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Journal Articles

Comparable Outcomes of Point-of-Care and Commercial CD19 CAR-T Therapies: A Patient-Matched Analysis in Large B-Cell Lymphoma

Ronit Marcus, Abraham Avigdor, Uri Greenbaum, Noa Golan Accav, Noga Shem-Tov, Ronit Yerushalmi, Ivetta Danylesko, Elad Jacoby, Arnon Nagler, Avichai Shimoni, Annamaria Ballweg, Xavier Deschênes-Simard, Efrat Luttwak, Gunjan L. Shah, Michael Scordo, Parastoo B Dahi, Miguel Angel Perales, Tsila Zuckerman, Israel Henig, Dana Yehudai-Ofir, Hazim Khatib, Roni Shouval, Ofrat Beyar Katz
Journal: Blood
Blood (2024) 144 (Supplement 1): 608.
https://doi.org/10.1182/blood-2024-207638
Published: 2024
Journal Articles

T-Lymphoblastic Lymphoma in a Patient with Pearson Syndrome Following Mitochondrial Augmentation

Elad Jacoby, Reut Fluss, Efrat Glick Saar, Shachar Naor, Ortal Barel, Niv Sabath, Noa Sher, Noa Greenberg-Kushnir, Bella Bielorai, Natalie Yivgi Ohana, Amos Toren, Gideon Rechavi
Journal: Blood
Blood (2024) 144 (Supplement 1): 2065.
https://doi.org/10.1182/blood-2024-199972
Published: 2024
Journal Articles

ATM germ line pathogenic variants affect outcomes in children with ataxia-telangiectasia and hematological malignancies

Clinical Trials & Observations
Sarah Elitzur, Ruth Shiloh, Jan L. C. Loeffen, Agata Pastorczak, Masatoshi Takagi, Simon Bomken, Andre Baruchel, Thomas Lehrnbecher, Sarah K. Tasian, Oussama Abla, Nira Arad-Cohen, Itziar Astigarraga, Miriam Ben-Harosh, Nicole Bodmer, Triantafyllia Brozou, Francesco Ceppi, Liliia Chugaeva, Luciano Dalla Pozza, Stephane Ducassou, Gabriele Escherich, Roula Farah, Amber Gibson, Henrik Hasle, Julieta Hoveyan, Elad Jacoby, Janez Jazbec, Stefanie Junk, Alexandra Kolenova, Jelena Lazic, Luca Lo Nigro, Nizar Mahlaoui, Lane Miller, Vassilios Papadakis, Lucie Pecheux, Marta Pillon, Ifat Sarouk, Jan Stary, Eftichia Stiakaki, Marion Strullu, Thai Hoa Tran, Marek Ussowicz, Jaime Verdu-Amoros, Anna Wakulinska, Joanna Zawitkowska, Dominique Stoppa-Lyonnet, A. Malcolm Taylor, Yosef Shiloh, Shai Izraeli, Veronique Minard-Colin, Kjeld Schmiegelow, Ronit Nirel, Andishe Attarbaschi, Arndt Borkhardt
Journal: Blood
Blood (2024) 144 (11): 1193–1205.
https://doi.org/10.1182/blood.2024024283
Published: 2024
Includes: Supplemental data
Journal Articles

ATM Germline Pathogenic Variants Affect Treatment Outcomes in Children with Acute Lymphoblastic Leukemia/Lymphoma and Ataxia Telangiectasia

Sarah Elitzur, Ruth Shiloh, Jan Loeffen, Agata Pastorczak, Masatoshi Takagi, Simon Bomken, Andre Baruchel, Stephane Ducassou, Nizar Mahlaoui, Marion Strullu, Thomas Lehrnbecher, Kjeld Schmiegelow, Oussama Abla, Liliia Anderzhanova, Nira Arad-Cohen, Itziar Astigarraga, Miriam Ben-Harosh, Francesco Ceppi, Nicole Bodmer, Triantafyllia Brozou, Luciano Dalla-Pozza, Gabriele Escherich, Roula Farah, Amber Gibson, Henrik Hasle, Julieta Hoveyan, Elad Jacoby, Janez Jazbec, Alexandra Kolenova, Jelena Lazic, Luca Lo Nigro, Lane Miller, Vassilios Papadakis, Lucie Pecheux, Marta Pillon, Ifat Sarouk, Jan Stary, Eftichia Stiakaki, Sarah K. Tasian, Thai Hoa Tran, Marek Ussowicz, Jose Jaime Verdu-Amoros, Anna Wakulinska, Joanna Zawitkowska, Dominique Stoppa-Lyonnet, Malcolm Taylor, Yosef Shiloh, Shai Izraeli, Ronit Nirel, Veronique Minard-Colin, Andishe Attarbaschi, Arndt Borkhardt
Journal: Blood
Blood (2023) 142 (Supplement 1): 520.
https://doi.org/10.1182/blood-2023-179333
Published: 2023
Journal Articles

