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Journal Articles

VISTA As a Mediator of Immune Suppression in AML Initiated By DNMT3A and NPM1 mutations

Tiankai Yin, Michael H. Kramer, Michael Bern, Nichole Helton, Daniel George, Mieke Hoock, Sai Mukund Ramakrishnan, Christopher A Miller, Timothy J Ley

Blood (2024) 144 (Supplement 1): 4100.

https://doi.org/10.1182/blood-2024-206063

Published: 2024

Journal Articles

Recurrent Amplification of Chromosome 7 in Murine AML with Dnmt3a R878H and Npm1 cA Mutations Identifies Gab2 As a Possible Therapeutic Target in AML

Michael H. Kramer, Stephanie N Richardson, Yang Li, Tiankai Yin, Nichole Helton, Daniel George, Michelle Cai, Sai Mukund Ramakrishnan, Christopher A Miller, Timothy J Ley

Blood (2024) 144 (Supplement 1): 1333.

https://doi.org/10.1182/blood-2024-199837

Published: 2024

Journal Articles

Reduced CBFB Expression Causes Compensatory Upregulation of RUNX1 Expression, Defining a Feedback Loop That May be Relevant for AML Pathogenesis

Ryan B. Day, Sai Mukund Ramakrishnan, Christopher A Miller, Timothy J Ley

Blood (2024) 144 (Supplement 1): 4107.

https://doi.org/10.1182/blood-2024-207713

Published: 2024

Journal Articles

Clearance of Leukemia Associated Mutations (LAMs) after Induction Therapy Is Associated with Favorable Outcomes in Intermediate Risk Acute Myeloid Leukemia: Interim Results of a Multicenter, Prospective Phase II Trial

Blood (2024) 144 (Supplement 1): 224.

https://doi.org/10.1182/blood-2024-201694

Published: 2024

Journal Articles

Overexpression of the Signaling Integrator Gab2 Accelerates AML Development in Mice with Dnmt3a R878H and Npm1 cA Mutations

Michael H. Kramer, Stephanie Richardson, Yang Li, Nichole Helton, Daniel George, Michelle Cai, Sai Mukund Ramakrishnan, Christopher A Miller, Timothy J Ley

Blood (2023) 142 (Supplement 1): 2752.

https://doi.org/10.1182/blood-2023-175053

Published: 2023

Journal Articles

Mechanisms of PML::Rara and GATA2 Protein Interactions in Hematopoietic Cells

Casey Katerndahl, Olivia Rogers, Nichole Helton, Sai Mukund Ramakrishnan, Christopher A Miller, Ziheng Xu, Sridhar N Srivatsan, Timothy J Ley

Blood (2023) 142 (Supplement 1): 2758.

https://doi.org/10.1182/blood-2023-181291

Published: 2023

Journal Articles

Assessment of T-Cell Receptor (TCR) Mediated T-Cell Activation in Acute Myeloid Leukemia at Diagnosis Has Implications for Risk Stratification and Response to Immune Checkpoint Inhibitors

Nancy BJ Arthur, Agata Gruszczynska, Ma Xenia G Illagan, Michael Prinsen, Sharon E Heath, Tasha Burton, Victoria Donaldson, Cara Lunn Shirai, Eric J. Duncavage, Amanda F Cashen, Geoffrey L Uy, David H Spencer, Stephen M Sykes, Timothy J Ley, Francesca Ferraro

Blood (2023) 142 (Supplement 1): 2928.

https://doi.org/10.1182/blood-2023-189573

Published: 2023

Journal Articles

Rapid and Accurate Remethylation of Dnmt3a Deficient Hematopoietic Cells with Restoration of DNMT3A Activity

Yang Li, Haley Abel, Michelle Cai, Taylor Lavalle, Tiankai Yin, Nichole Helton, Amanda Smith, Christopher A Miller, Timothy J Ley

Blood (2023) 142 (Supplement 1): 4124.

https://doi.org/10.1182/blood-2023-180255

Published: 2023

Journal Articles

Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions

Blood (2023) 141 (7): 800–805.

