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Journal Articles

Addition of Anti-T-Lymphocyte-Globuline As Graft Versus Host Disease Prophylaxis for Matched Unrelated Donors Equalizes Outcomes with Matched Sibling Donors: Results from the AML SCT-BFM 2007 Trial

Martin G. Sauer, Peter Lang, Michael H Albert, Peter Bader, Ursula Creutzig, Matthias Eyrich, Johann Greil, Bernd Gruhn, Wolfgang Holter, Thomas Klingebiel, Bernhard Kremens, Christine Mauz-Körholz, Roland Meisel, Kirsten Mischke, Ingo Muller, Charlotte Marie Niemeyer, Christina Peters, Dirk Reinhardt, Birgit Burkhardt, Paul-Gerhardt Schlegel, Ansgar Schulz, Johanna Schrum, Petr Sedlacek, Brigitte Strahm, Wilhelm Woessmann, Rupert Handgretinger, Martin Zimmermann, Arndt Borkhardt
Journal: Blood
Blood (2024) 144 (Supplement 1): 3563.
https://doi.org/10.1182/blood-2024-200574
Published: 2024
Journal Articles

Overcoming Stress Response-Induced Drug Resistance through Targeting CDK9 in Ph+ Leukemia

Melina Vogt, Marie Kemkes, Berna-Selin Bilen, Julian Schliehe-Diecks, Katerina Scharov, Jia-Wey Tu, Ute Fischer, Aleksandra A. Pandyra, Arndt Borkhardt, Sanil Bhatia
Journal: Blood
Blood (2024) 144 (Supplement 1): 5823.
https://doi.org/10.1182/blood-2024-198438
Published: 2024
Journal Articles

Immune Training Enhances Anti-Viral Responses and Improves Outcomes in Pax5 -/+ Mice Susceptible to Chronic Infection

Zhe Lu, Olivia Stencel, Wei Liu, Eleni Vasileiou, Haifeng Chris Xu, Piyush Pandey, Pawel Stachura, Abdelrahman Elwy, Anastassia Tsombal, Ann-Sophie Mai, Auer Franziska, Mina Morcos, Maximilian Seidl, Sarah Elitzur, Gunther Hartmann, Karl Sebastian Lang, Stefan Janssen, Sanil Bhatia, Philipp Lang, Ute Fischer, Julia Hauer, Arndt Borkhardt, Aleksandra A. Pandyra
Journal: Blood
Blood (2024) 144 (Supplement 1): 1160.
https://doi.org/10.1182/blood-2024-194227
Published: 2024
Journal Articles

ATM germ line pathogenic variants affect outcomes in children with ataxia-telangiectasia and hematological malignancies

Clinical Trials & Observations
Sarah Elitzur, Ruth Shiloh, Jan L. C. Loeffen, Agata Pastorczak, Masatoshi Takagi, Simon Bomken, Andre Baruchel, Thomas Lehrnbecher, Sarah K. Tasian, Oussama Abla, Nira Arad-Cohen, Itziar Astigarraga, Miriam Ben-Harosh, Nicole Bodmer, Triantafyllia Brozou, Francesco Ceppi, Liliia Chugaeva, Luciano Dalla Pozza, Stephane Ducassou, Gabriele Escherich, Roula Farah, Amber Gibson, Henrik Hasle, Julieta Hoveyan, Elad Jacoby, Janez Jazbec, Stefanie Junk, Alexandra Kolenova, Jelena Lazic, Luca Lo Nigro, Nizar Mahlaoui, Lane Miller, Vassilios Papadakis, Lucie Pecheux, Marta Pillon, Ifat Sarouk, Jan Stary, Eftichia Stiakaki, Marion Strullu, Thai Hoa Tran, Marek Ussowicz, Jaime Verdu-Amoros, Anna Wakulinska, Joanna Zawitkowska, Dominique Stoppa-Lyonnet, A. Malcolm Taylor, Yosef Shiloh, Shai Izraeli, Veronique Minard-Colin, Kjeld Schmiegelow, Ronit Nirel, Andishe Attarbaschi, Arndt Borkhardt
Journal: Blood
Blood (2024) 144 (11): 1193–1205.
https://doi.org/10.1182/blood.2024024283
Published: 2024
Includes: Supplemental data
Journal Articles

