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Journal Articles

CNS Invasion of TCF3::PBX1 + Leukemia Cells Requires Upregulation of AP-1 Signaling As Revealed By Brain Organoid Model

Philip Gebing, Stefanos Loizou, Sebastian Hänsch, Julian Schliehe-Diecks, Lea Spory, Pawel Stachura, Aleksandra Pandyra, Martin Schrappe, Gunnar Cario, Ameera Alsadeq, Denis Martin Schewe, Arndt Borkhardt, Lennart Lenk, Ute Fischer, Sanil Bhatia

Blood (2023) 142 (Supplement 1): 1407.

https://doi.org/10.1182/blood-2023-178613

Published: 2023

Journal Articles

Preclinical Evidence for the Efficacy of CD79b Immunotherapy in B Cell Precursor Acute Lymphoblastic Leukemia

Lennart Lenk, Dorothee Winterberg, Fotini Vogiatzi, Anna Laqua, Lea Spory, Ahmad Mayar, Christian Vokuhl, Julia Richter, Michela Carlet, Irmela Jeremias, Thomas Valerius, Martin Schrappe, Gunnar Cario, Hassan Jumaa, Elias Hobeika, Monika Brüggemann, Ameera Alsadeq, Denis Martin Schewe

Blood (2021) 138 (Supplement 1): 2388.

https://doi.org/10.1182/blood-2021-148429

Published: 2021

Journal Articles

CD79a Is Associated with Central Nervous System Infiltration of Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Lennart Lenk, PhD MSc, Fotini Vogiatzi, PhD, Michela Carlet, PhD, Christian Vokuhl, MD, Gunnar Cario, MD, Martin Schrappe, MD PhD, Irmela Jeremias, MD PhD, Stephan Fuhrmann, MD, Elias Hobeika, PhD, Hassan Jumaa, Prof. Dr., Ameera Alsadeq, PhD, Denis Martin Schewe, MD

Blood (2018) 132 (Supplement 1): 386.

https://doi.org/10.1182/blood-2018-99-114595

Published: 2018

Journal Articles

IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia

Ameera Alsadeq, Lennart Lenk, Anila Vadakumchery, Antony Cousins, Christian Vokuhl, Ahmad Khadour, Fotini Vogiatzi, Felix Seyfried, Lueder-Hinrich Meyer, Gunnar Cario, Elias Hobeika, Klaus-Michael Debatin, Christina Halsey, Martin Schrappe, Denis M. Schewe, Hassan Jumaa

Blood (2018) 132 (15): 1614–1617.

https://doi.org/10.1182/blood-2018-04-844209

Published: 2018

Includes: Supplemental data

Journal Articles

Targeting of the Interleukin-7 Receptor Alpha-Chain (IL-7Rα) Blocks B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Development and Reduces Leukemic Infiltration to the Central Nervous System (CNS)

Ameera Alsadeq, PhD, Anila George Vadakumchery, Ali Almasri, Hend Abdelrasoul, Markus Werner, PhD, Lennart Lenk, Felix Seyfried, Klaus-Michael Debatin, MD, Lueder-Hinrich Myer, MD, Gunnar Cario, MD, Martin Schrappe, MD PhD, Denis Martin Schewe, MD, Hassan Jumaa, PhD

Blood (2017) 130 (Supplement 1): 479.

https://doi.org/10.1182/blood.V130.Suppl_1.479.479

Published: 2017

Journal Articles

An Fc-engineered CD19 antibody eradicates MRD in patient-derived MLL -rearranged acute lymphoblastic leukemia xenografts

Denis M. Schewe, Ameera Alsadeq, Cornelia Sattler, Lennart Lenk, Fotini Vogiatzi, Gunnar Cario, Simon Vieth, Thomas Valerius, Sophia Rosskopf, Fabian Meyersieck, Julia Alten, Martin Schrappe, Martin Gramatzki, Matthias Peipp, Christian Kellner

Blood (2017) 130 (13): 1543–1552.

https://doi.org/10.1182/blood-2017-01-764316

Published: 2017

Includes: Supplemental data

Journal Articles

An Fc-Engineered CD19 Antibody Engages Macrophages and Is Effective in Xenograft Models of Pediatric Acute Lymphoblastic Leukemia

Denis M Schewe, MD, Ameera Alsadeq, PhD, Gunnar Cario, MD, Simon Vieth, MD, Thomas Valerius, MD, Martin Schrappe, MD PhD, Martin Gramatzki, MD, Matthias Peipp, PhD, Christian Kellner, PhD

Blood (2016) 128 (22): 277.

https://doi.org/10.1182/blood.V128.22.277.277

Published: 2016

Journal Articles

CD20 Antibodies of Human IgA Isotype Mediate CDC, and ADCC By Myeloid Effector Cells

