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Journal Articles

Efficacy and Safety of Avatrombopag in Japanese Adults with Chronic Immune Thrombocytopenia: Open-Label, Phase 3 Study

Hiroki Yamaguchi, Masaki Iino, Yutaka Imamura, Shugo Kowata, Ryusuke Yamamoto, Jun Yamanouchi, Masato Fujii, Jessica Zhang, Yoshiaki Tomiyama, Brian Jamieson

Blood (2024) 144 (Supplement 1): 5426.

https://doi.org/10.1182/blood-2024-205479

Published: 2024

Journal Articles

Proposal of New Diagnostic Criteria for Primary Immune Thrombocytopenia

Hirokazu Kashiwagi, Masataka Kuwana, Mitsuru Murata, Naoki Shimada, Toshiro Takafuta, Jun Yamanouchi, Hisashi Kato, Takaaki Hato, Yoshiaki Tomiyama

Blood (2023) 142 (Supplement 1): 1214.

https://doi.org/10.1182/blood-2023-179165

Published: 2023

Journal Articles

The Lack of Tolerable Treatments Options That Can Induce Durable Responses without Fear of Relapse after Discontinuation Represents a Significant Unmet Need for Patients (Pts) with Immune Thrombocytopenia (ITP): Results from the ITP World Impact Survey (I-WISh) 2.0

James B. Bussel, Nichola Cooper, Waleed Ghanima, Drew Provan, Yoshiaki Tomiyama, Ming Hou, Donald Arnold, Cristina Santoro, Francesco Zaja, Barbara Lovrencic, Mervyn Morgan, Leron Lahav, Michal Winograd, Jennifer MacWhirter - DiRaimo, Tom Bailey, Moyra Aziz, Roberto Abi Rached, Caroline Kruse

Blood (2023) 142 (Supplement 1): 1212.

https://doi.org/10.1182/blood-2023-188527

Published: 2023

Journal Articles

Long-Term Treatment with Fostamatinib in Japanese Patients with Primary Immune Thrombocytopenia: An Open-Label Extension Study Following a Phase 3 Placebo-Controlled, Double-Blind, Parallel-Group Study

Masataka Kuwana, Tomoki Ito, Shugo Kowata, Yoshihiro Hatta, Katsumichi Fujimaki, Kensuke Naito, Shingo Kurahashi, Toshiya Kagoo, Kazuki Tanimoto, Natsuko Shichiri, So Saotome, Esteban Masuda, Yoshiaki Tomiyama

Blood (2023) 142 (Supplement 1): 2578.

https://doi.org/10.1182/blood-2023-182113

Published: 2023

Journal Articles

Non-Activating Integrin β3(R734C) Mutation Associated with Macrothrombocytopenia and Impaired Platelet Function

Keiichi Nakata, Keigo Akuta, Takaya Endo, Midori Koike, Hisashi Kato, Yoshiaki Tomiyama, Naoki Hosen, Hirokazu Kashiwagi

Blood (2023) 142 (Supplement 1): 2564.

https://doi.org/10.1182/blood-2023-178475

Published: 2023

Journal Articles

Efficacy and Safety of Long-Term Romiplostim Use for Refractory Aplastic Anemia

Blood (2022) 140 (Supplement 1): 8634–8637.

https://doi.org/10.1182/blood-2022-162895

Published: 2022

Journal Articles

Fostamatinib for the Treatment of Japanese Patients with Primary Immune Thrombocytopenia: A Phase 3, Placebo-Controlled, Double-Blind, Parallel-Group Study

Blood (2022) 140 (Supplement 1): 11244–11245.

https://doi.org/10.1182/blood-2022-169782

Published: 2022

Journal Articles

Redefining outcomes in immune TTP: an international working group consensus report

Adam Cuker, Spero R. Cataland, Paul Coppo, Javier de la Rubia, Kenneth D. Friedman, James N. George, Paul N. Knoebl, Johanna A. Kremer Hovinga, Bernhard Lӓmmle, Masanori Matsumoto, Katerina Pavenski, Flora Peyvandi, Kazuya Sakai, Ravi Sarode, Mari R. Thomas, Yoshiaki Tomiyama, Agnès Veyradier, John-Paul Westwood, Marie Scully

