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Journal Articles

The Proteostasis Network Is a Therapeutic Target in Acute Myeloid Leukemia

Kentson Lam, Yoon Joon Kim, Carlo M. Ong, Andrea Z. Liu, Fanny Jiahua Jiahua Zhou, Bernadette A. Chua, Silvia Vicenzi, Pierce W. Ford, Jie-Hua Zhou, Eric Bennett, Leslie A Crews, Edward D. Ball, Robert Signer
Journal: Blood
Blood (2024) 144 (Supplement 1): 2767.
https://doi.org/10.1182/blood-2024-204380
Published: 2024
Journal Articles

Disrupting Autophagy Sensitizes Human Acute Myeloid Leukemia Cells to Proteasome Inhibition By Disrupting Protein Homeostasis

Kentson Lam, Yoon Joon Kim, Carlo M. Ong, Andrea Liu, Bernadette Chua, Jie-Hua Zhou, Edward D. Ball, Robert Signer
Journal: Blood
Blood (2023) 142 (Supplement 1): 2805.
https://doi.org/10.1182/blood-2023-182149
Published: 2023
Journal Articles

A Stress Response Pathway That Enhances Hematopoietic Stem Cell Longevity Promotes Acute Myeloid Leukemia Growth and Progression

Yoon Joon Kim, Kentson Lam, Fanny Zhou, Carlo M Ong, Jeffrey A. Magee, Robert Signer
Journal: Blood
Blood (2022) 140 (Supplement 1): 5872.
https://doi.org/10.1182/blood-2022-170243
Published: 2022
Journal Articles

Efficacy of Therapies Following Venetoclax Discontinuation in CLL: Focus on B-Cell Receptor Signal Transduction Inhibitors and Cellular Therapies

Anthony R. Mato, MDMSCE, Lindsey E. Roeker, MD, Toby A. Eyre, MBBChir, MRCP, Ryan Jacobs, MD, Brian T. Hill, MD, Nicole Lamanna, MD, Danielle M. Brander, MD, Mazyar Shadman, MD, Chaitra Ujjani, MD, Maryam Yazdy, MD, Guilherme Fleury Perini, MD, Javier Pinilla Ibarz, MD PhD, Jacqueline C Barrientos, MD, Alan Skarbnik, MD, Pallawi Torka, MD, Jeffrey J Pu, MD PhD, John M. Pagel, MD PhD DSc, Satyen Gohil, BSc, MBBS, MRCP, FRCPath, Bita Fakhri, MDMPH, Michael Y. Choi, MD, Catherine C. Coombs, MD, Joanna Rhodes, MD, Paul M. Barr, MD, Craig A. Portell, MD, Helen Parry, MB ChB, MRCP, PhD, Christine Ann Garcia, MD MPH, Kate J Whitaker, BA, Allison M. Winter, MD, Andrea Sitlinger, MD, Sirin Khajavian, MD, Ariel F Grajales-Cruz, MD, Krista Isaac, DO, MS, Pratik Shah, Othman S. Akhtar, MD, Rachael Pocock, MD, Kentson Lam, MD PhD, Timothy J Voorhees, MD, Stephen J. Schuster, MD, Thomas David Rodgers, MD, Nicolas Martinez-Calle, MD MSc, Talha Munir, MD, Erica B Bhavsar, BS, Neil Bailey, MSc, Jason C. Lee, MD, Hanna Weissbrot, BS, Chadi Nabhan, MDMBA, FACP, Julie Goodfriend, Amber C. King, PharmD, BCOP, Andrew D. Zelenetz, MD PhD, Colleen Dorsey, BSN, RN, Kayla Bigelow, Bruce D. Cheson, MD, Christopher P Fox, MBChB(Hons), MRCP, FRCPath, PhD, John N. Allan, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 502.
https://doi.org/10.1182/blood-2019-123747
Published: 2019
Journal Articles