Long-Term Hematopoietic Dysfunction in Patients with Single Large-Scale Mitochondrial DNA Deletion Syndromes

Noa Greenberg-Kushnir, Assaf Arie Barg, Ginette Schiby, Corine Mardoukh, Nira Varda-Bloom, Diana Bar, Yair Anikster, Bella Bielorai, Amos Toren, Elad Jacoby
Journal: Blood
Blood (2023) 142 (Supplement 1): 4105.
https://doi.org/10.1182/blood-2023-182562
Published: 2023
Journal Articles

Pre-Treatment Pulmonary Assessment Have Limited Utility in B-Cell Lymphoma Patients Treated with Autologous Anti-CD19 CAR T-Cell Therapy

Inbal Sdayoor, Roni Shouval, Shalev Fried, Ronit Marcus, Ivetta Danylesko, Ronit Yerushalmi, Noga Shem-Tov, Orit Itzhaki, Elad Jacoby, Meirav Kedmi, Arnon Nagler, Avichai Shimoni, Michael J Segel, Abraham Avigdor
Journal: Blood
Blood (2023) 142 (Supplement 1): 3519.
https://doi.org/10.1182/blood-2023-180115
Published: 2023
Journal Articles

High Response Rates Following Point-of-Care Anti-CD19 CAR T-Cell Therapy in Adults with Relapsed/Refractory Acute B Lymphoblastic Leukemia

Shalev Fried, Ivetta Danylesko, Ronit Marcus, Orit Itzhaki, Ronit Yerushalmi, Noga Shem-Tov, Inbal Sdayoor, Roni Shouval, Elad Jacoby, Meirav Kedmi, Arnon Nagler, Avichai Shimoni, Abraham Avigdor
Journal: Blood
Blood (2023) 142 (Supplement 1): 6875.
https://doi.org/10.1182/blood-2023-178477
Published: 2023
Journal Articles

Project Evolve, Evaluation of Lineage Switch (LS), an International Initiative: Preliminary Results Reveal Dismal Outcomes in Patients with LS

Sara K. Silbert, Cynthia Harrison, D. Nathan Biery, Alexandra Semchenkova, Elena Zerkalenkova, Anna Alonso-Saladrigues, Kaylyn Utley, Ibrahim Aldoss, Liping Zhao, Sneha Fernandes, Jeremy D. Rubinstein, Naomi Torres Carapia, Bill H. Chang, Anant Vatsayan, Barbara De Moerloose, Holly L. Pacenta, Dennis John Kuo, Gabriele Escherich, Benjamin J. Lee, Michele S. Redell, Mandi R. Fitzjohn, Daniel P. Larson, Nicolas Duployez, Raymund S. Cuevo, Rui Rochelle He, David Dickens, Firas El Chaer, Kelly Reed, Matthias Wolfl, Sunil S. Raikar, Süreyya Savaşan, Latika Puri, Zhubin J. Gahvari, Aimee C. Talleur, Hisham Abdel-Azim, Aghiad Chamdin, Marlie R.M. Provost, Vanessa A. Fabrizio, Kerstin Mezger, Alexandra McLean Stevens, Emily M. Hsieh, Hao-Wei Wang, Constance M. Yuan, Ulrich A. Duffner, Jing Pan, Sara Ghorashian, Susana Rives, Chloe Hoang, Kara L. Davis, Elad Jacoby, Alexander Popov, Adam Lamble, Nirali N. Shah
Journal: Blood
Blood (2023) 142 (Supplement 1): 4202.
https://doi.org/10.1182/blood-2023-182293
Published: 2023
Journal Articles

Drug Response Profiling Informs Personalized Bridging to Cell Therapy for Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia

