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Journal Articles

The Critical Role of Kindlin-3 in Intiation of Physiological Thrombus Formation ~ Analysis of Kindlin-3 Deficient Patient

Hisashi Kato, MD PhD, Shigenori Honda, MD, Hirokazu Kashiwagi, Nobuko Nishiura, Keigo Akuta, Koichi Kokame, Toshiyuki Miyata, Yoshiaki Tomiyama, MD

Blood (2019) 134 (Supplement_1): 1062.

https://doi.org/10.1182/blood-2019-129668

Published: 2019

Journal Articles

αIIb(R990W), a Gain-of Function Mutation of αIIbβ3, Knock-in Mice Show Moderately Impaired Thrombopoiesis

Keigo Akuta, Kazunobu Kiyomizu, MD, Hirokazu Kashiwagi, Shinji Kunishima, PhD, Fumiaki Banno, Koichi Kokame, Nobuko Nishiura, Hisashi Kato, MD PhD, Shigenori Honda, MD, Yuzuru Kanakura, MD PhD, Toshiyuki Miyata, Yoshiaki Tomiyama, MD

Blood (2018) 132 (Supplement 1): 3743.

https://doi.org/10.1182/blood-2018-99-115953

Published: 2018

Journal Articles

Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation

Hisashi Kato, Yozo Nakazawa, Yumi Kurokawa, Hirokazu Kashiwagi, Yoichiro Morikawa, Daisuke Morita, Fumiaki Banno, Shigenori Honda, Yuzuru Kanakura, Yoshiaki Tomiyama

Blood (2016) 128 (23): 2729–2733.

https://doi.org/10.1182/blood-2016-03-704825

Published: 2016

Includes: Supplemental data

Journal Articles

The Association of PAR4 Polymorphism with Human Platelet Reactivity in Japanese

Yoichiro Morikawa, MD, Hisashi Kato, MD PhD, Keigo Akuta, MD, Hirokazu Kashiwagi, MD PhD, Shigenori Honda, MD PhD, Yuzuru Kanakura, MD PhD, Yoshiaki Tomiyama, MD PhD

Blood (2016) 128 (22): 4908.

https://doi.org/10.1182/blood.V128.22.4908.4908

Published: 2016

Journal Articles

αIIb(R990W), a Constitutive Activating Mutation of Integrin αIIbβ3, Knock-in Mice Show Macrothrombocytopenia with Impairment of Platelet Function

Kazunobu Kiyomizu, Hirokazu Kashiwagi, Shinji Kunishima, PhD, Fumiaki Banno, PhD, Hisashi Kato, Youichiro Morikawa, Seiji Tadokoro, Koichi Kokame, PhD, Shigenori Honda, MD PhD, Toshiyuki Miyata, PhD, Yuzuru Kanakura, Yoshiaki Tomiyama

Blood (2014) 124 (21): 4182.

https://doi.org/10.1182/blood.V124.21.4182.4182

Published: 2014

Journal Articles

Analysis of Genetic and Predisposing Factors in Japanese Patients with Atypical Hemolytic Uremic Syndrome

Xinping Fan, MD, Yoko Yoshida, MS, Toshiyuki Miyata, PhD, Shigenori Honda, MD, PhD, Masanori Matsumoto, MD, PhD, Yoshihiro Fujimura, MD, PhD

Blood (2012) 120 (21): 3337.

https://doi.org/10.1182/blood.V120.21.3337.3337

Published: 2012

Journal Articles

Recognition of highly restricted regions in the β-propeller domain of αIIb by platelet-associated anti-αIIbβ3 autoantibodies in primary immune thrombocytopenia

Kazunobu Kiyomizu, Hirokazu Kashiwagi, Tsuyoshi Nakazawa, Seiji Tadokoro, Shigenori Honda, Yuzuru Kanakura, Yoshiaki Tomiyama

Blood (2012) 120 (7): 1499–1509.

https://doi.org/10.1182/blood-2012-02-409995

Published: 2012

Includes: Supplemental data

Journal Articles

Agonist Stimulation, Talin-1, and Kindlin-3 Are Crucial for α ¶b β 3 activation in a Human Megakaryoblastic Cell Line, CMK

Tsuyoshi Nakazawa, Seiji Tadokoro, Kazunobu Kiyomizu, Hirokazu Kashiwagi, Shigenori Honda, Yoshiaki Tomiyama, Yuzuru Kanakura

Blood (2011) 118 (21): 1137.