Anna Kretschmer, Stefan Lohse, PhD, Thies Rösner, PhD, Marco J.H. Jansen, Christian Kellner, PhD, Matthias Peipp, PhD, Mark S Cragg, PhD, Ameera Alsadeq, PhD, Denis M Schewe, MD, Jeanette H.W. Leusen, PhD, Thomas Valerius, MD

Blood (2016) 128 (22): 1835.

https://doi.org/10.1182/blood.V128.22.1835.1835

Published: 2016

Journal Articles

Zeta-Chain-Associated Protein Kinase-70 (Zap-70) Promotes Acute Lymphoblastic Leukemia (ALL) Infiltration into the Central Nervous System By Enhancing Chemokine Receptor 7 (CCR7) Expression

Ameera Alsadeq, PhD, Henning Fedders, PhD, Steffi Spielberg, Christian Vokuhl, MD, Gunnar Cario, MD, Martin Schrappe, MD PhD, Denis Martin Schewe, MD

Blood (2015) 126 (23): 901.

https://doi.org/10.1182/blood.V126.23.901.901

Published: 2015

Journal Articles

Constitutive Activation of FLT3 Is a Positive Prognostic Factor in Infants with MLL-Rearranged Acute Lymphoblastic Leukemia

Henning Fedders, PhD, Denis Martin Schewe, MD, Martin Zimmermann, PhD, Ameera Alsadeq, PhD, Anja Moericke, MD, Udo zur Stadt, PhD, Martin A. Horstmann, MD, Rob Pieters, MD PhD, Martin Schrappe, MD PhD, Gunnar Cario, MD, Martin Stanulla, MD

Blood (2015) 126 (23): 1417.

https://doi.org/10.1182/blood.V126.23.1417.1417

Published: 2015

Journal Articles

Mer tyrosine kinase promotes the survival of t(1;19)-positive acute lymphoblastic leukemia (ALL) in the central nervous system (CNS)

Sarah Krause, Christian Pfeiffer, Susanne Strube, Ameera Alsadeq, Henning Fedders, Christian Vokuhl, Sonja Loges, Jonas Waizenegger, Isabel Ben-Batalla, Gunnar Cario, Anja Möricke, Martin Stanulla, Martin Schrappe, Denis M. Schewe

Blood (2015) 125 (5): 820–830.

https://doi.org/10.1182/blood-2014-06-583062

Published: 2015

Includes: Supplemental data

Journal Articles

Analyses of a Pair of Concordant Twins with Infant ALL and Discordant Clinical Outcome Reveals Immunoescape As a Mechanism of Disease Persistence in MLL-Rearranged Leukemia

Henning Fedders, PhD, Ameera Alsadeq, PhD, Britt-Sabina Petersen, PhD, Christian Kellner, PhD, Matthias Peipp, PhD, Thomas Valerius, MD, Robert Haesler, PhD, Julia Alten, MD, Anja Möricke, Susanne Strube, PhD, Thomas Wiesel, MD, Gunnar Cario, MD, Martin Schrappe, Andre Franke, PhD, Martin Stanulla, MD, Denis Martin Schewe, MD

Blood (2014) 124 (21): 3791.

https://doi.org/10.1182/blood.V124.21.3791.3791

Published: 2014

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CNS Invasion of TCF3::PBX1 + Leukemia Cells Requires Upregulation of AP-1 Signaling As Revealed By Brain Organoid Model

Preclinical Evidence for the Efficacy of CD79b Immunotherapy in B Cell Precursor Acute Lymphoblastic Leukemia

CD79a Is Associated with Central Nervous System Infiltration of Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia

Targeting of the Interleukin-7 Receptor Alpha-Chain (IL-7Rα) Blocks B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Development and Reduces Leukemic Infiltration to the Central Nervous System (CNS)

An Fc-engineered CD19 antibody eradicates MRD in patient-derived MLL -rearranged acute lymphoblastic leukemia xenografts

An Fc-Engineered CD19 Antibody Engages Macrophages and Is Effective in Xenograft Models of Pediatric Acute Lymphoblastic Leukemia

CD20 Antibodies of Human IgA Isotype Mediate CDC, and ADCC By Myeloid Effector Cells

Zeta-Chain-Associated Protein Kinase-70 (Zap-70) Promotes Acute Lymphoblastic Leukemia (ALL) Infiltration into the Central Nervous System By Enhancing Chemokine Receptor 7 (CCR7) Expression

Constitutive Activation of FLT3 Is a Positive Prognostic Factor in Infants with MLL-Rearranged Acute Lymphoblastic Leukemia

Mer tyrosine kinase promotes the survival of t(1;19)-positive acute lymphoblastic leukemia (ALL) in the central nervous system (CNS)

Analyses of a Pair of Concordant Twins with Infant ALL and Discordant Clinical Outcome Reveals Immunoescape As a Mechanism of Disease Persistence in MLL-Rearranged Leukemia

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