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Armin Zebisch
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Journal Articles

RAS mutations are frequent in extramedullary AML and drive the tissue infiltration of leukemic cells via the induction of jaml

Free
Panagiota Chaida, Julia Frimmel, Lara Hopfer, Eva Gruden, Bianca Perfler, Akshaya Kailasnathan, Bernadette Bramreiter, Johannes Foßelteder, Sonja Wurm, Jennifer Neiss, Stefan Koeck, Dominik Wolf, Gudrun Ratzinger, Nassim Ghaffari Tabrizi-Wizsy, Kristina Glebova, Beate Rinner, Karoline Fechter, Katarina Vizar Cisarova, Gerald Höfler, Karl Kashofer, Claudia Baldus, Friedrich Stoelzel, Annkristin Heine, Albert Woelfler, Heinz Sill, Andreas Reinisch, Armin Zebisch
Journal: Blood
Blood (2025) 146 (Supplement 1): 659.
https://doi.org/10.1182/blood-2025-659
Published: 2025
Journal Articles

Nonclinical evaluation of APL-4098, a novel GCN2 kinase inhibitor, reveals potent anti-leukemic effects through mitochondrial stress induction and synergy with venetoclax, targeting AML blasts and LSCs

Free
Monica Roman-Trufero, Kevin Blighe, Armin Zebisch, Bianca Perfler, Sereina Annik Herzog, Richard Butt, Holger Auner, Nadine Clemo
Journal: Blood
Blood (2025) 146 (Supplement 1): 1503.
https://doi.org/10.1182/blood-2025-1503
Published: 2025
Journal Articles

Functional drug response profiling predicts clinical outcomes and shows utility for treatment stratification in AML

Free
Aleksej Drino, Artur Speiser, Peter Kovacs-Hajdu, Joost Van Ham, Rebecca Kirkley, Daniel Udvary, Claudia Baumgärtler, Sarah Himbert-Baudis, Bekir Ergüner, Tzi-Yang Lin, Giuseppe Fiume, Tom Kruitwagen, Sayantanee Dutta, Frederick Herzberg, Ulrich Keller, Jeffrey Verdoliva Boatman, Heikki Kuusanmäki, Heinz Sill, Mika Kontro, Armin Zebisch, Stephan Bohl, Nikolaus Krall
Journal: Blood
Blood (2025) 146 (Supplement 1): 1716.
https://doi.org/10.1182/blood-2025-1716
Published: 2025
Journal Articles

Unleashing intrinsic inflammation in AML using therapeutic cytokines overcomes pro-survival pathways and induces deep and durable remission In Vivo.

Free
Ulrike Hoeckendorf, Sayantanee Dutta, Arnold Kloos, Marah Runtsch, Carina Zoetsch, yongjie wang, Bianca Perfler, Sebastian Vosberg, Torsten Haferlach, Konstanze Döhner, Katharina S. Götze, Florian Bassermann, Mathias Heikenwälder, Johannes Schmoellerl, Johannes Zuber, Adam Wahida, Ann-Cathrin Burk, Robert Zeiser, Heinz Sill, Ashok Kumar Jayavelu, Armin Zebisch, Michael Heuser, Michael Dengler, Philipp Jost
Journal: Blood
Blood (2025) 146 (Supplement 1): 3280.
https://doi.org/10.1182/blood-2025-3280
Published: 2025
Journal Articles

Impact of Mono- and Bi-Allelic TP53 Aberrations on Transformation of Human HSPCs

Free
Karin Lind, Sayantanee Dutta, Marco Cosenza, Thomas Eder, Johannes Foßelteder, Gabriel Pabst, Wolfgang Schöll, Andreas Prokesch, Andreas Reinisch, Albert Woelfler, Armin Zebisch, Florian Grebien, Jan O. Korbel, Heinz Sill
Journal: Blood
Blood (2024) 144 (Supplement 1): 5631.
https://doi.org/10.1182/blood-2024-203217
Published: 2024
Journal Articles

Cox Proportional Hazards Deep Neural Network Identifies Peripheral Blood Complete Remission (PB-CR) to be at Least Equivalent to Morphologic CR in Predicting Outcomes of Patients Treated with Azacitidine - a Prospective Cohort Study By the AGMT

