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Journal Articles

iPLAT1: the first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study

Blood (2022) 140 (22): 2398–2402.

https://doi.org/10.1182/blood.2022017296

Published: 2022

Includes: Supplemental data

Journal Articles

The First-in-Human Clinical Trial of iPSC-Derived Platelets (iPLAT1): Autologous Transfusion to an Aplastic Anemia Patient with Alloimmune Platelet Transfusion Refractoriness

Naoshi Sugimoto, Junya Kanda, Sou Nakamura, Toshiyuki Kitano, Masakatsu Hishizawa, Tadakazu Kondo, Shin Shimizu, Akiko Shigemasa, Hideyo Hirai, Harue Tada, Manabu Minami, Naohide Watanabe, Masayuki Nogawa, Makoto Handa, Yoshihiko Tani, Akifumi Takaori-Kondo, Koji Eto

Blood (2021) 138 (Supplement 1): 351.

https://doi.org/10.1182/blood-2021-145814

Published: 2021

Journal Articles

High-Vorticity with Periodic Flow Enhances in Vitro Biogenesis of Healthy Platelets from iPSC-Derived-Megakaryocytes

Yukitaka Ito, Sou Nakamura, Tomohiro Shigemori, Naoshi Sugimoto, MD PhD, Yoshikazu Kato, Kazuya Hashimoto, Naohide Watanabe, Masayuki Nogawa, Makoto Handa, Satoshi Nishimura, Koji Eto

Blood (2016) 128 (22): 2181.

https://doi.org/10.1182/blood.V128.22.2181.2181

Published: 2016

Journal Articles

Enumeration of Peripheral Blood Hematopoietic Stem Cells Using Automated Hematology Analyzer, Sysmex-XN: Final Resutls of Multicenter Prospective Study

Ryuji Tanosaki, MD PhD, Yoshiki Okuyama, MD, Tohru Iseki, MD PhD, Makoto Handa, Shuichi Kino, MD, Katsuya Ikuta, MD PhD, Shigehisa Yoshida, M.T., Kyoko Haraguchi, MD, Naomi Shimizu, MD, Shio Sakai, MD PhD, Naohide Watanabe, MD PhD, Tomoe Uemura, M.T., Yoshie Kawahara, M.T., Kazuo Muroi, MD, PhD, Tokiko Nagamura-Inoue, MD PhD, Minoko Takanashi, MD PhD

Blood (2015) 126 (23): 4304.

https://doi.org/10.1182/blood.V126.23.4304.4304

Published: 2015

Journal Articles

Enumeration of Peripheral Blood Hematopoietic Stem Cells Using Automated Hematology Analyzer, Sysmex-XN: A Multicenter Prospective Study

Ryuji Tanosaki, MD, PhD, Yoshiki Okuyama, MD, PhD, Tohru Iseki, MD, PhD, Makoto Handa, MD, PhD, Shuichi Kino, MD, PhD, Tomoko Kumazawa, MT, Shigeyoshi Yoshida, MT, Kyoko Haraguchi, MD, Naomi Shimizu, MD, PhD, Shio Sakai, MD, PhD, Naohide Watanabe, MD, PhD, Tomoe Uemura, MT, Katsuya Ikuta, MD, PhD, Yoshie Kawahara, MT, Kazuo Muroi, MD, PhD, Tokiko Nagamura Inoue, MD, PhD, Minoko Takanashi, MD, PhD

Blood (2013) 122 (21): 2032.

https://doi.org/10.1182/blood.V122.21.2032.2032

Published: 2013

Journal Articles

Divalent Cations Define the Structural Requirements for αIIbβ3 Integrin Activation

Tetsuji Kamata, MD, Makoto Handa, MD, Yohko Kawai, MD, Yasuo Ikeda, MD, Sadakazu Aiso, MD

Blood (2012) 120 (21): 260.

https://doi.org/10.1182/blood.V120.21.260.260

Published: 2012

Journal Articles

Regulatory Role of the Extracellular α-Tail/β-Tail Interaction in αIIbβ3 Integrin Activation

Tetsuji Kamata, MD, Makoto Handa, MD, Yohko Kawai, MD, Yasuo Ikeda, MD, Sadakazu Aiso, MD

Blood (2010) 116 (21): 3199.

https://doi.org/10.1182/blood.V116.21.3199.3199

Published: 2010

Journal Articles

SHD1 is a novel cytokine-inducible, negative feedback regulator of STAT5-dependent transcription

Hideaki Nakajima, Toshiki Tamura, Miyuki Ito, Fumi Shibata, Kana Kuroda, Yumi Fukuchi, Naohide Watanabe, Toshio Kitamura, Yasuo Ikeda, Makoto Handa

Blood (2009) 113 (5): 1027–1036.

https://doi.org/10.1182/blood-2008-01-133405

Published: 2009

Includes: Supplemental data

Journal Articles

Dissociation of the Extracellular α-Tail/β-Tail Interface Interaction Activates αIIbβ3 Integrin.

