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Journal Articles

Thrombocytopenia Associated with Myelofibrosis Is Characterized By a Reduced Proportion of Megakaryocyte (MK) Biased Hematopoietic Stem Cells, Defects in MK Maturation and Increased Levels of Pro-Inflammatory Cytokines

Lilian Varricchio, Gohar Mosoyan, Sebastian Elghaity-beckley, John Mascarenhas, Ronald Hoffman

Blood (2023) 142 (Supplement 1): 1779.

https://doi.org/10.1182/blood-2023-178087

Published: 2023

Journal Articles

ATR Inhibitor Camonsertib (RP-3500) Suppresses Early Stage Erythroblasts By Mediating Ferroptosis

Maayan Levy, Gino Ferraro, Li Li, Yongshuai Han, Lilian Varricchio, Sara Fournier, Xiuli An, Ronald Hoffman, Adrian Fretland, Anne Roulston, Yelena Ginzburg

Blood (2022) 140 (Supplement 1): 8194–8195.

https://doi.org/10.1182/blood-2022-169951

Published: 2022

Journal Articles

The Glucocorticoid Receptor-Dependent Stress Response in Human Erythropoiesis Is BCL11A-Dependent

Lilian Varricchio, Eliza Geer, Fabrizio Martelli, Maria Mazzarini, Alister Funnell, James J Bieker, Thalia Papayannopoulou, Anna Rita Migliaccio

Blood (2021) 138 (Supplement 1): 939.

https://doi.org/10.1182/blood-2021-145568

Published: 2021

Journal Articles

Treatment of Myelofibrosis Patients with the TGF-β 1/3 Inhibitor AVID200 (MPN-RC 118) Induces a Profound Effect on Platelet Production

Blood (2021) 138 (Supplement 1): 142.

https://doi.org/10.1182/blood-2021-148995

Published: 2021

Journal Articles

Rationale for and Results of a Phase I Study of the TGF-β 1/3 Inhibitor AVID200 in Subjects with Myelofibrosis: MPN-RC 118 Trial

John Mascarenhas, MD, Heidi E. Kosiorek, MS, Lilian Varricchio, PhD, Rupali Bhave, MD, Andrew T. Kuykendall, MD, Rami Komrokji, MD, Aaron T. Gerds, MDMS, Jeanne M. Palmer, MD, Amelia R. Gabler, Lonette Sandy, Anna Rita Migliaccio, PhD, Mohamed E Salama, MD, Rona Singer Weinberg, PhD, Maureen O'Connor-McCourt, PhD, Gilles Tremblay, PhD, Paul I. Nadler, MD, Amylou C. Dueck, PhD, Ruben A. Mesa, MD FACP, Ronald Hoffman, MD

Blood (2020) 136 (Supplement 1): 6–8.

https://doi.org/10.1182/blood-2020-140830

Published: 2020

Journal Articles

AVID200, a Potent Trap for TGF-β Ligands Inhibits TGF-β1 Signaling in Human Myelofibrosis

Lilian Varricchio, PhD, John Mascarenhas, MD, Anna Rita Migliaccio, PhD, Maureen O'Connor-McCourt, PhD, Gilles Tremblay, Jean-François Denis, Camelia Iancu-Rubin, PhD, Ronald Hoffman, MD

Blood (2018) 132 (Supplement 1): 1791.

https://doi.org/10.1182/blood-2018-99-116474

Published: 2018

Journal Articles

Shared and Tissue-Specific Genetic Features of Primary Myelofibrosis, Hepatic Fibrosis, Idiopathic Pulmonary Fibrosis and Kidney Fibrosis

Anders B Dohlman, MS, Rosa S Kim, Hadassa Hirschfield, Lilian Varricchio, Fiorella Ciaffoni, Massimiliano Dall'ora, Yujin Hoshida, Naftali Kaminski, Giovanni Barosi, MD, Vittorio Rosti, MD, Scott Friedman, Ronald Hoffman, MD, Anna Rita Migliaccio, PhD

Blood (2017) 130 (Supplement 1): 4196.

https://doi.org/10.1182/blood.V130.Suppl_1.4196.4196

Published: 2017

Journal Articles

Systematic Analyses of Clinically Relevant Single Nucleotide Polymorphisms (SNPs) of NR3C1 in Patients from the Italian Registry of Diamond Blackfan Anemia

Jiawen Li, Mayte Suarez-Farinas, Stuart Scott, PhD, Lilian Varricchio, Carolyn F. Whitsett, MD, Ugo Ramenghi, MD, Irma Dianzani, Anna Rita Migliaccio, PhD

Blood (2017) 130 (Supplement 1): 2200.

https://doi.org/10.1182/blood.V130.Suppl_1.2200.2200

Published: 2017

Journal Articles

The Carboxy-Terminal Domain of Calreticulin (CALR) Exports the Glucocorticoid Receptor (GR) from the Nucleus to the Cytoplasm of Human Erythroid Cells Resetting Their Stress Response

