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Journal Articles

Antiphospholipid Syndrome (APS) Is a Platelet Factor 4 (PF4)-Centric Immunothrombotic Disorder

Conroy O Field, Amrita Sarkar, Khalil Bdeir, Keith R. McCrae, Thomas L. Ortel, M. Anna Kowalska, Lubica Rauova, Douglas B. Cines, Kandace Gollomp, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 185.

https://doi.org/10.1182/blood-2024-201682

Published: 2024

Journal Articles

A Novel Adenovirus (Adv)-Vaccinated Murine Model Simulates the Prothrombotic Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) Clinical Disorder

Lubica Rauova, Jenna Oberg, Nate Levine, Khalil Bdeir, Douglas B. Cines, Sarah Gilbert, Mortimer Poncz, Gowthami Arepally

Blood (2023) 142 (Supplement 1): 2631.

https://doi.org/10.1182/blood-2023-186729

Published: 2023

Journal Articles

Modulation of Ultralarge Immune Complexes in Heparin-Induced Thrombocytopenia

Lubica Rauova, Khalil Bdeir, Zheng Cai, Serge Yarovoi, Gowthami M. Arepally, Sanjay Khandelwal, Mortimer Poncz, Mark Greene, Douglas B. Cines

Blood (2022) 140 (Supplement 1): 2643–2644.

https://doi.org/10.1182/blood-2022-163590

Published: 2022

Journal Articles

Insights into Endogenous Vs Exogenous Cargo-Containing Platelet Alpha-Granules

Sergey Zaytsev, Hyunsook Ahn, Victoria Stepanova, M. Anna Kowalska, Khalil Bdeir, Deborah L French, Rodney M. Camire, Douglas B. Cines, Mortimer Poncz

Blood (2021) 138 (Supplement 1): 1028.

https://doi.org/10.1182/blood-2021-153348

Published: 2021

Journal Articles

A Novel Platelet-Targeting Fibrinolytic Strategy: Endocytosed Urokinase By Megakaryocytes Is Stored in α-Granules and Is Functional In Vivo in a Murine Model of Thrombosis

Hyunsook Ahn, MSc, John Tkaczynski, BS, Khalil Bdeir, PhD, Victoria Stepanova, Douglas B. Cines, MD, Mortimer Poncz, MD, Sergei Zaitsev

Blood (2019) 134 (Supplement_1): 3627.

https://doi.org/10.1182/blood-2019-124501

Published: 2019

Journal Articles

Neutrophil α-defensins promote thrombosis in vivo by altering fibrin formation, structure, and stability

Rami Abu-Fanne, Victoria Stepanova, Rustem I. Litvinov, Suhair Abdeen, Khalil Bdeir, Mohamed Higazi, Emad Maraga, Chandrasekaran Nagaswami, Alexander R. Mukhitov, John W. Weisel, Douglas B. Cines, Abd Al-Roof Higazi

Blood (2019) 133 (5): 481–493.

https://doi.org/10.1182/blood-2018-07-861237

Published: 2019

Includes: Supplemental data

Journal Articles

Synthetic Partially Reduced Human Neutrophil Peptide (HNP)-1 Inhibits Platelet Adhesion and Aggregation on Von Willebrand Factor-Collagen Surfaces Under Arterial Shear Stress through a Disulfide Bond Reduction Mechanism

Jenny K. McDaniel, MD, Khalil Bdeir, PhD, Douglas B. Cines, MD, X. Long Zheng, MD, PhD

Blood (2016) 128 (22): 3722.

https://doi.org/10.1182/blood.V128.22.3722.3722

Published: 2016

Journal Articles

Human neutrophil peptides inhibit cleavage of von Willebrand factor by ADAMTS13: a potential link of inflammation to TTP

Vikram G. Pillai, Jialing Bao, Catherine B. Zander, Jenny K. McDaniel, Palaniappan S. Chetty, Steven H. Seeholzer, Khalil Bdeir, Douglas B. Cines, X. Long Zheng

Blood (2016) 128 (1): 110–119.

