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Journal Articles

TP53 Alterations Confer Increased Risk of Leukemic Transformation and Worse Survival As Compared to High Molecular Risk Mutations in Patients with Myeloproliferative Neoplasms

Shivani Handa, Yosef Joseph Rene Amel Riazat-Kesh, Richard J Butterfield, Ganesh Sivakumar, Sangeetha Venugopal, Erin McGovern, Jonathan Feld, Douglas Tremblay, Sebastian Elghaity-Beckley, Marina Kremyanskaya, John O. Mascarenhas, Blake Langlais, Gina L. Mazza, Daniel I. Nathan, Joseph Tripodi, Vesna Najfeld, Amylou C Dueck, Raajit Rampal, Ronald Hoffman, Bridget Kelly Marcellino
Journal: Blood
Blood (2024) 144 (Supplement 1): 243.
https://doi.org/10.1182/blood-2024-206688
Published: 2024
Journal Articles

A Novel Three-Way Translocation Involving ETV6-IL3 Drives AML with Eosinophilia

Ariel Siegel, Joseph Tripodi, Brianna Kelly, Sebastian Elghaity-Beckley, Michelle Becker, Douglas Tremblay, Jonathan Feld, Hannah Levavi, Marina Kremyanskaya, Bridget Kelly Marcellino, Christian Salib, Alla Keyzner, Amy Duffield, John O. Mascarenhas, Vesna Najfeld, Alan Shih
Journal: Blood
Blood (2024) 144 (Supplement 1): 6098.
https://doi.org/10.1182/blood-2024-203588
Published: 2024
Journal Articles

High-Resolution Chromosomal Microarrays Reveals Exon-Level Deletion in Chromosome 12q14.3 in Patients with Myeloproliferative Neoplasms

Joseph Tripodi, Shivani Handa, Christoph Schaniel, Daiva Ahire, Ronald Hoffman, Vesna Najfeld
Journal: Blood
Blood (2024) 144 (Supplement 1): 4520.
https://doi.org/10.1182/blood-2024-206440
Published: 2024
Journal Articles

Role of HMGA2 Overexpression Caused By Specific Genetic HMGA2 Aberrations in Disease Progression in Calreticulin-Mutated Myelofibrosis Patients

Christoph Schaniel, Shivani Handa, Joseph Tripodi, MD Babu Mia, Christian Salib, Jeff Vierstra, Allison J Cote, Daiva Ahire, Douglas Tremblay, Bridget Kelly Marcellino, John A Stamatoyannopoulos, Vesna Najfeld, Ronald Hoffman
Journal: Blood
Blood (2024) 144 (Supplement 1): 4512.
https://doi.org/10.1182/blood-2024-205834
Published: 2024
Journal Articles

Conventional Cytogenetic Analysis and Array CGH+SNP Identify Essential Thrombocythemia (ET)/Prefibrotic Primary Myelofibrosis (pre-PMF) Patients Who Are at Risk for Disease Progression

Joseph Tripodi, Ronald Hoffman, Douglas Tremblay, John Mascarenhas, Marina Kremyanskaya, Ian Novoselac, Vesna Najfeld
Journal: Blood
Blood (2023) 142 (Supplement 1): 1832.
https://doi.org/10.1182/blood-2023-181092
Published: 2023
Journal Articles

A randomized phase 3 trial of interferon-α vs hydroxyurea in polycythemia vera and essential thrombocythemia

Clinical Trials & Observations
John Mascarenhas, Heidi E. Kosiorek, Josef T. Prchal, Alessandro Rambaldi, Dmitriy Berenzon, Abdulraheem Yacoub, Claire N. Harrison, Mary Frances McMullin, Alessandro M. Vannucchi, Joanne Ewing, Casey L. O'Connell, Jean-Jacques Kiladjian, Adam J. Mead, Elliott F. Winton, David S. Leibowitz, Valerio De Stefano, Murat O. Arcasoy, Craig M. Kessler, Rosalind Catchatourian, Damiano Rondelli, Richard T. Silver, Andrea Bacigalupo, Arnon Nagler, Marina Kremyanskaya, Max F. Levine, Juan E. Arango Ossa, Erin McGovern, Lonette Sandy, Mohamad E. Salama, Vesna Najfeld, Joseph Tripodi, Noushin Farnoud, Alexander V. Penson, Rona Singer Weinberg, Leah Price, Judith D. Goldberg, Tiziano Barbui, Roberto Marchioli, Gianni Tognoni, Raajit K. Rampal, Ruben A. Mesa, Amylou C. Dueck, Ronald Hoffman
Journal: Blood
Blood (2022) 139 (19): 2931–2941.
https://doi.org/10.1182/blood.2021012743
Published: 2022
Includes: Supplemental data
Journal Articles

