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Journal Articles

Proposal of New Diagnostic Criteria for Primary Immune Thrombocytopenia

Hirokazu Kashiwagi, Masataka Kuwana, Mitsuru Murata, Naoki Shimada, Toshiro Takafuta, Jun Yamanouchi, Hisashi Kato, Takaaki Hato, Yoshiaki Tomiyama

Blood (2023) 142 (Supplement 1): 1214.

https://doi.org/10.1182/blood-2023-179165

Published: 2023

Journal Articles

Non-Activating Integrin β3(R734C) Mutation Associated with Macrothrombocytopenia and Impaired Platelet Function

Keiichi Nakata, Keigo Akuta, Takaya Endo, Midori Koike, Hisashi Kato, Yoshiaki Tomiyama, Naoki Hosen, Hirokazu Kashiwagi

Blood (2023) 142 (Supplement 1): 2564.

https://doi.org/10.1182/blood-2023-178475

Published: 2023

Journal Articles

The Critical Role of Kindlin-3 in Intiation of Physiological Thrombus Formation ~ Analysis of Kindlin-3 Deficient Patient

Hisashi Kato, MD PhD, Shigenori Honda, MD, Hirokazu Kashiwagi, Nobuko Nishiura, Keigo Akuta, Koichi Kokame, Toshiyuki Miyata, Yoshiaki Tomiyama, MD

Blood (2019) 134 (Supplement_1): 1062.

https://doi.org/10.1182/blood-2019-129668

Published: 2019

Journal Articles

αIIb(R990W), a Gain-of Function Mutation of αIIbβ3, Knock-in Mice Show Moderately Impaired Thrombopoiesis

Keigo Akuta, Kazunobu Kiyomizu, MD, Hirokazu Kashiwagi, Shinji Kunishima, PhD, Fumiaki Banno, Koichi Kokame, Nobuko Nishiura, Hisashi Kato, MD PhD, Shigenori Honda, MD, Yuzuru Kanakura, MD PhD, Toshiyuki Miyata, Yoshiaki Tomiyama, MD

Blood (2018) 132 (Supplement 1): 3743.

https://doi.org/10.1182/blood-2018-99-115953

Published: 2018

Journal Articles

Platelet Integrin αIIbβ3 Activation Kinetics in Inherited Platelet Functional Disorders ∼ the Role of ADP Receptor P2Y12, Caldag-GEFI and Kindlin-3 αIIbβ3 Activation By inside-out Signaling

Hisashi Kato, MDPhD, Nobuko Nishiura, Keigo Akuta, Hirokazu Kashiwagi, Koichi Kokame, Toshiyuki Miyata, Yuzuru Kanakura, MD PhD, Yoshiaki Tomiyama, MD

Blood (2018) 132 (Supplement 1): 1136.

https://doi.org/10.1182/blood-2018-99-112852

Published: 2018

Journal Articles

Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation

Hisashi Kato, Yozo Nakazawa, Yumi Kurokawa, Hirokazu Kashiwagi, Yoichiro Morikawa, Daisuke Morita, Fumiaki Banno, Shigenori Honda, Yuzuru Kanakura, Yoshiaki Tomiyama

Blood (2016) 128 (23): 2729–2733.

https://doi.org/10.1182/blood-2016-03-704825

Published: 2016

Includes: Supplemental data

Journal Articles

The Association of PAR4 Polymorphism with Human Platelet Reactivity in Japanese

Yoichiro Morikawa, MD, Hisashi Kato, MD PhD, Keigo Akuta, MD, Hirokazu Kashiwagi, MD PhD, Shigenori Honda, MD PhD, Yuzuru Kanakura, MD PhD, Yoshiaki Tomiyama, MD PhD

Blood (2016) 128 (22): 4908.

https://doi.org/10.1182/blood.V128.22.4908.4908

Published: 2016

Journal Articles

αIIb(R990W), a Constitutive Activating Mutation of Integrin αIIbβ3, Knock-in Mice Show Macrothrombocytopenia with Impairment of Platelet Function

Kazunobu Kiyomizu, Hirokazu Kashiwagi, Shinji Kunishima, PhD, Fumiaki Banno, PhD, Hisashi Kato, Youichiro Morikawa, Seiji Tadokoro, Koichi Kokame, PhD, Shigenori Honda, MD PhD, Toshiyuki Miyata, PhD, Yuzuru Kanakura, Yoshiaki Tomiyama

Blood (2014) 124 (21): 4182.