Tetsuji Kamata, MD, Makoto Handa, MD, Yasuo Ikeda, MD, Sadakazu Aiso, MD, PhD

Blood (2006) 108 (11): 213.

https://doi.org/10.1182/blood.V108.11.213.213

Published: 2006

Journal Articles

Phosphoinositide3-Kinase Independent Regulation of Bruton’s Tyrosine Kinase in Platelet Immunoreceptor Signaling.

Naohide Watanabe, MD., PhD., Hideaki Nakajima, MD., PhD., Atsushi Oda, MD., PhD., Yasuo Ikeda, MD., PhD., Makoto Handa, MD., PhD.

Blood (2004) 104 (11): 3536.

https://doi.org/10.1182/blood.V104.11.3536.3536

Published: 2004

Journal Articles

Dissecting the Structural Rearrangement and Activation of αIIbβ3 Integrin with a Disulfide Bridge.

Tetsuji Kamata, M.D., Makoto Handa, M.D., Yasuo Ikeda, M.D., Sadakazu Aiso, M.D.

Blood (2004) 104 (11): 328.

https://doi.org/10.1182/blood.V104.11.328.328

Published: 2004

Journal Articles

Hemostatic Effects of Fibrinogen-γ Chain Dodecapeptide-Conjugated Polymerized Albumin Particles In Vitro and in Vivo .

Yosuke Okamura, Naohide Watanabe, MD, Shinji Takeoka, PhD, Hidenori Suzuki, MD, Mitsuru Murata, MD, Yasuo Ikeda, MD, Makoto Handa, MD

Blood (2004) 104 (11): 3883.

https://doi.org/10.1182/blood.V104.11.3883.3883

Published: 2004

Journal Articles

Functional phenotype of phosphoinositide 3-kinase p85α-null platelets characterized by an impaired response to GP VI stimulation

Naohide Watanabe, Hideaki Nakajima, Hidenori Suzuki, Atsushi Oda, Yumiko Matsubara, Masaaki Moroi, Yasuo Terauchi, Takashi Kadowaki, Harumi Suzuki, Shigeo Koyasu, Yasuo Ikeda, Makoto Handa

Blood (2003) 102 (2): 541–548.

https://doi.org/10.1182/blood-2002-11-3327

Published: 2003

Journal Articles

Reconstitution of adhesive properties of human platelets in liposomes carrying both recombinant glycoproteins Ia/IIa and Ibα under flow conditions: specific synergy of receptor–ligand interactions

Takako Nishiya, Mie Kainoh, Mitsuru Murata, Makoto Handa, Yasuo Ikeda

Blood (2002) 100 (1): 136–142.

https://doi.org/10.1182/blood.V100.1.136

Published: 2002

Journal Articles

CrkL is an adapter for Wiskott-Aldrich syndrome protein and Syk

Atsushi Oda, Hans D. Ochs, Laurence A. Lasky, Susan Spencer, Katsutoshi Ozaki, Mitsuhiro Fujihara, Makoto Handa, Kenji Ikebuchi, Hisami Ikeda

Blood (2001) 97 (9): 2633–2639.

https://doi.org/10.1182/blood.V97.9.2633

Published: 2001

Journal Articles

Rapid tyrosine phosphorylation and activation of Bruton's tyrosine/Tec kinases in platelets induced by collagen binding or CD32 cross-linking

Atsushi Oda, Yasuo Ikeda, Hans D. Ochs, Brian J. Druker, Katsutsohi Ozaki, Makoto Handa, Tadashi Ariga, Yukio Sakiyama, Owen N. Witte, Matthew I. Wahl

Blood (2000) 95 (5): 1663–1670.

https://doi.org/10.1182/blood.V95.5.1663.005k44_1663_1670

Published: 2000

Journal Articles

Association between diabetic retinopathy and genetic variations in α2β1 integrin, a platelet receptor for collagen

Yumiko Matsubara, Mitsuru Murata, Taro Maruyama, Makoto Handa, Norihiko Yamagata, Gentaro Watanabe, Takao Saruta, Yasuo Ikeda

