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Journal Articles

Complement biosensors identify a classical pathway stimulus in complement-mediated thrombotic microangiopathy

Michael A. Cole, Nikhil Ranjan, Gloria F. Gerber, Xiang-Zuo Pan, Daniel Flores-Guerrero, George McNamara, Shruti Chaturvedi, C. John Sperati, Keith R. McCrae, Robert A. Brodsky

Blood (2024) 144 (24): 2528–2545.

https://doi.org/10.1182/blood.2024025850

Published: 2024

Includes: Supplemental data

Journal Articles

Genetic or Epigenetic CR1 Deficiency Defines Catastrophic Antiphospholipid Syndrome (CAPS) and Response to Complement Inhibition

Nikhil Ranjan, Michael Cole, Gloria F. Gerber, Shruti Chaturvedi, Mark A. Crowther, Evan M. Braunstein, Daniel Flores-Guerrero, Alexis Reed, Michelle Petri, Keith R. McCrae, Robert A. Brodsky

Blood (2024) 144 (Supplement 1): 138.

https://doi.org/10.1182/blood-2024-207793

Published: 2024

Journal Articles

Complement Biosensors Can be Used to Identify Classical Pathway and Alternative Pathway Dysregulation in Complement-Mediated Thrombotic Microangiopathy

Michael Cole, Nikhil Ranjan, Gloria F. Gerber, Xiang-Zuo Pan, Daniel Flores-Guerrero, Shruti Chaturvedi, C. John Sperati, Keith R. McCrae, Robert A. Brodsky

Blood (2024) 144 (Supplement 1): 1225.

https://doi.org/10.1182/blood-2024-210885

Published: 2024

Journal Articles

Optimizing Complement Inhibitor Monitoring in PNH and Beyond

Michael Cole, Nikhil Ranjan, Daniel G. Flores, Molly Kuzma, Alexis Reed, Robert A. Brodsky, Gloria F. Gerber

Blood (2024) 144 (Supplement 1): 4071.

https://doi.org/10.1182/blood-2024-200838

Published: 2024

Journal Articles

Reduced Intensity Haploidentical Bone Marrow Transplantation in Adults with Severe Sickle Cell Disease: BMT CTN 1507

Blood (2023) 142 (Supplement 2): LBA-4.

https://doi.org/10.1182/blood-2023-192022

Published: 2023

Journal Articles

Circulating Platelets in Thrombotic Antiphospholipid Syndrome Display High Procoagulant Activity and Surface Complement Deposition: Correlation with Thrombotic Risk

Paresh P Kulkarni, Young Jun Shim, Anne K Hubben, Michael Cole, Shruti Chaturvedi, Robert A. Brodsky, Keith R McCrae

Blood (2023) 142 (Supplement 1): 5407.

https://doi.org/10.1182/blood-2023-184601

Published: 2023

Journal Articles

Sars-Cov-2 Spike Protein Triggers Inflammasome-Mediated Tissue Factor Activity

Nikhil Ranjan, Molly Kuzma, Xiang-Zuo Pan, Michael Cole, Robert A. Brodsky, Gloria F. Gerber

Blood (2023) 142 (Supplement 1): 5405.

https://doi.org/10.1182/blood-2023-187738

Published: 2023

Journal Articles

The Bioluminescent Modified Ham Test Identifies the Classical Pathway As the Major Driver of Complement Activation in Atypical Hemolytic Uremic Syndrome and Primary Antiphospholipid Syndrome

Michael Cole, Gloria F. Gerber, Xiang-Zuo Pan, Nikhil Ranjan, John Sperati, Shruti Chaturvedi, Keith R. McCrae, Robert A. Brodsky

Blood (2023) 142 (Supplement 1): 3947.

https://doi.org/10.1182/blood-2023-190615

Published: 2023

Journal Articles

Ravulizumab Effectiveness in the Real World: Evidence from the International PNH Registry

Alexander Roeth, Christopher J. Patriquin, Jeff Szer, Louis Terriou, Ami Patel, Philippe Gustovic, Jun-Ichi Nishimura, Robert A. Brodsky

Blood (2023) 142 (Supplement 1): 2722.

https://doi.org/10.1182/blood-2023-189165

Published: 2023

Journal Articles

Silent cerebral infarction during immune TTP remission: prevalence, predictors, and impact on cognition

Shruti Chaturvedi, Jia Yu, Jenna Brown, Aria Wei, Sruthi Selvakumar, Gloria F. Gerber, Alison R. Moliterno, Michael B. Streiff, Peggy Kraus, Claire M. Logue, Jennifer C. Yui, Rakhi P. Naik, Hira Latif, Sophie M. Lanzkron, Evan M. Braunstein, Robert A. Brodsky, Rebecca F. Gottesman, Doris D. Lin

Blood (2023) 142 (4): 325–335.

https://doi.org/10.1182/blood.2023019663

Published: 2023

Includes: Supplemental data

Journal Articles

A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism

John F. Andersen, Haotian Lei, Ethan C. Strayer, Tapan Kanai, Van Pham, Xiang-Zuo Pan, Patricia Hessab Alvarenga, Gloria F. Gerber, Oluwatoyin A. Asojo, Ivo M. B. Francischetti, Robert A. Brodsky, Jesus G. Valenzuela, José M. C. Ribeiro

Blood (2023) 141 (25): 3109–3121.

