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Adam J. de Smith
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Journal Articles

Genome-Wide Association Study of Acute Lymphoblastic Leukemia in Hispanic/Latino Children Identifies a Putatively Novel Risk Locus at Chromosome 5q31.1

Tanxin Liu, Jalen Langie, Wenjian Yang, Libby Morimoto, Xiaomei Ma, Catherine Metayer, Philip J Lupo, Michael E. Scheurer, Jun J. Yang, Joseph L. Wiemels, Charleston W.K. Chiang, Adam J. de Smith
Journal: Blood
Blood (2024) 144 (Supplement 1): 317.
https://doi.org/10.1182/blood-2024-208796
Published: 2024
Journal Articles

NBN: protein instability, ALL susceptibility

Adam J. de Smith
Journal: Blood
Blood (2024) 143 (22): 2221–2222.
https://doi.org/10.1182/blood.2024024409
Published: 2024
Journal Articles

Heritable Variation in Lymphocyte-Related Traits and Risk of Down Syndrome Acute Lymphoblastic Leukemia: A Mendelian Randomization Study

Yunqi Li, Melissa A. Richard, Linda Kachuri, Yao Yu, Ching-Ju Ruu Hsu, Tracie C. Rosser, Elizabeth J. Leslie, Meenakshi Devidas, Elizabeth A. Raetz, Mignon L. Loh, Stephen P. Hunger, Neetha Paul Eduthan, Matthew D. Galbraith, Joaquin Espinosa, Jun J. Yang, Stephanie L. Sherman, Chad D. Huff, Karen R. Rabin, Philip J. Lupo, Adam J. de Smith
Journal: Blood
Blood (2023) 142 (Supplement 1): 4198.
https://doi.org/10.1182/blood-2023-188434
Published: 2023
Journal Articles

Racial and Ethnic Disparities in Childhood Acute Lymphoblastic Leukemia Risk Due to an IKZF1 Noncoding Regulatory Variant

Adam J. de Smith, Lara Wahlster, Soyoung Jeon, Fulong Yu, Susan Black, Steven Gazal, Nicholas Mancuso, Catherine Metayer, Xiaomei Ma, Joseph L. Wiemels, Charleston W.K. Chiang, Vijay G. Sankaran
Journal: Blood
Blood (2022) 140 (Supplement 1): 8880–8881.
https://doi.org/10.1182/blood-2022-167965
Published: 2022
Journal Articles

Whole-Exome Sequencing in Multiplex Families to Identify Novel AYA Classical Hodgkin Lymphoma Predisposition Genes

Keren Xu, Niquelle B Wadé, Amie E. Hwang, David V Conti, Maryam Salehi, Thomas M Mack, Victoria Cortessis, David J Van Den Berg, Adam J. de Smith, Wendy Cozen
Journal: Blood
Blood (2021) 138 (Supplement 1): 3499.
https://doi.org/10.1182/blood-2021-153247
Published: 2021
Journal Articles

The Effect of Cytomegalovirus on Pediatric Acute Lymphoblastic Leukemia

Rachel Gallant, Katti Arroyo, Paige Bracci, Catherine Metayer, Adam J. de Smith, Joseph L. Wiemels
Journal: Blood
Blood (2021) 138 (Supplement 1): 2281.
https://doi.org/10.1182/blood-2021-147994
Published: 2021
Journal Articles

Evaluation of DNA Methylation at Birth in Monozygotic Twin Pairs Discordant for Acute Lymphoblastic Leukemia

Eric M. Nickels, Shaobo Li, Katti Arroyo, Swe Swe Myint, Adam J. de Smith, Joseph L. Wiemels
Journal: Blood
Blood (2021) 138 (Supplement 1): 2278.
https://doi.org/10.1182/blood-2021-152795
Published: 2021
Journal Articles

Epigenome-Wide Association Study of Acute Lymphoblastic Leukemia in Children with Down Syndrome

Shaobo Li, Pagna Sok, Keren Xu, Ivo S Muskens, Natalina Elliott, Swe Swe Myint, Priyatama Pandey, Helen M Hansen, Libby M Morimoto, Alice Y Kang, Catherine Metayer, Xiaomei Ma, Beth A Mueller, Anindita Roy, Irene Roberts, Karen R Rabin, Austin L Brown, Philip J. Lupo, Joseph L. Wiemels, Adam J. de Smith
Journal: Blood
Blood (2021) 138 (Supplement 1): 214.
https://doi.org/10.1182/blood-2021-151454
Published: 2021
Journal Articles

