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Journal Articles

Anti-Phospholipid Syndrome (APS) Antibody (Ab)-Induced Thrombosis Can be Blocked By Platelet Factor 4 (PF4)-Directed Abs: A Novel Therapeutic Approach for APS?

Amrita Sarkar, Santosh K Yadav, Conroy O Field, Kandace Gollomp, Keith R. McCrae, Thomas L. Ortel, Yves Gruel, Jérôme Rollin, Gowthami M Arepally, Lubica Rauova, Douglas B. Cines, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 2611.

https://doi.org/10.1182/blood-2024-200849

Published: 2024

Journal Articles

Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary xerocytosis

Pengfei Liang, Yang Zhang, Yui Chun S. Wan, Shang Ma, Ping Dong, Augustus J. Lowry, Samuel J. Francis, Sanjay Khandelwal, Martha Delahunty, Marilyn J. Telen, John J. Strouse, Gowthami M. Arepally, Huanghe Yang

Blood (2024) 143 (4): 357–369.

https://doi.org/10.1182/blood.2023021465

Published: 2024

Includes: Multimedia, Supplemental data

Journal Articles

Modulation of Ultralarge Immune Complexes in Heparin-Induced Thrombocytopenia

Lubica Rauova, Khalil Bdeir, Zheng Cai, Serge Yarovoi, Gowthami M. Arepally, Sanjay Khandelwal, Mortimer Poncz, Mark Greene, Douglas B. Cines

Blood (2022) 140 (Supplement 1): 2643–2644.

https://doi.org/10.1182/blood-2022-163590

Published: 2022

Journal Articles

Complement Shields Fc Regions on HIT Immune Complexes and Prevents Recognition By Cellular Fcγ Receptors

Hailey Harris, Sanjay Khandelwal, Lubica Rauova, John Lambris, Brandon Garcia, Douglas B. Cines, Gowthami M. Arepally

Blood (2022) 140 (Supplement 1): 8372–8373.

https://doi.org/10.1182/blood-2022-165586

Published: 2022

Journal Articles

Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes

Sanjay Khandelwal, Ayiesha Barnes, Lubica Rauova, Amrita Sarkar, Ann H. Rux, Serge V. Yarovoi, S. Sergei Zaitsev, John D. Lambris, Sooho S. Myoung, Alexandra Johnson, Grace M. Lee, Madelaine Duarte, Mortimer Poncz, Gowthami M. Arepally, Douglas B. Cines

Blood (2021) 138 (21): 2106–2116.

https://doi.org/10.1182/blood.2020009487

Published: 2021

Includes: Supplemental data

Journal Articles

Minimal Role for the Alternative Pathway in Complement Activation By HIT Immune Complexes

Ayiesha Barnes, Sanjay Khandelwal, Simone Sartoretto, Grace M Lee, Sooho Myoung, Samuel Francis, Lubica Rauova, Douglas B. Cines, Brandon Garcia, Jon Skare, Charles Booth, Gowthami M. Arepally

Blood (2021) 138 (Supplement 1): 2076.

https://doi.org/10.1182/blood-2021-150946

Published: 2021

Journal Articles

Vaccine-Induced Thrombocytopenia and Thrombosis (VITT) Antibodies Recognize Neutrophil-Activating Peptide 2 (NAP2) As Well As Platelet Factor 4 (PF4): Mechanistic and Clinical Implications

Lubica Rauova, Andy Wang, Serge Yarovoi, Sanjay Khandelwal, Anand Padmanabhan, Olga Oleshko, Matthew J. Charman, Andreas Tiede, Charles S. Abrams, Matthew D. Weitzman, Gowthami M. Arepally, Douglas B. Cines, Mortimer Poncz

Blood (2021) 138 (Supplement 1): 292.

https://doi.org/10.1182/blood-2021-151685

Published: 2021

Journal Articles

Neutrophil Phenotypes Result in Differential Responses to Pathogens

Stacey A Maskarinec, Halie Hotchkiss, Madelaine Duarte, Margaret McKelvy, Bechtler Addison, Gowthami M. Arepally, Grace M Lee

Blood (2021) 138 (Supplement 1): 988.

https://doi.org/10.1182/blood-2021-153070

Published: 2021

Journal Articles

Fc-Modified Kko: A Novel Therapeutic for Heparin-Induced Thrombocytopenia (HIT), Reversing Both the Thrombocytopenia and Thrombosis

Amrita Sarkar, Sanjay Khandelwal, Serge Yarovoi, Gowthami M. Arepally, Douglas B. Cines, Mortimer Poncz, Lubica Rauova

Blood (2021) 138 (Supplement 1): 581.

https://doi.org/10.1182/blood-2021-146233

Published: 2021

Journal Articles

COVID-19 and VITT: same or different?

