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Journal Articles

Immunoparesis Recovery in Transplant-Ineligible Newly Diagnosis Multiple Myeloma Patients: An Independent Prognosis Factor That Could Complement Prognostic Value of Minimal Residual Disease

Sunil Lakhwani, María Victoria Mateos, Joaquín Martínez-López, Bruno Paiva, Laura Rosinol Dachs, Rafael Martínez, Albert Oriol, Joan Bargay, Yolanda Gonzalez-Montes, Mercedes Gironella, Cristina Encinas, Jesus Martin, Isidro Jarque, Miquel Granell, Eugenia Abella, Aránzazu García Mateo, José Ángel Hernández-Rivas, Elena Ramila, Isabel Krsnik, Luis Felipe Casado Montero, Felipe De Arriba, Luis Palomera, Antonia Sampol, Jose Maria Moraleda, Maria Casanova, Pilar Delgado, Ana Lafuente, Elena Amutio, Aurelio Lopez Martínez, Albert Altés, M. Ángeles Ruíz, Lucia Lopez-Anglada, Joan Bladé Creixenti, Juan-José Lahuerta, Jesús San-Miguel, Miguel-Teodoro Hernández
Journal: Blood
Blood (2022) 140 (Supplement 1): 2344–2346.
https://doi.org/10.1182/blood-2022-166826
Published: 2022
Journal Articles

Randomized Phase 2 Study of Weekly Carfilzomib 70 Mg/m2 and Dexamethasone Plus/Minus Cyclophosphamide in Relapsed and/or Refractory Multiple Myeloma (RRMM) Patients (GEM-KyCyDex)

Maria-Victoria Mateos, MD PhD, Enrique M. Ocio, MDPhD, Anna Sureda Balari, MD PhD, Albert Oriol, Esther González Garcia, MD, Maria José Moreno, Miquel Granell, MD, Fernando Escalante, MD, Veronica Gonzalez De La Calle, MD PhD, Laura Rosinol Dachs, Estrella Carrillo-Cruz, MD, Joaquín Martínez-López, Maria Victoria Dourdil Sahun, Marta Sonia Gonzalez, MD, Jaime Perez De Oteyza, MDPhD, Felipe De Arriba, PhD, Miguel T Hernández, MD PhD, Aránzazu García Mateo, PhD, Ana Pilar Gonzalez, PhD, Rafael Rios, MD PhD, Carmen Cabrera, Juan Jose Bargay, Paula Rodriguez-Otero, MD, Felipe Casado, Maria Casanova, MD, María Jesús Blanchard, Joan Blade Creixenti, Juan Jose Lahuerta, MD PhD, Jesus F. San-Miguel, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-140934
Published: 2020
Journal Articles

ANCHOR (OP-104): Melflufen Plus Dexamethasone (dex) and Daratumumab (dara) or Bortezomib (BTZ) in Relapsed/Refractory Multiple Myeloma (RRMM) Refractory to an IMiD and/or a Proteasome Inhibitor (PI) - Updated Efficacy and Safety

Enrique M. Ocio, MDPhD, Yvonne A. Efebera, MD MPH, Roman Hájek, MD PhD, Miquel Granell, MD, Vladimir Maisnar, MD, Jan Straub, MD, Jean-Richard Eveillard, MD, Lionel Karlin, MD, Vincent Ribrag, MD, María-Victoria Mateos, MD PhD, Albert Oriol, Malin Sydvander, MSc, Stefan Norin, MD, Sofia Mannikko, MSc, Luděk Pour, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 9–10.
https://doi.org/10.1182/blood-2020-135991
Published: 2020
Journal Articles

ANCHOR (OP-104): Updated Efficacy and Safety from a Phase 1/2 Study of Melflufen and Dexamethasone Plus Bortezomib or Daratumumab in Patients with Relapsed/Refractory Multiple Myeloma (RRMM) Refractory to an IMiD or a Proteasome Inhibitor (PI)

