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Journal Articles

Selectivity and Long Action of In Vivo Efficacy of CS585, a Novel Prostacyclin Receptor Agonist, Compared to FDA-Approved Prostacyclin Agonists Iloprost and Selexipag in the Prevention of Thrombosis

Livia Stanger, Mariane Flores, Krista A Goerger, Bjorn Dahlof, Michael Holinstat

Blood (2024) 144 (Supplement 1): 2544.

https://doi.org/10.1182/blood-2024-202456

Published: 2024

Journal Articles

12-HETE, a Platelet Specific Oxylipin, As an Early Diagnostic Indicator for Thrombotic Risk

Krista A Goerger, Livia Stanger, Andrea Obi, Michael Holinstat

Blood (2024) 144 (Supplement 1): 5413.

https://doi.org/10.1182/blood-2024-212400

Published: 2024

Journal Articles

Comparison of the Anti-Platelet and Anti-Thrombotic Effects of the Dual SGLT1/2 Inhibitor Sotagliflozin to the Relatively Selective SGLT2 Inhibitor Empagliflozin

Livia Stanger, Pooja Yalavarthi, Mariane Flores, David Creen, Bertram Pitt, Michael Holinstat

Blood (2024) 144 (Supplement 1): 3933.

https://doi.org/10.1182/blood-2024-202339

Published: 2024

Journal Articles

12-Hepe Regulates the Antiplatelet Effects of Epa, the ω-3 Fatty Acid

Krista A Goerger, Livia Stanger, Andrew Rickenberg, Theodore Holman, Michael Holinstat

Blood (2024) 144 (Supplement 1): 3932.

https://doi.org/10.1182/blood-2024-212421

Published: 2024

Journal Articles

Identification of the Role of SEL1L in Platelet Function with Implications for Atypical Equine Thrombasthenia in Thoroughbred Horses

Anna R Dahlgren, Francesca Careddu, Raymond Adili, Erin Kropp, Qing Li, Michael Holinstat, Ida Biunno, Alessandra Balduini, Jordan Shavit, Fern Tablin, Carrie J Finno

Blood (2023) 142 (Supplement 1): 3944.

https://doi.org/10.1182/blood-2023-187146

Published: 2023

Journal Articles

Loss of 12-Lipoxygenase Improves the Post-Transfusion Function of Stored Platelets

Hannah Larsen, Daire Byrne, Hasan Tahsin Ozpolat, Aastha Chauhan, Shawn Bailey, Nicole Rhoads, Franklin Reed, Massiel Chavez Stolla, Raymond Adili, Michael Holinstat, Xiaoyun Fu, Moritz Stolla

Blood (2023) 142 (Supplement 1): 2668.

https://doi.org/10.1182/blood-2023-190021

Published: 2023

Journal Articles

HDAC Inhibitor CS014 Attenuates Thrombosis Alone and in Combination with Rivaroxaban without Increased Risk of Bleeding

Livia Stanger, Michael Holinstat, Sylviane Lambert, Pooja Yalavarthi, Niklas Bergh, Bjorn Dahlof

Blood (2023) 142 (Supplement 1): 1195.

https://doi.org/10.1182/blood-2023-186602

Published: 2023

Journal Articles

The oxylipin analog CS585 prevents platelet activation and thrombosis through activation of the prostacyclin receptor

Livia Stanger, Adriana Yamaguchi, Pooja Yalavarthi, Sylviane Lambert, Devin Gilmore, Andrew Rickenberg, Catherine Luke, Kiran Kumar, Andrea T. Obi, Andrew White, Niklas Bergh, Björn Dahlöf, Michael Holinstat

Blood (2023) 142 (18): 1556–1569.

https://doi.org/10.1182/blood.2023020622

Published: 2023

Includes: Supplemental data

Journal Articles

CS585 Demonstrates Favorable Selectivity and Sustained In Vivo Action in Preventing Platelet Activation and Thrombosis Compared to Existing IP Receptor Agonists

Livia Stanger, Pooja Yalavarthi, Sylviane Lambert, Andrew Rickenberg, Krista Goerger, Devin Gilmore, Bjorn Dahlof, Niklas Bergh, Michael Holinstat

Blood (2023) 142 (Supplement 1): 1188.

https://doi.org/10.1182/blood-2023-186300

Published: 2023

Journal Articles

Non-Enzymatic Role of Platelet 12-LOX in Platelet Activation

Durga Shankar Shankar Sharma, Eliana Botta, Wan-Chen Tsai, Theodore Holman, Michael Holinstat

Blood (2023) 142 (Supplement 1): 5397.

https://doi.org/10.1182/blood-2023-182035

Published: 2023

Journal Articles

Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors

Jesse I. Mobbs, Katrina A. Black, Michelle Tran, Wessel A. C. Burger, Hariprasad Venugopal, Theodore R. Holman, Michael Holinstat, David M. Thal, Alisa Glukhova

Blood (2023) 142 (14): 1233–1242.

https://doi.org/10.1182/blood.2023020441

Published: 2023

Includes: Multimedia, Supplemental data

Journal Articles

Deletion of 12-Lipoxygenase Improves Platelet Function after Storage and Transfusion in Thrombocytopenic Mice

Moritz Stolla, Hannah Johnson, Massiel Chavez Stolla, Shawn Lawrence Bailey, Daire Byrne, Michael Holinstat, Xiaoyun Fu

Blood (2022) 140 (Supplement 1): 8552.