https://doi.org/10.1182/blood.V118.21.1137.1137

Published: 2011

Journal Articles

A potential role for α-actinin in inside-out αIIbβ3 signaling

Seiji Tadokoro, Tsuyoshi Nakazawa, Tsuyoshi Kamae, Kazunobu Kiyomizu, Hirokazu Kashiwagi, Shigenori Honda, Yuzuru Kanakura, Yoshiaki Tomiyama

Blood (2011) 117 (1): 250–258.

https://doi.org/10.1182/blood-2009-10-246751

Published: 2011

Includes: Supplemental data

Journal Articles

Bleeding Tendency and Impaired Platelet Function In a Patient Carrying a Heterozygous Mutation In Thromboxane A2 Receptor

Tsuyoshi Kamae, MD, Kazunobu Kiyomizu, MD, Tsuyoshi Nakazawa, MD, Seiji Tadokoro, MD, Shigenori Honda, MD, Hirokazu Kashiwagi, MD, Yuzuru Kanakura, MD, PhD, Yoshiaki Tomiyama, MD

Blood (2010) 116 (21): 2524.

https://doi.org/10.1182/blood.V116.21.2524.2524

Published: 2010

Journal Articles

Integrin-linked kinase associated with integrin activation

Shigenori Honda, Hiroko Shirotani-Ikejima, Seiji Tadokoro, Yusuke Maeda, Taroh Kinoshita, Yoshiaki Tomiyama, Toshiyuki Miyata

Blood (2009) 113 (21): 5304–5313.

https://doi.org/10.1182/blood-2008-07-169136

Published: 2009

Journal Articles

Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura

Fumiaki Banno, Koichi Kokame, Tomohiko Okuda, Shigenori Honda, Shigeki Miyata, Hisashi Kato, Yoshiaki Tomiyama, Toshiyuki Miyata

Blood (2006) 107 (8): 3161–3166.

https://doi.org/10.1182/blood-2005-07-2765

Published: 2006

Journal Articles

Protein S–K196E mutation as a genetic risk factor for deep vein thrombosis in Japanese patients

Rina Kimura, Shigenori Honda, Tomio Kawasaki, Hajime Tsuji, Seiji Madoiwa, Yoichi Sakata, Tetsuhito Kojima, Mitsuru Murata, Kazuhiro Nishigami, Masaaki Chiku, Tokio Hayashi, Yoshihiro Kokubo, Akira Okayama, Hitonobu Tomoike, Yasuo Ikeda, Toshiyuki Miyata

Blood (2006) 107 (4): 1737–1738.

https://doi.org/10.1182/blood-2005-09-3892

Published: 2006

Journal Articles

Enhanced Platelet Aggregation and Thrombogenic Tendency in Adiponectin-Deficient Mice.

Hisashi Kato, Graduate Student, Hirokazu Kashiwagi, MD, Masamichi Shiraga, MD, Shigenori Honda, MD, Shigeki Miyata, MD, Junichiro Yamamoto, PhD, Yoshiyuki Kurata, MD, Tohru Funahashi, MD, Iichiro Shimomura, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD

Blood (2004) 104 (11): 800.

https://doi.org/10.1182/blood.V104.11.800.800

Published: 2004

Journal Articles

Impaired Platelet Function in a P2Y 12 -Deficient Patient Caused by a Mutation in the Translation Initiation Codon.

Masamichi Shiraga, MD, Shigeki Miyata, MD, Tsuyoshi Kamae, MD, Hisashi Kato, MD, Teruo Kiyoi, MD, Hirokazu Kashiwagi, MD, Shigenori Honda, MD, Yoshiyuki Kurata, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD

Blood (2004) 104 (11): 742.

https://doi.org/10.1182/blood.V104.11.742.742

Published: 2004

Journal Articles

A naturally occurring Tyr143Hisα IIb mutation abolishes α IIb β 3 function for soluble ligands but retains its ability for mediating cell adhesion and clot retraction: comparison with other mutations causing ligand-binding defects

Teruo Kiyoi, Yoshiaki Tomiyama, Shigenori Honda, Seiji Tadokoro, Morio Arai, Hirokazu Kashiwagi, Satoru Kosugi, Hisashi Kato, Yoshiyuki Kurata, Yuji Matsuzawa

Blood (2003) 101 (9): 3485–3491.