https://doi.org/10.1182/blood.V124.21.4182.4182

Published: 2014

Journal Articles

Recognition of highly restricted regions in the β-propeller domain of αIIb by platelet-associated anti-αIIbβ3 autoantibodies in primary immune thrombocytopenia

Kazunobu Kiyomizu, Hirokazu Kashiwagi, Tsuyoshi Nakazawa, Seiji Tadokoro, Shigenori Honda, Yuzuru Kanakura, Yoshiaki Tomiyama

Blood (2012) 120 (7): 1499–1509.

https://doi.org/10.1182/blood-2012-02-409995

Published: 2012

Includes: Supplemental data

Journal Articles

Agonist Stimulation, Talin-1, and Kindlin-3 Are Crucial for α ¶b β 3 activation in a Human Megakaryoblastic Cell Line, CMK

Tsuyoshi Nakazawa, Seiji Tadokoro, Kazunobu Kiyomizu, Hirokazu Kashiwagi, Shigenori Honda, Yoshiaki Tomiyama, Yuzuru Kanakura

Blood (2011) 118 (21): 1137.

https://doi.org/10.1182/blood.V118.21.1137.1137

Published: 2011

Journal Articles

Heterozygous ITGA2B R995W mutation inducing constitutive activation of the αIIbβ3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia

Shinji Kunishima, Hirokazu Kashiwagi, Makoto Otsu, Naoya Takayama, Koji Eto, Masafumi Onodera, Yuji Miyajima, Yasushi Takamatsu, Junji Suzumiya, Kousaku Matsubara, Yoshiaki Tomiyama, Hidehiko Saito

Blood (2011) 117 (20): 5479–5484.

https://doi.org/10.1182/blood-2010-12-323691

Published: 2011

Includes: Supplemental data

Journal Articles

A potential role for α-actinin in inside-out αIIbβ3 signaling

Seiji Tadokoro, Tsuyoshi Nakazawa, Tsuyoshi Kamae, Kazunobu Kiyomizu, Hirokazu Kashiwagi, Shigenori Honda, Yuzuru Kanakura, Yoshiaki Tomiyama

Blood (2011) 117 (1): 250–258.

https://doi.org/10.1182/blood-2009-10-246751

Published: 2011

Includes: Supplemental data

Journal Articles

Bleeding Tendency and Impaired Platelet Function In a Patient Carrying a Heterozygous Mutation In Thromboxane A2 Receptor

Tsuyoshi Kamae, MD, Kazunobu Kiyomizu, MD, Tsuyoshi Nakazawa, MD, Seiji Tadokoro, MD, Shigenori Honda, MD, Hirokazu Kashiwagi, MD, Yuzuru Kanakura, MD, PhD, Yoshiaki Tomiyama, MD

Blood (2010) 116 (21): 2524.

https://doi.org/10.1182/blood.V116.21.2524.2524

Published: 2010

Journal Articles

A Role for α-Actinin in Inside-out αIIbβ3 Signaling.

Seiji Tadokoro, Masamichi Shiraga, Hirokazu Kashiwagi, Tsuyoshi Kamae, Masao Akiyama, Tsuyoshi Nakazawa, Yuzuru Kanakura, Yoshiaki Tomiyama

Blood (2008) 112 (11): 1849.

https://doi.org/10.1182/blood.V112.11.1849.1849

Published: 2008

Journal Articles

P2Y 12 -Independent Transient Activation and P2Y 12 -Dependent Prolonged Activation of Platelet Integrin α IIb β 3 .

Masamichi Shiraga, MD, Tsuyoshi Kamae, MD, Masao Akiyama, MD, Seiji Tadokoro, MD, Hirokazu Kashiwagi, MD, Kenji Oritani, MD, Yoshiyuki Kurata, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD

Blood (2006) 108 (11): 1509.

https://doi.org/10.1182/blood.V108.11.1509.1509

Published: 2006

Journal Articles

Critical Role of Endogenous ADP Via P2Y12 Receptor in Maintenance of α Iib β 3 Activation.

