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Journal Articles

Prognostic Impact of Subclinical FLT3 -ITD Microclones in Patients with Acute Myeloid Leukemia

Paul Olson, Razif Gabdoulline, Rabia Shahswar, Arnold Kloos, Letizia Venturini, Isabell Arnhardt, Henri C. Hupe, Victoria Panagiota, Michael Stadler, Matthias Eder, Gernot Beutel, Elke Dammann, Piroska Poll, Anke Bergmann, Nataliya DiDonato, Florian H. Heidel, Felicitas R. Thol, Michael Heuser
Journal: Blood
Blood (2024) 144 (Supplement 1): 847.
https://doi.org/10.1182/blood-2024-207703
Published: 2024
Journal Articles

Characterizing Secondary-Site Mutations in Isocitrate-Dehydrogenase-1 (IDH1)

Jyoti Kandarp, Arnold Kloos, Kerstin Goerlich, Nadine Kattre, Thomas Plenge, Michael Heuser
Journal: Blood
Blood (2024) 144 (Supplement 1): 4139.
https://doi.org/10.1182/blood-2024-205636
Published: 2024
Journal Articles

Fla-IDA Chemotherapy with or without Venetoclax in Patients with Relapsed/Refractory Acute Myeloid Leukemia

Rabia Shahswar, Gernot Beutel, Razif Gabdoulline, Adrian Schwarzer, Arnold Kloos, Christian Koenecke, Michael Stadler, Gudrun Göhring, Brigitte Schlegelberger, Zhixiong Li, Louisa-Kristin Dallmann, Clara Wienecke, Piroska Klement, Catherin Albert, Martin Wichmann, Yasmine Alwie, Axel Benner, Maral Saadati, Arnold Ganser, Felicitas R. Thol, Michael Heuser
Journal: Blood
Blood (2022) 140 (Supplement 1): 3315–3316.
https://doi.org/10.1182/blood-2022-163430
Published: 2022
Journal Articles

DEK-NUP214 Acute Myeloid Leukemia Depends on CRM1 In Vivo

Fiorella Charles Cano, Arnold Kloos, Rucha Yeshwanta Hebalkar, Razif Gabdoulline, Thomas Fangmann, Yosef Landesman, Konstanze Döhner, Halyna R. Shcherbata, Arnold Ganser, Michael Heuser
Journal: Blood
Blood (2022) 140 (Supplement 1): 4938–4939.
https://doi.org/10.1182/blood-2022-155836
Published: 2022
Journal Articles

Single and Combinational Multiplex Base-Edited 'Universal' CAR T Cells in a Humanised Model of Primary CD7+CD33+ AML

Arnold Kloos, Christos Georgiadis, Annie Etuk, Soragia Athina Gkazi, Farhatullah Syed, Toni Braybrook, Hong Zhan, Renuka Kadirkamanathan, Nadine Kattre, Kerstin Görlich, Thomas Fangmann, Axel Schambach, Martin G. Sauer, Michael Heuser, Waseem Qasim
Journal: Blood
Blood (2022) 140 (Supplement 1): 7425–7426.
https://doi.org/10.1182/blood-2022-168719
Published: 2022
Journal Articles

Allogeneic, CD34 + , Umbilical Cordblood-Derived NK Cell Adoptive Immunotherapy for the Treatment of Acute Myeloid Leukemia Patients with Measurable Residual Disease

Michael Heuser, Astrid Tschan-Plessl, Felicitas Thol, Adrian Schwarzer, Arnold Kloos, Nadine Kattre, Jakob Passweg, Kai Pinkernell, Arnold Ganser
Journal: Blood
Blood (2021) 138 (Supplement 1): 1745.
https://doi.org/10.1182/blood-2021-150138
Published: 2021
Journal Articles

Post Transplantation Measurable Residual Disease (MRD) Monitoring Using Next-Generation Sequencing Is Highly Predictive for Relapseafter Allogeneic Stem Cell Transplantation

Felicitas Thol, MD, Bennet Heida, Konstatin Buettner, Clara Wienecke, Katrin Teich, Carolin Funke, Brandes Maximilian, Piroska Klement, Alessandro Liebich, Johannes Schiller, Martin Wichmann, Blerina Neziri, Anuhar Chaturvedi, PhD, Arnold Kloos, PhD, Verena I. Gaidzik, MD, Peter Paschka, MD, Lars Bullinger, Walter Fiedler, MD, Albert Heim, MD, Jürgen Krauter, MD, Konstanze Döhner, Hartmut Döhner, MD, Arnold Ganser, MD, Michael Stadler, MD PhD, Lothar Hambach, MD, Razif Gabdoulline, Michael Heuser, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 184.
https://doi.org/10.1182/blood-2019-125532
Published: 2019
Journal Articles

Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in AML

Sagarajit Mohanty, MSc, Nidhi Jyotsana, PhD, Amit Sharma, PhD, Basem Othman, Arnold Kloos, PhD, Madhvi Mandhania, MSc, Renate Schottmann, Euan Ramsay, PhD, Hans- Peter Vornlocher, PhD, Arnold Ganser, MD, Felicitas Thol, MD, Michael Heuser, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2545.
https://doi.org/10.1182/blood-2019-123709
Published: 2019
Journal Articles

Functional Screening for Pathways Regulating Chemoresistance and Sensitivity in Leukemia Stem Cells

Konstantinos Mintzas, MSc, Arnold Kloos, Razif Gabdoulline, Renate Schottmann, Simon Danisch, PhD, Renata Stripecke, Prof., Arnold Ganser, MD, Felicitas Thol, MD, Michael Heuser, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3933.
https://doi.org/10.1182/blood-2018-99-112373
Published: 2018
Journal Articles

Optimized Induction of Mitochondrial Apoptosis By Combination Therapies with Venetoclax for Chemotherapy-Free Treatment of BCR-ABL + Acute Lymphoblastic Leukemia in Preclinical Models

Matthias Eder, MD, Hanna Kirchhoff, Karin Battmer, Katharina Wohlan, Melanie Ricke-Hoch, PhD, Sergej Erschow, Edward Law, PhD, Arnold Kloos, Michael Heuser, MD, Arnold Ganser, MD, Denise Hilfiker-Kleiner, PhD, Olaf Heidenreich, PhD, Michaela Scherr, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4025.
https://doi.org/10.1182/blood-2018-99-114463
Published: 2018
Journal Articles

Frequency and Clinical Characteristics Associated with Putative CAR Targets ADGRE2, CCR1, CD70, and LILRB2 in Acute Myeloid Leukemia

Rabia Shahswar, Arnold Kloos, Razif Gabdoulline, Sagarajit Mohanty, Christian Koenecke, Martin Wichmann, Blerina Neziri, Piroska Klement, Johannes Schiller, Sabrina Klesse, Alessandro Liebich, Courteney Lai, Jürgen Krauter, MD, Arne Trummer, Walter Fiedler, MD, Hartmut Kirchner, Gerhard Heil, Zhixiong Li, MD, Lothar Hambach, Arnold Ganser, MD, Felicitas Thol, MD, Michael Heuser, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5259.
https://doi.org/10.1182/blood-2018-99-113037
Published: 2018
Journal Articles

Prolyl Hydroxylase 3 (Phd3) Is a Therapeutic Target in Isocitrate Dehydrogenase 1 (IDH1) Mutated Acute Myeloid Leukemia

Anuhar Chaturvedi, PhD, Michelle Maria Araujo Cruz, PhD, Ramya Goparaju, PhD, Razif Gabdoulline, Renate Schottmann, Kerstin Görlich, Arnold Kloos, Felicitas Thol, MD, Robert Geffers, PhD, Dimitrios Mougiakakos, Peter Carmeliet, MD PhD, Arnold Ganser, MD, Michael Heuser, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 759.
https://doi.org/10.1182/blood-2018-99-110425
Published: 2018
Journal Articles

Measurable residual disease monitoring by NGS before allogeneic hematopoietic cell transplantation in AML

Clinical Trials & Observations
Felicitas Thol, Razif Gabdoulline, Alessandro Liebich, Piroska Klement, Johannes Schiller, Christian Kandziora, Lothar Hambach, Michael Stadler, Christian Koenecke, Madita Flintrop, Mira Pankratz, Martin Wichmann, Blerina Neziri, Konstantin Büttner, Bennet Heida, Sabrina Klesse, Anuhar Chaturvedi, Arnold Kloos, Gudrun Göhring, Brigitte Schlegelberger, Verena I. Gaidzik, Lars Bullinger, Walter Fiedler, Albert Heim, Iyas Hamwi, Matthias Eder, Jürgen Krauter, Richard F. Schlenk, Peter Paschka, Konstanze Döhner, Hartmut Döhner, Arnold Ganser, Michael Heuser
Journal: Blood
Blood (2018) 132 (16): 1703–1713.
https://doi.org/10.1182/blood-2018-02-829911
Published: 2018
Includes: Supplemental data
Journal Articles