Free
Lisa Pleyer, Marc Vaisband, Michael Pfeilstocker, Reinhard Stauder, Sonja Heibl, Heinz Sill, Michael Girschikofsky, Margarete Stampfl-Mattersberger, Christoph Tinchon, Bernd L. Hartmann, Andreas Petzer, Martin Schreder, Clemens A. Schmitt, Sonia Vallet, Thomas Melchardt, Lukas Scagnetti, Armin Zebisch, Sigrid Machherndl-Spandl, Dominik Wolf, Felix Keil, Jan Hasenauer, Richard Greil
Journal: Blood
Blood (2022) 140 (Supplement 1): 1346–1349.
https://doi.org/10.1182/blood-2022-168521
Published: 2022
Journal Articles

Introduction and Genetic Correction of Calreticulin Mutations in Human Hematopoietic Stem and Progenitor Cells Sheds Light on MPN Pathogenesis

Free
Johannes Foßelteder, Angelika Schlacher, Gabriel Pabst, Bettina Amtmann, Wolfgang Schöll, Karl Kashofer, Christine Beham-Schmid, Peter Schlenke, Hildegard T. Greinix, Heinz Sill, Albert Woelfler, Armin Zebisch, Andreas Reinisch
Journal: Blood
Blood (2021) 138 (Supplement 1): 2541.
https://doi.org/10.1182/blood-2021-147919
Published: 2021
Journal Articles

Modeling the Development of SRSF2 Mutated Myeloid Malignancies By CRISPR/Cas9 Mediated Genome Engineering of Primary Human Hematopoietic Stem and Progenitor Cells

Free
Gabriel Pabst, Johannes Foßelteder, Angelika Schlacher, Lisa Auinger, Daniel Martinez-Krams, Asiri Ediriwickrema, Karl Kashofer, Christine Beham-Schmid, Hildegard T. Greinix, Albert Woelfler, Peter Schlenke, Heinz Sill, Armin Zebisch, Ravi Majeti, Andreas Reinisch
Journal: Blood
Blood (2021) 138 (Supplement 1): 2160.
https://doi.org/10.1182/blood-2021-149591
Published: 2021
Journal Articles

Peripheral Blood Complete Remission Provides Added Value to the Classical Definition of Morphologic Complete Remission - a Prospective Cohort Study of 1441 Patients with MDS, CMML and AML Treated within the Austrian Azacitidine Registry

Free
Lisa Pleyer, Michael Pfeilstocker, Reinhard Stauder, Sonja Heibl, Heinz Sill, Michael Girschikofsky, Margarete Stampfl-Mattesberger, Christoph Tinchon, Bernd Hartmann, Andreas Petzer, Branka Petricevic, Clemens A. Schmitt, Sonja Vallet, Klaus Geissler, Wolfgang R. Sperr, Michael Leisch, Alexander Egle, Thomas Melchardt, Gudrun Piringer, Armin Zebisch, Sigrid Machherndl-Spandl, Dominik Wolf, Felix Keil, Hubert Angermann, Manuel Drost, Julian Larcher-Senn, Richard Greil
Journal: Blood
Blood (2021) 138 (Supplement 1): 3387.
https://doi.org/10.1182/blood-2021-145401
Published: 2021
Journal Articles

Functional Classification of TP53 Mutations in Acute Myeloid Leukemia

Free
Sayantanee Dutta, PhD, Gudrun Pregartner, Frank G. Rücker, MD, Ellen Heitzer, PhD, Armin Zebisch, MD, Lars Bullinger, Andrea Berghold, PhD, Konstanze Döhner, Heinz Sill, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2725.
https://doi.org/10.1182/blood-2019-124316
Published: 2019
Journal Articles

Expanding on Current Definitions of Hematologic Improvement in MDS, CMML and AML: Landmark Analyses of 1301 Patients Treated with Azacitidine in the Austrian Registry of Hypomethylating Agents By the AGMT-Study Group