Enrique M. Ocio, Yvonne A. Efebera, MD MPH, Miquel Granell, MD, Roman Hajek, MD, Vladimir Maisnar, MD, Lionel Karlin, MD, María-Victoria Mateos, MD PhD, Paul G. Richardson, MD, Albert Oriol, MD, Stefan Norin, MD, Malin Sydvander, MSc, Jakob Obermüller, MSc, Luděk Pour, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3124.
https://doi.org/10.1182/blood-2019-124815
Published: 2019
Journal Articles

VTD (Bortezomib/Thalidomide/Dexamethasone) As Pretransplant Induction Therapy for Multiple Myeloma: Definitive Results of a Randomized Phase 3 Pethema/GEM Study

Laura Rosinol Dachs, Albert Oriol, MD, Ana Isabel Teruel, MDcal Doctor, Ana López de la Guía, M Jesús Blanchard, Isidro Jarque, Miquel Granell, MD, Antonia Sampol, Luis Palomera, MD PhD, Yolanda Gonzalez-Montes, Enrique Bengoechea, Rafael Martínez-Martínez, Miguel T Hernández, MD PhD, Felipe De Arriba, PhD, Maria Luisa Martin-Ramos, Norma C. Gutierrez, MD PhD, Maria Teresa Cibeira, MD PhD, Maria-Victoria Mateos, MD PhD, Joaquin Martinez-Lopez, MD PhD, Adrián Alegre, MD, Juan Jose Lahuerta, MD PhD, Jesus F San-Miguel, MD PhD, Joan Blade, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 126.
https://doi.org/10.1182/blood-2018-99-111924
Published: 2018
Journal Articles

The OP-104 Anchor Study: A Phase 1/2 Study of Safety and Efficacy of Melflufen and Dexamethasone in Combination with Either Bortezomib or Daratumumab in Patients with Rrmm; First Report on Phase 1 Data

Ludek Pour, MD, Miquel Granell, MD, Roman Hajek, MD PhD, Albert Oriol, MD, Yvonne Efebera, MD, Jacques Delaunay, MD, Katell Le Du, MD, Jean-Richard Eveillard, MD, Lionel Karlin, MD, Vladimir Maisnar, MD, Joaquin Martinez Lopez, MD, Maria-Victoria Mateos, MD PhD, Jan Moreb, MD, Vincent Ribrag, MD, Paul Richardson, Jan Straub, MD, Catriona Byrne, RN, Christian Jacques, MD, Hanan Zubair, MSc, Enrique Ocio, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1967.
https://doi.org/10.1182/blood-2018-99-112983
Published: 2018
Journal Articles

Ibrutinib Therapy in Rituximab-Refractory Patients with Waldenström's Macroglobulinemia: Initial Results from an International, Multicenter, Open-Label Phase 3 Substudy (iNNOVATE TM )

Meletios A. Dimopoulos, MD, Judith Trotman, FRACP, Alessandra Tedeschi, MD, Jeffrey V. Matous, MD, David Macdonald, MD MSc, FRCPC, Constantine Tam, MBBS, MD, Oliver Tournilhac, MD, Shuo Ma, MD PhD, Albert Oriol, MDPhD, Leonard T. Heffner, MD, Chaim Shustik, MD, Ramón García-Sanz, MD PhD, Robert F. Cornell, Carlos Fernández de Larrea, MD PhD, Jorge J. Castillo, MD, Miquel Granell, MD, Marie-Christine Kyrtsonis, MD, Veronique Leblond, MD PhD, Argiris Symeonidis, MD PhD, Priyanka Singh, MS, Jianling Li, MS, Thorsten Graef, MD PhD, Elizabeth Bilotti, MSN, Steven Treon, MD PhD, Christian Buske, MD
Journal: Blood
Blood (2015) 126 (23): 2745.
https://doi.org/10.1182/blood.V126.23.2745.2745
Published: 2015
Journal Articles

Usefulness of Serum-Free-Light-Chains-Ratio (SFLCR) and Serum Heavy-Light-Chains-Ratio (SHLCR) in Multiple Myeloma in the Context of Three GEM/Pethema Clinical Trials