https://doi.org/10.1182/blood-2015-12-688747

Published: 2016

Journal Articles

Human Neutrophil Peptides (HNPs) Enhance Thrombus Formation Under Flow By Inhibiting Proteolytic Activity of Plasma ADAMTS13 Metalloprotease

Vikram G. Pillai, PhD, Jialing Bao, PhD, Jenny McDaniel, MD, Catherine B. Zander1, PhD, Wenjing Cao, MD, PhD, Khalil Bdeir, PhD, Douglas B. Cines, MD, X. Long Zheng, MD PhD

Blood (2015) 126 (23): 105.

https://doi.org/10.1182/blood.V126.23.105.105

Published: 2015

Journal Articles

Inhibition of ADAMTS13 Activity By Human Neutrophil Peptide 1 (HNP-1): Potential Link Between Inflammation, Onset of Thrombotic Thrombocytopenic Purpura, and Other Thrombosis

Jialing Bao, PhD, Khalil Bdeir, PhD, Don L. Siegel, MD, PhD, Douglas B. Cines, MD, X. Long Zheng, MD, PhD

Blood (2014) 124 (21): 599.

https://doi.org/10.1182/blood.V124.21.599.599

Published: 2014

Journal Articles

Nuclear translocation of urokinase-type plasminogen activator

Victoria Stepanova, Tatiana Lebedeva, Alice Kuo, Serge Yarovoi, Sergei Tkachuk, Sergei Zaitsev, Khalil Bdeir, Inna Dumler, Michael S. Marks, Yelena Parfyonova, Vsevolod A. Tkachuk, Abd Al-Roof Higazi, Douglas B. Cines

Blood (2008) 112 (1): 100–110.

https://doi.org/10.1182/blood-2007-07-104455

Published: 2008

Includes: Multimedia, Supplemental data

Journal Articles

Inhibition of pathologic retinal neovascularization by α-defensins

Matina Economopoulou, Khalil Bdeir, Douglas B. Cines, Franz Fogt, Yasmina Bdeir, Jacek Lubkowski, Wuyuan Lu, Klaus T. Preissner, Hans-Peter Hammes, Triantafyllos Chavakis

Blood (2005) 106 (12): 3831–3838.

https://doi.org/10.1182/blood-2005-03-0889

Published: 2005

Journal Articles

Inhibition of Pathological Retinal Neovascularization by α-Defensins.

Triantafyllos Chavakis, Khalil Bdeir, Douglas B. Cines, Franz Fogt, Yasmina Bdeir, Jacek Lubkowski, Klaus T. Preissner, Hans-Peter Hammes, Matina Economopoulou

Blood (2005) 106 (11): 3678.

https://doi.org/10.1182/blood.V106.11.3678.3678

Published: 2005

Journal Articles

The Role of Erythropoietin in Vascular Endothelial Cells and Thrombosis.

Kenneth R. LaMontagne, PhD, Khalil Bdeir, PhD, Maria E. Carinato, MS, Jeannene Butler, BS, Douglas B. Cines, MD, Francis X. Farrell, PhD

Blood (2005) 106 (11): 4035.

https://doi.org/10.1182/blood.V106.11.4035.4035

Published: 2005

Journal Articles

Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-κB–dependent manner

Guangyao Yu, Ann H. Rux, Peihong Ma, Khalil Bdeir, Bruce S. Sachais

Blood (2005) 105 (9): 3545–3551.

https://doi.org/10.1182/blood-2004-07-2617

Published: 2005

Journal Articles

Expression of Urokinase-Type Plasminogen Activator in Platelets Decreases Oxygen-Induced Lung Injury in Mice.

Sandra Z. Perkowski, V.M.D., Ph.D., M. Anna Kowalska, Ph.D., Steven M. Albelda, M.D., Khalil Bdeir, Ph.D., Douglas B. Cines, M.D., Mortimer Poncz, M.D.

Blood (2004) 104 (11): 688.

https://doi.org/10.1182/blood.V104.11.688.688

Published: 2004

Journal Articles

Conjugation of Plasminogen Activators to Carrier Erythrocytes Imparts New Biological Properties to Their Soluble Counterparts.