Exon-Level Genomic Abnormalities Are Frequent in Cytogenetically Normal Patients with Philadelphia-Chromosome Negative Myeloproliferative Neoplasms (MPNs)

Joseph Tripodi, Douglas Tremblay, MD, Ronald Hoffman, MD, Umut Ozbek, PhD, John Mascarenhas, MD, Marina Kremyanskaya, Vesna Najfeld, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1687.
https://doi.org/10.1182/blood-2019-128948
Published: 2019
Journal Articles

Significance of Abnormalities of PPM1D in Myeloproliferative Neoplasms

Bridget Marcellino, MD PhD, Joseph Tripodi, Michal Bar-Natan, MD, Harry Fruchtman, Noushin Farnoud, PhD, Min Lu, PhD, Heidi E. Kosiorek, MS, Amylou C. Dueck, PhD, Raajit K. Rampal, MD PhD, John Mascarenhas, MD, Vesna Najfeld, PhD, Ronald Hoffman, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4207.
https://doi.org/10.1182/blood-2019-129565
Published: 2019
Journal Articles

Dual Driver Mutant BCR-ABL1-Negative Myeloid Neoplasms: Multicenter Clinicopathologic and Genomic Analysis

Zachary D. Epstein-Peterson, MD, Joseph Tripodi, Maria E Arcila, MD, Filiz Sen, MD, Vesna Najfeld, PhD, John Mascarenhas, MD, Ronald Hoffman, MD, Rajit K. Rampal, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4173.
https://doi.org/10.1182/blood-2019-125379
Published: 2019
Journal Articles

Pegylated interferon alfa-2a for polycythemia vera or essential thrombocythemia resistant or intolerant to hydroxyurea

Clinical Trials & Observations
Abdulraheem Yacoub, John Mascarenhas, Heidi Kosiorek, Josef T. Prchal, Dmitry Berenzon, Maria R. Baer, Ellen Ritchie, Richard T. Silver, Craig Kessler, Elliott Winton, Maria Chiara Finazzi, Alessandro Rambaldi, Alessandro M. Vannucchi, David Leibowitz, Damiano Rondelli, Murat O. Arcasoy, Rosalind Catchatourian, Joseph Vadakara, Vittorio Rosti, Elizabeth Hexner, Marina Kremyanskaya, Lonette Sandy, Joseph Tripodi, Vesna Najfeld, Noushin Farnoud, Elli Papaemmanuil, Mohamed Salama, Rona Singer-Weinberg, Raajit Rampal, Judith D. Goldberg, Tiziano Barbui, Ruben Mesa, Amylou C. Dueck, Ronald Hoffman
Journal: Blood
Blood (2019) 134 (18): 1498–1509.
https://doi.org/10.1182/blood.2019000428
Published: 2019
Includes: Supplemental data
Journal Articles

Results of the Myeloproliferative Neoplasms - Research Consortium (MPN-RC) 112 Randomized Trial of Pegylated Interferon Alfa-2a (PEG) Versus Hydroxyurea (HU) Therapy for the Treatment of High Risk Polycythemia Vera (PV) and High Risk Essential Thrombocythemia (ET)

John Mascarenhas, MD, Heidi E. Kosiorek, MS, Josef T. Prchal, MD, Alessandro Rambaldi, MD, Dmitriy Berenzon, MD, Abdulraheem Yacoub, MD, Claire N. Harrison, MD DM, FRCP, PRCPath, Mary Frances McMullin, MD, Alessandro M. Vannucchi, MD, Joanne Ewing, PhD BMBS, BSc, FRPATH,, Casey L. O'Connell, MD, Jean-Jacques Kiladjian, MD PhD, Adam J. Mead, MD PhD, Elliott F. Winton, MD, David S. Leibowitz, MD, Valerio De Stefano, MD, Murat O. Arcasoy, MD, Craig M. Kessler, Rosalind Catchatourian, MD, Damiano Rondelli, MD, Richard T. Silver, MD, Andrea Bacigalupo, MD, Arnon Nagler, MD, Marina Kremyanskaya, MD PhD, Lonette Sandy, Mohamed E. Salama, MD, Vesna Najfeld, PhD, Joseph Tripodi, Rona Singer Weinberg, PhD, Leah Price, Judith D Goldberg, ScD, Raajit K. Rampal, MD PhD, Ruben A. Mesa, MD FACP, Amylou C. Dueck, PhD, Ronald Hoffman, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 577.
https://doi.org/10.1182/blood-2018-99-111946
Published: 2018
Journal Articles

