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Journal Articles

Anti-Phospholipid Syndrome (APS) Antibody (Ab)-Induced Thrombosis Can be Blocked By Platelet Factor 4 (PF4)-Directed Abs: A Novel Therapeutic Approach for APS?

Amrita Sarkar, Santosh K Yadav, Conroy O Field, Kandace Gollomp, Keith R. McCrae, Thomas L. Ortel, Yves Gruel, Jérôme Rollin, Gowthami M Arepally, Lubica Rauova, Douglas B. Cines, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 2611.

https://doi.org/10.1182/blood-2024-200849

Published: 2024

Journal Articles

The PF4-Centric Immunothrombotic Disorders, HIT, Vitt and APS, Lead to Complement Activation Responsive to Complement-Blocking Therapeutics

Amrita Sarkar, Conroy O Field, Keith R. McCrae, Thomas L. Ortel, Gow Arepally, Roxanne Cofiell, Sung-Kwon Kim, Lubica Rauova, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 2606.

https://doi.org/10.1182/blood-2024-198182

Published: 2024

Journal Articles

Complement Activation As a Biomarker for Platelet Activating Antibodies in Heparin-Induced Thrombocytopenia (HIT)

Sooho S Myoung, Samuel Francis, Jonah Chen, Grace M Lee, Lubica Rauova, Mortimer Poncz, Douglas B. Cines, Maragatha Kuchibhatla, Sanjay Khandelwal, Gow Arepally

Blood (2024) 144 (Supplement 1): 2605.

https://doi.org/10.1182/blood-2024-208062

Published: 2024

Journal Articles

Antiphospholipid Syndrome (APS) Is a Platelet Factor 4 (PF4)-Centric Immunothrombotic Disorder

Conroy O Field, Amrita Sarkar, Khalil Bdeir, Keith R. McCrae, Thomas L. Ortel, M. Anna Kowalska, Lubica Rauova, Douglas B. Cines, Kandace Gollomp, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 185.

https://doi.org/10.1182/blood-2024-201682

Published: 2024

Journal Articles

Platelet Factor 4 Enhances Endothelial Cell Antimicrobial Activity in Vitro and Promotes Bacterial Clearance In Vivo , Improving Sepsis Outcomes

Anh T.P. Ngo, Veronica Bochenek, Hyunjun Kim, Nate Levine, Samir Maarouf, Jenna Oberg, Manuela Roggiani, Amrita Sarkar, Lubica Rauova, Caroline Diorio, Zachary Martinez, Mark Goulian, Mortimer Poncz, Victor Nizet, Kandace Gollomp

Blood (2024) 144 (Supplement 1): 1231.

https://doi.org/10.1182/blood-2024-211717

Published: 2024

Journal Articles

A Novel Adenovirus (Adv)-Vaccinated Murine Model Simulates the Prothrombotic Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) Clinical Disorder

Lubica Rauova, Jenna Oberg, Nate Levine, Khalil Bdeir, Douglas B. Cines, Sarah Gilbert, Mortimer Poncz, Gowthami Arepally

Blood (2023) 142 (Supplement 1): 2631.

https://doi.org/10.1182/blood-2023-186729

Published: 2023

Journal Articles

Modulation of Ultralarge Immune Complexes in Heparin-Induced Thrombocytopenia

Lubica Rauova, Khalil Bdeir, Zheng Cai, Serge Yarovoi, Gowthami M. Arepally, Sanjay Khandelwal, Mortimer Poncz, Mark Greene, Douglas B. Cines

Blood (2022) 140 (Supplement 1): 2643–2644.

https://doi.org/10.1182/blood-2022-163590

Published: 2022

Journal Articles

Complement Shields Fc Regions on HIT Immune Complexes and Prevents Recognition By Cellular Fcγ Receptors

Hailey Harris, Sanjay Khandelwal, Lubica Rauova, John Lambris, Brandon Garcia, Douglas B. Cines, Gowthami M. Arepally

Blood (2022) 140 (Supplement 1): 8372–8373.

https://doi.org/10.1182/blood-2022-165586

Published: 2022

Journal Articles

Aggregation of Enveloped Viruses By Platelet Factor 4 (PF4) and Neutrophil Extracellular Traps (NETs): Implications for the Anti-Viral Properties of NETs