https://doi.org/10.1182/blood-2022-163781

Published: 2022

Journal Articles

Novel Snake Venom Derived Hemocoagulase Reverses Anticoagulant Effect of Factor Xa Inhibitors, Restores Hemostatic Clot Formation, and Limits Bleeding in Vitro and In Vivo

Nicole Rhoads, Michael Wong, Benjamin Li, Michael Holinstat, Raymond Adili

Blood (2022) 140 (Supplement 1): 8426–8427.

https://doi.org/10.1182/blood-2022-169398

Published: 2022

Journal Articles

Role of 12-LOX in the Platelet Storage Lesion

Hannah Johnson, Xiaoyun Fu, Shawn Lawrence Bailey, Daire Byrne, Michael Holinstat, Moritz Stolla

Blood (2021) 138 (Supplement 1): 3241.

https://doi.org/10.1182/blood-2021-150335

Published: 2021

Journal Articles

Popping the lid on PAR4 activation

Michael Holinstat

Blood (2020) 136 (19): 2101–2102.

https://doi.org/10.1182/blood.2020007334

Published: 2020

Journal Articles

Resolvin the clot: DVT resolution through RvD4

Michael Holinstat

Blood (2019) 134 (17): 1370–1371.

https://doi.org/10.1182/blood.2019002419

Published: 2019

Journal Articles

Complement factors (H) into thrombosis

Michael Holinstat

Blood (2017) 129 (9): 1065–1066.

https://doi.org/10.1182/blood-2017-01-761528

Published: 2017

Journal Articles

Potent Anti-Platelet Metabolite, 12-HETrE, Inhibits Platelet Activation and Thrombosis In Vivo Via Activation of the IP Receptor

Benjamin Tourdot, PhD, Zitha Isingizwe, BS, Jennifer Yeung, Reheman Adili, MD, Michael Holinstat, PhD

Blood (2016) 128 (22): 714.

https://doi.org/10.1182/blood.V128.22.714.714

Published: 2016

Journal Articles

The Common PAR4 Ala120Thr Variant Has a Major Effect on Platelet Reactivity to Thrombin and These Effects Are Enhanced with PAR1 and P2Y12 Inhibition

Michael J. Whitley, Joanne Vesci, Michael Holinstat, PhD, Leonard C. Edelstein, PhD, Paul F. Bray, MD

Blood (2016) 128 (22): 709.

https://doi.org/10.1182/blood.V128.22.709.709

Published: 2016

Journal Articles

Identification of the Genetic Mechanism Responsible for Racially-Dimorphic Expression of the Thrombin-Receptor Regulator, Pctp

Xiango Kong, MD, Lukas Simon, B.A, Katrina Leung, Michael Holinstat, PhD, Chad Shaw, PhD, Paul F. Bray, MD, Leonard C. Edelstein, PhD

Blood (2015) 126 (23): 415.

https://doi.org/10.1182/blood.V126.23.415.415

Published: 2015

NARROW

Selectivity and Long Action of In Vivo Efficacy of CS585, a Novel Prostacyclin Receptor Agonist, Compared to FDA-Approved Prostacyclin Agonists Iloprost and Selexipag in the Prevention of Thrombosis

12-HETE, a Platelet Specific Oxylipin, As an Early Diagnostic Indicator for Thrombotic Risk

Comparison of the Anti-Platelet and Anti-Thrombotic Effects of the Dual SGLT1/2 Inhibitor Sotagliflozin to the Relatively Selective SGLT2 Inhibitor Empagliflozin

12-Hepe Regulates the Antiplatelet Effects of Epa, the ω-3 Fatty Acid

Identification of the Role of SEL1L in Platelet Function with Implications for Atypical Equine Thrombasthenia in Thoroughbred Horses

Loss of 12-Lipoxygenase Improves the Post-Transfusion Function of Stored Platelets

HDAC Inhibitor CS014 Attenuates Thrombosis Alone and in Combination with Rivaroxaban without Increased Risk of Bleeding

The oxylipin analog CS585 prevents platelet activation and thrombosis through activation of the prostacyclin receptor

CS585 Demonstrates Favorable Selectivity and Sustained In Vivo Action in Preventing Platelet Activation and Thrombosis Compared to Existing IP Receptor Agonists

Non-Enzymatic Role of Platelet 12-LOX in Platelet Activation

Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors

Deletion of 12-Lipoxygenase Improves Platelet Function after Storage and Transfusion in Thrombocytopenic Mice

Novel Snake Venom Derived Hemocoagulase Reverses Anticoagulant Effect of Factor Xa Inhibitors, Restores Hemostatic Clot Formation, and Limits Bleeding in Vitro and In Vivo

Role of 12-LOX in the Platelet Storage Lesion

Popping the lid on PAR4 activation

Resolvin the clot: DVT resolution through RvD4

Complement factors (H) into thrombosis

Potent Anti-Platelet Metabolite, 12-HETrE, Inhibits Platelet Activation and Thrombosis In Vivo Via Activation of the IP Receptor

The Common PAR4 Ala120Thr Variant Has a Major Effect on Platelet Reactivity to Thrombin and These Effects Are Enhanced with PAR1 and P2Y12 Inhibition

Identification of the Genetic Mechanism Responsible for Racially-Dimorphic Expression of the Thrombin-Receptor Regulator, Pctp

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American Society of Hematology

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ASH Publications

American Society of Hematology

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