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Martin K Safo
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Journal Articles

A Novel Direct Hemoglobin S Polymerization Inhibitor for the Treatment of Sickle Cell Disease - In Vivo Efficacy of Ilx-002 in Humanized Mice

Osheiza Abdulmalik, Kandace Gollomp, Veronica Bochenek, Conroy O Field, Mariana Macias, Benita Balogun, Salma Roland, Martin K Safo, Yan Zhang, Akua Donkor, Abdelsattar Omar, Moustafa El-Araby, David R. Light, Clark Brown, Andrew N Fleischman
Journal: Blood
Blood (2024) 144 (Supplement 1): 173.
https://doi.org/10.1182/blood-2024-202714
Published: 2024
Journal Articles

Compound Nanoparticle 5HMF-Prodrug Formulations for Optimized Anti-Sickling Therapy

Stephen C Rogers, Parikshit Moitra, Mary Brummet, Zohreh Safari, Qihong Wang, Joy Okhuevbie, Nancy Anabaraonye, Osheiza Y. Abdulmalik, Martin K. Safo, Nicole Glynn-Cunningham, Jennie Y. Law, Maria R. Baer, Dipanjan Pan, Allan Doctor
Journal: Blood
Blood (2022) 140 (Supplement 1): 5380–5381.
https://doi.org/10.1182/blood-2022-168781
Published: 2022
Journal Articles

MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease

Melanie Demers, PhD, Sarah Sturtevant, BSc, Kevin Guertin, PhD, Dipti Gupta, Kunal Desai, MS, Benjamin Vieira, BS, Alexandra Hicks, PhD, Ayman Ismail, PhD, Yukio Nakamura, MD PhD, Bronner Goncalves, MD PhD, Giuseppe Di Caprio, PhD, Ethan Schonbrun, PhD, Scott Hansen, BS, Martin K. Safo, PhD, David K. Wood, PhD, John M. Higgins, MD PhD, David R. Light, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2260.
https://doi.org/10.1182/blood-2019-128727
Published: 2019
Journal Articles

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Martin K. Safo, PhD, Piyusha P Pagare, PhD, Mohini Ghatge, PhD, Carla Casu, PhD, Valentina Ghiaccio, PhD, Nancy Anabaraonye, Xiaomeng Xu, MS, Stefano Rivella, PhD, Patrick C. Hines, MD PhD, Ke Liu, PhD, Yan Zhang, PhD, Jürgen Venitz, MD PhD, Osheiza Abdulmalik, DVM
Journal: Blood
Blood (2019) 134 (Supplement_1): 73.
https://doi.org/10.1182/blood-2019-128646
Published: 2019
Journal Articles

LC-MS Analysis of Anti-Sickling Compounds in Cord Blood Derived RBCs Demonstrates Modification of Fetal Hemoglobin and Globin Chain Binding Preferences

Benjamin Vieira, Vu P. Hong, Kunal Desai, Martin K. Safo, David R. Light
Journal: Blood
Blood (2018) 132 (Supplement 1): 1074.
https://doi.org/10.1182/blood-2018-99-116319
Published: 2018
Journal Articles

Development of a Triazolyldisulfide Compound That Increases the Affinity of Hemoglobin for Oxygen and Reduces Hypoxic Sickling of Sickle Cells

Akito Nakagawa, PhD, Ferrari Michele, MD, Chen Liu, PhD, Lorenzo Berra, MD, Elizabeth S. Klings, MD, Martin K. Safo, PhD, Donald B. Bloch, MD, Osheiza Abdulmalik, DVM, MS, Warren M. Zapol, MD
Journal: Blood
Blood (2016) 128 (22): 3642.
https://doi.org/10.1182/blood.V128.22.3642.3642
Published: 2016
Journal Articles

Vzhe-039, a Novel Structurally-Enhanced Allosteric Hemoglobin Effector Inhibits Sickling of SS Erythrocytes In Vitro , and Exhibits Improved Pharmacologic Properties In Vivo

