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Journal Articles

Enhanced Selective Inhibition of KRAS Mutant Hematopoietic Progenitor Cell Expansion By MEK and Bcl-2 Inhibition

Huan-Ting Lin, PhD, Kenji Kubara, Kazuto Yamazaki, PhD, Masatoshi Takagi, MD PhD, Takuya Naruto, MD PhD, Tomohiro Morio, MD PhD, Takashi Okumura, PhD, Makoto Otsu, MD PhD

Blood (2018) 132 (Supplement 1): 1278.

https://doi.org/10.1182/blood-2018-99-117889

Published: 2018

Journal Articles

Proof of Benefit in Multiple-Cord Blood Transplantation Evidenced By Early Hematopoietic Reconstitution

Takashi Ishida, MD, Satoshi Takahashi, MD,PhD, Chen-Yi Lai, PhD, Masaaki Higashihara, MD, PhD, Hiromitsu Nakauchi, MD PhD, Makoto Otsu, MD, PhD

Blood (2015) 126 (23): 3071.

https://doi.org/10.1182/blood.V126.23.3071.3071

Published: 2015

Journal Articles

Protection of Transplanted Hematopoietic Stem Cells from Inflammatory Recipient Marrow Environment through Specific TNF-α Signal Blockade

Takashi Ishida, MD, Sachie Suzuki, MD, Chen-Yi Lai, PhD, Masaaki Higashihara, MD, PhD, Hiromitsu Nakauchi, MD PhD, Makoto Otsu, MD, PhD

Blood (2015) 126 (23): 1867.

https://doi.org/10.1182/blood.V126.23.1867.1867

Published: 2015

Journal Articles

A New Strategy to Overcome the Cell Dose Barrier to Umbilical Cord Blood Transplants: A Proof of Early Hematopoietic Reconstitution By Combined Multiple Units of Allogeneic Stem/Progenitor Cells

Takashi Ishida, MD, Makoto Otsu, MD PhD, Satoshi Takahashi, MD PhD, Masaaki Higashihara, MD PhD, Hiromitsu Nakauchi, MD PhD

Blood (2014) 124 (21): 3810.

https://doi.org/10.1182/blood.V124.21.3810.3810

Published: 2014

Journal Articles

Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells

Blood (2014) 123 (25): 3932–3942.

https://doi.org/10.1182/blood-2013-01-476747

Published: 2014

Includes: Supplemental data

Journal Articles

Role Of Sf3b1 On Hematopoiesis

Manabu Matsunawa, MD, Ryo Yamamoto, MD, PhD, Masashi Sanada, MD, Aiko Sato, PhD, Yusuke Shiozawa, MD, Kenichi Yoshida, MD, Yasunobu Nagata, MD, Ayana Kon, MD, Tetsuichi Yoshizato, MD, Makoto Otsu, MD, PhD, Kyoichi Isono, Haruhiko Koseki, MD, PhD, Hiromitsu Nakauchi, MD, PhD, Seishi Ogawa, MD, PhD

Blood (2013) 122 (21): 600.

https://doi.org/10.1182/blood.V122.21.600.600

Published: 2013

Journal Articles

Biological Analysis of SRSF2 Mutations in Leukemogenesis

Manabu Matsunawa, MD, Masashi Sanada, MD, Ryo Yamamoto, MD, PhD, Kenichi Yoshida, MD, Yasunobu Nagata, MD, Ayana Kon, MD, Tetsuichi Yoshizato, MD, Makoto Otsu, MD, PhD, Hiromitsu Nakauchi, MD, PhD, Seishi Ogawa, MD, PhD

Blood (2012) 120 (21): 1282.

https://doi.org/10.1182/blood.V120.21.1282.1282

Published: 2012

Journal Articles

Recurrent Mutations of Multiple Components of Cohesin Complex in Myeloid Neoplasms

