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Journal Articles

Experience of compassionate-use pegcetacoplan for paroxysmal nocturnal hemoglobinuria

Clinical Trials & Observations
Morag Griffin, Petra Muus, Talha Munir, Sateesh Nagumantry, Alexandra Pike, Louise Arnold, Briony Forrest, Catherine Barnfield, Nicola Houghton, Nora Youngs, Richard Kelly
Journal: Blood
Blood (2023) 141 (1): 116–120.
https://doi.org/10.1182/blood.2022017266
Published: 2023
Journal Articles

Treatment Outcomes of Complement Protein C5 Inhibition in 509 Patients with Paroxysmal Nocturnal Hemoglobinuria in the United Kingdom

Richard Kelly, Matthew Holt, Jennifer Vidler, Louise Arnold, Joanna Large, Briony Forrest, Catherine Barnfield, Alexandra Pike, Morag Griffin, Talha Munir, Petra Muus, Sateesh K. Nagumantry, Roochi Trikha, Austin Kulasekararaj, Lindsay Mitchell, Shreyans Ghandi
Journal: Blood
Blood (2022) 140 (Supplement 1): 5792–5794.
https://doi.org/10.1182/blood-2022-167725
Published: 2022
Journal Articles

Terminal Complement Inhibition and Control of Hemolysis in Paroxysmal Nocturnal Hemoglobinuria Following Switching from High-Dose Eculizumab to Ravulizumab: An Interim Analysis

Morag Griffin, Shreyans Gandhi, Eden Hicks, Deepak Jain, Richard Kelly, Talha Munir, Petra Muus, Masayo Ogawa, Roochi Trikha, Ji Yu, Austin Kulasekararaj
Journal: Blood
Blood (2022) 140 (Supplement 1): 2928–2930.
https://doi.org/10.1182/blood-2022-159498
Published: 2022
Journal Articles

Intensive Pegcetacoplan Dosing in the Management of Acute Hemolysis As Part of the 307 Open-Label Extension Study

Morag Griffin, Richard Kelly, Dries Deeren, Yeow Tee Goh, Eric Tse, Kensuke Usuki, Raymond Wong, Regina Horneff, Lisa Tan, Michael Yeh, Jessica Savage, Jeff Szer
Journal: Blood
Blood (2022) 140 (Supplement 1): 2937–2939.
https://doi.org/10.1182/blood-2022-163117
Published: 2022
Journal Articles

Patient-Reported Outcomes from a Phase 2, Randomized Trial Evaluating the Safety and Efficacy of Pozelimab and Cemdisiran in Patients with Paroxysmal Nocturnal Hemoglobinuria

Chris Hartford, Bradley Dain, Steven Sherman, Yi Zhang, Rodrigo Pavani, Lisa Aurand, Diana Rofail, Richard Kelly
Journal: Blood
Blood (2022) 140 (Supplement 1): 10849–10850.
https://doi.org/10.1182/blood-2022-163510
Published: 2022
Journal Articles

Long-Term Safety and Efficacy of Pegcetacoplan Treatment in Adults with Paroxysmal Nocturnal Hemoglobinuria

Christopher J. Patriquin, Andrija Bogdanovic, Morag Griffin, Richard Kelly, Jaroslaw P. Maciejewski, Brian Mulherin, Régis Peffault de Latour, Alexander Roeth, Veena Selvaratnam, Jeffrey Szer, Jessica Savage, Regina Horneff, Lisa Tan, Michael Yeh, Jens Panse
Journal: Blood
Blood (2022) 140 (Supplement 1): 2921–2923.
https://doi.org/10.1182/blood-2022-163625
Published: 2022
Journal Articles

Pregnancy in Paroxysmal Nocturnal Hemoglobinuria - a Systematic Review

James E. Manning, Etienne Ciantar, Morag Griffin, Richard Kelly
Journal: Blood
Blood (2022) 140 (Supplement 1): 11438–11440.
https://doi.org/10.1182/blood-2022-166545
Published: 2022
Journal Articles

A Phase 2, Open-Label Study Evaluating the Safety and Efficacy of Combination Pozelimab and Cemdisiran Therapy in Patients with Paroxysmal Nocturnal Hemoglobinuria Who Switch from Eculizumab