https://doi.org/10.1182/blood-2002-07-2144

Published: 2003

Journal Articles

Missense mutations in the β 3 subunit have a different impact on the expression and function between α IIb β 3 and α v β 3

Seiji Tadokoro, Yoshiaki Tomiyama, Shigenori Honda, Hirokazu Kashiwagi, Satoru Kosugi, Masamichi Shiraga, Teruo Kiyoi, Yoshiyuki Kurata, Yuji Matsuzawa

Blood (2002) 99 (3): 931–938.

https://doi.org/10.1182/blood.V99.3.931

Published: 2002

Journal Articles

Platelet-associated anti–GPIIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura recognizing epitopes close to the ligand-binding site of glycoprotein (GP) IIb

Satoru Kosugi, Yoshiaki Tomiyama, Shigenori Honda, Hisashi Kato, Teruo Kiyoi, Hirokazu Kashiwagi, Yoshiyuki Kurata, Yuji Matsuzawa

Blood (2001) 98 (6): 1819–1827.

https://doi.org/10.1182/blood.V98.6.1819

Published: 2001

Journal Articles

Ligand binding to integrin α v β 3 requires tyrosine 178 in the α v subunit

Shigenori Honda, Yoshiaki Tomiyama, Nisar Pampori, Hirokazu Kashiwagi, Teruo Kiyoi, Satoru Kosugi, Seiji Tadokoro, Yoshiyuki Kurata, Sanford J. Shattil, Yuji Matsuzawa

Blood (2001) 97 (1): 175–182.

https://doi.org/10.1182/blood.V97.1.175

Published: 2001

Journal Articles

A Mutation in the Extracellular Cysteine-Rich Repeat Region of the β 3 Subunit Activates Integrins  IIb β 3 and  V β 3

Hirokazu Kashiwagi, Yoshiaki Tomiyama, Seiji Tadokoro, Shigenori Honda, Masamichi Shiraga, Hajime Mizutani, Makoto Handa, Yoshiyuki Kurata, Yuji Matsuzawa, Sanford J. Shattil

Blood (1999) 93 (8): 2559–2568.

https://doi.org/10.1182/blood.V93.8.2559

Published: 1999

NARROW

The Critical Role of Kindlin-3 in Intiation of Physiological Thrombus Formation ~ Analysis of Kindlin-3 Deficient Patient

αIIb(R990W), a Gain-of Function Mutation of αIIbβ3, Knock-in Mice Show Moderately Impaired Thrombopoiesis

Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation

The Association of PAR4 Polymorphism with Human Platelet Reactivity in Japanese

αIIb(R990W), a Constitutive Activating Mutation of Integrin αIIbβ3, Knock-in Mice Show Macrothrombocytopenia with Impairment of Platelet Function

Analysis of Genetic and Predisposing Factors in Japanese Patients with Atypical Hemolytic Uremic Syndrome

Recognition of highly restricted regions in the β-propeller domain of αIIb by platelet-associated anti-αIIbβ3 autoantibodies in primary immune thrombocytopenia

Agonist Stimulation, Talin-1, and Kindlin-3 Are Crucial for α ¶b β 3 activation in a Human Megakaryoblastic Cell Line, CMK

A potential role for α-actinin in inside-out αIIbβ3 signaling

Bleeding Tendency and Impaired Platelet Function In a Patient Carrying a Heterozygous Mutation In Thromboxane A2 Receptor

Integrin-linked kinase associated with integrin activation

Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura

Protein S–K196E mutation as a genetic risk factor for deep vein thrombosis in Japanese patients

Enhanced Platelet Aggregation and Thrombogenic Tendency in Adiponectin-Deficient Mice.

Impaired Platelet Function in a P2Y 12 -Deficient Patient Caused by a Mutation in the Translation Initiation Codon.

A naturally occurring Tyr143Hisα IIb mutation abolishes α IIb β 3 function for soluble ligands but retains its ability for mediating cell adhesion and clot retraction: comparison with other mutations causing ligand-binding defects

Missense mutations in the β 3 subunit have a different impact on the expression and function between α IIb β 3 and α v β 3

Platelet-associated anti–GPIIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura recognizing epitopes close to the ligand-binding site of glycoprotein (GP) IIb

Ligand binding to integrin α v β 3 requires tyrosine 178 in the α v subunit

A Mutation in the Extracellular Cysteine-Rich Repeat Region of the β 3 Subunit Activates Integrins  IIb β 3 and  V β 3

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American Society of Hematology

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American Society of Hematology

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