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David Irvine
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Journal Articles

Incorporation of 8Gy total body irradiation into reduced intensity conditioning does not improve allogeneic transplant outcomes for high-risk adult acute lymphoblastic leukemia: Results from the randomised prospective phase 2 UK multicentre ALL-RIC impact study

Free
Anna Castleton, Jak Laight, Aimee Jackson, Matthew Beasley, Jordan Evans, Patricia Diez, Adele Fielding, Andrea Hodgkinson, Stephanie Lane, David Irvine, George Mikhaeel, Nick Morley, Eduardo Olavarria, Fiona Dignan, Bela Patel Wrench, Deborah Yallop, Victoria Potter, Wendy Ingram, Ronjon Chakraverty, Charles Craddock, David Marks
Journal: Blood
Blood (2025) 146 (Supplement 1): 374.
https://doi.org/10.1182/blood-2025-374
Published: 2025
Journal Articles

An updated UK real-world analysis of factors affecting outcome following brexucabtagene autoleucel for relapsed or refractory adult acute lymphoblastic leukemia

Free
Anna Castleton, Michelle Lannon, Ned Atiyah, Alexandra Smith, Ahmed Abdulgawad, Mariam Amer, Farhan Anjum, Kathleen Cheok, David Burns, Richard Burt, Sridhar Chaganti, Johannes De Vos, Gerardo Errico, Adele Fielding, Lindsay George, Katharine Hodby, David Irvine, Shenbagaram Kasivisvanathan, Philippa Kelsey, Katja Kimberger, Andrew King, Anne-Louise Latif, David Marks, Navta Masand, Pierre McCarthy, Tobias Menne, Anthony Moorman, Nick Morley, Emma Nicholson, Maeve O'Reilly, Deborah Richardson, Huw Roddie, Clare Rowntree, Muhammad Saif, Thomas Seddon, Belen Sevillano, Kirsty Sharplin, Eleni Tholouli, Bela Patel Wrench, Deborah Yallop
Journal: Blood
Blood (2025) 146 (Supplement 1): 1565.
https://doi.org/10.1182/blood-2025-1565
Published: 2025
Journal Articles

Long-Term Efficacy and Safety of Obecabtagene Autoleucel (obe-cel) in Adult Patients (pts) with Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia ([R/R B-ALL]; Pooled Analysis from ALLCAR19 and FELIX Phase Ib Studies) or Other B-cell Malignancies (ALLCAR19 Extension Study)

Free
Claire Roddie, Eleni Tholouli, Paul Shaughnessy, Elias Jabbour, Aaron C. Logan, Katharine Hodby, Luke Mountjoy, Adrian John Clifton Bloor, David Irvine, David C. Linch, Kim H. Orchard, William Wilson, Bilyana Popova, Juliana Dias, Giulia Agliardi, Victoria Spanswick, Helen Lowe, Marina Mitsikakou, Eftychia Charalambous, Joanna Dawes, Meera Raymond, Yanqing Hu, Wolfram Brugger, Martin A. Pule, Jae H. Park, Karl Peggs
Journal: Blood
Blood (2023) 142 (Supplement 1): 2114.
https://doi.org/10.1182/blood-2023-180666
Published: 2023
Journal Articles

Dual targeting of CD19 and CD22 with bicistronic CAR-T cells in patients with relapsed/refractory large B-cell lymphoma

Free
Clinical Trials & Observations
Claire Roddie, Lazaros J. Lekakis, Maria A. V. Marzolini, Aravind Ramakrishnan, Yiyun Zhang, Yanqing Hu, Vijay G. R. Peddareddigari, Nushmia Khokhar, Robert Chen, Silvia Basilico, Meera Raymond, Frederick Arce Vargas, Kevin Duffy, Wolfram Brugger, Maeve A. O’Reilly, Leigh Wood, David C. Linch, Karl S. Peggs, Carlos Bachier, Elizabeth Lihua Budde, Connie Lee Batlevi, Nancy Bartlett, David Irvine, Eleni Tholouli, Wendy Osborne, Kirit M. Ardeshna, Martin A. Pule
Journal: Blood
Blood (2023) 141 (20): 2470–2482.
https://doi.org/10.1182/blood.2022018598
Published: 2023
Includes: Supplemental data
Journal Articles

RAD52-Dependent Synthetic Lethality Eradicates Leukemia Stem Cells

Free
Kimberly Cramer, Ph.D., Margaret Nieborowska-Skorska, MD, PhD, Artur Slupianek, PhD, Tomasz Sliwinski, David Irvine, Mhairi Copland, PhD, BSc, MRCP, FRCPath, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3.
https://doi.org/10.1182/blood.V120.21.3.3
Published: 2012
Journal Articles

Inhibition of Chronic Myeloid Leukemia Stem Cells by the Combination of the Hedgehog Pathway Inhibitor LDE225 with Nilotinib

Free
Bin Zhang, David Irvine, Yin Wei Ho, Silvia Buonamici, PhD, Paul Manley, PhD, Tessa L. Holyoake, PhD, FRCP, FRCPath, Mhairi Copland, PhD, BSc, MRCP, FRCPath, Ravi Bhatia, MD
Journal: Blood
Blood (2010) 116 (21): 514.
https://doi.org/10.1182/blood.V116.21.514.514
Published: 2010