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Journal Articles

Complement biosensors identify a classical pathway stimulus in complement-mediated thrombotic microangiopathy

Michael A. Cole, Nikhil Ranjan, Gloria F. Gerber, Xiang-Zuo Pan, Daniel Flores-Guerrero, George McNamara, Shruti Chaturvedi, C. John Sperati, Keith R. McCrae, Robert A. Brodsky

Blood (2024) 144 (24): 2528–2545.

https://doi.org/10.1182/blood.2024025850

Published: 2024

Includes: Supplemental data

Journal Articles

Genetic or Epigenetic CR1 Deficiency Defines Catastrophic Antiphospholipid Syndrome (CAPS) and Response to Complement Inhibition

Nikhil Ranjan, Michael Cole, Gloria F. Gerber, Shruti Chaturvedi, Mark A. Crowther, Evan M. Braunstein, Daniel Flores-Guerrero, Alexis Reed, Michelle Petri, Keith R. McCrae, Robert A. Brodsky

Blood (2024) 144 (Supplement 1): 138.

https://doi.org/10.1182/blood-2024-207793

Published: 2024

Journal Articles

Plasma Kallikrein, Prolylcarboxypeptidase, and Bradykinin Receptors Mediate Experimental Murine Cerebral Malaria

Alessandro S. Pinheiro, Douglas E Teixeira, Rodrigo P. Silva-Aguiar, Alona Merkulova, Yelenna Skomorovska-Prokvolit, Young Jun Shim, Keith R. McCrae, David Midem, Sidney Ogolla, Ana Acacia S. Pinheiro, James Kazura, Alvin H. Schmaier

Blood (2024) 144 (Supplement 1): 136.

https://doi.org/10.1182/blood-2024-205900

Published: 2024

Journal Articles

Patient Reported Outcomes during Long-Term Follow-up of Atypical Hemolytic Uremic Syndrome in the Era of Terminal Complement Inhibition

Anne K Hubben, Jenna Brown, Linda Burke, Len Woodward, Clare Martin, Keith R. McCrae, Shruti Chaturvedi

Blood (2024) 144 (Supplement 1): 1238.

https://doi.org/10.1182/blood-2024-200224

Published: 2024

Journal Articles

Complement Biosensors Can be Used to Identify Classical Pathway and Alternative Pathway Dysregulation in Complement-Mediated Thrombotic Microangiopathy

Michael Cole, Nikhil Ranjan, Gloria F. Gerber, Xiang-Zuo Pan, Daniel Flores-Guerrero, Shruti Chaturvedi, C. John Sperati, Keith R. McCrae, Robert A. Brodsky

Blood (2024) 144 (Supplement 1): 1225.

https://doi.org/10.1182/blood-2024-210885

Published: 2024

Journal Articles

Molecular Genetics of Fletcher and Fitzgerald Traits

Anke Adenaeuer, Alessandro S. Pinheiro, Young Jun Shim, Keith R. McCrae, Friederike Häuser, Bernhard Lämmle, Alvin H. Schmaier, Heidi Rossmann

Blood (2024) 144 (Supplement 1): 5504.

https://doi.org/10.1182/blood-2024-204657

Published: 2024

Journal Articles

Role of Interferon-Gamma (IFN-γ) Signaling in Immune Checkpoint Inhibitor-Associated Thrombosis: Tissue Factor Upregulation and Proinflammatory Cytokine Signature

Young Jun Shim, Keith R. McCrae

Blood (2024) 144 (Supplement 1): 3989.

https://doi.org/10.1182/blood-2024-207751

Published: 2024

Journal Articles

The PF4-Centric Immunothrombotic Disorders, HIT, Vitt and APS, Lead to Complement Activation Responsive to Complement-Blocking Therapeutics

Amrita Sarkar, Conroy O Field, Keith R. McCrae, Thomas L. Ortel, Gow Arepally, Roxanne Cofiell, Sung-Kwon Kim, Lubica Rauova, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 2606.

https://doi.org/10.1182/blood-2024-198182

Published: 2024

Journal Articles

Antiphospholipid Syndrome (APS) Is a Platelet Factor 4 (PF4)-Centric Immunothrombotic Disorder

