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Thomas Melchardt
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Journal Articles

Using Different Vaf Cut-Offs, Myeloid NGS Analysis of 924 Paired Peripheral Blood/Bone Marrow Samples Yielding 6944 Result Pairs Reveal Peripheral Blood As Safe Alternative Sample to Bone Marrow, Irrespective of the Degree of Neutropenia or Circulating Blast Counts

Lisa Pleyer, Manuel Drost, Jakob Wagner, Bettina Jansko-Gadermeir, Franz F Gassner, Nadja Zaborsky, Thomas Dillinger, Sonja Hutter, Viktoria Faber, Thomas Melchardt, Richard Greil
Journal: Blood
Blood (2024) 144 (Supplement 1): 6145.
https://doi.org/10.1182/blood-2024-209613
Published: 2024
Journal Articles

Validation of Recent Response Criteria (ELN-22, IWG-23 and PB-CR) in 1634 MDS/CMML/AML Patients Treated with HMA or HMA-Ven Using CPH Models and a CPH Deep Neural Network - Can or Should Response Criteria be Harmonized for Similarly Treated Patients?

Lisa Pleyer, Marc Vaisband, Patrick Klammer, Manuel Drost, Hubert Angermann, Felix Keil, Verena Petzer, Sonja Heibl, Jennifer Moritz, Michael Girschikofsky, Margarete Stampfl-Mattersberger, Angelika Pichler, Bernd L. Hartmann, Gregor Aschauer, Clemens Schmitt, Sonia Vallet, Szilvia Boros, Petra Pichler, Andrea Hammerl-Steiner, Felix Renneberg, Dilyan Majjiga, Gudrun Russ, Alexander Egle, Michael Leisch, Thomas Melchardt, Nadja Zaborsky, Viktoria Faber, Jan Philipp Bewersdorf, Amer M. Zeidan, Jan Hasenauer, Richard Greil
Journal: Blood
Blood (2024) 144 (Supplement 1): 7511.
https://doi.org/10.1182/blood-2024-208073
Published: 2024
Journal Articles

Outcomes of Tagraxofusp in Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): A Multicenter Real-World Analysis

Philipp Berning, David Baden, Philipp Faustmann, Snjezana Janjetovic, Hanna Katharina Zieger, Jan Christian Schroeder, Giuliano Filippini Velazquez, Anna Ossami Saidy, Hristo Boyadzhiev, Tim Sauer, Jan-Henrik Mikesch, Niklas Gebauer, Susanne Ghandili, Paul J. Bröckelmann, Friederike Hildebrand, Veit L. Buecklein, Rebecca Wurm-Kuczera, Ulrich Keller, Georg Lenz, Thomas Pabst, Thomas Melchardt, Claudia Lengerke, Maher Hanoun, Evgenii Shumilov, Ulrike Bacher
Journal: Blood
Blood (2024) 144 (Supplement 1): 3818.
https://doi.org/10.1182/blood-2024-211227
Published: 2024
Journal Articles

Time of CAR-T Failure Is a Strong Predictor of Outcome for Bispecific Antibody Therapy in Relapsed/Refractory Large B-Cell Lymphoma

Evgenii Shumilov, Rebecca Wurm-Kuczera, Vladan Vucinic, Maximilian Seib, Udo Holtick, Paolo Mazzeo, Julia Katharina Scholz, Hristo Boyadzhiev, Thomas Melchardt, Alexander Hölscher, Christian R Schultze-Florey, Giuliano Filippini Velazquez, Anna Ossami Saidy, Vadim Lesan, Ulf Schnetzke, Andrea Kerkhoff, Ulrike Bacher, Susanne Ghandili, Enver Aydilek, Niklas Gebauer, Thomas Weber, Gerald Wulf, Bertram Glass, Lorenz Thurner, Florian Heidel, Christoph Schmid, Andreas Viardot, Mathias Hänel, Sascha Dietrich, Thomas Pabst, Francis A. Ayuk, Bastian von Tresckow, Björn Chapuy, Christiane Pott, Fabian Mueller, Georg Lenz
Journal: Blood
Blood (2024) 144 (Supplement 1): 114.
https://doi.org/10.1182/blood-2024-198883
Published: 2024
Journal Articles

