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Journal Articles

Pathogenic Significance of the DDX41 p.R525H Variant Revealed By Single-Cell RNA-Seq Analysis

Hirotaka Matsui, Minori Koizumi, Rei Kudo, Akiko Nagamachi, Masahiko Ajiro, Hironori Harada, Yuka Harada, Shigeyuki Shichino, Akihide Yoshimi

Blood (2024) 144 (Supplement 1): 5719.

https://doi.org/10.1182/blood-2024-200394

Published: 2024

Journal Articles

PRC2-Mediated Apoptosis Evasion Is a Therapeutic Target of MDS/AML Harboring Inv(3)/t(3;3) and -7

Hiroyoshi Kunimoto, Ayaka Miura, Maiko Sagisaka, Mieko Ito, Daisuke Honma, Shinji Tsutsumi, Takayuki Sakuma, Takuma Ohashi, Hiroshi Teranaka, Junji Ikeda, Takashi Toya, Yuka Harada, Noriko Doki, Sheng F. Cai, Akihide Yoshimi, Hiroaki Goto, Ross L Levine, Hideaki Nakajima

Blood (2023) 142 (Supplement 1): 2803.

https://doi.org/10.1182/blood-2023-178436

Published: 2023

Journal Articles

Transposable Elements Are Differentially Expressed in MDS Stem Cells in a Disease-Stage-Specific Manner

Blood (2023) 142 (Supplement 1): 6458.

https://doi.org/10.1182/blood-2023-172607

Published: 2023

Journal Articles

Venetoclax-Based Therapy before Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia

Blood (2023) 142 (Supplement 1): 4990.

https://doi.org/10.1182/blood-2023-184814

Published: 2023

Journal Articles

Clinical, Cytogenetic, and Molecular Characteristics Analysis in Myelodysplastic Syndromes with Elevated Ferritin Levels

Blood (2021) 138 (Supplement 1): 4664.

https://doi.org/10.1182/blood-2021-152359

Published: 2021

Journal Articles

Clinical and Genetic Features of Constitutional Partial Trisomy 8 Mosaicism (CT8M) Patients with Cytopenia

Blood (2019) 134 (Supplement_1): 5413.

https://doi.org/10.1182/blood-2019-129711

Published: 2019

Journal Articles

Clinical and Genetic Characteristics of Adolescent and Young Adult Patients with Myelodysplastic Syndromes

Blood (2019) 134 (Supplement_1): 3336.

https://doi.org/10.1182/blood-2019-122401

Published: 2019

Journal Articles

Presence of TP53 Mutation and Monosomal Karyotype Predict the Outcome of Patients with Acute Myeloid Leukemia in Non-Remission at Allogeneic Stem Cell Transplantation

Yuho Najima, MD, Daichi Sadato, MS, Yuka Harada, MD PhD, Chizuko Hirama, BS, Keisuke Oboki, MD PhD, Takashi Toya, MD PhD, Noriko Doki, MD PhD, Kyoko Haraguchi, MD PhD, Kota Yoshifuji, MD, Megumi Akiyama, MD, Kyoko Inamoto, MD, Aiko Igarashi, MD, Takeshi Kobayashi, MD, Kazuhiko Kakihana, MD PhD, Yoshiki Okuyama, MD PhD, Hisashi Sakamaki, MD PhD, Hironori Harada, MD PhD, Kazuteru Ohashi, MD PhD

Blood (2018) 132 (Supplement 1): 2168.

https://doi.org/10.1182/blood-2018-99-116469

Published: 2018

Journal Articles

RUNX3 Promotes the Development of MDS/MPN Overlap Syndrome Via Enhancing Expression of Myc in the Absence of Tet2

Takako Yokomizo, PhD, Daiki Tanaka, Sho Kubota, PhD, Motohiko Oshima, PhD, Yuka Harada, MD PhD, Akinori Kanai, PhD, Atsushi Iwama, MD PhD, Hironori Harada, Motomi Osato, MD PhD, Goro Sashida, MD PhD

Blood (2017) 130 (Supplement 1): 2494.

https://doi.org/10.1182/blood.V130.Suppl_1.2494.2494

Published: 2017

Journal Articles

Dysregulation of RUNX1 Plays a Critical Role in the Progression of Myelodysplastic Syndromes