Kumkum Ganguly, PhD, Tatiana Krasik, BSN, Khalil Bdeir, PhD, Douglas B. Cines, MD, PhD, Vladimir R. Muzykantov, MD, PhD, JuanCarlos Murciano, PhD

Blood (2004) 104 (11): 534.

https://doi.org/10.1182/blood.V104.11.534.534

Published: 2004

Journal Articles

In vitro and in vivo effects of tPA and PAI-1 on blood vessel tone

Taher Nassar, Sa'ed Akkawi, Ahuva Shina, Abdullah Haj-Yehia, Khalil Bdeir, Mark Tarshis, Samuel N. Heyman, Abd Al-Roof Higazi

Blood (2004) 103 (3): 897–902.

https://doi.org/10.1182/blood-2003-05-1685

Published: 2004

Journal Articles

The kringle stabilizes urokinase binding to the urokinase receptor

Khalil Bdeir, Alice Kuo, Bruce S. Sachais, Ann H. Rux, Yasmina Bdeir, Andrew Mazar, Abd Al-Roof Higazi, Douglas B. Cines

Blood (2003) 102 (10): 3600–3608.

https://doi.org/10.1182/blood-2003-03-0949

Published: 2003

Journal Articles

Antithrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in platelets

Dubravka Kufrin, Don E. Eslin, Khalil Bdeir, Juan-Carlos Murciano, Alice Kuo, M. Anna Kowalska, Jay L. Degen, Bruce S. Sachais, Douglas B. Cines, Mortimer Poncz

Blood (2003) 102 (3): 926–933.

https://doi.org/10.1182/blood-2003-01-0054

Published: 2003

NARROW

Antiphospholipid Syndrome (APS) Is a Platelet Factor 4 (PF4)-Centric Immunothrombotic Disorder

A Novel Adenovirus (Adv)-Vaccinated Murine Model Simulates the Prothrombotic Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) Clinical Disorder

Modulation of Ultralarge Immune Complexes in Heparin-Induced Thrombocytopenia

Insights into Endogenous Vs Exogenous Cargo-Containing Platelet Alpha-Granules

A Novel Platelet-Targeting Fibrinolytic Strategy: Endocytosed Urokinase By Megakaryocytes Is Stored in α-Granules and Is Functional In Vivo in a Murine Model of Thrombosis

Neutrophil α-defensins promote thrombosis in vivo by altering fibrin formation, structure, and stability

Synthetic Partially Reduced Human Neutrophil Peptide (HNP)-1 Inhibits Platelet Adhesion and Aggregation on Von Willebrand Factor-Collagen Surfaces Under Arterial Shear Stress through a Disulfide Bond Reduction Mechanism

Human neutrophil peptides inhibit cleavage of von Willebrand factor by ADAMTS13: a potential link of inflammation to TTP

Human Neutrophil Peptides (HNPs) Enhance Thrombus Formation Under Flow By Inhibiting Proteolytic Activity of Plasma ADAMTS13 Metalloprotease

Inhibition of ADAMTS13 Activity By Human Neutrophil Peptide 1 (HNP-1): Potential Link Between Inflammation, Onset of Thrombotic Thrombocytopenic Purpura, and Other Thrombosis

Nuclear translocation of urokinase-type plasminogen activator

Inhibition of pathologic retinal neovascularization by α-defensins

Inhibition of Pathological Retinal Neovascularization by α-Defensins.

The Role of Erythropoietin in Vascular Endothelial Cells and Thrombosis.

Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-κB–dependent manner

Expression of Urokinase-Type Plasminogen Activator in Platelets Decreases Oxygen-Induced Lung Injury in Mice.

Conjugation of Plasminogen Activators to Carrier Erythrocytes Imparts New Biological Properties to Their Soluble Counterparts.

In vitro and in vivo effects of tPA and PAI-1 on blood vessel tone

The kringle stabilizes urokinase binding to the urokinase receptor

Antithrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in platelets

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American Society of Hematology

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American Society of Hematology

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