Free
Lisa Pleyer, Michael Pfeilstocker, MD, Reinhard Stauder, MD MSc, Sonja Heibl, MD, Heinz Sill, MD, Michael Girschikofsky, MD, Margarete Stampfl-Mattersberger, MD, Christoph Tinchon, MD, Andreas Petzer, MD, Clemens A. Schmitt, MD, Sonia Vallet, MD, Inga Mandac, MD, Klaus Geissler, MD, Wolfgang R. Sperr, MD, Michael Leisch, MD, Alexander Egle, MD, Thomas Melchardt, MD PhD, Julia Fusinato, BSc, Gudrun Piringer, MD MSc, Armin Zebisch, MD, Sigrid Machherndl-Spandl, MD, Dominik Wolf, MD, Felix Keil, MD, Richard Greil, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3821.
https://doi.org/10.1182/blood-2019-128153
Published: 2019
Journal Articles

Impact of TP53 Mutated Subclones in Acute Myeloid Leukemia

Free
Gabriel Pabst, Katharina Prochazka, MD, Gudrun Pregartner, Frank G. Rücker, MD, Ellen Heitzer, PhD, Albert Woelfler, MD, Armin Zebisch, MD, Andrea Berghold, PhD, Konstanze Döhner, MD, Heinz Sill, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1483.
https://doi.org/10.1182/blood-2018-99-110667
Published: 2018
Journal Articles

Loss of RKIP is a frequent event in myeloid sarcoma and promotes leukemic tissue infiltration

Free
Veronica Caraffini, Bianca Perfler, Johannes Lorenz Berg, Barbara Uhl, Silvia Schauer, Karl Kashofer, Nassim Ghaffari-Tabrizi-Wizsy, Herbert Strobl, Albert Wölfler, Gerald Hoefler, Heinz Sill, Armin Zebisch
Journal: Blood
Blood (2018) 131 (7): 826–830.
https://doi.org/10.1182/blood-2017-09-804906
Published: 2018
Includes: Supplemental data
Journal Articles

Real World Data on Decitabine Treatment in 296 Patients with Acute Myeloid Leukemia: Outcome and Impact of TP53 Mutations

Free
Christoph Rollig, MD MSC, Jan Moritz Middeke, MD, Sebastian Stasik, Armin Zebisch, MD, Heinz Sill, MD, Michael Kramer, M.Sc., Sebastian Scholl, MD, Andreas Hochhaus, MD, Edgar Jost, Tim H. Brümmendorf, MD, Ralph Naumann, MD, Björn Steffen, Hubert Serve, Heidi Altmann, Volker Kunzmann, MD PhD, Hermann Einsele, Stefani Barbara Parmentier, MD, Markus Schaich, MD, Andreas Burchert, MD, Andreas Neubauer, MD, Frank Heits, MD, Wolfgang E. Berdel, Katja Sockel, MD, Friedrich Stoelzel, MD, Uwe Platzbecker, MD, Gerhard Ehninger, Martin Bornhäuser, MD, Johannes Schetelig, MD, Christian Thiede, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3896.
https://doi.org/10.1182/blood.V130.Suppl_1.3896.3896
Published: 2017
Journal Articles

Cytarabine dose in the consolidation treatment of AML: a systematic review and meta-analysis

Free
Clinical Trials & Observations
Kinkini N. Magina, Gudrun Pregartner, Armin Zebisch, Albert Wölfler, Peter Neumeister, Hildegard T. Greinix, Andrea Berghold, Heinz Sill
Journal: Blood
Blood (2017) 130 (7): 946–948.
https://doi.org/10.1182/blood-2017-04-777722
Published: 2017
Includes: Supplemental data
Journal Articles

Somatic TP53 mutations characterize preleukemic stem cells in acute myeloid leukemia

Free
Ridhima Lal, Karin Lind, Ellen Heitzer, Peter Ulz, Kristina Aubell, Karl Kashofer, Jan M. Middeke, Christian Thiede, Eduard Schulz, Angelika Rosenberger, Sybille Hofer, Birgit Feilhauer, Beate Rinner, Vendula Svendova, Michael G. Schimek, Frank G. Rücker, Gerald Hoefler, Konstanze Döhner, Armin Zebisch, Albert Wölfler, Heinz Sill
Journal: Blood
Blood (2017) 129 (18): 2587–2591.
https://doi.org/10.1182/blood-2016-11-751008
Published: 2017
Includes: Supplemental data
Journal Articles

Clinical, Hematological, and Biologic Characteristics in Chronic Myelomonocytic Leukemia Patients with a JAK2 V617F Mutation