Hiroko Sakurai, MD, Yuka Harada, MD PhD, Hirotaka Matsui, MD PhD, Hideaki Nakajima, MD PhD, Toshio Kitamura, MD PhD, Norio Komatsu, MD PhD, Hironori Harada, MD PhD

Blood (2015) 126 (23): 4108.

https://doi.org/10.1182/blood.V126.23.4108.4108

Published: 2015

Journal Articles

A Patient-Derived EZH2 Mutant Induces MDS-like Diseases with Derepressed ABCG2 Expression in Mice

Kimihito Cojin Kawabata, MD PhD, Daichi Inoue, MD PhD, Jiro Kitaura, MD PhD, Yuka Harada, MD PhD, Susumu Goyama, MD PhD, Hironori Harada, MD PhD, Hiroyuki Aburatani, MD PhD, Toshio Kitamura, MD PhD

Blood (2015) 126 (23): 4116.

https://doi.org/10.1182/blood.V126.23.4116.4116

Published: 2015

Journal Articles

SETBP1 Mutations Drive Leukemic Transformation in ASXL1 -Mutated MDS

Daichi Inoue, MD PhD, Hirotaka Matsui, MD PhD, Hsin-An Hou, MD PhD, Wen-Chien Chou, MD PhD, Akiko Nagamachi, PhD, Jiro Kitaura, MD PhD, Kimihito Cojin Kawabata, MD PhD, Katsuhiro Togami, MD PhD, Reina Nagase, Sayuri Horikawa, Makoto Saika, MD, Jean-Baptiste Micol, MD, Yasutaka Hayashi, MD, Yuka Harada, MD PhD, Hironori Harada, MD PhD, Hwei-Fang Tien, MD PhD, Omar Abdel-Wahab, MD, Toshio Kitamura, MD PhD

Blood (2014) 124 (21): 525.

https://doi.org/10.1182/blood.V124.21.525.525

Published: 2014

Journal Articles

Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice

Kentson Lam, Alexander Muselman, Randal Du, Yuka Harada, Amanda G. Scholl, Ming Yan, Shinobu Matsuura, Stephanie Weng, Hironori Harada, Dong-Er Zhang

Blood (2014) 124 (14): 2203–2212.

https://doi.org/10.1182/blood-2014-02-554543

Published: 2014

Includes: Supplemental data

Journal Articles

Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells

Blood (2014) 123 (25): 3932–3942.

https://doi.org/10.1182/blood-2013-01-476747

Published: 2014

Includes: Supplemental data

Journal Articles

RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes

Yuka Harada, Daichi Inoue, Ye Ding, Jun Imagawa, Noriko Doki, Hirotaka Matsui, Takashi Yahata, Hiromichi Matsushita, Kiyoshi Ando, Goro Sashida, Atsushi Iwama, Toshio Kitamura, Hironori Harada

Blood (2013) 121 (17): 3434–3446.

https://doi.org/10.1182/blood-2012-06-434423

Published: 2013

Includes: Supplemental data

Journal Articles

RUNX1/AML1 Mutants Collaborate with BMI1 in the Development of Myelodysplastic Syndromes (MDS) / Acute Myeloid Leukemia (AML) in a Mouse BMT Model.

Hironori Harada, MD, PhD, Daichi Inoue, MD, Noriko Doki, MD, Ye Ding, MD, PhD, Yuka Harada, MD, PhD, Toshio Kitamura, MD, PhD

Blood (2012) 120 (21): 2820.

https://doi.org/10.1182/blood.V120.21.2820.2820

Published: 2012

Journal Articles

Impaired Hematopoietic Differentiation of iPSCs Derived From Patients with FPD/AML

Masatoshi Sakurai, MD, Hiroyoshi Kunimoto, MD, Naohide Watanabe, MD, PhD, Yumi Fukuchi, PhD, Ken Sadahira, MD, Shinsuke Yuasa, MD, PhD, Keiichi Fukuda, MD, PhD, Satoshi Yamazaki, PhD, Hiromitsu Nakauchi, MD, PhD, Yasuhiro Ebihara, MD, PhD, Kohichiro Tsuji, MD, PhD, Etsuro Ito, Yuka Harada, MD, PhD, Hironori Harada, MD, PhD, Shinichiro Okamoto, MD, PhD, Hideaki Nakajima, MD, PhD

