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Journal Articles

A Novel Direct Hemoglobin S Polymerization Inhibitor for the Treatment of Sickle Cell Disease - In Vivo Efficacy of Ilx-002 in Humanized Mice

Osheiza Abdulmalik, Kandace Gollomp, Veronica Bochenek, Conroy O Field, Mariana Macias, Benita Balogun, Salma Roland, Martin K Safo, Yan Zhang, Akua Donkor, Abdelsattar Omar, Moustafa El-Araby, David R. Light, Clark Brown, Andrew N Fleischman

Blood (2024) 144 (Supplement 1): 173.

https://doi.org/10.1182/blood-2024-202714

Published: 2024

Journal Articles

Anti-Phospholipid Syndrome (APS) Antibody (Ab)-Induced Thrombosis Can be Blocked By Platelet Factor 4 (PF4)-Directed Abs: A Novel Therapeutic Approach for APS?

Amrita Sarkar, Santosh K Yadav, Conroy O Field, Kandace Gollomp, Keith R. McCrae, Thomas L. Ortel, Yves Gruel, Jérôme Rollin, Gowthami M Arepally, Lubica Rauova, Douglas B. Cines, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 2611.

https://doi.org/10.1182/blood-2024-200849

Published: 2024

Journal Articles

Platelet Factor 4 (PF4) Binding to Neutrophil Extracellular Traps (NETs) and Von Willebrand Factor (vWF) Improves Bacterial Capture and Killing in an Electrostatic Charge-Dependent Manner

Santosh K Yadav, Abigail E Skidmore, Anh T.P. Ngo, Veronica Bochenek, Manuela Roggiani, Mark Goulian, Mortimer Poncz, Kandace Gollomp

Blood (2024) 144 (Supplement 1): 3986.

https://doi.org/10.1182/blood-2024-206506

Published: 2024

Journal Articles

Why Do Peptidyl Arginine Deiminase (PAD) 4-Deficient Mice Have Improved Survival Following Cecal Ligation and Puncture (CLP) Sepsis? Implications for the Role Neutrophil Extracellular Trap (NETs) in Immune Homeostasis

Veronica Bochenek, Abigail E Skidmore, Anh T.P. Ngo, Samir Maarouf, Weiming Hu, Santosh K Yadav, Ethan Mack, M. Anna Kowalska, Mortimer Poncz, Kandace Gollomp

Blood (2024) 144 (Supplement 1): 2528.

https://doi.org/10.1182/blood-2024-203321

Published: 2024

Journal Articles

Antiphospholipid Syndrome (APS) Is a Platelet Factor 4 (PF4)-Centric Immunothrombotic Disorder

Conroy O Field, Amrita Sarkar, Khalil Bdeir, Keith R. McCrae, Thomas L. Ortel, M. Anna Kowalska, Lubica Rauova, Douglas B. Cines, Kandace Gollomp, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 185.

https://doi.org/10.1182/blood-2024-201682

Published: 2024

Journal Articles

Altered Calcium Signaling Via STIM1 Drives Aberrant Megakaryopoiesis and Myelofibrosis

Molly Brakhane, Vittorio Abbonante, Angelo Laranjeira, Christian Andrea Di Buduo, Brooke Sadler, Katrina Ashworth, Tim Kong, Fan He, Mary Fulbright, Dong Chen, Regina Clemens, Elena Pegoraro, Michele P. Lambert, Kandace Gollomp, Jorge Di Paola, Alessandra Balduini, Stephen Oh

Blood (2024) 144 (Supplement 1): 1169.

https://doi.org/10.1182/blood-2024-210283

Published: 2024

Journal Articles

Platelet Factor 4 Enhances Endothelial Cell Antimicrobial Activity in Vitro and Promotes Bacterial Clearance In Vivo , Improving Sepsis Outcomes

Anh T.P. Ngo, Veronica Bochenek, Hyunjun Kim, Nate Levine, Samir Maarouf, Jenna Oberg, Manuela Roggiani, Amrita Sarkar, Lubica Rauova, Caroline Diorio, Zachary Martinez, Mark Goulian, Mortimer Poncz, Victor Nizet, Kandace Gollomp

Blood (2024) 144 (Supplement 1): 1231.

https://doi.org/10.1182/blood-2024-211717

Published: 2024

Journal Articles

Platelet Factor 4 Modulates the Bactericidal Ability of Neutrophil Extracellular Traps

Abigail E Skidmore, Nate Levine, Veronica Bochenek, Manuela Roggiani, Mark Goulian, Kandace Gollomp, Anh T.P. Ngo

Blood (2023) 142 (Supplement 1): 3911.

https://doi.org/10.1182/blood-2023-186380

Published: 2023

Journal Articles

Aberrant Activity of the Calcium Sensor STIM1 Underlies Congenital Platelet Disorders and Myeloproliferative Neoplasms