Lucia Lopez-Anglada, MDPhD, Cecilia Cueto-Felgueroso, Maria-Victoria Mateos, Laura Rosiñol, MDPhD, Albert Oriol, MDPhD, Ana Isabel Teruel, MD, Ana Lopez de la Guia, MD, Luis Palomera, MDPhD, Felipe de Arriba, MDPhD, Jose Mariano Hernandez, MD, Miquel Granell, MD, Francisco Javier Peñalver, MD, Ramon Garcia-Sanz, MDPhD, Juan Besalduch, MDPhD, Yolanda Gonzalez, MD, Rafael Martinez, MDPhD, Miguel Teodoro Hernandez, MDPhD, Norma C Gutierrez, Paloma Puerta, MD, Joan Blade, MDPhD, Jesús San Miguel, MDPhD, Juan José Lahuerta, MDPhD, Joaquin Martinez Lopez, MDPhD
Journal: Blood
Blood (2015) 126 (23): 2962.
https://doi.org/10.1182/blood.V126.23.2962.2962
Published: 2015
Journal Articles

Phase II Trial of Cyclophosphamide, Lenalidomide and Dexamethasone (CYCLO-LEN-DEX) for Previously Untreated Patients with Light-Chain Amyloidosis (AL)

Joan Blade, MDPhD, Albert Oriol, Juan José Lahuerta, MD PhD, Maria-Victoria Mateos, MD PhD, Javier de la Rubia, MD PhD, Miguel T Hernandez, Miquel Granell, Carlos Fernandez de Larrea, Jesus F. San Miguel, M Teresa Cibeira
Journal: Blood
Blood (2014) 124 (21): 2135.
https://doi.org/10.1182/blood.V124.21.2135.2135
Published: 2014
Journal Articles

Kinetics of Response to Bortezomib/Thalidomide/Dexamethasone (VTD) in Multiple Myeloma: Implications for the Choice and Design of Pretransplantation Induction Regimens

Laura Rosiñol, MD PhD, Albert Oriol, MD, Ana Isabel Teruel, Dolores Hernández, M Jesús Blanchard, Javier De La Rubia, Miquel Granell, MD, Juan Besalduch, Luis Palomera, Yolanda Gonzalez, Etxebeste Mª Asunción, Joaquín Díaz-Mediavilla, Miguel T. Hernandez, Felipe de Arriba, Norma Carmen Gutierrez, PhD MD, Maria-Victoria Mateos, MD PhD, Joaquin Martinez-Lopez, MD PhD, Adrian Alegre, MD, Huaibao Feng, Helgi van de Velde, Juan José Lahuerta, MD PhD, Jesus F. San Miguel, Joan Blade
Journal: Blood
Blood (2014) 124 (21): 2108.
https://doi.org/10.1182/blood.V124.21.2108.2108
Published: 2014
Journal Articles

Persistent Benefit of VTD (Bortezomib/Thalidomide/Dexamethasone) As Pretransplant Induction Therapy for Multiple Myeloma: Long-Term Follow-up of a Randomized Phase 3 Pethema/GEM Study

Laura Rosiñol, MD PhD, Albert Oriol, MD, Ana Isabel Teruel, MD, Dolores Hernandez, M Jesús Blanchard, Javier De La Rubia, Miquel Granell, MD, Juan Besalduch, MD PhD, Luis Palomera, Yolanda Gonzalez, M Asunción Echebeste, Joaquín Díaz-Mediavilla, Miguel T Hernandez, MD, Felipe de Arriba, Norma Carmen Gutierrez, PhD MD, M Luisa Martín-Ramos, M Teresa Cibeira, Maria Victoria Mateos, Joaquin Martinez-Lopez, MD PhD, Adrian Alegre, MD, Juan José Lahuerta, MD PhD, Jesus F. San Miguel, Joan Blade
Journal: Blood
Blood (2014) 124 (21): 3457.
https://doi.org/10.1182/blood.V124.21.3457.3457
Published: 2014
Journal Articles