Blood (2012) 120 (21): 767.

https://doi.org/10.1182/blood.V120.21.767.767

Published: 2012

Journal Articles

BMI1 Collaborates with RUNX1/AML1 Mutants in the Development of Human Myelodysplastic Syndrome (MDS) / Acute Myeloid Leukemia (AML)

Hironori Harada, MD, Ye Ding, MD, Jun Imagawa, MD, Takahiko Miyama, MD, Akiro Kimura, MD, Yuka Harada, MD

Blood (2011) 118 (21): 275.

https://doi.org/10.1182/blood.V118.21.275.275

Published: 2011

Journal Articles

Expansion of CD8 + /perforin + T-Cell Subset in Patients Predicts Response to Cyclosporin A Therapy in Patients with Erythroid Hypoplasia/Aplasia

Hideaki Nitta, MD, Yuka Harada, MD, Hideo Hyodo, MD, Akiro Kimura, MD, Hironori Harada, MD

Blood (2011) 118 (21): 1337.

https://doi.org/10.1182/blood.V118.21.1337.1337

Published: 2011

Journal Articles

Two types of C/EBPα mutations play distinct but collaborative roles in leukemogenesis: lessons from clinical data and BMT models

Naoko Kato, Jiro Kitaura, Noriko Doki, Yukiko Komeno, Naoko Watanabe-Okochi, Katsuhiro Togami, Fumio Nakahara, Toshihiko Oki, Yutaka Enomoto, Yumi Fukuchi, Hideaki Nakajima, Yuka Harada, Hironori Harada, Toshio Kitamura

Blood (2011) 117 (1): 221–233.

https://doi.org/10.1182/blood-2010-02-270181

Published: 2011

Includes: Supplemental data

NARROW

Pathogenic Significance of the DDX41 p.R525H Variant Revealed By Single-Cell RNA-Seq Analysis

PRC2-Mediated Apoptosis Evasion Is a Therapeutic Target of MDS/AML Harboring Inv(3)/t(3;3) and -7

Transposable Elements Are Differentially Expressed in MDS Stem Cells in a Disease-Stage-Specific Manner

Venetoclax-Based Therapy before Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia

Clinical, Cytogenetic, and Molecular Characteristics Analysis in Myelodysplastic Syndromes with Elevated Ferritin Levels

Clinical and Genetic Features of Constitutional Partial Trisomy 8 Mosaicism (CT8M) Patients with Cytopenia

Clinical and Genetic Characteristics of Adolescent and Young Adult Patients with Myelodysplastic Syndromes

Presence of TP53 Mutation and Monosomal Karyotype Predict the Outcome of Patients with Acute Myeloid Leukemia in Non-Remission at Allogeneic Stem Cell Transplantation

RUNX3 Promotes the Development of MDS/MPN Overlap Syndrome Via Enhancing Expression of Myc in the Absence of Tet2

Dysregulation of RUNX1 Plays a Critical Role in the Progression of Myelodysplastic Syndromes

A Patient-Derived EZH2 Mutant Induces MDS-like Diseases with Derepressed ABCG2 Expression in Mice

SETBP1 Mutations Drive Leukemic Transformation in ASXL1 -Mutated MDS

Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice

Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells

RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes

RUNX1/AML1 Mutants Collaborate with BMI1 in the Development of Myelodysplastic Syndromes (MDS) / Acute Myeloid Leukemia (AML) in a Mouse BMT Model.

Impaired Hematopoietic Differentiation of iPSCs Derived From Patients with FPD/AML

BMI1 Collaborates with RUNX1/AML1 Mutants in the Development of Human Myelodysplastic Syndrome (MDS) / Acute Myeloid Leukemia (AML)

Expansion of CD8 + /perforin + T-Cell Subset in Patients Predicts Response to Cyclosporin A Therapy in Patients with Erythroid Hypoplasia/Aplasia

Two types of C/EBPα mutations play distinct but collaborative roles in leukemogenesis: lessons from clinical data and BMT models

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American Society of Hematology

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American Society of Hematology

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