Blood (2000) 95 (5): 1560–1564.

https://doi.org/10.1182/blood.V95.5.1560.005k43_1560_1564

Published: 2000

Journal Articles

Phosphatidylinositol 3-Kinase Is Involved in the Protection of Primary Cultured Human Erythroid Precursor Cells From Apoptosis

Yoshihito Haseyama, Ken-ichi Sawada, Atsushi Oda, Kazuki Koizumi, Hina Takano, Takashi Tarumi, Mitsufumi Nishio, Makoto Handa, Yasuo Ikeda, Takao Koike

Blood (1999) 94 (5): 1568–1577.

https://doi.org/10.1182/blood.V94.5.1568

Published: 1999

Journal Articles

A Mutation in the Extracellular Cysteine-Rich Repeat Region of the β 3 Subunit Activates Integrins  IIb β 3 and  V β 3

Hirokazu Kashiwagi, Yoshiaki Tomiyama, Seiji Tadokoro, Shigenori Honda, Masamichi Shiraga, Hajime Mizutani, Makoto Handa, Yoshiyuki Kurata, Yuji Matsuzawa, Sanford J. Shattil

Blood (1999) 93 (8): 2559–2568.

https://doi.org/10.1182/blood.V93.8.2559

Published: 1999

Journal Articles

Thrombopoietin Induces Association of Crkl With STAT5 But Not STAT3 in Human Platelets

Katsutoshi Ozaki, Atsushi Oda, Hiroshi Wakao, Jennifer Rhodes, Brian J. Druker, Akaru Ishida, Masatoshi Wakui, Shinichiro Okamoto, Kayo Morita, Makoto Handa, Norio Komatsu, Hideya Ohashi, Atsushi Miyajima, Yasuo Ikeda

Blood (1998) 92 (12): 4652–4662.

https://doi.org/10.1182/blood.V92.12.4652

Published: 1998

NARROW

iPLAT1: the first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study

The First-in-Human Clinical Trial of iPSC-Derived Platelets (iPLAT1): Autologous Transfusion to an Aplastic Anemia Patient with Alloimmune Platelet Transfusion Refractoriness

High-Vorticity with Periodic Flow Enhances in Vitro Biogenesis of Healthy Platelets from iPSC-Derived-Megakaryocytes

Enumeration of Peripheral Blood Hematopoietic Stem Cells Using Automated Hematology Analyzer, Sysmex-XN: Final Resutls of Multicenter Prospective Study

Enumeration of Peripheral Blood Hematopoietic Stem Cells Using Automated Hematology Analyzer, Sysmex-XN: A Multicenter Prospective Study

Divalent Cations Define the Structural Requirements for αIIbβ3 Integrin Activation

Regulatory Role of the Extracellular α-Tail/β-Tail Interaction in αIIbβ3 Integrin Activation

SHD1 is a novel cytokine-inducible, negative feedback regulator of STAT5-dependent transcription

Dissociation of the Extracellular α-Tail/β-Tail Interface Interaction Activates αIIbβ3 Integrin.

Phosphoinositide3-Kinase Independent Regulation of Bruton’s Tyrosine Kinase in Platelet Immunoreceptor Signaling.

Dissecting the Structural Rearrangement and Activation of αIIbβ3 Integrin with a Disulfide Bridge.

Hemostatic Effects of Fibrinogen-γ Chain Dodecapeptide-Conjugated Polymerized Albumin Particles In Vitro and in Vivo .

Functional phenotype of phosphoinositide 3-kinase p85α-null platelets characterized by an impaired response to GP VI stimulation

Reconstitution of adhesive properties of human platelets in liposomes carrying both recombinant glycoproteins Ia/IIa and Ibα under flow conditions: specific synergy of receptor–ligand interactions

CrkL is an adapter for Wiskott-Aldrich syndrome protein and Syk

Rapid tyrosine phosphorylation and activation of Bruton's tyrosine/Tec kinases in platelets induced by collagen binding or CD32 cross-linking

Association between diabetic retinopathy and genetic variations in α2β1 integrin, a platelet receptor for collagen

Phosphatidylinositol 3-Kinase Is Involved in the Protection of Primary Cultured Human Erythroid Precursor Cells From Apoptosis

A Mutation in the Extracellular Cysteine-Rich Repeat Region of the β 3 Subunit Activates Integrins  IIb β 3 and  V β 3

Thrombopoietin Induces Association of Crkl With STAT5 But Not STAT3 in Human Platelets

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American Society of Hematology

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American Society of Hematology

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