Kandace Gollomp, Irina Chernysh, Anh T.P. Ngo, Nathan Levine, Sergey Zaytsev, Veronica Bochenek, Lubica Rauova, Nicholas Parenti, Susan R Weiss, John W. Weisel, Douglas B. Cines, Mortimer Poncz

Blood (2022) 140 (Supplement 1): 1405–1406.

https://doi.org/10.1182/blood-2022-170781

Published: 2022

Journal Articles

Neutrophil Extracellular Traps (NETs) Thrombogenicity and Endothelial Cell Toxicity Are Ameliorated By Platelet Factor 4 (PF4): Implications to the Treatment of Sepsis

Anh T.P. Ngo, Amrita Sarkar, Nathan Levine, Veronica Bochenek, Guohua Zhao, Lubica Rauova, M. Anna Kowalska, Kaitlyn Eckart, Nilam S. Mangalmurti, Ann Rux, Douglas B. Cines, Mortimer Poncz, Kandace Gollomp

Blood (2022) 140 (Supplement 1): 5529–5530.

https://doi.org/10.1182/blood-2022-169709

Published: 2022

Journal Articles

Platelets get particular

Lubica Rauova, Douglas B. Cines

Blood (2022) 140 (5): 413–414.

https://doi.org/10.1182/blood.2022016773

Published: 2022

Journal Articles

A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice

Junsong Zhou, Yi Wu, Lubica Rauova, Gavin Koma, Lu Wang, Mortimer Poncz, Hong Li, Tong Liu, Karen P. Fong, Joel S. Bennett, Satya P. Kunapuli, David W. Essex

Blood (2022) 139 (13): 2050–2065.

https://doi.org/10.1182/blood.2021012055

Published: 2022

Includes: Supplemental data

Journal Articles

Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes

Sanjay Khandelwal, Ayiesha Barnes, Lubica Rauova, Amrita Sarkar, Ann H. Rux, Serge V. Yarovoi, S. Sergei Zaitsev, John D. Lambris, Sooho S. Myoung, Alexandra Johnson, Grace M. Lee, Madelaine Duarte, Mortimer Poncz, Gowthami M. Arepally, Douglas B. Cines

Blood (2021) 138 (21): 2106–2116.

https://doi.org/10.1182/blood.2020009487

Published: 2021

Includes: Supplemental data

Journal Articles

The Role of PF4 Antibodies in Pediatric Sars-Cov-2 Infections

Meady Chiem, Lubica Rauova, Caroline Diorio, Kevin O McNerney, Hamid Bassiri, Kathleen Sullivan, Edward M Behrens, David T. Teachey, Michele P. Lambert

Blood (2021) 138 (Supplement 1): 1004.

https://doi.org/10.1182/blood-2021-151529

Published: 2021

Journal Articles

In Situ Microscopy Studies of Infused Megakaryocytes: Implications in Thrombopoiesis

Hyunjun Kim, Danuta Jadwiga Jarocha, Ian Johnston, Hyunsook Ahn, Deborah L French, Lubica Rauova, Mortimer Poncz

Blood (2021) 138 (Supplement 1): 4287.

https://doi.org/10.1182/blood-2021-150764

Published: 2021

Journal Articles

Vaccine-Induced Thrombocytopenia and Thrombosis (VITT) Antibodies Recognize Neutrophil-Activating Peptide 2 (NAP2) As Well As Platelet Factor 4 (PF4): Mechanistic and Clinical Implications

Lubica Rauova, Andy Wang, Serge Yarovoi, Sanjay Khandelwal, Anand Padmanabhan, Olga Oleshko, Matthew J. Charman, Andreas Tiede, Charles S. Abrams, Matthew D. Weitzman, Gowthami M. Arepally, Douglas B. Cines, Mortimer Poncz

Blood (2021) 138 (Supplement 1): 292.

https://doi.org/10.1182/blood-2021-151685

Published: 2021

Journal Articles

Fc-Modified Kko: A Novel Therapeutic for Heparin-Induced Thrombocytopenia (HIT), Reversing Both the Thrombocytopenia and Thrombosis