https://doi.org/10.1182/blood.2022017874

Published: 2023

Includes: Supplemental data

Journal Articles

A Comprehensive Reassessment of the Direct DNA Binding Sites of PML-Rara within the Genomes of Primary Hematopoietic Progenitor Cells, and Their Effects on Chromatin Structure and Gene Expression

Casey D.S. Katerndahl, Olivia R.S. Rogers, Sai Mukund Ramakrishnan, Christopher A Miller, Nichole M Helton, Mieke Hoock, Timothy J Ley

Blood (2022) 140 (Supplement 1): 5858–5859.

https://doi.org/10.1182/blood-2022-167204

Published: 2022

Journal Articles

Spatial Organization of Hematopoietic Clones in the Bone Marrow of a Patient with Polycythemia Vera

Andrew L Young, Hannah C Davis, David H Spencer, Timothy J Ley, Stephen T Oh, Matthew J Walter, Grant A Challen

Blood (2022) 140 (Supplement 1): 2910–2911.

https://doi.org/10.1182/blood-2022-167351

Published: 2022

Journal Articles

MYC Influences mRNA Processing and Nuclear Export to Initiate Acute Myeloid Leukemia

Nancy Arthur, Keegan A Christensen, Kathleen Mannino, Stephen M. Sykes, Ashutosh Kumar, Nichole M Helton, Agata Gruszczynska, Timothy J Ley, Francesca Ferraro

Blood (2022) 140 (Supplement 1): 2960–2961.

https://doi.org/10.1182/blood-2022-166712

Published: 2022

Journal Articles

Re-Sensitization of Allogeneic T Cell Resistant Murine AML with Pegylated IFN-Gamma

Ezhilarasi Chendamarai, Julie K. Ritchey, Leah Gehrs, Michael P. Rettig, Sai Mukund Ramakrishnan, Christopher A Miller, George Cox, Lana Anderson, Timothy J Ley, John F. DiPersio

Blood (2022) 140 (Supplement 1): 7345–7346.

https://doi.org/10.1182/blood-2022-167415

Published: 2022

Journal Articles

The Protein Interactomes of CBFB-MYH11 and RUNX1-RUNX1T1 Suggest Different Mechanisms of Action for Initiating Acute Myeloid Leukemia

Ryan B Day, Julia Hickman, Ziheng Xu, Casey D.S. Katerndahl, Francesca Ferraro, Petra Erdmann-Gilmore, R. Reid Townsend, Timothy J Ley

Blood (2022) 140 (Supplement 1): 1277–1278.

https://doi.org/10.1182/blood-2022-160457

Published: 2022

Journal Articles

The Protein Interactome of DNMT3A , and Altered Interactions Caused By Missense Mutations Associated with AML and/or the DNMT3A Overgrowth Syndrome

Yang Li, Ziheng Xu, Ryan B Day, Yiling Mi, Petra Erdmann-Gilmore, R. Reid Townsend, Timothy J Ley

Blood (2022) 140 (Supplement 1): 8727–8728.

https://doi.org/10.1182/blood-2022-170287

Published: 2022

Journal Articles

IL-1β expression in bone marrow dendritic cells is induced by TLR2 agonists and regulates HSC function

Sidan Li, Juo-Chin Yao, Karolyn A. Oetjen, Joseph R. Krambs, Jun Xia, Jingzhu Zhang, Amy P. Schmidt, Nichole M. Helton, Robert S. Fulton, Sharon E. Heath, Isaiah R. Turnbull, Gabriel Mbalaviele, Timothy J. Ley, Matthew J. Walter, Daniel C. Link

Blood (2022) 140 (14): 1607–1620.

https://doi.org/10.1182/blood.2022016084

Published: 2022

Includes: Supplemental data

Journal Articles

Proteomic and phosphoproteomic landscapes of acute myeloid leukemia

Michael H. Kramer, Qiang Zhang, Robert Sprung, Ryan B. Day, Petra Erdmann-Gilmore, Yang Li, Ziheng Xu, Nichole M. Helton, Daniel R. George, Yiling Mi, Peter Westervelt, Jacqueline E. Payton, Sai M. Ramakrishnan, Christopher A. Miller, Daniel C. Link, John F. DiPersio, Matthew J. Walter, R. Reid Townsend, Timothy J. Ley

Blood (2022) 140 (13): 1533–1548.