Impact of Response Quality on Survival Outcomes in Transplant-Ineligible Newly Diagnosed Multiple Myeloma (NDMM) Patients (Pts): Results from the First Trial

Nizar J Bahlis, MD, Alessandro Corso, Lars-Olof Mugge, Zhi-Xiang Shen, Pierre Desjardins, Anne-Marie Stoppa, MD, Olivier Decaux, Thierry De Revel, Miquel Granell, Gerald Marit, Hareth Nahi, Hilde Demuynck, Shang-Yi Huang, Supratik Basu, Troy H. Guthrie, Annette Ervin-Haynes, Nicolas Leupin, Jennifer Marek, Guang Chen, Thierry Facon
Journal: Blood
Blood (2014) 124 (21): 3458.
https://doi.org/10.1182/blood.V124.21.3458.3458
Published: 2014
Journal Articles

GEM2005 trial update comparing VMP/VTP as induction in elderly multiple myeloma patients: do we still need alkylators?

Clinical Trials & Observations
María-Victoria Mateos, Albert Oriol, Joaquín Martínez-López, Ana-Isabel Teruel, Ana López de la Guía, Javier López, Enrique Bengoechea, Montserrat Pérez, Rafael Martínez, Luis Palomera, Felipe de Arriba, Yolanda González, José Mariano Hernández, Miquel Granell, José-Luis Bello, Joan Bargay, Francisco-Javier Peñalver, María-Luisa Martín-Mateos, Bruno Paiva, María-Angeles Montalbán, Joan Bladé, Juan-Jose Lahuerta, Jesús F. San-Miguel
Journal: Blood
Blood (2014) 124 (12): 1887–1893.
https://doi.org/10.1182/blood-2014-05-573733
Published: 2014
Journal Articles

Long-Term Follow-Up Of Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplantation For High Risk Follicular Lymphoma

Silvana Novelli, MD, Albert Esquirol, MD, Javier Briones, MD, Pilar Leoz, MD, Rodrigo Martino, MD, PhD, Garrido Ana, MD, Irene Garcia, MD, Saavedra Silvana, Miquel Granell, MD, Carol Moreno, MD, Salut Brunet, MD, PhD, Jorge Sierra, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 5519.
https://doi.org/10.1182/blood.V122.21.5519.5519
Published: 2013
Journal Articles

Maintenance Therapy After Stem-Cell Transplantation for Multiple Myeloma with Bortezomib/Thalidomide Vs. Thalidomide Vs. alfa2b-Interferon: Final Results of a Phase III Pethema/GEM Randomized Trial

Laura Rosiñnol, MD, Albert Oriol, Ana Isabel Teruel, Dolores Hernández, Javier Lopez-Jimenez, MD, Javier De La Rubia, MD, Miquel Granell, MD, Juan Besalduch, MD, PhD, Luis Palomera, MD, Yolanda González, MD, Maria Asunción Etxebeste, Joaquín Díaz-Mediavilla, Miguel Teodoro Hernández, Felipe de Arriba, Adrian Alegre, María Teresa Cibeira, Maria Victoria Mateos, MD, PhD, Joaquin Martinez, MD, Juan José Lahuerta, Jesús F San Miguel, Joan Bladé, MD
Journal: Blood
Blood (2012) 120 (21): 334.
https://doi.org/10.1182/blood.V120.21.334.334
Published: 2012
Journal Articles

Analysis of Zoledronic ACID Therapy for Patients with Multiple Myeloma with Asymptomatic Biochemical Relaps.