Fabio D. Steffen, Andrej Lissat, Julia Alten, Cornelia Eckert, Nicole Bodmer, Bodil E. Thorhauge Als-Nielsen, Adriana Balduzzi, Barbara Buldini, Sarah Elitzur, Andras Kriston, Gergely Nyiri, Imre Västrik, Ferenc Kovacs, Francesco Ceppi, Lucie Sramkova, Larissa Schori, Arianna Arpagaus, Silvia Gutnik, Andishe Attarbaschi, Birgitte Klug Albertsen, Jeanette Greiner, Marc Ansari, Judith M. Boer, Elad Jacoby, Martin Stanulla, Uri Ilan, Peter M. Hoogerbrugge, Tim Lammens, Barbara De Moerloose, Petter Svenberg, Nicolas von der Weid, David O'Connor, Hélène Cavé, Franco Locatelli, Martin Schrappe, André Baruchel, Andreas Kulozik, Kjeld Schmiegelow, Gunnar Cario, Arend von Stackelberg, Peter Horvath, Beat Bornhauser, Jean-Pierre Bourquin
Journal: Blood
Blood (2023) 142 (Supplement 1): 4350.
https://doi.org/10.1182/blood-2023-179306
Published: 2023
Journal Articles

Inflammatory Biomarker Clusters Are Predictive of Response and Toxicity in Large B-Cell Lymphoma Treated with CD19 CAR-T Cell Therapy

Sandeep Raj, Miguel-Angel Perales, Joshua A Fein, Ana Alarcon Tomas, Connie Lee Batlevi, Magdalena Corona De Lapuerta, Parastoo B Dahi, Ivetta Danylesko, Shalev Fried, Tyler Funnell, Sergio A. Giralt, Elad Jacoby, Meirav Kedmi, Richard J. Lin, Arnon Nagler, Karthik Nath, Allison Parascondola, M.Lia Palomba, Gilles Salles, Michael Scordo, Gunjan L. Shah, Noga Shem-Tov, Avichai Shimoni, John Slingerland, Moneeza Walji, Ronit Yerushalmi, Abraham Avigdor, Marcel R M van den Brink, Roni Shouval
Journal: Blood
Blood (2022) 140 (Supplement 1): 648–650.
https://doi.org/10.1182/blood-2022-162286
Published: 2022
Journal Articles

Potential Impact of Treatment with Inotuzumab Ozogamicin on Chimeric Antigen Receptor T-Cell Therapy in Children with Relapsed or Refractory Acute Lymphoblastic Leukemia

Valeria Ceolin, Erica Brivio, Susan R. Rheingold, Allison Barz Leahy, Britta Julia Vormoor, Maureen M. O'Brien, Jeremy Rubinstein, Krzysztof Kalwak, Barbara De Moerloose, Elad Jacoby, Peter Bader, José L. Fuster, Franco Locatelli, Peter Hoogerbrugge, Friso Calkoen, Christian M. Zwaan
Journal: Blood
Blood (2021) 138 (Supplement 1): 3824.
https://doi.org/10.1182/blood-2021-146556
Published: 2021
Journal Articles

Encouraging Survival and High Rates of Toxicity: Allogeneic Hematopoietic Cell Transplantation after Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy in Aggressive Lymphoma Patients

Shalev Fried, Ivetta Danylesko, Ronit Yerushalmi, Noga Shem-Tov, Roni Shouval, Joshua A Fein, Zachary Cohen, Elad Jacoby, Michal Besser, Arnon Nagler, Avichai Shimoni, Abraham Avigdor
Journal: Blood
Blood (2021) 138 (Supplement 1): 910.
https://doi.org/10.1182/blood-2021-147148
Published: 2021
Journal Articles

Safety and Efficacy of CD19 CAR T-Cells for Pediatric Relapsed Acute Lymphoblastic Leukemia with Active CNS Involvement

Elad Jacoby, MD, Sara Ghorashian, FRCPath, PhD, Britta Julia Vormoor, MD, Barbara De Moerloose, MD, Nicole Bodmer, Michael Maschan, MD, Asaf David Yanir, MD, Bella Bielorai, MD, Srdan Rogosic, Olga Molostova, MD, Claudia Rossig, Amos Toren, MD PhD, Arend von Stackelberg, MD, Jean-Pierre Bourquin, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-141940
Published: 2020
Journal Articles