Somatic and Germline Cohesin Genes Alterations in Pediatric Acute Lymphoblastic Leukemia

Stefano Rebellato, Claudia Saitta, Laura Rachele Bettini, Daniela Silvestri, Orietta Spinelli, Agata Pastorczak, Danielle Brandes, Ute Fischer, Arndt Borkhardt, Sabine Strehl, Luca Lo Nigro, Barbara Buldini, Julia Hauer, Franziska Auer, Lennart Kester, Roland P. Kuiper, Luciana Vinti, Franco Locatelli, Andrea Biondi, Grazia Fazio, Giovanni Cazzaniga
Journal: Blood
Blood (2023) 142 (Supplement 1): 1600.
https://doi.org/10.1182/blood-2023-189244
Published: 2023
Journal Articles

ATM Germline Pathogenic Variants Affect Treatment Outcomes in Children with Acute Lymphoblastic Leukemia/Lymphoma and Ataxia Telangiectasia

Sarah Elitzur, Ruth Shiloh, Jan Loeffen, Agata Pastorczak, Masatoshi Takagi, Simon Bomken, Andre Baruchel, Stephane Ducassou, Nizar Mahlaoui, Marion Strullu, Thomas Lehrnbecher, Kjeld Schmiegelow, Oussama Abla, Liliia Anderzhanova, Nira Arad-Cohen, Itziar Astigarraga, Miriam Ben-Harosh, Francesco Ceppi, Nicole Bodmer, Triantafyllia Brozou, Luciano Dalla-Pozza, Gabriele Escherich, Roula Farah, Amber Gibson, Henrik Hasle, Julieta Hoveyan, Elad Jacoby, Janez Jazbec, Alexandra Kolenova, Jelena Lazic, Luca Lo Nigro, Lane Miller, Vassilios Papadakis, Lucie Pecheux, Marta Pillon, Ifat Sarouk, Jan Stary, Eftichia Stiakaki, Sarah K. Tasian, Thai Hoa Tran, Marek Ussowicz, Jose Jaime Verdu-Amoros, Anna Wakulinska, Joanna Zawitkowska, Dominique Stoppa-Lyonnet, Malcolm Taylor, Yosef Shiloh, Shai Izraeli, Ronit Nirel, Veronique Minard-Colin, Andishe Attarbaschi, Arndt Borkhardt
Journal: Blood
Blood (2023) 142 (Supplement 1): 520.
https://doi.org/10.1182/blood-2023-179333
Published: 2023
Journal Articles

High-Hyperdiploid Acute Lymphoblastic Leukemia in Children with LZTR1 Germline Variants

Triantafyllia Brozou, Arndt Borkhardt, Ute Fischer, Danielle Brandes, Layal Yasin, Oskar A. Haas, Stefanie Junk, Martin Stanulla, Ammarah Anwar, Stavrieta Soura, Julia Hauer, Franziska Auer, Martin Dugas, Carolin Walter, Julian Varghese, Tobias Reiff, Lisa Zipper, Anna Emilia Hoffmann, Rabea Wagener
Journal: Blood
Blood (2023) 142 (Supplement 1): 1408.
https://doi.org/10.1182/blood-2023-174500
Published: 2023
Journal Articles

Pax5 Heterozygosity Affects B-Cell Differentiation and Generates a Deregulated Precursor Population in the Bone Marrow

Franziska Auer, Mina Morcos, Mikko Sipola, Sanni Moisio, Anna Viitasalo, Aleksandra Pandyra, Arndt Borkhardt, Merja Heinäniemi, Julia Hauer
Journal: Blood
Blood (2023) 142 (Supplement 1): 2768.
https://doi.org/10.1182/blood-2023-184384
Published: 2023
Journal Articles