Genetic Determinants of Blood Cell Traits Play a Role in Susceptibility to Acute Lymphoblastic Leukemia

Linda Kachuri, PhD MPH, Soyoung Jeon, BSc, Andrew T. DeWan, PhD, Catherine Metayer, MD PhD, John S. Witte, PhD, Xiaomei Ma, PhD, Charleston W. K. Chiang, PhD, Joseph L. Wiemels, PhD, Adam J. de Smith, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10–11.
https://doi.org/10.1182/blood-2020-141443
Published: 2020
Journal Articles

Genetic Alterations Precede DNA Methylation Changes in Juvenile Myelomonocytic Leukemia

Astrid Behnert, MD, Julia Meyer, PhD, Jahan-Yar Parsa, PhD, Aaron Hechmer, PhD, Mignon L. Loh, MD, Adam B. Olshen, PhD, Adam J. de Smith, PhD, Elliot Stieglitz, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 19–20.
https://doi.org/10.1182/blood-2020-143443
Published: 2020
Journal Articles

The Genome-Wide Impact of Trisomy 21 on DNA Methylation and Its Implications for Hematologic Malignancies

Joseph L. Wiemels, PhD, Ivo S Muskens, Shaobo Li, Priyatama Pandey, Ritu Roy, PhD, Helen M Hansen, BSc, Kimberly D Siegmund, PhD, Beth A Mueller, PhD, Xiaomei Ma, PhD, Catherine Metayer, MD PhD, Adam J de Smith, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2510.
https://doi.org/10.1182/blood-2019-131455
Published: 2019
Journal Articles

Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome

Austin L. Brown, Adam J. de Smith, Vincent U. Gant, Wenjian Yang, Michael E. Scheurer, Kyle M. Walsh, Jonathan M. Chernus, Noah A. Kallsen, Shanna A. Peyton, Gareth E. Davies, Erik A. Ehli, Naomi Winick, Nyla A. Heerema, Andrew J. Carroll, Michael J. Borowitz, Brent L. Wood, William L. Carroll, Elizabeth A. Raetz, Eleanor Feingold, Meenakshi Devidas, Lisa F. Barcellos, Helen M. Hansen, Libby Morimoto, Alice Y. Kang, Ivan Smirnov, Jasmine Healy, Caroline Laverdière, Daniel Sinnett, Jeffrey W. Taub, Jillian M. Birch, Pamela Thompson, Logan G. Spector, Maria S. Pombo-de-Oliveira, Andrew T. DeWan, Charles G. Mullighan, Stephen P. Hunger, Ching-Hon Pui, Mignon L. Loh, Michael E. Zwick, Catherine Metayer, Xiaomei Ma, Beth A. Mueller, Stephanie L. Sherman, Joseph L. Wiemels, Mary V. Relling, Jun J. Yang, Philip J. Lupo, Karen R. Rabin
Journal: Blood
Blood (2019) 134 (15): 1227–1237.
https://doi.org/10.1182/blood.2018890764
Published: 2019
Includes: Supplemental data
Journal Articles

Germline GAB2 Mutations in Childhood Acute Lymphoblastic Leukemia

Adam J de Smith, PhD, Geneviève Lavoie, PhD, Kyle M Walsh, PhD, Sumeet Aujla, BSc, Erica Evans, BSc, Helen M Hansen, BSc, Ivan Smirnov, PhD, Alice Y Kang, MPH, Martin Zenker, MD, John J Ceremsak, BSc, Elliot Stieglitz, MD, Roberta McKean-Cowdin, PhD, Catherine Metayer, PhD, Philippe P Roux, PhD, Joseph L Wiemels, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 388.
https://doi.org/10.1182/blood-2018-99-119235
Published: 2018
Journal Articles

Large Multi-Ethnic Genome Wide Association Study Reveals Novel Genetic Associations with Childhood Acute Lymphoblastic Leukemia at Chromosomes 8q24 and 17q12