Anna Rita Migliaccio, PhD, Mario Falchi, PhD, Lilian Varricchio, PhD, Fabrizio Martelli, PhD, Francesca Masiello, MS, Manuela Marra, PhD, Orietta Picconi, Agostino Tafuri, MD, Gabriella Girelli, MD, Carolyn F. Whitsett, MD

Blood (2016) 128 (22): 545.

https://doi.org/10.1182/blood.V128.22.545.545

Published: 2016

Journal Articles

Ribosomal Deficiency Due to Activation of the Thrombopoietin Axis May be Involved in the Reduced Levels of GATA1 Expressed By Megakaryocytes (MKs) from the Gata1 low Model of Myelofibrosis

Anna Rita F Migliaccio, PhD, Maria Zingariello, MD, Laura Sancillo, MS, Fabrizio Martelli, PhD, Fiorella Ciaffoni, PhD, Francesca Masiello, MS, Ilaria Ceglia, PhD, Lilian Varricchio, PhD, Rosa Alba Rana, MD, Changsheng Zhao, PhD, John Crispino, PhD

Blood (2016) 128 (22): 4275.

https://doi.org/10.1182/blood.V128.22.4275.4275

Published: 2016

Journal Articles

Phosphoproteomic Landscaping Unveils Constitutive cKIT Activation in Human Erythroblasts from Polycythemia Vera (PV) Patients

Lilian Varricchio, PhD, Giulia Federici, PhD, Francesca Masiello, MS, Fabrizio Martelli, PhD, Mario Falchi, PhD, Orietta Picconi, Gabriella Girelli, MD, Agostino Tafuri, MD, Emanuel Petricoin III, PhD, Ann Zeuner, PhD, Anna Rita Migliaccio, PhD

Blood (2016) 128 (22): 399.

https://doi.org/10.1182/blood.V128.22.399.399

Published: 2016

Journal Articles

Glucocorticoid Regulation of Erythropoiesis in Humans: A Study of Patients with Cushing's Disease

Eliza B Geer, MD, Lilian Varricchio, PhD, Fabrizio Martelli, PhD, Wu He, PhD, Lizette Couto, Yelena Lazar, Vanessa Cohen, Anna Rita Migliaccio, PhD

Blood (2015) 126 (23): 2135.

https://doi.org/10.1182/blood.V126.23.2135.2135

Published: 2015

Journal Articles

The JAK2 V617F Mutation Disrupts the Regulatory Activity Exerted By Calreticulin on the Glucocorticoid Receptor in Erythroid Cells

Mario Falchi, PhD, Lilian Varricchio, PhD, Fabrizio Martelli, PhD, Francesca Masiello, Orietta Piccioni, Agostino Tafuri, MD, Gabriella Girelli, Camelia Iancu-Rubin, PhD, Ronald Hoffman, MD, Anna Rita Migliaccio, PhD

Blood (2015) 126 (23): 5216.

https://doi.org/10.1182/blood.V126.23.5216.5216

Published: 2015

Journal Articles

2p15-p16.1 microdeletions encompassing and proximal to BCL11A are associated with elevated HbF in addition to neurologic impairment

Alister P. W. Funnell, Paolo Prontera, Valentina Ottaviani, Maria Piccione, Antonino Giambona, Aurelio Maggio, Fiorella Ciaffoni, Sandra Stehling-Sun, Manuela Marra, Francesca Masiello, Lilian Varricchio, John A. Stamatoyannopoulos, Anna R. Migliaccio, Thalia Papayannopoulou

Blood (2015) 126 (1): 89–93.

https://doi.org/10.1182/blood-2015-04-638528

Published: 2015

Includes: Supplemental data

Journal Articles

Different Stress Responses Mediate the Massive Erythroblast Expansion Occurring in Cultures of Human Progenitor Cells Derived From Cord Blood and Adult Blood in the Presence of Glucocorticoid Receptor Agonists.

Giulia Federici, MS, Valentina Tirelli, MS, Francesca Masiello, MS, Lilian Varricchio, PhD, Gabriella Girelli, MD, Ann Zeuner, PhD, Emanuel F. Petricoin, PhD, Anna Rita F Migliaccio, PhD

Blood (2012) 120 (21): 2339.

https://doi.org/10.1182/blood.V120.21.2339.2339

Published: 2012

Journal Articles

Identification of a New Functional HDAC Complex Composed by HDAC5, GATA1 and EKLF in Human Erythroid Cells

Lilian Varricchio, PhD, Carmela Dell'Aversana, PhD, Angela Nebbioso, MD, Giovanni Migliaccio, PhD, Lucia Altucci, MD, James J. Bieker, PhD, Anna Rita F Migliaccio, PhD

Blood (2012) 120 (21): 979.

https://doi.org/10.1182/blood.V120.21.979.979

Published: 2012

Journal Articles

Structural Specificity of the Biological Activity of Human and Murine Stem Cell Factor in Stress Erythropoiesis,

Elena Masselli, Lilian Varricchio, Barbara Ghinassi, Anna Rita F Migliaccio, PhD

Blood (2011) 118 (21): 3395.