Ramón García-Sanz, Albert Oriol, Javier De La Rubia, MD, Luis Palomera, MD, Paz Ribas, Miguel Teodoro Hernández, Maria José Moreno, Joan Bargay, Angel Ramírez, Ana Isabel Teruel, María Jesús Blanchard, Mercedes Gironella, MD, Miquel Granell, MD, Eugenia Abella, J.F. San Miguel
Journal: Blood
Blood (2012) 120 (21): 2967.
https://doi.org/10.1182/blood.V120.21.2967.2967
Published: 2012
Journal Articles

Maintenance therapy with bortezomib plus thalidomide or bortezomib plus prednisone in elderly multiple myeloma patients included in the GEM2005MAS65 trial

Clinical Trials & Observations
María-Victoria Mateos, Albert Oriol, Joaquín Martínez-López, Norma Gutiérrez, Ana-Isabel Teruel, Ana López de la Guía, Javier López, Enrique Bengoechea, Montserrat Pérez, Marta Polo, Luis Palomera, Felipe de Arriba, Yolanda González, Jose-Mariano Hernández, Miquel Granell, José-Luis Bello, Joan Bargay, Francisco-Javier Peñalver, José-María Ribera, María-Luisa Martín-Mateos, Ramón García-Sanz, Juan-José Lahuerta, Joan Bladé, Jesús F. San-Miguel
Journal: Blood
Blood (2012) 120 (13): 2581–2588.
https://doi.org/10.1182/blood-2012-05-427815
Published: 2012
Includes: Supplemental data
Journal Articles

Superiority of bortezomib, thalidomide, and dexamethasone (VTD) as induction pretransplantation therapy in multiple myeloma: a randomized phase 3 PETHEMA/GEM study

Clinical Trials & Observations
Laura Rosiñol, Albert Oriol, Ana Isabel Teruel, Dolores Hernández, Javier López-Jiménez, Javier de la Rubia, Miquel Granell, Joan Besalduch, Luis Palomera, Yolanda González, Mª Asunción Etxebeste, Joaquín Díaz-Mediavilla, Miguel T. Hernández, Felipe de Arriba, Norma C. Gutiérrez, Mª Luisa Martín-Ramos, Mª Teresa Cibeira, Mª Victoria Mateos, Joaquín Martínez, Adrián Alegre, Juan José Lahuerta, Jesús San Miguel, Joan Bladé
Journal: Blood
Blood (2012) 120 (8): 1589–1596.
https://doi.org/10.1182/blood-2012-02-408922
Published: 2012
Includes: Supplemental data
Journal Articles

A Phase III PETHEMA/GEM Randomized Trial of Postransplant (ASCT) Maintenance in Multiple Myeloma: Superiority of Bortezomib/Thalidomide Compared with Thalidomide and Alfa-2b Interferon,

Laura Rosiñol, MD, María Teresa Cibeira, Maria Victoria Mateos, Joaquin Martinez, MD, Albert Oriol, Ana Isabel Teruel, Dolores Hernández, Javier López, MD, Javier de la Rubia, Miquel Granell, MD, Juan Besalduch, MD, PhD, Luis Palomera, Yolanda González, MD, Maria Asunción Etxebeste, MD, Joaquín Díaz-Mediavilla, Miguel T Hernández, MD, Felipe de Arriba, Adrian Alegre, Juan José Lahuerta, Jesus F San Miguel, MD PhD, Joan Blade
Journal: Blood
Blood (2011) 118 (21): 3962.
https://doi.org/10.1182/blood.V118.21.3962.3962
Published: 2011
Journal Articles

Gene Expression Profiling Distinguishes Essential Thrombocythemia from Polycythemia Vera Patients and Identifies a Common Expressed Set of Genes in Relation to JAK2V 617F Status

Eulalia Puigdecanet, Blanca Espinet, PhD, Juan Jose Lozano, PhD, Lauro Sumoy, PhD, Beatriz Bellosillo, PhD, Miquel Granell, MD, Alberto Alvarez-Larrán, MD, PhD, Leonor Arenillas, MD, Francesc Sole, PhD, Sergi Serrano, MD, PhD, Francisco Cervantes, MD, PhD, Carles Besses, MD, PhD, Lourdes Florensa, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2788.
https://doi.org/10.1182/blood.V112.11.2788.2788
Published: 2008