Adam J. de Smith, PhD, Kyle M. Walsh, PhD, Stephen S. Francis, PhD, Semira Gonseth, MD, Helen M. Hansen, BSc, Ivan Smirnov, PhD, Lisa Barcellos, PhD, Rong Wang, PhD, Andrew T. DeWan, PhD, Catherine Metayer, PhD, Xiaomei Ma, MD PhD, Joseph L. Wiemels, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 30.
https://doi.org/10.1182/blood.V130.Suppl_1.30.30
Published: 2017
Journal Articles

In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia

Clinical Trials & Observations Brief Report
Stephen Starko Francis, Amelia D. Wallace, George A. Wendt, Linlin Li, Fenyong Liu, Lee W. Riley, Scott Kogan, Kyle M. Walsh, Adam J. de Smith, Gary V. Dahl, Xiaomei Ma, Eric Delwart, Catherine Metayer, Joseph L. Wiemels
Journal: Blood
Blood (2017) 129 (12): 1680–1684.
https://doi.org/10.1182/blood-2016-07-723148
Published: 2017
Includes: Supplemental data
Journal Articles

Somatic and Germline Mutational Heterogeneity in High Hyperdiploid Acute Lymphoblastic Leukemia

Adam J de Smith, PhD, Kyle M Walsh, PhD, Ivan Smirnov, PhD, Sumeet Aujla, Erica Sanders, Hansen M Helen, Catherine Metayer, PhD, Joseph L. Wiemels, PhD
Journal: Blood
Blood (2016) 128 (22): 1727.
https://doi.org/10.1182/blood.V128.22.1727.1727
Published: 2016
Journal Articles

Two-Track Epigenetic Remodeling and Backtracking to Embryonic Stem Cell Bivalency in B-Cell Acute Lymphoblastic Leukemias

Seung-Tae Lee, MD, Marcus O. Muench, Marina Fomin, Jianqiao Xiao, Mi Zhou, MD PhD, Adam J. de Smith, PhD, José Martín-Subero, Simon Heath, E. Andres Houseman, Ritu Roy, Margaret R. Wrensch, PhD, John K. Wiencke, PhD, Catherine Metayer, Joseph L. Wiemels, PhD
Journal: Blood
Blood (2014) 124 (21): 3557.
https://doi.org/10.1182/blood.V124.21.3557.3557
Published: 2014
Journal Articles

Missense SNP rs3731249 Explains the CDKN2A Association with Childhood ALL and Shows Risk Allele Selection in Tumors with Somatic CDKN2A Alterations

Adam J. de Smith, PhD, Kyle M. Walsh, PhD, Helen M. Hansen, Lisa F. Barcellos, PhD, Anand P. Chokkalingam, PhD, Robert B. Jenkins, MD PhD, Margaret R. Wrensch, PhD, John K. Wiencke, PhD, Catherine Metayer, MD PhD, Joseph L. Wiemels, PhD
Journal: Blood
Blood (2014) 124 (21): 129.
https://doi.org/10.1182/blood.V124.21.129.129
Published: 2014
Journal Articles

A Novel Functional Polymorphism in the CCAAT/Enhancer Binding Protein (C/EBP), Epsilon (CEBPE) Gene Promoter Influences Acute Lymphoblastic Leukemia Risk Via Interaction with IKZF1

Kyle M. Walsh, PhD, Adam J. de Smith, PhD, Jianqiao Xiao, Marcus O. Muench, Marina Fomin, Helen M. Hansen, Catherine Metayer, Joseph L. Wiemels, PhD
Journal: Blood
Blood (2014) 124 (21): 489.
https://doi.org/10.1182/blood.V124.21.489.489
Published: 2014
Journal Articles

The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia

Adam J. de Smith, Kyle M. Walsh, Martha B. Ladner, Siming Zhang, Carmen Xiao, Franziska Cohen, Theodore B. Moore, Anand P. Chokkalingam, Catherine Metayer, Patricia A. Buffler, Elizabeth A. Trachtenberg, Joseph L. Wiemels
Journal: Blood
Blood (2014) 123 (16): 2497–2503.
https://doi.org/10.1182/blood-2013-11-540625
Published: 2014
Includes: Supplemental data