Usp18 Is Required for Normal Stem Cell Maintenance

Kei-ichiro Arimoto, PhD, Yue Zhang, Ming Yan, PhD, Sayuri Miyauchi, DDS, PhD, Stephanie Weng, PhD, Samuel A. Stoner, Takahiro Shima, MD PhD, Yukiko Komeno, MD PhD, Kentson Lam, MD PhD, Dong-Er Zhang, PhD
Journal: Blood
Blood (2016) 128 (22): 3863.
https://doi.org/10.1182/blood.V128.22.3863.3863
Published: 2016
Journal Articles

Gtpase Immunity-Associated Protein Family Member 4 Contributes to the Enhanced Expansion of HSPCs in RUNX1 Deficient Mice

Amanda Scholl, BS, Kentson Lam, PhD, Alex Muselman, Tingdong Tang, PhD, Shinobu Matsuura, DVM, PhD, Dong-Er Zhang, PhD
Journal: Blood
Blood (2014) 124 (21): 4344.
https://doi.org/10.1182/blood.V124.21.4344.4344
Published: 2014
Journal Articles

Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice

Kentson Lam, Alexander Muselman, Randal Du, Yuka Harada, Amanda G. Scholl, Ming Yan, Shinobu Matsuura, Stephanie Weng, Hironori Harada, Dong-Er Zhang
Journal: Blood
Blood (2014) 124 (14): 2203–2212.
https://doi.org/10.1182/blood-2014-02-554543
Published: 2014
Includes: Supplemental data
Journal Articles

Runx1 exon 6–related alternative splicing isoforms differentially regulate hematopoiesis in mice

Yukiko Komeno, Ming Yan, Shinobu Matsuura, Kentson Lam, Miao-Chia Lo, Yi-Jou Huang, Daniel G. Tenen, James R. Downing, Dong-Er Zhang
Journal: Blood
Blood (2014) 123 (24): 3760–3769.
https://doi.org/10.1182/blood-2013-08-521252
Published: 2014
Includes: Supplemental data
Journal Articles

RUNX1-ETO Expressing Hematopoietic Stem/Progenitor Cells (HSPCs) Display a Hypersensitivity To GM-CSF That Reduces Leukemogenic Potential

Stephanie Weng, BS, Shinobu Matsuura, DVM, PhD, Miao-Chia Lo, PhD, Kentson Lam, BA, Dan Ran, MD PhD, Dong-Er Zhang, PhD
Journal: Blood
Blood (2013) 122 (21): 1258.
https://doi.org/10.1182/blood.V122.21.1258.1258
Published: 2013
Journal Articles

Hmga2 Is a RUNX1 Target Gene In Hematopoietic Stem and Progenitor Cells

Kentson Lam, BA, Randal Du, BS, Shinobu Matsuura, DVM, PhD, Dong-Er Zhang, PhD
Journal: Blood
Blood (2013) 122 (21): 3673.
https://doi.org/10.1182/blood.V122.21.3673.3673
Published: 2013
Journal Articles

Response: the role of RUNX1 isoforms in hematopoietic commitment of human pluripotent stem cells

Dan Ran, Kentson Lam, Wei-Jong Shia, Miao-Chia Lo, Jun-Bao Fan, David A. Knorr, Patrick I. Ferrell, Zhaohui Ye, Ming Yan, Linzhao Cheng, Dan S. Kaufman, Dong-Er Zhang
Journal: Blood
Blood (2013) 121 (26): 5252–5253.
https://doi.org/10.1182/blood-2013-04-494914
Published: 2013
Journal Articles

Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome

Shinobu Matsuura, Yukiko Komeno, Kristen E. Stevenson, Joseph R. Biggs, Kentson Lam, Tingdong Tang, Miao-Chia Lo, Xiuli Cong, Ming Yan, Donna S. Neuberg, Dong-Er Zhang
Journal: Blood
Blood (2012) 120 (19): 4028–4037.
https://doi.org/10.1182/blood-2012-01-404533
Published: 2012
Includes: Supplemental data