Real-World Comparison of Outcomes of Patients Treated with HMA Monotherapy Versus HMA-Ven - Insights from 1634 Patients Included within the Austrian Myeloid Registry of the AGMT Study Group

Lisa Pleyer, Patrick Klammer, Manuel Drost, Hubert Angermann, Felix Keil, Verena Petzer, Sonja Heibl, Jennifer Moritz, Michael Girschikofsky, Margarete Stampfl-Mattersberger, Angelika Pichler, Bernd L. Hartmann, Gregor Aschauer, Clemens Schmitt, Sonia Vallet, Szilvia Boros, Petra Pichler, Andrea Hammerl-Steiner, Felix Renneberg, Susanne Schnabel, Dilyan Majjiga, Thomas Melchardt, Alexander Egle, Michael Leisch, Richard Greil
Journal: Blood
Blood (2024) 144 (Supplement 1): 3793.
https://doi.org/10.1182/blood-2024-207230
Published: 2024
Journal Articles

Tafasitamab and Lenalidomide in Relapsed/Refractory B-Cell Lymphoma: A Multicenter Retrospective Real-World-Study of Patients from Germany and Austria

Anna Ruckdeschel, Koemm Sabrina, Max S. Topp, Richard Greil, Thomas Melchardt, Georg Lenz, Andrea Kerkhoff, Evgenii Shumilov, Georg Hess, Marta Baumgaertner, Lorenz Thurner, Igor Age Kos, Stephanie Mayer, Francis A. Ayuk, Rolf Krause, Marco Herling, Vladan Vucinic, Claudia Chapuy, Gerald Illerhaus, Markus Knott, Andreas Viardot, Alexander Grunenberg, Sascha Dietrich, Leandra Caille, Mareike C. Tometten, Hyunyee Rosa Cho, Julia Scholz, Fabian Mueller, Katharina Prochazka, Bjoern Chapuy, David Böckle, Bastian von Tresckow, Natalie Schub, Götz Gelbrich, Hermann Einsele, Johannes Duell
Journal: Blood
Blood (2023) 142 (Supplement 1): 1771.
https://doi.org/10.1182/blood-2023-185992
Published: 2023
Journal Articles

Feasibility and Safety of the First-in-Human Chemotherapy-Light Combination of Rituximab, Polatuzumab Vedotin and Glofitamab in Previously Untreated Aggressive B-Cell Lymphoma Patients Above 60 Years of Age Ineligible for a Fully Dosed R-CHOP - R-Pola-Glo/Ikf-t062, a Study of the Austrian Group for Medical Tumor Therapy (AGMT-NHL-16) and the German Lymphoma Alliance (GLA2022-10)

Thomas Melchardt, Rebecca I Wurm-Kuczera, Bettina Altmann, Petra Pichler, Manuel Orlinger, Michael Panny, Luisa Wohn, Andreas Rosenwald, Dirk Hellwig, Sascha Dietrich, Bertram Glass, Georg Lenz, Ulrich Keller, Marita Ziepert, Richard Greil, Bjoern Chapuy
Journal: Blood
Blood (2023) 142 (Supplement 1): 1734.
https://doi.org/10.1182/blood-2023-188854
Published: 2023
Journal Articles

Cox Proportional Hazards Deep Neural Network Identifies Peripheral Blood Complete Remission (PB-CR) to be at Least Equivalent to Morphologic CR in Predicting Outcomes of Patients Treated with Azacitidine - a Prospective Cohort Study By the AGMT

