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Gurushankar Chandramouly
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Journal Articles

Inactivation of DNA Polymerase Theta (PolΘ) Is Synthetic Lethal in DNMT3A Mutated Myeloid Malignancies - Potential Clinical Applications

Bac Viet Le, Umeshkumar Vekariya, Monika Toma, Margaret Nieborowska-Skorska, Marie-Christine Caron, George Vassiliou, Malgorzata Gozdecka, Zayd Haydar, Gurushankar Chandramouly, Emir Hadzijusufovic, Wolfgang R. Sperr, Richard Pomerantz, Peter Valent, Jean-Yves Masson, Gaorav Gupta, Grant A Challen, Tomasz Skorski
Journal: Blood
Blood (2023) 142 (Supplement 1): 580.
https://doi.org/10.1182/blood-2023-174333
Published: 2023
Journal Articles

Poly(ADP-Ribose) Glycohydrolase (PARG) Removes Repressive Poly-ADP Ribose Marks from DNA Polymerase Theta (PolΘ) to Stimulate DNA Double-Strand Breaks Repair in Myeloid Malignancies

Umeshkumar Vekariya, Leonid Minakhin, Mrityunjay Tyagi, Tatiana Kent, Gurushankar Chandramouly, Katherine Sullivan-Reed, Jessica Atkins, Margaret Nieborowska-Skorska, Anna-Mariya Kukuyan, Richard Pomerantz, Tomasz Skorski
Journal: Blood
Blood (2023) 142 (Supplement 1): 5693.
https://doi.org/10.1182/blood-2023-174330
Published: 2023
Journal Articles

DNA polymerase θ protects leukemia cells from metabolically induced DNA damage

Umeshkumar Vekariya, Monika Toma, Margaret Nieborowska-Skorska, Bac Viet Le, Marie-Christine Caron, Anna-Mariya Kukuyan, Katherine Sullivan-Reed, Paulina Podszywalow-Bartnicka, Kumaraswamy N. Chitrala, Jessica Atkins, Malgorzata Drzewiecka, Wanjuan Feng, Joe Chan, Srinivas Chatla, Konstantin Golovine, Jaroslav Jelinek, Tomasz Sliwinski, Jayashri Ghosh, Ksenia Matlawska-Wasowska, Gurushankar Chandramouly, Reza Nejati, Mariusz Wasik, Stephen M. Sykes, Katarzyna Piwocka, Emir Hadzijusufovic, Peter Valent, Richard T. Pomerantz, George Morton, Wayne Childers, Huaqing Zhao, Elisabeth M. Paietta, Ross L. Levine, Martin S. Tallman, Hugo F. Fernandez, Mark R. Litzow, Gaorav P. Gupta, Jean-Yves Masson, Tomasz Skorski
Journal: Blood
Blood (2023) 141 (19): 2372–2389.
https://doi.org/10.1182/blood.2022018428
Published: 2023
Includes: Supplemental data
Journal Articles

Identification of a Novel Nucleoside Prodrug with Preferential Activity in Lymphoma and Leukemia Subtypes

Marissa L Calbert, Gurushankar Chandramouly, Tatiana Kent, Clare M Adams, Mrityunjay Tyagi, Yifan Wang, John Krais, Hoora Shaghaghi, Jessica Atkins, Tomasz Skorski, Neil Johnson, Christine M Eischen, Richard Pomerantz
Journal: Blood
Blood (2022) 140 (Supplement 1): 10701.
https://doi.org/10.1182/blood-2022-165514
Published: 2022