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Journal Articles

Enhancement of mTORC1 Activity in Engineered Therapeutic CD4+ T Cells Amplifies Tumour Infiltration but Impairs Cytotoxicity

Francesca Emily Sillito, Angelika Holler, Aideen T O'Neill, Lauren A Callender, Sian M Henson, Hans Stauss, Ronjon Chakraverty
Journal: Blood
Blood (2024) 144 (Supplement 1): 7196.
https://doi.org/10.1182/blood-2024-207047
Published: 2024
Journal Articles

CD27 is required for protective lytic EBV antigen–specific CD8 + T-cell expansion

Yun Deng, Bithi Chatterjee, Kyra Zens, Hana Zdimerova, Anne Müller, Patrick Schuhmachers, Laure-Anne Ligeon, Antonino Bongiovanni, Riccarda Capaul, Andrea Zbinden, Angelika Holler, Hans Stauss, Wolfgang Hammerschmidt, Christian Münz
Journal: Blood
Blood (2021) 137 (23): 3225–3236.
https://doi.org/10.1182/blood.2020009482
Published: 2021
Includes: Supplemental data
Journal Articles

A Phase I Study Evaluating the Safety and Persistence of Allorestricted WT1-TCR Gene Modified Autologous T Cells in Patients with High-Risk Myeloid Malignancies Unsuitable for Allogeneic Stem Cell Transplantation

Emma C Morris, Rita Tendeiro-Rego, Rachel Richardson, MSc, Thomas A Fox, BSc, MSc, MRCP, Francesca Sillito, BSc, MRCP, FRCPath, Angelika Holler, Sharyn Thomas, Shao-An Xue, Irma Alicia Martínez-Dávila, Emma Nicholson, Mandana Ahmadi, Judith King, Panagiotis Kottaridis, Ronjon Chakraverty, BMBS, PhD, Kirsty Thomson, Stephen Robinson, MBBS, PhD BSc, Andres E. Virchis, FRCP, FRCPath, Asim Khwaja, Michelle Quaye, Hong Zhan, Waseem Qasim, MBBS, PhD, Nourredine Himoudi, Jacqueline Barry, Natalie Mount, PhD, Terri Gaskell, Michaela Sharpe, Shannon M Inman, Kurt C. Gunter, MD, Hans Stauss
Journal: Blood
Blood (2019) 134 (Supplement_1): 1367.
https://doi.org/10.1182/blood-2019-128044
Published: 2019
Journal Articles

Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations

Tie Zheng Hou, Nisha Verma, Jennifer Wanders, Alan Kennedy, Blagoje Soskic, Daniel Janman, Neil Halliday, Behzad Rowshanravan, Austen Worth, Waseem Qasim, Helen Baxendale, Hans Stauss, Suranjith Seneviratne, Olaf Neth, Peter Olbrich, Sophie Hambleton, Peter D. Arkwright, Siobhan O. Burns, Lucy S. K. Walker, David M. Sansom
Journal: Blood
Blood (2017) 129 (11): 1458–1468.
https://doi.org/10.1182/blood-2016-10-745174
Published: 2017
Journal Articles

Functional Evaluation of T-Cells Generated from WT1-TCR Transduced Human Hematopoietic Stem Cells Using the OP9-DL1 Coculture System

Sarah Bonte, Master in Biomedical MDcine, Sylvia Snauwaert, MD PhD, Jasper Van Heuverswyn, Glenn Goetgeluk, Mirjam H.M. Heemskerk, PhD, Hans Stauss, MD PhD, Renata Stripecke, PhD, Bart Vandekerckhove, MD PhD, Tessa Kerre, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2152.
https://doi.org/10.1182/blood.V124.21.2152.2152
Published: 2014
Journal Articles

Tuning Of mTOR In Therapeutic T Cells As A Strategy To Manufacture Effector and Memory T Cells

Velica Pedro, PhD, Mathias Zech, Hans Stauss, MD, PhD, Ronjon Chakraverty, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4488.
https://doi.org/10.1182/blood.V122.21.4488.4488
Published: 2013
Journal Articles

Enhancing the Efficacy of T Cell Receptor (TCR) Gene Therapy by Co-Transfer of TCR and Additional CD3 Molecules Into CD4+ T Cells

Emma K Nicholson, MD, Maryam Ahmadi, PhD, Angelika Holler, Rebecca Pike, PhD, Ben Carpenter, MD, Sharyn Thomas, PhD, Sara Ghorashian, MD, Shao-An Xue, PhD, Hans Stauss, MD, PhD, Emma Morris, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2044.
https://doi.org/10.1182/blood.V120.21.2044.2044
Published: 2012
Journal Articles

In Vivo Selection of Mycophenolate Mofetil-Resistant T Cells for Adoptive Immunotherapy.

James Edward Griffin, MD, Ben Carpenter, MD, Emma Nicholson, MD, Shao-an Xue, PhD, Martin Pule, MD, Hans Stauss, MD, PhD, Ronjon Chakraverty, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3008.
https://doi.org/10.1182/blood.V120.21.3008.3008
Published: 2012
Journal Articles

Targeting Therapeutic T Cells to Tumour Niches.

Ben Carpenter, MD, Sara Ghorashian, MD, Emma Nicholson, MD, James Edward Griffin, MD, Maryam Ahmadi, PhD, Angelika Holler, Barry Flutter, PhD, Noha Edwards, Hans Stauss, MD, PhD, Emma Morris, MD, PhD, Ronjon Chakraverty, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3009.
https://doi.org/10.1182/blood.V120.21.3009.3009
Published: 2012
Journal Articles

CD4 Cells Engineered to Express an MHC Class I Restricted TCR Can Rescue CD8 Cells Tolerized to Tumour-Associated Antigens

Sara Ghorashian, MD, Ben Carpenter, MD, Angelika Holler, Emma Nicholson, MD, Maryam Ahmadi, PhD, Mathias Zech, MD, Clare Bennett, PhD, Shao-An Xue, PhD, Emma Morris, MD, PhD, Hans Stauss, MD, PhD, Ronjon Chakraverty, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 952.
https://doi.org/10.1182/blood.V120.21.952.952
Published: 2012
Journal Articles

Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene–transduced human T cells

Shao-An Xue, Liquan Gao, Daniel Hart, Roopinder Gillmore, Waseem Qasim, Adrian Thrasher, Jane Apperley, Boris Engels, Wolfgang Uckert, Emma Morris, Hans Stauss
Journal: Blood
Blood (2005) 106 (9): 3062–3067.
https://doi.org/10.1182/blood-2005-01-0146
Published: 2005
Journal Articles

T Cell Receptor Gene Transfer to Produce MHC Class I-Restricted CD4 Helper T Cells: Implications for Immunotherapy of Leukaemia.

Emma Morris, MD, PhD, Aristotle Tsallios, MSc, Gavin Bendle, MSc, Shao-an Xue, PhD, Hans Stauss, MD, PhD
Journal: Blood
Blood (2004) 104 (11): 5262.
https://doi.org/10.1182/blood.V104.11.5262.5262
Published: 2004