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John Sperati
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Journal Articles

Glucarpidase for Treatment of High-Dose Methotrexate Toxicity

Clinical Trials & Observations
Shruti Gupta, Sarah Allison Kaunfer, Kevin L Chen, Julie-Alexia Dias, Anitha Vijayan, Arun Rajasekaran, Jason Prosek, Huong L. Truong, Anthony Wood, Claude Bassil, Amanda DeMauro Renaghan, Chintan V Shah, Jingjing Zhang, Ilya Glezerman, Christopher Carlos, Katherine Kelly, Christopher J Passero, Jan Drappatz, Ala Abudayyeh, Daniel Shin, C. John Sperati, Bradley J Yelvington, Swetha Rani Kanduri, Javier A Neyra, Daniel Edmonston, Anushree C Shirali, Anip Bansal, Abdallah Geara, Zain Mithani, Susan L Ziolkowski, Arash Rashidi, Jonathan Jakubowski, Ashwini Pujari, David A Bond, Emily K Dotson, Sarah A Wall, John T. Patton, Jason N Barreto, Sandra M Hermann, Mohammad Salman Sheikh, Rachid C Baz, Jae Hui Lee, Nicholas Lucchesi, Michael Kolman, Muhammad Ahsan Rasheed, Afsheen Afzal, Dasol Kang, Amrita Mahesh, Raymond Hsu, Anthony Nicolaysen, Kibrewessen Tefera, Claire Schretlen, Ryan M Miller, Juan Carlos Q Velez, Alexander H Flannery, Abinet M Aklilu, Shuchi Anand, Soniya Chandrasekhara, Vicki Donley, Ashka Patel, Jian Ni, Shobana Krishnamurthy, Rafia Ali, Osman A Yilmam, Sophia L Wells, Jessica L Ortega, Olivia L Green-Lingren, Rebecca Karp Leaf, Meghan E Sise, Lakshmi Nayak, Ann S. LaCasce, Nelson Leung, David E Leaf
Journal: Blood
Blood blood.2024026211.
https://doi.org/10.1182/blood.2024026211
Published: 2025
Includes: Supplemental data
Journal Articles

Complement biosensors identify a classical pathway stimulus in complement-mediated thrombotic microangiopathy

Michael A. Cole, Nikhil Ranjan, Gloria F. Gerber, Xiang-Zuo Pan, Daniel Flores-Guerrero, George McNamara, Shruti Chaturvedi, C. John Sperati, Keith R. McCrae, Robert A. Brodsky
Journal: Blood
Blood (2024) 144 (24): 2528–2545.
https://doi.org/10.1182/blood.2024025850
Published: 2024
Includes: Supplemental data
Journal Articles

Complement Biosensors Can be Used to Identify Classical Pathway and Alternative Pathway Dysregulation in Complement-Mediated Thrombotic Microangiopathy

Michael Cole, Nikhil Ranjan, Gloria F. Gerber, Xiang-Zuo Pan, Daniel Flores-Guerrero, Shruti Chaturvedi, C. John Sperati, Keith R. McCrae, Robert A. Brodsky
Journal: Blood
Blood (2024) 144 (Supplement 1): 1225.
https://doi.org/10.1182/blood-2024-210885
Published: 2024
Journal Articles

The Bioluminescent Modified Ham Test Identifies the Classical Pathway As the Major Driver of Complement Activation in Atypical Hemolytic Uremic Syndrome and Primary Antiphospholipid Syndrome

Michael Cole, Gloria F. Gerber, Xiang-Zuo Pan, Nikhil Ranjan, John Sperati, Shruti Chaturvedi, Keith R. McCrae, Robert A. Brodsky
Journal: Blood
Blood (2023) 142 (Supplement 1): 3947.
https://doi.org/10.1182/blood-2023-190615
Published: 2023
Journal Articles

Reduced ADAMTS13 activity during TTP remission is associated with stroke in TTP survivors

Clinical Trials & Observations
Harshvardhan Upreti, Jamil Kasmani, Kathryn Dane, Evan M. Braunstein, Michael B. Streiff, Satish Shanbhag, Alison R. Moliterno, C. John Sperati, Rebecca F. Gottesman, Robert A. Brodsky, Thomas S. Kickler, Shruti Chaturvedi
Journal: Blood
Blood (2019) 134 (13): 1037–1045.
https://doi.org/10.1182/blood.2019001056
Published: 2019
Includes: Supplemental data
Journal Articles

Chronic Kidney Disease, Hypertension and Cardiovascular Sequelae during Long Term Follow up of Adults with Atypical Hemolytic Uremic Syndrome

Shruti Chaturvedi, MBBS, MS, Alison R. Moliterno, MD, Samuel A. Merrill, MD PhD, Evan M Braunstein, MD PhD, Xuan Yuan, MD MSc, Christopher John Sperati, MD, Gebran Khneizer, Robert A. Brodsky, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3754.
https://doi.org/10.1182/blood-2018-99-119999
Published: 2018
Journal Articles

Eculizumab cessation in atypical hemolytic uremic syndrome

Clinical Trials & Observations
Samuel A. Merrill, Zachary D. Brittingham, Xuan Yuan, Alison R. Moliterno, C. John Sperati, Robert A. Brodsky
Journal: Blood
Blood (2017) 130 (3): 368–372.
https://doi.org/10.1182/blood-2017-02-770214
Published: 2017
Includes: Supplemental data
Journal Articles

β-2-Glycoprotein Antibodies Activate the Alternative Pathway of Complement in Antiphospholipid Antibody Syndrome

Andrea C. Baines, MD PhD, Xuan Yuan, MD MSc, Eleni Gavriilaki, MD PhD, Alexander J. Ambinder, MD MPH, Alka Jain, PhD, Neal S. Fedarko, PhD, C. John Sperati, MD MHS, Alison R. Moliterno, MD, Rakhi P. Naik, MD MHS, Michael Streiff, MD, Wei Fu, MS, Michelle Petri, MD MPH, Robert A. Brodsky, MD
Journal: Blood
Blood (2016) 128 (22): 3818.
https://doi.org/10.1182/blood.V128.22.3818.3818
Published: 2016
Journal Articles

Modified Ham Test Distinguishes aHUS from TTP and Predicts Response to Eculizumab

Eleni Gavriilaki, MD, Xuan Yuan, MD MSc, Zhaohui Ye, PhD, Michael B. Streiff, MD, Thomas S Kickler, MD, Alison R Moliterno, MD, John Sperati, MD, Robert A. Brodsky, MD
Journal: Blood
Blood (2015) 126 (23): 103.
https://doi.org/10.1182/blood.V126.23.103.103
Published: 2015
Journal Articles

Modified Ham test for atypical hemolytic uremic syndrome

Eleni Gavriilaki, Xuan Yuan, Zhaohui Ye, Alexander J. Ambinder, Satish P. Shanbhag, Michael B. Streiff, Thomas S. Kickler, Alison R. Moliterno, C. John Sperati, Robert A. Brodsky
Journal: Blood
Blood (2015) 125 (23): 3637–3646.
https://doi.org/10.1182/blood-2015-02-629683
Published: 2015
Includes: Supplemental data