Conroy O Field, Amrita Sarkar, Khalil Bdeir, Keith R. McCrae, Thomas L. Ortel, M. Anna Kowalska, Lubica Rauova, Douglas B. Cines, Kandace Gollomp, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 185.

https://doi.org/10.1182/blood-2024-201682

Published: 2024

Journal Articles

Concordance between Acr/EULAR and Sapporo Criteria for Antiphospholipid Syndrome: New Domains Unveil Associations with Procoagulant Platelets

Maierdan Palihati, Anne K Hubben, Kelsey Pandrangi, Paresh P Kulkarni, Keith R. McCrae

Blood (2024) 144 (Supplement 1): 4024.

https://doi.org/10.1182/blood-2024-211423

Published: 2024

Journal Articles

Anti-Phospholipid Syndrome (APS) Antibody (Ab)-Induced Thrombosis Can be Blocked By Platelet Factor 4 (PF4)-Directed Abs: A Novel Therapeutic Approach for APS?

Amrita Sarkar, Santosh K Yadav, Conroy O Field, Kandace Gollomp, Keith R. McCrae, Thomas L. Ortel, Yves Gruel, Jérôme Rollin, Gowthami M Arepally, Lubica Rauova, Douglas B. Cines, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 2611.

https://doi.org/10.1182/blood-2024-200849

Published: 2024

Journal Articles

A “backup plan” for ADAMTS13 deficiency in TTP

Anne Hubben, Keith R. McCrae

Blood (2024) 143 (20): 2021–2023.

https://doi.org/10.1182/blood.2024024065

Published: 2024

Journal Articles

PATH-HHT, a Double-Blind, Randomized, Placebo-Controlled Trial in Hereditary Hemorrhagic Telangiectasia Demonstrates That Pomalidomide Reduces Epistaxis and Improves Quality of Life

Blood (2023) 142 (Supplement 2): LBA-3.

https://doi.org/10.1182/blood-2023-191983

Published: 2023

Journal Articles

Circulating Platelets in Thrombotic Antiphospholipid Syndrome Display High Procoagulant Activity and Surface Complement Deposition: Correlation with Thrombotic Risk

Paresh P Kulkarni, Young Jun Shim, Anne K Hubben, Michael Cole, Shruti Chaturvedi, Robert A. Brodsky, Keith R McCrae

Blood (2023) 142 (Supplement 1): 5407.

https://doi.org/10.1182/blood-2023-184601

Published: 2023

Journal Articles

The Bioluminescent Modified Ham Test Identifies the Classical Pathway As the Major Driver of Complement Activation in Atypical Hemolytic Uremic Syndrome and Primary Antiphospholipid Syndrome

Michael Cole, Gloria F. Gerber, Xiang-Zuo Pan, Nikhil Ranjan, John Sperati, Shruti Chaturvedi, Keith R. McCrae, Robert A. Brodsky

Blood (2023) 142 (Supplement 1): 3947.

https://doi.org/10.1182/blood-2023-190615

Published: 2023

Journal Articles

Cytokine Profiling in Antiphospholipid Syndrome Demonstrates Persistent Immune Dysregulation and a Procoagulant Phenotype

Anne K Hubben, Peter Bazeley, Shadi Swaidani, Ahmed Alarabi, Paresh P Kulkarni, Young Jun Shim, Maierdan Palihati, John Barnard, Keith R. McCrae

Blood (2023) 142 (Supplement 1): 5400.

https://doi.org/10.1182/blood-2023-187962

Published: 2023

Journal Articles

Improving Patient Access and Provider Availability in Classical Hematology: The Development of an Advanced Practice Provider Led Virtual Anemia Consult Clinic

Mailey L. Wilks, Heather Koniarczyk, Dana E. Angelini, Laurie Aiken, Peter E. Hakos, Tracy Evans-Walker, Keith R. McCrae

Blood (2023) 142 (Supplement 1): 2298.

https://doi.org/10.1182/blood-2023-181967

Published: 2023

Journal Articles

A Syngeneic Murine Model of Antiphospholipid Syndrome (APS) Recapitulates Aspects of Human APS

Young Jun Shim, Paresh P Kulkarni, Ahmed Alarabi, Maierdan Palihati, Anne K Hubben, Keith R. McCrae

Blood (2023) 142 (Supplement 1): 1190.