Impact on MPN Symptoms and Quality of Life of Front Line Pegylated Interferon Alpha-2a Vs. Hydroxyurea in High Risk Polycythemia Vera and Essential Thrombocythemia: Results of Myeloproliferative Disorders Research Consortium (MPD-RC) 112 Global Phase III Trial

Ruben A. Mesa, MD FACP, Heidi E. Kosiorek, MS, John Mascarenhas, MD, Josef T. Prchal, MD, Alessandro Rambaldi, MD, Dmitriy Berenzon, MD, Abdulraheem Yacoub, MD, Claire N. Harrison, MD DM, FRCP, PRCPath, Mary Frances McMullin, MD, Alessandro M. Vannucchi, MD, Joanne Ewing, PhD BMBS, BSc, FRPATH,, Casey L. O'Connell, MD, Jean-Jacques Kiladjian, MD PhD, Adam J. Mead, MD PhD, Elliott F. Winton, MD, David S. Leibowitz, MD, Valerio De Stefano, MD, Murat O. Arcasoy, MD, Craig M. Kessler, Rosalind Catchatourian, MD, Damiano Rondelli, MD, Richard T. Silver, MD, Andrea Bacigalupo, MD, Arnon Nagler, MD, Marina Kremyanskaya, MD PhD, Lonette Sandy, Mohamed E. Salama, MD, Vesna Najfeld, PhD, Joseph Tripodi, Rona Singer Weinberg, PhD, Raajit K. Rampal, MD PhD, Ronald Hoffman, MD, Amylou C. Dueck, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3032.
https://doi.org/10.1182/blood-2018-99-111929
Published: 2018
Journal Articles

Myeloproliferative Neoplasm (MPN) Blastic Transformation Occurs at the Level of Hematopoietic Stem Cells

Xiaoli Wang, PhD, Cing Siang Hu, Joseph Tripodi, Vesna Najfeld, PhD, Bruce Petersen, MD, Raajit K. Rampal, MD PhD, Noushin Farnoud, Christopher Famulare, MS, John Mascarenhas, MD, Ronald Hoffman, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 101.
https://doi.org/10.1182/blood-2018-99-117348
Published: 2018
Journal Articles

Single-Arm Salvage Therapy with Pegylated Interferon Alfa-2a for Patients with High-Risk Polycythemia Vera or High-Risk Essential Thrombocythemia Who Are Either Hydroxyurea-Resistant or Intolerant: Final Results of the Myeloproliferative Disorders-Research Consortium (MPD-RC) Protocol 111 Global Phase II Trial

Abdulraheem Yacoub, MD, John Mascarenhas, MD, Heidi Elizabeth Kosiorek, MS, Josef T. Prchal, MD, Dmitriy Berenzon, MD, Maria R. Baer, MD, Ellen K Ritchie, MD, Richard T Silver, MD, Craig M. Kessler, MD, Elliott F. Winton, MD, Maria Chiara Finazzi, MD, Alessandro Rambaldi, MD Prof, Alessandro M. Vannucchi, David S. Leibowitz, MD, Damiano Rondelli, MD, Murat O. Arcasoy, MD, Rosalind Catchatourian, MD, Joseph Vadakara, MBBS, Vittorio Rosti, MD, Elizabeth Hexner, MDMS, Marina Kremyanskaya, MD PhD, Alicia Orellana, MD MPH, Lonette Sandy, Joseph Tripodi, Vesna Najfeld, PhD, Mohamed E. Salama, MD, Rona Singer Weinberg, PhD, Raajit K. Rampal, MD PhD, Ruben A Mesa, MD, Judith D Goldberg, ScD, Amylou C. Dueck, PhD, Ronald Hoffman, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 321.
https://doi.org/10.1182/blood.V130.Suppl_1.321.321
Published: 2017
Journal Articles