Tsuyoshi Kamae, MD, Masamichi Shiraga, MD, Hirokazu Kashiwagi, MD, Hisashi Kato, MD, Seiji Tadokoro, MD, Yoshiyuki Kurata, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD

Blood (2005) 106 (11): 1655.

https://doi.org/10.1182/blood.V106.11.1655.1655

Published: 2005

Journal Articles

Negative regulation of platelet function by a secreted cell repulsive protein, semaphorin 3A

Hirokazu Kashiwagi, Masamichi Shiraga, Hisashi Kato, Tsuyoshi Kamae, Naoko Yamamoto, Seiji Tadokoro, Yoshiyuki Kurata, Yoshiaki Tomiyama, Yuzuru Kanakura

Blood (2005) 106 (3): 913–921.

https://doi.org/10.1182/blood-2004-10-4092

Published: 2005

Journal Articles

Negative Regulation of Platelet Function by a Secreted Cell Repulsive Protein, Semaphorin 3A.

Hirokazu Kashiwagi, MD, Masamichi Shiraga, MD, Hisashi Kato, MD, Tsuyoshi Kamae, MD, Naoko Yamamoto, MD, Seiji Tadokoro, MD, Yoshiyuki Kurata, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD, PhD

Blood (2004) 104 (11): 1546.

https://doi.org/10.1182/blood.V104.11.1546.1546

Published: 2004

Journal Articles

Enhanced Platelet Aggregation and Thrombogenic Tendency in Adiponectin-Deficient Mice.

Hisashi Kato, Graduate Student, Hirokazu Kashiwagi, MD, Masamichi Shiraga, MD, Shigenori Honda, MD, Shigeki Miyata, MD, Junichiro Yamamoto, PhD, Yoshiyuki Kurata, MD, Tohru Funahashi, MD, Iichiro Shimomura, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD

Blood (2004) 104 (11): 800.

https://doi.org/10.1182/blood.V104.11.800.800

Published: 2004

Journal Articles

Impaired Platelet Function in a P2Y 12 -Deficient Patient Caused by a Mutation in the Translation Initiation Codon.

Masamichi Shiraga, MD, Shigeki Miyata, MD, Tsuyoshi Kamae, MD, Hisashi Kato, MD, Teruo Kiyoi, MD, Hirokazu Kashiwagi, MD, Shigenori Honda, MD, Yoshiyuki Kurata, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD

Blood (2004) 104 (11): 742.

https://doi.org/10.1182/blood.V104.11.742.742

Published: 2004

NARROW

Proposal of New Diagnostic Criteria for Primary Immune Thrombocytopenia

Non-Activating Integrin β3(R734C) Mutation Associated with Macrothrombocytopenia and Impaired Platelet Function

The Critical Role of Kindlin-3 in Intiation of Physiological Thrombus Formation ~ Analysis of Kindlin-3 Deficient Patient

αIIb(R990W), a Gain-of Function Mutation of αIIbβ3, Knock-in Mice Show Moderately Impaired Thrombopoiesis

Platelet Integrin αIIbβ3 Activation Kinetics in Inherited Platelet Functional Disorders ∼ the Role of ADP Receptor P2Y12, Caldag-GEFI and Kindlin-3 αIIbβ3 Activation By inside-out Signaling

Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation

The Association of PAR4 Polymorphism with Human Platelet Reactivity in Japanese

αIIb(R990W), a Constitutive Activating Mutation of Integrin αIIbβ3, Knock-in Mice Show Macrothrombocytopenia with Impairment of Platelet Function

Recognition of highly restricted regions in the β-propeller domain of αIIb by platelet-associated anti-αIIbβ3 autoantibodies in primary immune thrombocytopenia

Agonist Stimulation, Talin-1, and Kindlin-3 Are Crucial for α ¶b β 3 activation in a Human Megakaryoblastic Cell Line, CMK

Heterozygous ITGA2B R995W mutation inducing constitutive activation of the αIIbβ3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia

A potential role for α-actinin in inside-out αIIbβ3 signaling

Bleeding Tendency and Impaired Platelet Function In a Patient Carrying a Heterozygous Mutation In Thromboxane A2 Receptor

A Role for α-Actinin in Inside-out αIIbβ3 Signaling.

P2Y 12 -Independent Transient Activation and P2Y 12 -Dependent Prolonged Activation of Platelet Integrin α IIb β 3 .

Critical Role of Endogenous ADP Via P2Y12 Receptor in Maintenance of α Iib β 3 Activation.

Negative regulation of platelet function by a secreted cell repulsive protein, semaphorin 3A

Negative Regulation of Platelet Function by a Secreted Cell Repulsive Protein, Semaphorin 3A.

Enhanced Platelet Aggregation and Thrombogenic Tendency in Adiponectin-Deficient Mice.

Impaired Platelet Function in a P2Y 12 -Deficient Patient Caused by a Mutation in the Translation Initiation Codon.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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