Blood
Blood (2007) 110 (11): 2057.
https://doi.org/10.1182/blood.V110.11.2057.2057
Published: 2007
Journal Articles

Enhancing Neutrophil Differentiation - A Novel Role for the Death-Associated Protein Kinase 2 (DAPK2).

Mattia Rizzi, MD, Christian Britschgi, MD, Mario P. Tschan, PhD, Tobias J. Grob, MD, PhD, Barbara Huegli, Nicolas Leupin, MD, Beatrice U. Mueller, MD, Andrew Ziemiecki, PhD, Bruce E. Torbett, PhD, Martin F. Fey, MD, Andreas Tobler, MD
Journal: Blood
Blood (2005) 106 (11): 1348.
https://doi.org/10.1182/blood.V106.11.1348.1348
Published: 2005
Journal Articles

A high-resolution allelotype of B-cell chronic lymphocytic leukemia (B-CLL)

Urban Novak, Elisabeth Oppliger Leibundgut, Jörg Hager, Dominique Mühlematter, Martine Jotterand, Celine Besse, Nicolas Leupin, Daniel Ratschiller, Jeanette Papp, Gina Kearsey, Stefan Aebi, Hans Graber, Rolf Jaggi, Jean-Marc Lüthi, Sandrine Meyer-Monard, Mark Lathrop, Andreas Tobler, Martin F. Fey
Journal: Blood
Blood (2002) 100 (5): 1787–1794.
https://doi.org/10.1182/blood.V100.5.1787.h81702001787_1787_1794
Published: 2002