Single-Arm Phase II Trial of Pegylated Interferon Alpha 2a in Patients with High-Risk Essential Thrombocythemia or Polycythemia Vera Resistant or Intolerant to Hydroxyurea: MPN Symptom Impact & Quality of Life Results of the Myeloproliferative Disorders-Research Consortium (MPD-RC) Protocol 111 Global Phase II Trial

Amylou C. Dueck, PhD, John Mascarenhas, MD, Heidi Elizabeth Kosiorek, MS, Abdulraheem Yacoub, MD, Josef T. Prchal, MD, Dmitriy Berenzon, MD, Maria R. Baer, MD, Ellen K Ritchie, MD, Richard T Silver, MD, Craig M. Kessler, MD, Elliott F. Winton, MD, Maria Chiara Finazzi, MD, Alessandro Rambaldi, MD Prof, Alessandro M. Vannucchi, David S. Leibowitz, MD, Damiano Rondelli, MD, Murat O. Arcasoy, MD, Rosalind Catchatourian, MD, Joseph Vadakara, MBBS, Vittorio Rosti, MD, Elizabeth Hexner, MDMS, Marina Kremyanskaya, MD PhD, Alicia Orellana, MD MPH, Lonette Sandy, Joseph Tripodi, Vesna Najfeld, PhD, Mohamed E. Salama, MD, Rona Singer Weinberg, PhD, Raajit K. Rampal, MD PhD, Ronald Hoffman, MD, Ruben A Mesa, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4206.
https://doi.org/10.1182/blood.V130.Suppl_1.4206.4206
Published: 2017
Journal Articles

Myeloproliferative Neoplasm (MPN) Blastic Transformation Occurs at the Level of Both Short and Long Term Hematopoietic Stem Cells

Xiaoli Wang, PhD, Cing Siang Hu, Raajit K. Rampal, MD PhD, Joseph Tripodi, Vesna Najfeld, PhD, Bruce Petersen, MD, John Mascarenhas, MD, Ronald Hoffman, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2943.
https://doi.org/10.1182/blood.V130.Suppl_1.2943.2943
Published: 2017
Journal Articles

Advanced Forms of the Myeloproliferative Neoplasms Are Associated with Chromosomal Abnormalities Involving 1q and 12q: Implicating MDM2 and MDM4 in Disease Progression

Bridget Marcellino, MD PhD, Joseph Tripodi, Min Lu, PhDMD, Heidi Kosiorek, MS, John Mascarenhas, MD, Raajit K. Rampal, MD PhD, Amylou Constance Dueck, PhD, Ronald Hoffman, MD, Vesna Najfeld, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 204.
https://doi.org/10.1182/blood.V130.Suppl_1.204.204
Published: 2017
Journal Articles

Specific and Recurrent Cytogenomic Abnormalities Originate in the Spleens of Myelofibrosis Patients and Contribute to Clonal Diversity and Disease Progression

Vesna Najfeld, PhD, Joseph Tripodi, MS, Xiaoli Wang, MD PhD, Myron Schwartz, MD, Marina Kremyanskaya, MDPhD, Edward Cytryn, Sharon Zirkiev, Raajit K. Rampal, MD, PhD, John O Mascarenhas, MD MS, Ronald Hoffman, MD
Journal: Blood
Blood (2014) 124 (21): 1871.
https://doi.org/10.1182/blood.V124.21.1871.1871
Published: 2014
Journal Articles

JAK2 inhibitors do not affect stem cells present in the spleens of patients with myelofibrosis

Xiaoli Wang, Fei Ye, Joseph Tripodi, Cing Siang Hu, Jiajing Qiu, Vesna Najfeld, Jesse Novak, Yan Li, Raajit Rampal, Ronald Hoffman
Journal: Blood
Blood (2014) 124 (19): 2987–2995.
https://doi.org/10.1182/blood-2014-02-558015
Published: 2014
Includes: Supplemental data
Journal Articles

Characterization Of Splenic Fibroblasts From Patients With Myelofibrosis

Xiaoli Wang, Joseph Tripodi, MS, Vesna Najfeld, PhD, Min Lu, PhD, Ronald Hoffman, MD
Journal: Blood
Blood (2013) 122 (21): 4107.
https://doi.org/10.1182/blood.V122.21.4107.4107
Published: 2013