Next-Generation Sequencing-Based Measurable Residual Disease (MRD) Monitoring Is Highly Predictive for Outcome after Allogeneic Stem Cell Transplantation

Felicitas Thol, MD, Alessandro Liebich, Razif Gabdoulline, PhD, Piroska Klement, Johannes Schiller, Christian Kandziora, Madita Flintrop, Mira Pankratz, Martin Wichmann, Blerina Neziri, Sabrina Klesse, Anuhar Chaturvedi, PhD, Arnold Kloos, PhD, Verena I. Gaidzik, MD, Peter Paschka, MD, Lars Bullinger, MD, Walter Fiedler, MD, Albert Heim, MD, Lothar Hambach, MD, Michael Stadler, MD PhD, Iyas Hamwi, MD, Matthias Eder, Jürgen Krauter, MD, Richard F. Schlenk, MD, Konstanze Dohner, MD, Hartmut Döhner, MD, Arnold Ganser, MD, Michael Heuser, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4513.
https://doi.org/10.1182/blood.V130.Suppl_1.4513.4513
Published: 2017
Journal Articles

Serially Transplantable Patient-Derived Xenograft Model of Chronic Myelomonocytic Leukemia (CMML)

Arnold Kloos, PhD, Felicitas Thol, MD, Lina Winckler, Razif Gabdoulline, PhD, Konstantinos Mintzas, Nidhi Jyotsana, PhD, Renate Schottmann, Felix F. Adams, Adrian Schwarzer, MD PhD, Dirk Heckl, PhD, Suzan Imren, MD, R. Keith Humphries, Arnold Ganser, MD, Michael Heuser, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4236.
https://doi.org/10.1182/blood.V130.Suppl_1.4236.4236
Published: 2017
Journal Articles

Characteristics and Prognosis of AML Patients with or without a History of Clonal Hematopoiesis

Felicitas Thol, MD, Larissa Köhler, Sabrina Klesse, Razif Gabdoulline, Arnold Kloos, PhD, Alessandro Liebich, Martin Wichmann, Anuhar Chaturvedi, PhD MS, BPharm, Jana Fabisch, Verena I. Gaidzik, MD, Peter Paschka, MD, Lars Bullinger, MD, Gesine Bug, MD, Hubert Serve, MD, Gudrun Göhring, MD, Brigitte Schlegelberger, MD PhD, Michael Luebbert, MD, Hartmut H. Kirchner, MD, Mohammad Amen Wattad, MD, Doris Kraemer, MD, Bernd Hertenstein, MD, Gerhard Heil, MD, Walter Fiedler, MD, Juergen Krauter, MD, Richard F. Schlenk, MD, Konstanze Döhner, MD, Hartmut Döhner, MD, Arnold Ganser, MD, Michael Heuser, MD
Journal: Blood
Blood (2015) 126 (23): 224.
https://doi.org/10.1182/blood.V126.23.224.224
Published: 2015
Journal Articles

Patient Derived Xenotransplantation Model of Atypical Chronic Myeloid Leukemia (aCML)

Arnold Kloos, PhD, Felicitas Thol, MD, Sabrina Klesse, Alessandro Liebich, Arne Trummer, MD, Renate Schottmann, Rubén Trespando Jiménez, Gudrun Göhring, MD, Brigitte Schlegelberger, MD PhD, Arnold Ganser, MD, Michael Heuser, MD
Journal: Blood
Blood (2015) 126 (23): 2836.
https://doi.org/10.1182/blood.V126.23.2836.2836
Published: 2015
Journal Articles

A Novel Inhibitor of Mutant IDH1 Induces Differentiation in Vivo and Prolongs Survival in a Mouse Model of Leukemia

Anuhar Chaturvedi, PhD, Michelle Maria Araujo Cruz, Ramya Goparaju, Nidhi Jyotsana, Heike Baehre, PhD, Kerstin Goerlich, Renate Schottmann, Matthias Preller, PhD, Eduard A. Struys, PhD, Arnold Kloos, PhD, Volkhard Kaever, PhD, Arnold Ganser, Felicitas Thol, MD, Michael Heuser, MD
Journal: Blood
Blood (2014) 124 (21): 3598.
https://doi.org/10.1182/blood.V124.21.3598.3598
Published: 2014