https://doi.org/10.1182/blood.2022019359

Published: 2023

Includes: Supplemental data

Journal Articles

Alternative donor BMT with posttransplant cyclophosphamide as initial therapy for acquired severe aplastic anemia

Amy E. DeZern, Marianna Zahurak, Heather J. Symons, Kenneth R. Cooke, Carol Ann Huff, Tania Jain, Lode J. Swinnen, Philip H. Imus, Nina D. Wagner-Johnston, Richard F. Ambinder, Mark Levis, Leo Luznik, Javier Bolaños-Meade, Ephraim J. Fuchs, Richard J. Jones, Robert A. Brodsky

Blood (2023) 141 (25): 3031–3038.

https://doi.org/10.1182/blood.2023020435

Published: 2023

Includes: Supplemental data

Journal Articles

Pegcetacoplan for paroxysmal nocturnal hemoglobinuria

Gloria F. Gerber, Robert A. Brodsky

Blood (2022) 139 (23): 3361–3365.

https://doi.org/10.1182/blood.2021014868

Published: 2022

Journal Articles

SARS-CoV-2 vaccination and immune thrombotic thrombocytopenic purpura

Hridaya Shah, Ann Kim, Senthil Sukumar, Marshall Mazepa, Ruhail Kohli, Evan M. Braunstein, Robert A. Brodsky, Spero Cataland, Shruti Chaturvedi

Blood (2022) 139 (16): 2570–2573.

https://doi.org/10.1182/blood.2022015545

Published: 2022

Includes: Supplemental data

Journal Articles

Phase 2 study of danicopan in patients with paroxysmal nocturnal hemoglobinuria with an inadequate response to eculizumab

Austin G. Kulasekararaj, Antonio M. Risitano, Jaroslaw P. Maciejewski, Rosario Notaro, Peter Browett, Jong Wook Lee, Mingjun Huang, Michael Geffner, Robert A. Brodsky

Blood (2021) 138 (20): 1928–1938.

https://doi.org/10.1182/blood.2021011388

Published: 2021

Includes: Supplemental data

Journal Articles

COVID-19 vaccines induce severe hemolysis in paroxysmal nocturnal hemoglobinuria

Gloria F. Gerber, Xuan Yuan, Jia Yu, Benjamin A. Y. Cher, Evan M. Braunstein, Shruti Chaturvedi, Robert A. Brodsky

Blood (2021) 137 (26): 3670–3673.

https://doi.org/10.1182/blood.2021011548

Published: 2021

Includes: Supplemental data

Journal Articles

Eculizumab and aHUS: to stop or not

Robert A. Brodsky

Blood (2021) 137 (18): 2419–2420.

https://doi.org/10.1182/blood.2020010234

Published: 2021

Journal Articles

How I treat paroxysmal nocturnal hemoglobinuria

Robert A. Brodsky

Blood (2021) 137 (10): 1304–1309.

https://doi.org/10.1182/blood.2019003812

Published: 2021

Journal Articles

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition

Jia Yu, Xuan Yuan, Hang Chen, Shruti Chaturvedi, Evan M. Braunstein, Robert A. Brodsky

Blood (2020) 136 (18): 2080–2089.

https://doi.org/10.1182/blood.2020008248

Published: 2020

Includes: Supplemental data

Journal Articles

A complementary new drug for PNH

Robert A. Brodsky

Blood (2020) 135 (12): 884–885.

https://doi.org/10.1182/blood.2020004959

Published: 2020

NARROW

Complement biosensors identify a classical pathway stimulus in complement-mediated thrombotic microangiopathy

Genetic or Epigenetic CR1 Deficiency Defines Catastrophic Antiphospholipid Syndrome (CAPS) and Response to Complement Inhibition

Complement Biosensors Can be Used to Identify Classical Pathway and Alternative Pathway Dysregulation in Complement-Mediated Thrombotic Microangiopathy

Optimizing Complement Inhibitor Monitoring in PNH and Beyond

Reduced Intensity Haploidentical Bone Marrow Transplantation in Adults with Severe Sickle Cell Disease: BMT CTN 1507

Circulating Platelets in Thrombotic Antiphospholipid Syndrome Display High Procoagulant Activity and Surface Complement Deposition: Correlation with Thrombotic Risk

Sars-Cov-2 Spike Protein Triggers Inflammasome-Mediated Tissue Factor Activity

The Bioluminescent Modified Ham Test Identifies the Classical Pathway As the Major Driver of Complement Activation in Atypical Hemolytic Uremic Syndrome and Primary Antiphospholipid Syndrome

Ravulizumab Effectiveness in the Real World: Evidence from the International PNH Registry

Silent cerebral infarction during immune TTP remission: prevalence, predictors, and impact on cognition

A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism

Alternative donor BMT with posttransplant cyclophosphamide as initial therapy for acquired severe aplastic anemia

Pegcetacoplan for paroxysmal nocturnal hemoglobinuria

SARS-CoV-2 vaccination and immune thrombotic thrombocytopenic purpura

Phase 2 study of danicopan in patients with paroxysmal nocturnal hemoglobinuria with an inadequate response to eculizumab

COVID-19 vaccines induce severe hemolysis in paroxysmal nocturnal hemoglobinuria

Eculizumab and aHUS: to stop or not

How I treat paroxysmal nocturnal hemoglobinuria

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition

A complementary new drug for PNH

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American Society of Hematology

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American Society of Hematology

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