Amrita Sarkar, Sanjay Khandelwal, Serge Yarovoi, Gowthami M. Arepally, Douglas B. Cines, Mortimer Poncz, Lubica Rauova

Blood (2021) 138 (Supplement 1): 581.

https://doi.org/10.1182/blood-2021-146233

Published: 2021

Journal Articles

Platelet Factor 4 (PF4) Modulates the Prothrombotic Nature of Neutrophil-Extracellular Traps (NETs): Therapeutic Implications of a NET-Stabilization Strategy

Anh T.P. Ngo, Irene Yarovoi, Guohua Zhao, Amrita Sarkar, Lubica Rauova, M. Anna Kowalska, Mortimer Poncz, Kandace Gollomp

Blood (2021) 138 (Supplement 1): 2096.

https://doi.org/10.1182/blood-2021-153352

Published: 2021

Journal Articles

Minimal Role for the Alternative Pathway in Complement Activation By HIT Immune Complexes

Ayiesha Barnes, Sanjay Khandelwal, Simone Sartoretto, Grace M Lee, Sooho Myoung, Samuel Francis, Lubica Rauova, Douglas B. Cines, Brandon Garcia, Jon Skare, Charles Booth, Gowthami M. Arepally

Blood (2021) 138 (Supplement 1): 2076.

https://doi.org/10.1182/blood-2021-150946

Published: 2021

Journal Articles

Understanding VITT(ual) reality

Lubica Rauova, Mortimer Poncz

Blood (2021) 138 (4): 285–286.

https://doi.org/10.1182/blood.2021012524

Published: 2021

NARROW

Anti-Phospholipid Syndrome (APS) Antibody (Ab)-Induced Thrombosis Can be Blocked By Platelet Factor 4 (PF4)-Directed Abs: A Novel Therapeutic Approach for APS?

The PF4-Centric Immunothrombotic Disorders, HIT, Vitt and APS, Lead to Complement Activation Responsive to Complement-Blocking Therapeutics

Complement Activation As a Biomarker for Platelet Activating Antibodies in Heparin-Induced Thrombocytopenia (HIT)

Antiphospholipid Syndrome (APS) Is a Platelet Factor 4 (PF4)-Centric Immunothrombotic Disorder

Platelet Factor 4 Enhances Endothelial Cell Antimicrobial Activity in Vitro and Promotes Bacterial Clearance In Vivo , Improving Sepsis Outcomes

A Novel Adenovirus (Adv)-Vaccinated Murine Model Simulates the Prothrombotic Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) Clinical Disorder

Modulation of Ultralarge Immune Complexes in Heparin-Induced Thrombocytopenia

Complement Shields Fc Regions on HIT Immune Complexes and Prevents Recognition By Cellular Fcγ Receptors

Aggregation of Enveloped Viruses By Platelet Factor 4 (PF4) and Neutrophil Extracellular Traps (NETs): Implications for the Anti-Viral Properties of NETs

Neutrophil Extracellular Traps (NETs) Thrombogenicity and Endothelial Cell Toxicity Are Ameliorated By Platelet Factor 4 (PF4): Implications to the Treatment of Sepsis

Platelets get particular

A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice

Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes

The Role of PF4 Antibodies in Pediatric Sars-Cov-2 Infections

In Situ Microscopy Studies of Infused Megakaryocytes: Implications in Thrombopoiesis

Vaccine-Induced Thrombocytopenia and Thrombosis (VITT) Antibodies Recognize Neutrophil-Activating Peptide 2 (NAP2) As Well As Platelet Factor 4 (PF4): Mechanistic and Clinical Implications

Fc-Modified Kko: A Novel Therapeutic for Heparin-Induced Thrombocytopenia (HIT), Reversing Both the Thrombocytopenia and Thrombosis

Platelet Factor 4 (PF4) Modulates the Prothrombotic Nature of Neutrophil-Extracellular Traps (NETs): Therapeutic Implications of a NET-Stabilization Strategy

Minimal Role for the Alternative Pathway in Complement Activation By HIT Immune Complexes

Understanding VITT(ual) reality

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American Society of Hematology

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American Society of Hematology

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