https://doi.org/10.1182/blood-2023-187593

Published: 2023

Journal Articles

Immune Checkpoint Blockade Promotes Thrombosis Via T-Cell and Neutrophil Activation, and Tumor-Cell Associated Tissue Factor (TF) in a Murine Model of Colorectal Cancer

Young Jun Shim, Bal Krishan Sharma, Yohei Hisada, Nigel Mackman, Joseph S Palumbo, Claudia Diaz-Montero, Alok A. Khorana, Keith R. McCrae

Blood (2023) 142 (Supplement 1): 1192.

https://doi.org/10.1182/blood-2023-184570

Published: 2023

Journal Articles

Initial Report of Povetacicept, an Enhanced Dual BAFF/APRIL Antagonist, in Autoimmune Cytopenias: The RUBY-4 Study

Catherine Broome, David J Kuter, Keith R. McCrae, Rupert Davies, Amanda Enstrom, Allison Chunyk, Heather Thomas, Allison Naumovski, Steven R. Lentz

Blood (2023) 142 (Supplement 1): 5520.

https://doi.org/10.1182/blood-2023-179305

Published: 2023

NARROW

Complement biosensors identify a classical pathway stimulus in complement-mediated thrombotic microangiopathy

Genetic or Epigenetic CR1 Deficiency Defines Catastrophic Antiphospholipid Syndrome (CAPS) and Response to Complement Inhibition

Plasma Kallikrein, Prolylcarboxypeptidase, and Bradykinin Receptors Mediate Experimental Murine Cerebral Malaria

Patient Reported Outcomes during Long-Term Follow-up of Atypical Hemolytic Uremic Syndrome in the Era of Terminal Complement Inhibition

Complement Biosensors Can be Used to Identify Classical Pathway and Alternative Pathway Dysregulation in Complement-Mediated Thrombotic Microangiopathy

Molecular Genetics of Fletcher and Fitzgerald Traits

Role of Interferon-Gamma (IFN-γ) Signaling in Immune Checkpoint Inhibitor-Associated Thrombosis: Tissue Factor Upregulation and Proinflammatory Cytokine Signature

The PF4-Centric Immunothrombotic Disorders, HIT, Vitt and APS, Lead to Complement Activation Responsive to Complement-Blocking Therapeutics

Antiphospholipid Syndrome (APS) Is a Platelet Factor 4 (PF4)-Centric Immunothrombotic Disorder

Concordance between Acr/EULAR and Sapporo Criteria for Antiphospholipid Syndrome: New Domains Unveil Associations with Procoagulant Platelets

Anti-Phospholipid Syndrome (APS) Antibody (Ab)-Induced Thrombosis Can be Blocked By Platelet Factor 4 (PF4)-Directed Abs: A Novel Therapeutic Approach for APS?

A “backup plan” for ADAMTS13 deficiency in TTP

PATH-HHT, a Double-Blind, Randomized, Placebo-Controlled Trial in Hereditary Hemorrhagic Telangiectasia Demonstrates That Pomalidomide Reduces Epistaxis and Improves Quality of Life

Circulating Platelets in Thrombotic Antiphospholipid Syndrome Display High Procoagulant Activity and Surface Complement Deposition: Correlation with Thrombotic Risk

The Bioluminescent Modified Ham Test Identifies the Classical Pathway As the Major Driver of Complement Activation in Atypical Hemolytic Uremic Syndrome and Primary Antiphospholipid Syndrome

Cytokine Profiling in Antiphospholipid Syndrome Demonstrates Persistent Immune Dysregulation and a Procoagulant Phenotype

Improving Patient Access and Provider Availability in Classical Hematology: The Development of an Advanced Practice Provider Led Virtual Anemia Consult Clinic

A Syngeneic Murine Model of Antiphospholipid Syndrome (APS) Recapitulates Aspects of Human APS

Immune Checkpoint Blockade Promotes Thrombosis Via T-Cell and Neutrophil Activation, and Tumor-Cell Associated Tissue Factor (TF) in a Murine Model of Colorectal Cancer

Initial Report of Povetacicept, an Enhanced Dual BAFF/APRIL Antagonist, in Autoimmune Cytopenias: The RUBY-4 Study

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American Society of Hematology

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American Society of Hematology

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