Free
Klaus Geissler, MD, Agnes Barna, MSc, Eva Jäger, BSc, Temeida Alendar, Elmir Ljubuncic, Ruth Jilch, MD, Thomas Nösslinger, MD, Michael Pfeilstöcker, MD, Heinz Tüchler, MD, Regina Reisner, MD, Thamer Sliwa, MD, Felix Keil, MD, Sonja Burgstaller, MD, Josef Thaler, MD, Sigrid Machherndl-Spandl, MD, Otto Zach, PhD, Ansgar Weltermann, MD, Peter Bettelheim, MD, Reinhard Stauder, MD, Ilse Schwarzinger, MD, Gregor Hörmann, MD, Ulrich Jäger, MD, Wolfgang R. Sperr, MD, Paul Knöbl, MD PhD, Bruno Schneeweiss, MD, Jörg Berger, MD, Rajko Kusec, MD PhD, Leopold Öhler, MD, Armin Zebisch, MD, Heinz Sill, Ulrich Germing, Peter Valent, MD
Journal: Blood
Blood (2016) 128 (22): 3189.
https://doi.org/10.1182/blood.V128.22.3189.3189
Published: 2016
Journal Articles

High Spontaneous In Vitro Myeloid Colony Formation in Chronic Myelomonocytic Leukemia is Associated with Mutations in Rasopathy Genes, Myeloproliferation and Inferior Prognosis

Free
Klaus Geissler, MD, Agnes Barna, MSc, Eva Jäger, BSc, Temeida Alendar, Elmir Ljubuncic, Ruth Jilch, MD, Thomas Nösslinger, MD, Michael Pfeilstöcker, MD, Heinz Tüchler, MD, Regina Reisner, MD, Thamer Sliwa, MD, Felix Keil, MD, Sonja Burgstaller, MD, Josef Thaler, MD, Sigrid Machherndl-Spandl, MD, Otto Zach, PhD, Ansgar Weltermann, MD, Peter Bettelheim, MD, Reinhard Stauder, MD, Ilse Schwarzinger, MD, Gregor Hörmann, MD, Ulrich Jäger, MD, Wolfgang R. Sperr, MD, Paul Knöbl, MD PhD, Bruno Schneeweiss, MD, Jörg Berger, MD, Rajko Kusec, MD PhD, Leopold Öhler, MD, Armin Zebisch, MD, Heinz Sill, Ulrich Germing, Peter Valent, MD
Journal: Blood
Blood (2016) 128 (22): 5503.
https://doi.org/10.1182/blood.V128.22.5503.5503
Published: 2016
Journal Articles

Acute myeloid leukemia with TP53 germ line mutations

Free
Armin Zebisch, Ridhima Lal, Marian Müller, Karin Lind, Karl Kashofer, Michael Girschikofsky, David Fuchs, Albert Wölfler, Jochen B. Geigl, Heinz Sill
Journal: Blood
Blood (2016) 128 (18): 2270–2272.
https://doi.org/10.1182/blood-2016-08-732610
Published: 2016
Includes: Supplemental data
Journal Articles

Azacitidine in Acute Myeloid Leukemia with >30% Bone Marrow Blasts and <15 G/L White Blood Cell Count: Results from the Austrian Azacitidine Registry of the AGMT Study Group Versus Randomized Controlled Phase III Clinical Trial Data

Free
Lisa Pleyer, MD DI, Sonja Burgstaller, MD, Reinhard Stauder, MD MSc, Michael Girschikofsky, MD, Heinz Sill, MD, Konstantin Schlick, MD, Josef Thaler, MD, Britta Halter, MSc, Sigrid Machherndl-Spandl, MD, Armin Zebisch, MD, Angelika Pichler, MD, Michael Pfeilstöcker, MD, Eva-Maria Autzinger, MD, Alois Lang, MD, Klaus Geissler, MD, Daniela Voskova, MD, Dietmar Geissler, MD, Wolfgang R Sperr, MD, Sabine Hojas, MD, Inga Mandac Rogulj, MD, Johannes Andel, MD, Richard Greil, MD
Journal: Blood
Blood (2015) 126 (23): 2515.
https://doi.org/10.1182/blood.V126.23.2515.2515
Published: 2015