Molly Brakhane, Vittorio Abbonante, Angelo B. A. Laranjeira, Christian Di Buduo, Brooke Sadler, Katrina Ashworth, Tim Kong, Fan He, Mary C. Fulbright, Dong Chen, Regina Clemens, Elena Pegoraro, Michele P. Lambert, Kandace Gollomp, Jorge Di Paola, Alessandra Balduini, Stephen T. Oh

Blood (2023) 142 (Supplement 1): 995.

https://doi.org/10.1182/blood-2023-186413

Published: 2023

Journal Articles

Peptidyl Arginine Deiminase (PAD) 4 Modulates the GI Microbiome and Baseline Inflammation in Mice: Implications for Sepsis

Veronica Bochenek, Nate Levine, Anh T.P. Ngo, Samir Maarouf, Abigail E Skidmore, M. Anna Kowalska, Caroline Diorio, Zachary Martinez, Mortimer Poncz, Kandace Gollomp

Blood (2023) 142 (Supplement 1): 1169.

https://doi.org/10.1182/blood-2023-189931

Published: 2023

Journal Articles

Platelet Factor 4 Enhances Antimicrobial Function of the Endothelium and Improves Outcome in a Murine Model of Sepsis

Anh T.P. Ngo, Nate Levine, Abigail E Skidmore, Amrita Sarkar, Veronica Bochenek, Manuela Roggiani, Mark Goulian, Mortimer Poncz, Kandace Gollomp

Blood (2023) 142 (Supplement 1): 1198.

https://doi.org/10.1182/blood-2023-186989

Published: 2023

Journal Articles

Socioeconomic and Inflammatory Correlates of Plasma Cortisol Among Individuals with Sickle Cell Disease

Kemar V. Prussien, Andrea H. Roe, Veronica Bochenek, Jessica Wu, Sandy Luz, Seema Bhatnagar, Kandace Gollomp

Blood (2023) 142 (Supplement 1): 3893.

https://doi.org/10.1182/blood-2023-181918

Published: 2023

Journal Articles

TORing the impact of sirolimus on immune health

Kandace Gollomp, David T. Teachey

Blood (2023) 141 (3): 212–214.

https://doi.org/10.1182/blood.2022018568

Published: 2023

Journal Articles

Quantification of Neutrophil Extracellular Traps (NETs) in Pediatric Patients with COVID-19 and Multisystem Inflammatory Syndrome (MIS-C) through Plasma and Peripheral Smear Analysis

Rachelle Thompson, Megan Zoltowski, Derick Lim, Caroline Diorio, Elizabeth Margolskee, Michele Paessler, Veronica Bochenek, Edward M Behrens, David T. Teachey, Hamid Bassiri, Michele P. Lambert, Kandace Gollomp

Blood (2022) 140 (Supplement 1): 5481–5482.

https://doi.org/10.1182/blood-2022-170932

Published: 2022

Journal Articles

Aggregation of Enveloped Viruses By Platelet Factor 4 (PF4) and Neutrophil Extracellular Traps (NETs): Implications for the Anti-Viral Properties of NETs

Kandace Gollomp, Irina Chernysh, Anh T.P. Ngo, Nathan Levine, Sergey Zaytsev, Veronica Bochenek, Lubica Rauova, Nicholas Parenti, Susan R Weiss, John W. Weisel, Douglas B. Cines, Mortimer Poncz

Blood (2022) 140 (Supplement 1): 1405–1406.

https://doi.org/10.1182/blood-2022-170781

Published: 2022

Journal Articles

Lnp-Targeting Hematopoietic Stem Cells and Lentiviral Gene Transfer to Generate and Rescue a Novel Mouse Model of Lethal Alpha-Thalassemia

Maxwell Chappell, Laura Breda, Danuta Jadwiga Jarocha, Michael Triebwasser, Tyler E Papp, Valentina Ghiaccio, Megan T Fedorky, Amaliris Guerra, Kandace Gollomp, Osheiza Y. Abdulmalik, Nattiya Teawtrakul, Stavros Glentis, Antonis Kattamis, Hamideh Parhiz, Stefano Rivella

Blood (2022) 140 (Supplement 1): 300–302.

https://doi.org/10.1182/blood-2022-166621

Published: 2022

Journal Articles

Neutrophil Extracellular Traps (NETs) Thrombogenicity and Endothelial Cell Toxicity Are Ameliorated By Platelet Factor 4 (PF4): Implications to the Treatment of Sepsis

Anh T.P. Ngo, Amrita Sarkar, Nathan Levine, Veronica Bochenek, Guohua Zhao, Lubica Rauova, M. Anna Kowalska, Kaitlyn Eckart, Nilam S. Mangalmurti, Ann Rux, Douglas B. Cines, Mortimer Poncz, Kandace Gollomp

Blood (2022) 140 (Supplement 1): 5529–5530.

https://doi.org/10.1182/blood-2022-169709

Published: 2022

Journal Articles

A Severe Mouse Model of Alpha-Thalassemia to Study Abnormal Iron Metabolism and Erythropoiesis, Hematopoietic Stem Cell Behavior and Development of a Gene Therapy Approach for Its Treatment