CNS Invasion of TCF3::PBX1 + Leukemia Cells Requires Upregulation of AP-1 Signaling As Revealed By Brain Organoid Model

Philip Gebing, Stefanos Loizou, Sebastian Hänsch, Julian Schliehe-Diecks, Lea Spory, Pawel Stachura, Aleksandra Pandyra, Martin Schrappe, Gunnar Cario, Ameera Alsadeq, Denis Martin Schewe, Arndt Borkhardt, Lennart Lenk, Ute Fischer, Sanil Bhatia
Journal: Blood
Blood (2023) 142 (Supplement 1): 1407.
https://doi.org/10.1182/blood-2023-178613
Published: 2023
Journal Articles

EBV-driven lymphoid neoplasms associated with pediatric ALL maintenance therapy

Clinical Trials & Observations
Sarah Elitzur, Ajay Vora, Birgit Burkhardt, Hiroto Inaba, Andishe Attarbaschi, Andre Baruchel, Gabriele Escherich, Brenda Gibson, Hsi-Che Liu, Mignon Loh, Anthony V. Moorman, Anja Möricke, Rob Pieters, Anne Uyttebroeck, Susan Baird, Jack Bartram, Shlomit Barzilai-Birenboim, Sandeep Batra, Miriam Ben-Harosh, Yves Bertrand, Trudy Buitenkamp, Kenneth Caldwell, Ricardo Drut, Ashley V. Geerlinks, Gil Gilad, John Grainger, Stephanie Haouy, Nicholas Heaney, Mary Huang, Danielle Ingham, Zdenka Krenova, Michaela Kuhlen, Thomas Lehrnbecher, Atsushi Manabe, Felix Niggli, Claudia Paris, Shoshana Revel-Vilk, Pierre Rohrlich, Mohamad G. Sinno, Tomasz Szczepanski, Melanie Tamesberger, Rajasekharan Warrier, Matthias Wolfl, Ronit Nirel, Shai Izraeli, Arndt Borkhardt, Kjeld Schmiegelow
Journal: Blood
Blood (2023) 141 (7): 743–755.
https://doi.org/10.1182/blood.2022016975
Published: 2023
Includes: Supplemental data
Journal Articles

Familial Predisposition to B-Cell Precursor Acute Lymphoblastic Leukemia Mediated By PAX5 Germline Variants

Franziska Auer, Adela Escuerdo, Ulrike Anne Friedrich, Polina Stepensky, Arndt Borkhardt, Sarah Elitzur, Masatoshi Takagi, Julia Hauer
Journal: Blood
Blood (2022) 140 (Supplement 1): 8888–8889.
https://doi.org/10.1182/blood-2022-166646
Published: 2022
Journal Articles

The Role of Adult Cancer Predisposition Genes in Hematological Malignancies of Childhood

Triantafyllia Brozou, Rabea Wagener, Danielle Brandes, Ute Fischer, Arndt Borkhardt
Journal: Blood
Blood (2022) 140 (Supplement 1): 8750–8751.
https://doi.org/10.1182/blood-2022-159655
Published: 2022
Journal Articles

A Human iPSC Model Reveals Specific Upregulation of Linker Histone H1-0 in ETV6::RUNX1 + Preleukemia and B Cell Precursor Acute Lymphoblastic Leukemia

Vera H Jepsen, Daniel Hein, Daniel Picard, Tobias Lautwein, Rabea Wagener, Nan Qin, Annika Filip, Merja Heinäniemi, Arndt Borkhardt, Ute Fischer
Journal: Blood
Blood (2022) 140 (Supplement 1): 3469–3470.
https://doi.org/10.1182/blood-2022-163564
Published: 2022
Journal Articles

Targeting Hyperactivated Lck in PAX5 Rearranged Pediatric B-Cell Precursors Acute Lymphoblastic Leukemia