Blood (2021) 137 (14): 1855–1861.

https://doi.org/10.1182/blood.2020009150

Published: 2021

Includes: Supplemental data

Journal Articles

ITP World Impact Survey (I-WISh) 2.0: Further Exploration of the Impact of ITP on Patients

Waleed Ghanima, Drew Provan, Nichola Cooper, MD, Axel Matzdorff, MDPhD, Ming Hou, Cristina Santoro, Mervyn Morgan, Caroline Kruse, Francesco Zaja, Leron Lahav, Yoshiaki Tomiyama, Michal Winograd, Barbara Lovrencic, Tom Bailey, MSci, Jens Haenig, James B. Bussel

Blood (2020) 136 (Supplement 1): 2–3.

https://doi.org/10.1182/blood-2020-136651

Published: 2020

Journal Articles

The Critical Role of Kindlin-3 in Intiation of Physiological Thrombus Formation ~ Analysis of Kindlin-3 Deficient Patient

Hisashi Kato, MD PhD, Shigenori Honda, MD, Hirokazu Kashiwagi, Nobuko Nishiura, Keigo Akuta, Koichi Kokame, Toshiyuki Miyata, Yoshiaki Tomiyama, MD

Blood (2019) 134 (Supplement_1): 1062.

https://doi.org/10.1182/blood-2019-129668

Published: 2019

Journal Articles

Physicians' and Patients' Perspectives on Treatments in ITP - a Multi-Country Perspective: Results from the ITP World Impact Survey (I-WISh)

James B. Bussel, MD, Waleed Ghanima, MD PhD, Yoshiaki Tomiyama, MD, Donald M. Arnold, MD, Drew Provan, MD, Ming Hou, MD PhD, Cristina Santoro, MD PhD, Serge Laborde, Alexandra Kruse, Caroline Kruse, Mervyn Morgan, Barbara Lovrencic, John Waller, PhD, Jens Haenig, Nichola Cooper, MD MRCP

Blood (2019) 134 (Supplement_1): 1097.

https://doi.org/10.1182/blood-2019-130591

Published: 2019

Journal Articles

αIIb(R990W), a Gain-of Function Mutation of αIIbβ3, Knock-in Mice Show Moderately Impaired Thrombopoiesis

Keigo Akuta, Kazunobu Kiyomizu, MD, Hirokazu Kashiwagi, Shinji Kunishima, PhD, Fumiaki Banno, Koichi Kokame, Nobuko Nishiura, Hisashi Kato, MD PhD, Shigenori Honda, MD, Yuzuru Kanakura, MD PhD, Toshiyuki Miyata, Yoshiaki Tomiyama, MD

Blood (2018) 132 (Supplement 1): 3743.

https://doi.org/10.1182/blood-2018-99-115953

Published: 2018

Journal Articles

Efficacy and Safety of Romiplostim in Patients with Acquired Aplastic Anemia Ineligible or Refractory to Immunosuppressive Therapy: Interim Analysis of Phase 2/3 Clinical Trial

Blood (2018) 132 (Supplement 1): 1306.

https://doi.org/10.1182/blood-2018-99-112478

Published: 2018

Journal Articles

Results from the ITP World IMPACT Survey (I-WISh): Patients with Immune Thrombocytopenia (ITP) Experience Impaired Quality of Life (QoL) Regarding Daily Activities, Social Interactions, Emotional Well-Being and Working Lives

Nichola Cooper, MRCP, Alexandra Kruse, Caroline Kruse, Shirley Watson, Mervyn Morgan, James B. Bussel, MD, Waleed Ghanima, Donald M. Arnold, MD MSc, FRCPC, Cristina Santoro, Ming Hou, MD, Yoshiaki Tomiyama, MD, Serge Laborde, Barbara Lovrencic, John Waller, PhD BSc, Tom Bailey, Gavin Taylor-Stokes, Miona Stankovic, Andrew Provan

Blood (2018) 132 (Supplement 1): 4804.