Ayana Kon, MD, Lee-Yung Shih, MD, Masashi Minamino, MA, Masashi Sanada, MD, Yuichi Shiraishi, PhD, Yasunobu Nagata, MD, Kenichi Yoshida, MD, Yusuke Okuno, MD, Masashige Bando, PhD, Shumpei Ishikawa, MD, PhD, Aiko Sato-Otsubo, PhD, Genta Nagae, MD, PhD, Claudia Haferlach, MD, Daniel Nowak, MD, Yusuke Sato, MD, Tamara Alpermann, Masao Nagasaki, PhD, Teppei Shimamura, MD, PhD, Hiroko Tanaka, BA, Kenichi Chiba, BA, Ryo Yamamoto, MD, PhD, Tomoyuki Yamaguchi, PhD, Makoto Otsu, MD, PhD, Naoshi Obara, MD, PhD, Mamiko Sakata-Yanagimoto, MD, PhD, Tsuyoshi Nakamaki, MD, Ken Ishiyama, MD, PhD, Florian Nolte, MD, Wolf-Karsten Hofmann, Shuichi Miyawaki, MD, Shigeru Chiba, MD, PhD, Hiraku Mori, MD, PhD, Hiromitsu Nakauchi, MD, PhD, H. Phillip Koeffler, MD, PhD, Hiroyuki Aburatani, MD, PhD, Torsten Haferlach, MD, Katsuhiko Shirahige, PhD, Satoru Miyano, PhD, Seishi Ogawa, MD, PhD

Blood (2012) 120 (21): 782.

https://doi.org/10.1182/blood.V120.21.782.782

Published: 2012

Journal Articles

Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples

Keiki Kumano, Shunya Arai, Masataka Hosoi, Kazuki Taoka, Naoya Takayama, Makoto Otsu, Genta Nagae, Koki Ueda, Kumi Nakazaki, Yasuhiko Kamikubo, Koji Eto, Hiroyuki Aburatani, Hiromitsu Nakauchi, Mineo Kurokawa

Blood (2012) 119 (26): 6234–6242.

https://doi.org/10.1182/blood-2011-07-367441

Published: 2012

Includes: Supplemental data

Journal Articles

In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling

Blood (2012) 119 (8): e45–e56.

https://doi.org/10.1182/blood-2011-09-381400

Published: 2012

Includes: Multimedia, Supplemental data

Journal Articles

Functional Analysis of SRSF2 Mutations in Myelodysplastic Syndromes and Related Disorders

Ayana Kon, MD, Masashi Sanada, MD, PhD, Kenichi Yoshida, M.D., Yasunobu Nagata, MD, Yuichi Shiraishi, PhD, Yusuke Sato, MD, Aiko Sato-Otsubo, PhD, Ryo Yamamoto, MD, PhD, Masao Nagasaki, PhD, Yutaka Suzuki, PhD, Tomoyuki Yamaguchi, PhD, Makoto Otsu, MD, PhD, Sumio Sugano, PhD, Shigeru Chiba, MD, PhD, H. Phillip Koeffler, MD, PhD, Lee-Yung Shih, MD, PhD, Hiromitsu Nakauchi, MD, PhD, Satoru Miyano, PhD, Seishi Ogawa, M.D., Ph.D.

Blood (2011) 118 (21): 1706.

https://doi.org/10.1182/blood.V118.21.1706.1706

Published: 2011

Journal Articles

Evidence for the Involvement of CXCR4 Signaling in In Vivo Self-Renewal of Transplanted Hematopoietic Stem Cells

Chen-YI LAI, Makoto Otsu, MD, PhD, Motohito Okabe, Sachie Suzuki, M.D., Satoshi Yamazaki, Masafumi Onodera, M.D., Ph.D., Hideo Ema, M.D., Ph.D., Shigeru Kakuta, Ph.D., Yoichiro Iwakura, PhD, Hiromitsu Nakauchi, MD, PhD

Blood (2011) 118 (21): 1888.

https://doi.org/10.1182/blood.V118.21.1888.1888

Published: 2011

Journal Articles

Frequent Pathway Mutations of Splicing Machinery in Myelodysplasia

Blood (2011) 118 (21): 458.

https://doi.org/10.1182/blood.V118.21.458.458

Published: 2011

Journal Articles

Heterozygous ITGA2B R995W mutation inducing constitutive activation of the αIIbβ3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia

Shinji Kunishima, Hirokazu Kashiwagi, Makoto Otsu, Naoya Takayama, Koji Eto, Masafumi Onodera, Yuji Miyajima, Yasushi Takamatsu, Junji Suzumiya, Kousaku Matsubara, Yoshiaki Tomiyama, Hidehiko Saito

Blood (2011) 117 (20): 5479–5484.

https://doi.org/10.1182/blood-2010-12-323691

Published: 2011

Includes: Supplemental data

Journal Articles

Irradiated Bone Marrow Environment Impairs Hematopoietic Stem Cells by Exposure to Tumor Necrosis Factor a.