Lisa Pleyer, Marc Vaisband, Michael Pfeilstocker, Reinhard Stauder, Sonja Heibl, Heinz Sill, Michael Girschikofsky, Margarete Stampfl-Mattersberger, Christoph Tinchon, Bernd L. Hartmann, Andreas Petzer, Martin Schreder, Clemens A. Schmitt, Sonia Vallet, Thomas Melchardt, Lukas Scagnetti, Armin Zebisch, Sigrid Machherndl-Spandl, Dominik Wolf, Felix Keil, Jan Hasenauer, Richard Greil
Journal: Blood
Blood (2022) 140 (Supplement 1): 1346–1349.
https://doi.org/10.1182/blood-2022-168521
Published: 2022
Journal Articles

Randomized Comparison between Krd and Ktd Induction, Followed By K Maintenance or Control in Transplant Non-Eligible Patients with NDMM: Efficacy and Qol Data (AGMT-MM02 Trial)

Heinz Ludwig, Thomas Melchardt, Siegfried Sormann, Niklas Zojer, Johannes Andel, Bernd L. Hartmann, Christoph Tinchon, Eberhard Gunsilius, Klaus Podar, Alexander Egle, Wolfgang Willenbacher, Ewald Wöll, Martin Schreder, Reinhard Ruckser, Boris Bozic, Maria-Theresa Krauth, Andreas Petzer, Clemens A. Schmitt, Sigrid Machherndl-Spandl, Hermine Agis, Michael Fillitz, Song-Yau Wang, Stefan Knop, Sarah Kainz, Bruno Paiva, Richard Greil
Journal: Blood
Blood (2022) 140 (Supplement 1): 10185–10188.
https://doi.org/10.1182/blood-2022-162336
Published: 2022
Journal Articles

The EQ-5D-5L Predicts Treatment Outcomes and Provides Added Value to the R-IPSS in Patients with MDS, CMML or AML Treated within the Austrian Azacitidine Registry - a Prospective Cohort Study By the AGMT Study Group

Lisa Pleyer, Sonja Heibl, Christoph Tinchon, Sonja Vallet, Branka Petricevic, Michael Leisch, Alexander Egle, Thomas Melchardt, Gudrun Piringer, Dominik Wolf, Richard Beswick, Manuel Drost, Julian Larcher-Senn, Thomas Grochtdreis, Richard Greil, Reinhard Stauder
Journal: Blood
Blood (2021) 138 (Supplement 1): 64.
https://doi.org/10.1182/blood-2021-145281
Published: 2021
Journal Articles

Peripheral Blood Complete Remission Provides Added Value to the Classical Definition of Morphologic Complete Remission - a Prospective Cohort Study of 1441 Patients with MDS, CMML and AML Treated within the Austrian Azacitidine Registry

Lisa Pleyer, Michael Pfeilstocker, Reinhard Stauder, Sonja Heibl, Heinz Sill, Michael Girschikofsky, Margarete Stampfl-Mattesberger, Christoph Tinchon, Bernd Hartmann, Andreas Petzer, Branka Petricevic, Clemens A. Schmitt, Sonja Vallet, Klaus Geissler, Wolfgang R. Sperr, Michael Leisch, Alexander Egle, Thomas Melchardt, Gudrun Piringer, Armin Zebisch, Sigrid Machherndl-Spandl, Dominik Wolf, Felix Keil, Hubert Angermann, Manuel Drost, Julian Larcher-Senn, Richard Greil
Journal: Blood
Blood (2021) 138 (Supplement 1): 3387.
https://doi.org/10.1182/blood-2021-145401
Published: 2021
Journal Articles

Composition of the Immune Environment at Baseline Correlates with Time to Response and Treatment Outcome in Newly Diagnosed Transplant-Ineligible Multiple Myeloma (MM) Patients Randomized to Krd or Ktd Followed By Carfilzomib Maintenance or Observation (AGMT_MM 02 Study)

Irene Manrique, Richard Greil, Johannes Andel, Siegfried Sormann, Bernd L. Hartmann, Klaus Podar, Alexander Egle, Andreas Petzer, Niklas Zojer, Eberhard Gunsilius, Reinhard Ruckser, Boris Bozic, Clemens A. Schmitt, Sigrid Machherndl-Spandl, Hermine Agis, Martin Schreder, Song-Yau Wang, Wolfgang Willenbacher, Maria-Theresa Krauth, Christoph Tinchon, Michael Fillitz, Thomas Melchardt, Stefan Knop, Bruno Paiva, Heinz Ludwig
Journal: Blood
Blood (2021) 138 (Supplement 1): 1669.
https://doi.org/10.1182/blood-2021-150311
Published: 2021
Journal Articles