https://doi.org/10.1182/blood.V118.21.3395.3395

Published: 2011

Journal Articles

The dominant negative β isoform of the glucocorticoid receptor is uniquely expressed in erythroid cells expanded from polycythemia vera patients

Lilian Varricchio, Elena Masselli, Elena Alfani, Angela Battistini, Giovanni Migliaccio, Alessandro Maria Vannucchi, Wenyong Zhang, Damiano Rondelli, James Godbold, Barbara Ghinassi, Carolyn Whitsett, Ronald Hoffman, Anna Rita Migliaccio

Blood (2011) 118 (2): 425–436.

https://doi.org/10.1182/blood-2010-07-296921

Published: 2011

Includes: Supplemental data

Journal Articles

Increased frequency of the glucocorticoid receptor A3669G (rs6198) polymorphism in patients with Diamond-Blackfan anemia

Lilian Varricchio, James Godbold, Stuart A. Scott, Carolyn Whitsett, Lydie Da Costa, Dagmar Pospisilova, Emanuela Garelli, Paola Quarello, Ugo Ramenghi, Anna Rita Migliaccio

Blood (2011) 118 (2): 473–474.

https://doi.org/10.1182/blood-2011-03-342139

Published: 2011

Journal Articles

Mature Erythroblasts Die of Autophagy and Induce Autophagy of Immature Erythroblasts, Limiting the Final Cellular Output In Human Erythroid Massive Amplification (HEMA) Culture

Giovanni Migliaccio, PhD, Francesca Masiello, Valentina Tirelli, Massimo Sanchez, Lilian Varricchio, Carolyn Whitsett, Anna Rita F Migliaccio, PhD

Blood (2010) 116 (21): 339.

https://doi.org/10.1182/blood.V116.21.339.339

Published: 2010

NARROW

Thrombocytopenia Associated with Myelofibrosis Is Characterized By a Reduced Proportion of Megakaryocyte (MK) Biased Hematopoietic Stem Cells, Defects in MK Maturation and Increased Levels of Pro-Inflammatory Cytokines

ATR Inhibitor Camonsertib (RP-3500) Suppresses Early Stage Erythroblasts By Mediating Ferroptosis

The Glucocorticoid Receptor-Dependent Stress Response in Human Erythropoiesis Is BCL11A-Dependent

Treatment of Myelofibrosis Patients with the TGF-β 1/3 Inhibitor AVID200 (MPN-RC 118) Induces a Profound Effect on Platelet Production

Rationale for and Results of a Phase I Study of the TGF-β 1/3 Inhibitor AVID200 in Subjects with Myelofibrosis: MPN-RC 118 Trial

AVID200, a Potent Trap for TGF-β Ligands Inhibits TGF-β1 Signaling in Human Myelofibrosis

Shared and Tissue-Specific Genetic Features of Primary Myelofibrosis, Hepatic Fibrosis, Idiopathic Pulmonary Fibrosis and Kidney Fibrosis

Systematic Analyses of Clinically Relevant Single Nucleotide Polymorphisms (SNPs) of NR3C1 in Patients from the Italian Registry of Diamond Blackfan Anemia

The Carboxy-Terminal Domain of Calreticulin (CALR) Exports the Glucocorticoid Receptor (GR) from the Nucleus to the Cytoplasm of Human Erythroid Cells Resetting Their Stress Response

Ribosomal Deficiency Due to Activation of the Thrombopoietin Axis May be Involved in the Reduced Levels of GATA1 Expressed By Megakaryocytes (MKs) from the Gata1 low Model of Myelofibrosis

Phosphoproteomic Landscaping Unveils Constitutive cKIT Activation in Human Erythroblasts from Polycythemia Vera (PV) Patients

Glucocorticoid Regulation of Erythropoiesis in Humans: A Study of Patients with Cushing's Disease

The JAK2 V617F Mutation Disrupts the Regulatory Activity Exerted By Calreticulin on the Glucocorticoid Receptor in Erythroid Cells

2p15-p16.1 microdeletions encompassing and proximal to BCL11A are associated with elevated HbF in addition to neurologic impairment

Different Stress Responses Mediate the Massive Erythroblast Expansion Occurring in Cultures of Human Progenitor Cells Derived From Cord Blood and Adult Blood in the Presence of Glucocorticoid Receptor Agonists.

Identification of a New Functional HDAC Complex Composed by HDAC5, GATA1 and EKLF in Human Erythroid Cells

Structural Specificity of the Biological Activity of Human and Murine Stem Cell Factor in Stress Erythropoiesis,

The dominant negative β isoform of the glucocorticoid receptor is uniquely expressed in erythroid cells expanded from polycythemia vera patients

Increased frequency of the glucocorticoid receptor A3669G (rs6198) polymorphism in patients with Diamond-Blackfan anemia

Mature Erythroblasts Die of Autophagy and Induce Autophagy of Immature Erythroblasts, Limiting the Final Cellular Output In Human Erythroid Massive Amplification (HEMA) Culture

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American Society of Hematology

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American Society of Hematology

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