In Vitro Drug Response Profiling in BCP- and T-ALL Primary Samples Adds a Robust Functional Layer Enabling Optimized Guidance of Individualized Therapy in Relapsed and Refractory Pediatric Acute Leukemia Patients

Andrej Lissat, Despina Maniotis, Michael Nosswitz, Julia Alten, MD, Silvia Jenni, PhD, Yi-Chien Tsai, Gunnar Cario, MD PhD, Roberta La Starza, MDPhD, Ondrej Hrusak, MD PhD, Andreas E. Kulozik, MD PhD, Olaf Witt, Martin Stanulla, MD, Martin Schrappe, MDPhD, Christian M. Zwaan, MD PhD, Cornelia Eckert, PhD, Arend von Stackelberg, MD, Andre Baruchel, Elad Jacoby, MD, Axel Karow, Francesco Ceppi, MD, Beat Bornhauser, Jean-Pierre Bourquin, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 15–16.
https://doi.org/10.1182/blood-2020-142314
Published: 2020
Journal Articles

Upregulation of Senescent/Exhausted Phenotype of CAR T Cells and Induction of Both Treg and Myeloid Suppressive Cells Correlate with Reduced Response to CAR T Cell Therapy in Relapsed/Refractory B Cell Malignancies

Katia Beider, Michal J Besser, PhD, Jacob Schachter, MD, Ania Hava Grushchenko-Polaq, Valeria Voevoda, Idit Wolf, Olga Ostrovsky, PhD, Elad Jacoby, MD, Avichai Shimoni, MD, Arnon Nagler, MD MSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 3234.
https://doi.org/10.1182/blood-2019-128068
Published: 2019
Journal Articles

First-in-Human Mitochondrial Augmentation of Hematopoietic Stem Cells in Pearson Syndrome

Elad Jacoby, MD, Moriya Blumkin, PhD, Yair Anikster, MD PhD, Nira Varda-Bloom, PhD, Julia Pansheen, Omer Bar Yoseph, MD PhD, Noah Gruber, MD, Einat Lahav, MD, Michal J Besser, PhD, Jacob Schachter, MD, Noa Sher, PhD, Natalie Yivgi Ohana, PhD, Amos Toren, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1024.
https://doi.org/10.1182/blood-2018-99-113773
Published: 2018
Journal Articles

Murine allogeneic CD19 CAR T cells harbor potent antileukemic activity but have the potential to mediate lethal GVHD

Elad Jacoby, Yinmeng Yang, Haiying Qin, Christopher D. Chien, James N. Kochenderfer, Terry J. Fry
Journal: Blood
Blood (2016) 127 (10): 1361–1370.
https://doi.org/10.1182/blood-2015-08-664250
Published: 2016
Includes: Supplemental data
Journal Articles

Lineage Switch As a Relapse Mechanism of Pre-B Acute Lymphoblastic Leukemia Following CD19 CAR

Elad Jacoby, MD, Sang Minh Nguyen, BS, Kathryn M Welp, Haiying Qin, MS, Yinmeng Yang, BS, Christopher Daniel Chien, PhD, John Shern, MD, Terry J. Fry, MD
Journal: Blood
Blood (2015) 126 (23): 2524.
https://doi.org/10.1182/blood.V126.23.2524.2524
Published: 2015
Journal Articles

CD4 CAR T Cells Mediate CD8-like Cytotoxic Anti-Leukemic Effects Resulting in Leukemic Clearance and Are Less Susceptible to Attenuation By Endogenous TCR Activation Than CD8 CAR T Cells

Yinmeng Yang, BS, Tasha Lin, MD, Elad Jacoby, MD, Haiying Qin, MS, Elizabeth Grier Gardner, MD, Christopher Daniel Chien, PhD, Daniel W. Lee, III, MD, Terry J. Fry, MD
Journal: Blood
Blood (2015) 126 (23): 100.
https://doi.org/10.1182/blood.V126.23.100.100
Published: 2015
Journal Articles

CRLF2 /Tslpr Overexpressing Acute Lymphoblastic Leukemia Relapse Is Driven By Chemotherapy-Induced TSLP from Bone Marrow Stromal Cells

Christopher Daniel Chien, PhD, Sang Minh Nguyen, BS, Haiying Qin, MS, Elad Jacoby, MD, Terry J. Fry, MD
Journal: Blood
Blood (2015) 126 (23): 1432.
https://doi.org/10.1182/blood.V126.23.1432.1432
Published: 2015