Richard Kelly, Nicola Houghton, Talha Munir, Petra Muus, Nora Youngs, Lisa Aurand, Bradley Dain, Rodrigo Pavani, Lorah Perlee, Amal Souttou, Morag Griffin
Journal: Blood
Blood (2022) 140 (Supplement 1): 8174–8175.
https://doi.org/10.1182/blood-2022-166547
Published: 2022
Journal Articles

A Phase 2, Randomized Trial Evaluating the Safety and Efficacy of Pozelimab and Cemdisiran in Patients with Paroxysmal Nocturnal Hemoglobinuria

Jun Ho Jang, Raymond Wong, Rodrigo Pavani, Lisa Aurand, Bradley Dain, Lorah Perlee, Amal Souttou, Jonathan Weyne, Richard Kelly
Journal: Blood
Blood (2022) 140 (Supplement 1): 8172–8173.
https://doi.org/10.1182/blood-2022-163236
Published: 2022
Journal Articles

Thrombotic Events with Neisseria Meningitidis Vaccination in Patients with Paroxysmal Nocturnal Hemoglobinuria, UK Experience

Louise Arnold, Richard Kelly, BSc, MD, Talha Munir, MBBS, Petra Muus, MD PhD, Alexandra Pike, MBBS, Kathryn Riley, Briony Forrest, Jeanifer Gachev, Morag Griffin, MBChB, FRCPath, Peter Hillmen, MBChB, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 35–36.
https://doi.org/10.1182/blood-2020-141769
Published: 2020
Journal Articles

Management of Meningococcal Disease Risk in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) on Complement Inhibitors: 18 Years' Experience from the UK National PNH Service in Leeds

Louise Arnold, Ray Borrow, PhD FRCPath, Kathryn Riley, Talha Munir, MBBS, Richard Kelly, BSc, MD, Rachael Jones, BSc, Jeanifer Gachev, Briony Forrest, Alexandra Pike, MBBS, Petra Muus, MD PhD, Peter Hillmen, MBChB, PhD, Morag Griffin, MBChB, FRCPath
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-141780
Published: 2020
Journal Articles

Vorinostat Does Not Improve Outcome in Patients with Acute Myeloid Leukemia and High Risk Myelodysplasia Treated with Azacitidine: Results of the UK Trials Acceleration Programme Ravva Trial

Charles Craddock, MD PhD, Aimee E Houlton, BSc, MSc, Paul Ferguson, MBChB MRCP PhD, Manoj Raghavan, Sonia Fox, Louise Dudley, BSc, MRes, Lynn Swun Quek, FRCPath, DPhil, MBBS, Jamie D. Cavenagh, Michael Dennis, FRCPath, Mary Frances McMullin, MD, Srinivas P Pillai, Richard Kelly, BSc, MD, Shamyla Siddique, Keith Wheatley, DPhil, Paresh Vyas, BM, DPhil, FRCP, FRCPath
Journal: Blood
Blood (2016) 128 (22): 1065.
https://doi.org/10.1182/blood.V128.22.1065.1065
Published: 2016
Journal Articles

Insights Into The Natural History Of Paroxysmal Nocturnal Hemoglobinuria (PNH): Analysis Of The Presenting Clinical, Haematological and Flow Cytometric Features Of 705 Patients Leads To Improved Classification and Prediction Of Clinical Course

Stephen John Richards, PhD, Richard Kelly, MD, Anita Hill, MBChB, PhD, Anita Dickinson, MSc, Fiona Cullen, MSc, Jane Shingles, PhD, Matthew Cullen, MSc, Peter Hillmen, MB ChB, PhD
Journal: Blood
Blood (2013) 122 (21): 3718.
https://doi.org/10.1182/blood.V122.21.3718.3718
Published: 2013
Journal Articles

A Spontaneous Reduction of Clone Size in Paroxysmal Nocturnal Hemoglobinuria Patients Treated with Eculizumab for Greater Than 12 Months.