Immunophenotyping of Baseline Bone Marrow Reveals a Specific Pattern of Immune Cells Associated with Greater Depth and Sustained Response in Newly Diagnosed Patients Randomized to Krd or Ktd Followed By Carfilzomib Maintenance or Control (AGMT MM 02 Study)

Irene Manrique, PhD, Richard Greil, MD, Johannes Andel, MD, Siegfried Sormann, MD, Bernd L. Hartmann, MD, Klaus Podar, MDPhD, Alexander Egle, MD, Andreas Petzer, MD, Niklas Zojer, MD, Reinhard Ruckser, MD, Boris Bozic, MD, Clemens A. Schmitt, MD, Sigrid Machherndl-Spandl, MD, Hermine Agis, MD, Martin Schreder, MD, Maria-Theresa Krauth, MD, Christoph Tinchon, MD, Michael Fillitz, MD, Thomas Melchardt, MD PhD, Bruno Paiva, PhD, Heinz Ludwig, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29–30.
https://doi.org/10.1182/blood-2020-140918
Published: 2020
Journal Articles

Quality of Life in Newly Diagnosed Patients with Multiple Myeloma Randomized to Either Krd or Ktd Induction Therapy Followed By Carfilzomib Maintenance or Control (AGMT MM 02 trial)

Heinz Ludwig, MD, Thomas Melchardt, MD PhD, Johannes Andel, MD, Eberhard Gunsilius, MD, Siegfried Sormann, MD, Axel Hinke, PhD, Bernd L. Hartmann, MD, Klaus Podar, MDPhD, Wolfgang Willenbacher, MD PhD, Alexander Egle, MD, Andreas Petzer, MD, Niklas Zojer, MD, Ewald Wöll, MD, Reinhard Ruckser, MD, Boris Bozic, MD, Clemens A. Schmitt, MD, Sigrid Machherndl-Spandl, MD, Maria-Theresa Krauth, MD, Martin Schreder, MD, Hermine Agis, MD, Christoph Tinchon, MD, Michael Fillitz, MD, Richard Greil, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 27–29.
https://doi.org/10.1182/blood-2020-140701
Published: 2020
Journal Articles

Expanding on Current Definitions of Hematologic Improvement in MDS, CMML and AML: Landmark Analyses of 1301 Patients Treated with Azacitidine in the Austrian Registry of Hypomethylating Agents By the AGMT-Study Group

Lisa Pleyer, Michael Pfeilstocker, MD, Reinhard Stauder, MD MSc, Sonja Heibl, MD, Heinz Sill, MD, Michael Girschikofsky, MD, Margarete Stampfl-Mattersberger, MD, Christoph Tinchon, MD, Andreas Petzer, MD, Clemens A. Schmitt, MD, Sonia Vallet, MD, Inga Mandac, MD, Klaus Geissler, MD, Wolfgang R. Sperr, MD, Michael Leisch, MD, Alexander Egle, MD, Thomas Melchardt, MD PhD, Julia Fusinato, BSc, Gudrun Piringer, MD MSc, Armin Zebisch, MD, Sigrid Machherndl-Spandl, MD, Dominik Wolf, MD, Felix Keil, MD, Richard Greil, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3821.
https://doi.org/10.1182/blood-2019-128153
Published: 2019
Journal Articles

Long-Term Efficacy and Safety of Ropeginterferon Alfa-2b in Patients with Polycythemia Vera — Final Phase I/II Peginvera Study Results