Grazia Fazio, Manuel Quadri, Silvia Bresolin, Chiara Palmi, Michela Bardini, Athanasios Oikonomou, Jia-Wey Tu, Katerina Scharov, Alberto Peloso, Titus Watrin, Sanil Bhatia, Arndt Borkhardt, Andrea Biondi, Giovanni Cazzaniga
Journal: Blood
Blood (2022) 140 (Supplement 1): 3107–3108.
https://doi.org/10.1182/blood-2022-169023
Published: 2022
Journal Articles

Novel Drugs to Target JAK2 Rearrangements in Pediatric Acute Lymphoblastic Leukemia

Manuel Quadri, Claudia Saitta, Sonia Palamini, Chiara Palmi, Jia-Wey Tu, Sanil Bhatia, Arndt Borkhardt, Andrea Biondi, Giovanni Cazzaniga, Grazia Fazio
Journal: Blood
Blood (2022) 140 (Supplement 1): 364–365.
https://doi.org/10.1182/blood-2022-169437
Published: 2022
Journal Articles

Deciphering the Somatic and Germline Structural Variation Landscape in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia By Whole Genome Optical Mapping

Danielle Brandes, Triantafyllia Brozou, Karin Nebral, Anke K. Bergmann, Oskar A. Haas, Stefan Köhrer, Martin Stanulla, Ute Fischer, Arndt Borkhardt, Rabea Wagener
Journal: Blood
Blood (2022) 140 (Supplement 1): 9203–9204.
https://doi.org/10.1182/blood-2022-163110
Published: 2022
Journal Articles

Ph-like and IKZF1plus Features in Children with Down Syndrome and B Cell Precursor Acute Lymphoblastic Leukemia

Chiara Palmi, Silvia Bresolin, Stefanie V. Junk, Grazia Fazio, Daniela Silvestri, Marketa Zaliova, Athanasios Oikonomou, Katerina Scharov, Martin Stanulla, Anja Moericke, Martin Zimmermann, Martin Schrappe, Barbara Buldini, Claudia Saitta, Marta Galbiati, Michela Bardini, Sanil Bhatia, Arndt Borkhardt, Luca Lo Nigro, Valentino Conter, Maria Grazia Valsecchi, Andrea Biondi, Geertruij Te Kronnie, Gunnar Cario, Giovanni Cazzaniga
Journal: Blood
Blood (2022) 140 (Supplement 1): 6367–6368.
https://doi.org/10.1182/blood-2022-169131
Published: 2022
Journal Articles

Pax5 Heterozygosity Delays BCR Expression in Preb-II Cells and Generates a Preleukemic Population

Franziska Auer, Juha Mehtonen, Mikko Sipola, Mina Morcos, Aleksandra Pandyra, Arndt Borkhardt, Merja Heinäniemi, Julia Hauer
Journal: Blood
Blood (2021) 138 (Supplement 1): 1140.
https://doi.org/10.1182/blood-2021-150144
Published: 2021
Journal Articles

Novel Germline POT1 Variant Predisposes to Childhood Acute Myeloid Leukemia

Pia Michler, Franziska Auer, Rabea Wagener, Triantafyllia Brozou, Ulrike Anne Friedrich, Carolin Walter, Martin Dugas, Arndt Borkhardt, Friedrich Stölzel, Julia Hauer
Journal: Blood
Blood (2021) 138 (Supplement 1): 3449.
https://doi.org/10.1182/blood-2021-150456
Published: 2021
Journal Articles

Recurrent Germline Variant in the Cohesin Complex Gene RAD21 Predisposes Children to Lymphoblastic Leukemia and Lymphoma

Anne Schedel, Ulrike Anne Friedrich, Rabea Wagener, Juha Mehtonen, Claudia Saitta, Triantafyllia Brozou, Pia Michler, Carolin Walter, Peter Horak, Nagarajan Paramasivam, Grazia Fazio, Stefan Fröhling, Martin Dugas, Daniela Richter, Hanno Glimm, Merja Heinäniemi, Rolf Jessberger, Giovanni Cazzaniga, Arndt Borkhardt, Julia Hauer, Franziska Auer
Journal: Blood
Blood (2021) 138 (Supplement 1): 3358.
https://doi.org/10.1182/blood-2021-150284
Published: 2021