https://doi.org/10.1182/blood.2022016033

Published: 2022

Includes: Supplemental data

Journal Articles

DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults

Margaret A. Ferris, Amanda M. Smith, Sharon E. Heath, Eric J. Duncavage, Matthew Oberley, David Freyer, Robert Wynn, Sofia Douzgou, John M. Maris, Anne F. Reilly, Melinda D. Wu, Florence Choo, Roel B. Fiets, Saskia Koene, David H. Spencer, Christopher A. Miller, Marwan Shinawi, Timothy J. Ley

Blood (2022) 139 (3): 461–464.

https://doi.org/10.1182/blood.2021014052

Published: 2022

Includes: Supplemental data

Journal Articles

Adverse Outcomes in Acute Myeloid Leukemia Are Associated with Tumor Cell-Mediated Immunosuppression

Blood (2021) 138 (Supplement 1): 800.

https://doi.org/10.1182/blood-2021-148645

Published: 2021

Journal Articles

Analysis of the Proteomes of Primary, De Novo Acute Myeloid Leukemia Cells from Adults

Michael H Kramer, Qiang Zhang, Robert W. Sprung, Petra Erdmann-Gilmore, Daniel R George, Nichole M Helton, Sharon E Heath, Jacqueline E. Payton, Peter Westervelt, Christopher A Miller, Matthew J. Walter, Daniel C. Link, John F. DiPersio, R Reid Townsend, Timothy J Ley

Blood (2021) 138 (Supplement 1): 3427.

https://doi.org/10.1182/blood-2021-148819

Published: 2021

NARROW

VISTA As a Mediator of Immune Suppression in AML Initiated By DNMT3A and NPM1 mutations

Recurrent Amplification of Chromosome 7 in Murine AML with Dnmt3a R878H and Npm1 cA Mutations Identifies Gab2 As a Possible Therapeutic Target in AML

Reduced CBFB Expression Causes Compensatory Upregulation of RUNX1 Expression, Defining a Feedback Loop That May be Relevant for AML Pathogenesis

Clearance of Leukemia Associated Mutations (LAMs) after Induction Therapy Is Associated with Favorable Outcomes in Intermediate Risk Acute Myeloid Leukemia: Interim Results of a Multicenter, Prospective Phase II Trial

Overexpression of the Signaling Integrator Gab2 Accelerates AML Development in Mice with Dnmt3a R878H and Npm1 cA Mutations

Mechanisms of PML::Rara and GATA2 Protein Interactions in Hematopoietic Cells

Assessment of T-Cell Receptor (TCR) Mediated T-Cell Activation in Acute Myeloid Leukemia at Diagnosis Has Implications for Risk Stratification and Response to Immune Checkpoint Inhibitors

Rapid and Accurate Remethylation of Dnmt3a Deficient Hematopoietic Cells with Restoration of DNMT3A Activity

Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions

A Comprehensive Reassessment of the Direct DNA Binding Sites of PML-Rara within the Genomes of Primary Hematopoietic Progenitor Cells, and Their Effects on Chromatin Structure and Gene Expression

Spatial Organization of Hematopoietic Clones in the Bone Marrow of a Patient with Polycythemia Vera

MYC Influences mRNA Processing and Nuclear Export to Initiate Acute Myeloid Leukemia

Re-Sensitization of Allogeneic T Cell Resistant Murine AML with Pegylated IFN-Gamma

The Protein Interactomes of CBFB-MYH11 and RUNX1-RUNX1T1 Suggest Different Mechanisms of Action for Initiating Acute Myeloid Leukemia

The Protein Interactome of DNMT3A , and Altered Interactions Caused By Missense Mutations Associated with AML and/or the DNMT3A Overgrowth Syndrome

IL-1β expression in bone marrow dendritic cells is induced by TLR2 agonists and regulates HSC function

Proteomic and phosphoproteomic landscapes of acute myeloid leukemia

DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults

Adverse Outcomes in Acute Myeloid Leukemia Are Associated with Tumor Cell-Mediated Immunosuppression

Analysis of the Proteomes of Primary, De Novo Acute Myeloid Leukemia Cells from Adults

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American Society of Hematology

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ASH Publications

American Society of Hematology

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