Gowthami M. Arepally

Blood (2021) 138 (14): 1206–1207.

https://doi.org/10.1182/blood.2021013362

Published: 2021

Journal Articles

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know

Gowthami M. Arepally, Thomas L. Ortel

Blood (2021) 138 (4): 293–298.

https://doi.org/10.1182/blood.2021012152

Published: 2021

Journal Articles

Complement Regulates the Procoagulant Effects of HIT Immune Complexes

Sanjay Khandelwal, PhD, Lubica Rauova, MD PhD, Ayiesha Barnes, MS, Ann Rux, Serge Yarovoi, Sooho S Myoung, Alexandra Johnson, Grace M Lee, MD, Madelaine Duarte, BA, Mortimer Poncz, MD, Gowthami M. Arepally, MD, Douglas B. Cines, MD

Blood (2020) 136 (Supplement 1): 11–12.

https://doi.org/10.1182/blood-2020-138631

Published: 2020

Journal Articles

Variation in Neutrophil Function Among Healthy Subjects Influences Response to Bacteria

Madelaine Duarte, BA, Stacey A Maskarinec, MD PhD, Sanjay Khandelwal, PhD, Gowthami M. Arepally, MD, Grace M Lee, MD

Blood (2020) 136 (Supplement 1): 34.

https://doi.org/10.1182/blood-2020-141674

Published: 2020

Journal Articles

Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation

Ian Johnston, Amrita Sarkar, Vincent Hayes, Gavin T. Koma, Gowthami M. Arepally, Junmei Chen, Dominic W. Chung, José A. López, Douglas B. Cines, Lubica Rauova, Mortimer Poncz

Blood (2020) 135 (15): 1270–1280.

https://doi.org/10.1182/blood.2018881607

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis

Kandace Gollomp, Amrita Sarkar, Sanjiv Harikumar, Steven H. Seeholzer, Gowthami M. Arepally, Kristin Hudock, Lubica Rauova, M. Anna Kowalska, Mortimer Poncz

Blood (2020) 135 (10): 743–754.

https://doi.org/10.1182/blood.2019002329

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Bad weed: synthetic cannabinoid–associated coagulopathy

Gowthami M. Arepally, Thomas L. Ortel

Blood (2019) 133 (9): 902–905.

https://doi.org/10.1182/blood-2018-11-876839

Published: 2019

Journal Articles

Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway

Sanjay Khandelwal, Joann Ravi, Lubica Rauova, Alexandra Johnson, Grace M. Lee, Jennifer B. Gilner, Sreenivasulu Gunti, Abner L. Notkins, Maragatha Kuchibhatla, Michael Frank, Mortimer Poncz, Douglas B. Cines, Gowthami M. Arepally

Blood (2018) 132 (23): 2431–2440.

https://doi.org/10.1182/blood-2018-03-834598

Published: 2018

Includes: Supplemental data

Journal Articles

Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia

Jing Dai, Daria Madeeva, Vincent Hayes, Hyun Sook Ahn, Valerie Tutwiler, Gowthami M. Arepally, Douglas B. Cines, Mortimer Poncz, Lubica Rauova

Blood (2018) 132 (7): 727–734.

https://doi.org/10.1182/blood-2018-02-830737

Published: 2018

Includes: Supplemental data

Journal Articles

Heparin-induced thrombocytopenia

Gowthami M. Arepally

Blood (2017) 129 (21): 2864–2872.

https://doi.org/10.1182/blood-2016-11-709873

Published: 2017

Journal Articles

Mechanism of Complement Activation By PF4/ Heparin Complexes

Sanjay Khandelwal, PhD, Johnson M Alexandra, BS, C. Garren Hester, Michael M Frank, MD, Gowthami M Arepally, MD

Blood (2016) 128 (22): 137.

https://doi.org/10.1182/blood.V128.22.137.137

Published: 2016

NARROW

Anti-Phospholipid Syndrome (APS) Antibody (Ab)-Induced Thrombosis Can be Blocked By Platelet Factor 4 (PF4)-Directed Abs: A Novel Therapeutic Approach for APS?

Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary xerocytosis

Modulation of Ultralarge Immune Complexes in Heparin-Induced Thrombocytopenia

Complement Shields Fc Regions on HIT Immune Complexes and Prevents Recognition By Cellular Fcγ Receptors

Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes

Minimal Role for the Alternative Pathway in Complement Activation By HIT Immune Complexes

Vaccine-Induced Thrombocytopenia and Thrombosis (VITT) Antibodies Recognize Neutrophil-Activating Peptide 2 (NAP2) As Well As Platelet Factor 4 (PF4): Mechanistic and Clinical Implications

Neutrophil Phenotypes Result in Differential Responses to Pathogens

Fc-Modified Kko: A Novel Therapeutic for Heparin-Induced Thrombocytopenia (HIT), Reversing Both the Thrombocytopenia and Thrombosis

COVID-19 and VITT: same or different?

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know

Complement Regulates the Procoagulant Effects of HIT Immune Complexes

Variation in Neutrophil Function Among Healthy Subjects Influences Response to Bacteria

Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation

Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis

Bad weed: synthetic cannabinoid–associated coagulopathy

Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway

Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia

Heparin-induced thrombocytopenia

Mechanism of Complement Activation By PF4/ Heparin Complexes

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American Society of Hematology

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American Society of Hematology

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