Martin K. Safo, PhD, Guoyan Xu, PhD, Mohini Ghatge, PhD, Qiukan Chen, Carla Casu, PhD, David Tanya, PhD, Yan Zhang, PhD, Jurgen Venitz, MD PhD, Osheiza Abdulmalik, DVM, MS
Journal: Blood
Blood (2016) 128 (22): 3645.
https://doi.org/10.1182/blood.V128.22.3645.3645
Published: 2016
Journal Articles

Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease

Kaiqi Sun, BS, Yang Xia, MD PhD, Angelo D'Alessandro, PhD, Mostafa H Ahmed, PhD, Yujin Zhang, MD, Anren Song, PhD, Tzu-Ping KO, Travis Nemkov, Julie Haines, Hongyu Wu, PhD, Morayo G. Adebiyi, BS, Hong Liu, MD, Aji Huang, BS, MS, Zhangzhe Peng, MD, Yuan Edward Wen, Alexander Wen, Vladimir Berka, PhD, Mikhail Bogdanov, PhD, Osheiza Abdulmalik, DVM, MS, Gregory J Kato, MD, Ah-lim Tsai, Modupe Idowu, MD, Harinder S. Juneja, MD, Rodney E. Kellems, PhD, Kirk C Hansen, PhD, Martin K. Safo, PhD
Journal: Blood
Blood (2016) 128 (22): 2474.
https://doi.org/10.1182/blood.V128.22.2474.2474
Published: 2016
Journal Articles

Novel Structurally-Modified Allosteric Effectors of Hemoglobin Exhibit Superior Antisickling Properties

Osheiza Abdulmalik, DVM, MS, Tanvi Deshpande, MS, Mohini Ghatge, PhD, Yan Zhang, PhD, Jurgen Venitz, MDPhD, Apurvasena Parikh, PhD, Martin K. Safo, PhD
Journal: Blood
Blood (2014) 124 (21): 218.
https://doi.org/10.1182/blood.V124.21.218.218
Published: 2014
Journal Articles

Liganded Hb ζ 2 β S 2 Exhibits Antipolymer Activity Despite a T-like Quaternary Structure

Martin K. Safo, PhD, J. Eric Russell, MD
Journal: Blood
Blood (2014) 124 (21): 4062.
https://doi.org/10.1182/blood.V124.21.4062.4062
Published: 2014
Journal Articles

Various Drugs with or without an Antisickling Effect in the In Vitro Tests Showed a Strong Antisickling Effect in the In Vivo Studies in Transgenic Sickle Mice.

Toshio Asakura, MD, PhD, Osheiza Abdulmalik, DVM, Efe Iyamu, PhD, Qiukan Chen, MD, Jisheng Yang, Donald J. Abraham, PhD, Martin K. Safo, PhD, Carlo Brugnara, MD, Greg Evans, PhD
Journal: Blood
Blood (2005) 106 (11): 3190.
https://doi.org/10.1182/blood.V106.11.3190.3190
Published: 2005
Journal Articles

In Vitro Antisickling Effects of Novel Pyridyl Derivatives with Enhanced Potency.

Osheiza Y. Abdulmalik, DVM, Martin K. Safo, PhD, Gajanan Joshi, PhD, Jisheng Yang, Qiukan Chen, Daniel Obeng, Donald J. Abraham, PhD, Toshio Asakura, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 2347.
https://doi.org/10.1182/blood.V106.11.2347.2347
Published: 2005
Journal Articles

MSDD1, a Prodrug of 5-Hydroxymethyl-2-Furfural (5HMF), Prolongs the Antisickling Effect of 5HMF in Transgenic Sickle Mice.

Osheiza Abdulmalik, DVM, Martin K. Safo, PhD, Richmond Danso-Danquah, PhD, Jisheng Yang, Qiukan Chen, MD, Carlo Brugnara, MD, Donald J. Abraham, PhD, Toshio Asakura, MD, PhD
Journal: Blood
Blood (2004) 104 (11): 3576.
https://doi.org/10.1182/blood.V104.11.3576.3576
Published: 2004