Heinz Gisslinger, Veronika Buxhofer-Ausch, MD, Josef Thaler, MD, Ernst Forjan, MD, Ella Willenbacher, MD, Dominik Wolf, MD, Robert Kralovics, PhD, Bettina Gisslinger, Margarete Stampfl-Mattersberger, Alexander Egle, MD, Thomas Melchardt, MD, Sonja Burgstaller, MD, Martin Schalling, MSc, Maria-Theresa Krauth, MD, Richard Greil, MD, Pavla Kadlecova, Michael Zoerer, Victoria Empson, MSc, Barbara Grohmann-Izay, MD MSc, Christoph Klade, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3030.
https://doi.org/10.1182/blood-2018-99-118584
Published: 2018
Journal Articles

A phase 2 study of rituximab plus lenalidomide for mucosa-associated lymphoid tissue lymphoma

Clinical Trials & Observations
Barbara Kiesewetter, Ella Willenbacher, Wolfgang Willenbacher, Alexander Egle, Peter Neumeister, Daniela Voskova, Marius Erik Mayerhoefer, Ingrid Simonitsch-Klupp, Thomas Melchardt, Richard Greil, Markus Raderer
Journal: Blood
Blood (2017) 129 (3): 383–385.
https://doi.org/10.1182/blood-2016-06-720599
Published: 2017
Journal Articles

Four Weeks Administration Schedule of Ropeginterferon Alfa-2b (AOP2014/P1101) in Polycythemia Very Patients Allows Maintaining of Efficacy with Favorable Toxicity Profile in the Phase I/II Peginvera Stud

Veronika Buxhofer-Ausch, Heinz Gisslinger, MD, Josef Thaler, MD, Ernst Schlögl, MD, Gunther Gastl, MD Prof, Dominik Wolf, MD, Robert Kralovics, PhD, Bettina Gisslinger, Sarita Ban, MD, Alexander Egle, MD, Thomas Melchardt, MD, Sonja Burgstaller, MD, Ella Willenbacher, MD, Martin Schalling, MSc, Maria Theresa Krauth, MD, Nicole C.C. Them, Michael Zörer, Oliver Ammann-Mwathi, Pavla Kadlecova, Oleh Zagrijtschuk, Christoph Klade, Richard Greil, MD
Journal: Blood
Blood (2015) 126 (23): 1603.
https://doi.org/10.1182/blood.V126.23.1603.1603
Published: 2015
Journal Articles

Long Term Efficacy and Safety Results and Analysis of Dose Correlations from the Phase I/II Peginvera Study of Ropeginterferon Alfa-2b, a Novel IFNa-2b, in Polycythemia Vera Patient

Heinz Gisslinger, MD, Veronika Buxhofer-Ausch, Josef Thaler, MD, Ernst Schlögl, MD, Gunther Gastl, MD Prof,, Dominik Wolf, MD, Martin Schalling, MSc, Bettina Gisslinger, Sarita Ban, MD, Alexander Egle, MD, Thomas Melchardt, MD, Sonja Burgstaller, MD, Ella Willenbacher, Maria Theresa Krauth, MD, Nicole C.C. Them, Robert Kralovics, PhD, Michael Zörer, Oliver Ammann-Mwathi, Pavla Kadlecova, Oleh Zagrijtschuk, Christoph Klade, Richard Greil, MD
Journal: Blood
Blood (2015) 126 (23): 4056.
https://doi.org/10.1182/blood.V126.23.4056.4056
Published: 2015
Journal Articles

Ropeginterferon alfa-2b, a novel IFNα-2b, induces high response rates with low toxicity in patients with polycythemia vera

Clinical Trials & Observations
Heinz Gisslinger, Oleh Zagrijtschuk, Veronika Buxhofer-Ausch, Josef Thaler, Ernst Schloegl, Guenther A. Gastl, Dominik Wolf, Robert Kralovics, Bettina Gisslinger, Karin Strecker, Alexander Egle, Thomas Melchardt, Sonja Burgstaller, Ella Willenbacher, Martin Schalling, Nicole C. Them, Pavla Kadlecova, Christoph Klade, Richard Greil
Journal: Blood
Blood (2015) 126 (15): 1762–1769.
https://doi.org/10.1182/blood-2015-04-637280
Published: 2015
Includes: Supplemental data