Maxwell Chappell, Danuta Jadwiga Jarocha, Laura Breda, Valentina Ghiaccio, Michael Triebwasser, Megan Fedorky, Amaliris Guerra, Kandace Gollomp, Nattiya Teawtrakul, Stavros Glentis, Antonis Kattamis, Osheiza Abdulmalik, Stefano Rivella

Blood (2021) 138 (Supplement 1): 2012.

https://doi.org/10.1182/blood-2021-151217

Published: 2021

Journal Articles

Platelet Factor 4 (PF4) Modulates the Prothrombotic Nature of Neutrophil-Extracellular Traps (NETs): Therapeutic Implications of a NET-Stabilization Strategy

Anh T.P. Ngo, Irene Yarovoi, Guohua Zhao, Amrita Sarkar, Lubica Rauova, M. Anna Kowalska, Mortimer Poncz, Kandace Gollomp

Blood (2021) 138 (Supplement 1): 2096.

https://doi.org/10.1182/blood-2021-153352

Published: 2021

Journal Articles

Neutrophils promote clearance of nuclear debris following acid-induced lung injury

Joseph H. Oved, Andrew J. Paris, Kandace Gollomp, Ning Dai, Kathryn Rubey, Ping Wang, Lynn A. Spruce, Steven H. Seeholzer, Mortimer Poncz, G. Scott Worthen

Blood (2021) 137 (3): 392–397.

https://doi.org/10.1182/blood.2020005505

Published: 2021

Includes: Multimedia, Supplemental data

NARROW

A Novel Direct Hemoglobin S Polymerization Inhibitor for the Treatment of Sickle Cell Disease - In Vivo Efficacy of Ilx-002 in Humanized Mice

Anti-Phospholipid Syndrome (APS) Antibody (Ab)-Induced Thrombosis Can be Blocked By Platelet Factor 4 (PF4)-Directed Abs: A Novel Therapeutic Approach for APS?

Platelet Factor 4 (PF4) Binding to Neutrophil Extracellular Traps (NETs) and Von Willebrand Factor (vWF) Improves Bacterial Capture and Killing in an Electrostatic Charge-Dependent Manner

Why Do Peptidyl Arginine Deiminase (PAD) 4-Deficient Mice Have Improved Survival Following Cecal Ligation and Puncture (CLP) Sepsis? Implications for the Role Neutrophil Extracellular Trap (NETs) in Immune Homeostasis

Antiphospholipid Syndrome (APS) Is a Platelet Factor 4 (PF4)-Centric Immunothrombotic Disorder

Altered Calcium Signaling Via STIM1 Drives Aberrant Megakaryopoiesis and Myelofibrosis

Platelet Factor 4 Enhances Endothelial Cell Antimicrobial Activity in Vitro and Promotes Bacterial Clearance In Vivo , Improving Sepsis Outcomes

Platelet Factor 4 Modulates the Bactericidal Ability of Neutrophil Extracellular Traps

Aberrant Activity of the Calcium Sensor STIM1 Underlies Congenital Platelet Disorders and Myeloproliferative Neoplasms

Peptidyl Arginine Deiminase (PAD) 4 Modulates the GI Microbiome and Baseline Inflammation in Mice: Implications for Sepsis

Platelet Factor 4 Enhances Antimicrobial Function of the Endothelium and Improves Outcome in a Murine Model of Sepsis

Socioeconomic and Inflammatory Correlates of Plasma Cortisol Among Individuals with Sickle Cell Disease

TORing the impact of sirolimus on immune health

Quantification of Neutrophil Extracellular Traps (NETs) in Pediatric Patients with COVID-19 and Multisystem Inflammatory Syndrome (MIS-C) through Plasma and Peripheral Smear Analysis

Aggregation of Enveloped Viruses By Platelet Factor 4 (PF4) and Neutrophil Extracellular Traps (NETs): Implications for the Anti-Viral Properties of NETs

Lnp-Targeting Hematopoietic Stem Cells and Lentiviral Gene Transfer to Generate and Rescue a Novel Mouse Model of Lethal Alpha-Thalassemia

Neutrophil Extracellular Traps (NETs) Thrombogenicity and Endothelial Cell Toxicity Are Ameliorated By Platelet Factor 4 (PF4): Implications to the Treatment of Sepsis

A Severe Mouse Model of Alpha-Thalassemia to Study Abnormal Iron Metabolism and Erythropoiesis, Hematopoietic Stem Cell Behavior and Development of a Gene Therapy Approach for Its Treatment

Platelet Factor 4 (PF4) Modulates the Prothrombotic Nature of Neutrophil-Extracellular Traps (NETs): Therapeutic Implications of a NET-Stabilization Strategy

Neutrophils promote clearance of nuclear debris following acid-induced lung injury

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American Society of Hematology

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