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Bianca Perfler
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Journal Articles

RAS mutations are frequent in extramedullary AML and drive the tissue infiltration of leukemic cells via the induction of jaml

Free
Panagiota Chaida, Julia Frimmel, Lara Hopfer, Eva Gruden, Bianca Perfler, Akshaya Kailasnathan, Bernadette Bramreiter, Johannes Foßelteder, Sonja Wurm, Jennifer Neiss, Stefan Koeck, Dominik Wolf, Gudrun Ratzinger, Nassim Ghaffari Tabrizi-Wizsy, Kristina Glebova, Beate Rinner, Karoline Fechter, Katarina Vizar Cisarova, Gerald Höfler, Karl Kashofer, Claudia Baldus, Friedrich Stoelzel, Annkristin Heine, Albert Woelfler, Heinz Sill, Andreas Reinisch, Armin Zebisch
Journal: Blood
Blood (2025) 146 (Supplement 1): 659.
https://doi.org/10.1182/blood-2025-659
Published: 2025
Journal Articles

Nonclinical evaluation of APL-4098, a novel GCN2 kinase inhibitor, reveals potent anti-leukemic effects through mitochondrial stress induction and synergy with venetoclax, targeting AML blasts and LSCs

Free
Monica Roman-Trufero, Kevin Blighe, Armin Zebisch, Bianca Perfler, Sereina Annik Herzog, Richard Butt, Holger Auner, Nadine Clemo
Journal: Blood
Blood (2025) 146 (Supplement 1): 1503.
https://doi.org/10.1182/blood-2025-1503
Published: 2025
Journal Articles

Unleashing intrinsic inflammation in AML using therapeutic cytokines overcomes pro-survival pathways and induces deep and durable remission In Vivo.

Free
Ulrike Hoeckendorf, Sayantanee Dutta, Arnold Kloos, Marah Runtsch, Carina Zoetsch, yongjie wang, Bianca Perfler, Sebastian Vosberg, Torsten Haferlach, Konstanze Döhner, Katharina S. Götze, Florian Bassermann, Mathias Heikenwälder, Johannes Schmoellerl, Johannes Zuber, Adam Wahida, Ann-Cathrin Burk, Robert Zeiser, Heinz Sill, Ashok Kumar Jayavelu, Armin Zebisch, Michael Heuser, Michael Dengler, Philipp Jost
Journal: Blood
Blood (2025) 146 (Supplement 1): 3280.
https://doi.org/10.1182/blood-2025-3280
Published: 2025
Journal Articles

Loss of RKIP is a frequent event in myeloid sarcoma and promotes leukemic tissue infiltration

Free
Veronica Caraffini, Bianca Perfler, Johannes Lorenz Berg, Barbara Uhl, Silvia Schauer, Karl Kashofer, Nassim Ghaffari-Tabrizi-Wizsy, Herbert Strobl, Albert Wölfler, Gerald Hoefler, Heinz Sill, Armin Zebisch
Journal: Blood
Blood (2018) 131 (7): 826–830.
https://doi.org/10.1182/blood-2017-09-804906
Published: 2018
Includes: Supplemental data