Sachie Suzuki, M.D., Motohito Okabe, Makoto Otsu, M.D., Ph.D., Hideo Ema, MD, PhD, Hiromitsu Nakauchi, M.D., Ph.D.

Blood (2010) 116 (21): 3724.

https://doi.org/10.1182/blood.V116.21.3724.3724

Published: 2010

Journal Articles

Unique Gain-of-Function of Mutated c-CBL Tumor Suppresor in Myeloid Neoplasms.

Blood (2009) 114 (22): 2970.

https://doi.org/10.1182/blood.V114.22.2970.2970

Published: 2009

Journal Articles

Definitive proof for direct reprogramming of hematopoietic cells to pluripotency

Motohito Okabe, Makoto Otsu, Dong Hyuck Ahn, Toshihiro Kobayashi, Yohei Morita, Yukiko Wakiyama, Masafumi Onodera, Koji Eto, Hideo Ema, Hiromitsu Nakauchi

Blood (2009) 114 (9): 1764–1767.

https://doi.org/10.1182/blood-2009-02-203695

Published: 2009

Includes: Supplemental data

Journal Articles

Reconstitution of lymphoid development and function in ZAP-70–deficient mice following gene transfer into bone marrow cells

Makoto Otsu, Marcos Steinberg, Christophe Ferrand, Peggy Merida, Cosette Rebouissou, Pierre Tiberghien, Naomi Taylor, Fabio Candotti, Nelly Noraz

Blood (2002) 100 (4): 1248–1256.

https://doi.org/10.1182/blood-2002-01-0247

Published: 2002

Journal Articles

Lack of dominant-negative effects of a truncated γc on retroviral-mediated gene correction of immunodeficient mice

Makoto Otsu, Kazuo Sugamura, Fabio Candotti

Blood (2001) 97 (6): 1618–1624.

https://doi.org/10.1182/blood.V97.6.1618

Published: 2001

Journal Articles

Lentiviral-mediated gene transfer into human lymphocytes: role of HIV-1 accessory proteins

Dhanalakshmi Chinnasamy, Nachimuthu Chinnasamy, Melissa J. Enriquez, Makoto Otsu, Richard A. Morgan, Fabio Candotti

Blood (2000) 96 (4): 1309–1316.

https://doi.org/10.1182/blood.V96.4.1309

Published: 2000

NARROW

Enhanced Selective Inhibition of KRAS Mutant Hematopoietic Progenitor Cell Expansion By MEK and Bcl-2 Inhibition

Proof of Benefit in Multiple-Cord Blood Transplantation Evidenced By Early Hematopoietic Reconstitution

Protection of Transplanted Hematopoietic Stem Cells from Inflammatory Recipient Marrow Environment through Specific TNF-α Signal Blockade

A New Strategy to Overcome the Cell Dose Barrier to Umbilical Cord Blood Transplants: A Proof of Early Hematopoietic Reconstitution By Combined Multiple Units of Allogeneic Stem/Progenitor Cells

Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells

Role Of Sf3b1 On Hematopoiesis

Biological Analysis of SRSF2 Mutations in Leukemogenesis

Recurrent Mutations of Multiple Components of Cohesin Complex in Myeloid Neoplasms

Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples

In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling

Functional Analysis of SRSF2 Mutations in Myelodysplastic Syndromes and Related Disorders

Evidence for the Involvement of CXCR4 Signaling in In Vivo Self-Renewal of Transplanted Hematopoietic Stem Cells

Frequent Pathway Mutations of Splicing Machinery in Myelodysplasia

Heterozygous ITGA2B R995W mutation inducing constitutive activation of the αIIbβ3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia

Irradiated Bone Marrow Environment Impairs Hematopoietic Stem Cells by Exposure to Tumor Necrosis Factor a.

Unique Gain-of-Function of Mutated c-CBL Tumor Suppresor in Myeloid Neoplasms.

Definitive proof for direct reprogramming of hematopoietic cells to pluripotency

Reconstitution of lymphoid development and function in ZAP-70–deficient mice following gene transfer into bone marrow cells

Lack of dominant-negative effects of a truncated γc on retroviral-mediated gene correction of immunodeficient mice

Lentiviral-mediated gene transfer into human lymphocytes: role of HIV-1 accessory proteins

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American Society of Hematology

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ASH Publications

American Society of Hematology

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