Richard Kelly, MBChB, Stephen Richards, PhD, Louise Arnold, BSc, MA, Gemma Valters, BSc, Matthew Cullen, MA, Anita Hill, MBChB, (Hons), PhD, Peter Hillmen, PhD
Journal: Blood
Blood (2009) 114 (22): 1992.
https://doi.org/10.1182/blood.V114.22.1992.1992
Published: 2009
Journal Articles

Successful Pregnancy Outcomes in Paroxysmal Nocturnal Hemoglobinuria with Long-Term Eculizumab Treatment

Richard Kelly, MD, Louise Arnold, BSc, MA, Stephen J. Richards, PhD, Anita Hill, MD, Charlotte Bomken, MD, John Hanley, MD, Andrew Loughney, MD, PhD, Gus Khursigara, PhD, Russell P. Rother, PhD, Elizabeth Chalmers, MD, Edward Fitzsimons, MD, Ryotaro Nakamura, MD, Anna Gaya, MD, Bruno Rotoli, MD, Antonio M. Risitano, MD, PhD, Joerg Schubert, MD, Peter Hillmen, MB, PhD
Journal: Blood
Blood (2008) 112 (11): 4576.
https://doi.org/10.1182/blood.V112.11.4576.4576
Published: 2008
Journal Articles

Home Infusion of Eculizumab: A Unique and Innovative Model of Drug Delivery to Reduce Treatment-Associated Burden and Enhance Quality of Life for Patients with PNH

Louise M Arnold, RGN, BSc, Jill Stephenson, RGN, Richard Kelly, MD, David Buchanan, RGN, BSc, MA, Gareth Jones, MD, Peter Hillmen, MBChB, PhD
Journal: Blood
Blood (2008) 112 (11): 4671.
https://doi.org/10.1182/blood.V112.11.4671.4671
Published: 2008
Journal Articles

Modification of the Eculizumab Dose to Successfully Manage Intravascular Breakthrough Hemolysis in Patients with Paroxysmal Nocturnal Hemoglobinuria.

Richard Kelly, MD, Louise Arnold, BSc, MA, Stephen Richards, PhD, Anita Hill, MD, Sandra vanBijnen, MD, Petra Muus, MD, PhD, Donna Dorr, RN, MSN, AOCN, Robert Brodsky, MD, Gus Khursigara, PhD, Russell P. Rother, PhD, Peter Hillmen, MBChB, PhD
Journal: Blood
Blood (2008) 112 (11): 3441.
https://doi.org/10.1182/blood.V112.11.3441.3441
Published: 2008
Journal Articles

Eculizumab Reduces Pulmonary Hypertension through Inhibition of Hemolysis-Associated Nitric Oxide Consumption in Patients with Paroxysmal Nocturnal Hemoglobinuria

Anita Hill, MD, Russell P. Rother, PhD, Xunde Wang, MD, Robert J Sapsford, MD, Paul O Collinson, MD, David C Gaze, PhD, Sidney M Morris, Jr., PhD, Andrew Scally, Kerry Quinn-Senger, PhD, Stephen J Richards, PhD, Monica Bessler, MD, PhD, Richard Kelly, MD, Peter Hillmen, MBChB, PhD, Mark Gladwin, MD
Journal: Blood
Blood (2008) 112 (11): 486.
https://doi.org/10.1182/blood.V112.11.486.486
Published: 2008
Journal Articles

Defective Telomerase in Familial Myelodysplasia and Leukemia

Michael Kirwan, Tom Vulliamy, Amanda J. Walne, Richard Beswick, Peter Hillmen, Richard Kelly, Andrew Stewart, David Bowen, Stefan Schonland, Annika Maria Whittle, Tony McVerry, Maria Gilleece, Inderjeet Dokal
Journal: Blood
Blood (2008) 112 (11): 849.
https://doi.org/10.1182/blood.V112.11.849.849
Published: 2008
Journal Articles

High Incidence of Progression to Chronic Renal Insufficiency in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH).

Peter Hillmen, MB, ChB, Modupe O. Elebute, MD, Richard Kelly, MD, Alvaro Urbano-Ispizua, MD, Russell P. Rother, PhD, Chieh-Lin Fu, MD, Paul Browne, MB
Journal: Blood
Blood (2007) 110 (11): 3678.
https://doi.org/10.1182/blood.V110.11.3678.3678
Published: 2007