https://doi.org/10.1182/blood-2018-99-112858

Published: 2018

Journal Articles

Platelet Integrin αIIbβ3 Activation Kinetics in Inherited Platelet Functional Disorders ∼ the Role of ADP Receptor P2Y12, Caldag-GEFI and Kindlin-3 αIIbβ3 Activation By inside-out Signaling

Hisashi Kato, MDPhD, Nobuko Nishiura, Keigo Akuta, Hirokazu Kashiwagi, Koichi Kokame, Toshiyuki Miyata, Yuzuru Kanakura, MD PhD, Yoshiaki Tomiyama, MD

Blood (2018) 132 (Supplement 1): 1136.

https://doi.org/10.1182/blood-2018-99-112852

Published: 2018

Journal Articles

Patients with Immune Thrombocytopenia (ITP) Frequently Experience Severe Fatigue but Is It Under-Recognized By Physicians: Results from the ITP World Impact Survey (I-WISh)

Caroline Kruse, Alexandra Kruse, Shirley Watson, Mervyn Morgan, Nichola Cooper, MRCP, Waleed Ghanima, Andrew Provan, Donald M. Arnold, MD MSc, FRCPC, Cristina Santoro, Ming Hou, MD, Yoshiaki Tomiyama, MD, Serge Laborde, Barbara Lovrencic, John Waller, PhD BSc, Gavin Taylor-Stokes, Tom Bailey, Miona Stankovic, James B. Bussel, MD

Blood (2018) 132 (Supplement 1): 2273.

https://doi.org/10.1182/blood-2018-99-112378

Published: 2018

Journal Articles

Addition of Melphalan to Fludarabine/Busulfan (FLU/BU4/MEL) Provides Survival Benefit for Patients with Myeloid Malignancy Following Allogeneic Bone Marrow Transplantation/Peripheral Blood Stem Cell Transplantation

Tomoaki Ueda, Tetsuo Maeda, MD, Kentaro Fukushima, MD PhD, Jiro Fujita, MD PhD, Shinsuke Kusakabe, MD, Takafumi Yokota, MD PhD, Hirohiko Shibayama, MD PhD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD PhD

Blood (2018) 132 (Supplement 1): 2099.

https://doi.org/10.1182/blood-2018-99-112328

Published: 2018

Journal Articles

Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation

Hisashi Kato, Yozo Nakazawa, Yumi Kurokawa, Hirokazu Kashiwagi, Yoichiro Morikawa, Daisuke Morita, Fumiaki Banno, Shigenori Honda, Yuzuru Kanakura, Yoshiaki Tomiyama

Blood (2016) 128 (23): 2729–2733.

https://doi.org/10.1182/blood-2016-03-704825

Published: 2016

Includes: Supplemental data

Journal Articles

The Association of PAR4 Polymorphism with Human Platelet Reactivity in Japanese

Yoichiro Morikawa, MD, Hisashi Kato, MD PhD, Keigo Akuta, MD, Hirokazu Kashiwagi, MD PhD, Shigenori Honda, MD PhD, Yuzuru Kanakura, MD PhD, Yoshiaki Tomiyama, MD PhD

Blood (2016) 128 (22): 4908.

https://doi.org/10.1182/blood.V128.22.4908.4908

Published: 2016

Journal Articles

αIIb(R990W), a Constitutive Activating Mutation of Integrin αIIbβ3, Knock-in Mice Show Macrothrombocytopenia with Impairment of Platelet Function

Kazunobu Kiyomizu, Hirokazu Kashiwagi, Shinji Kunishima, PhD, Fumiaki Banno, PhD, Hisashi Kato, Youichiro Morikawa, Seiji Tadokoro, Koichi Kokame, PhD, Shigenori Honda, MD PhD, Toshiyuki Miyata, PhD, Yuzuru Kanakura, Yoshiaki Tomiyama

Blood (2014) 124 (21): 4182.

https://doi.org/10.1182/blood.V124.21.4182.4182

Published: 2014

NARROW

Efficacy and Safety of Avatrombopag in Japanese Adults with Chronic Immune Thrombocytopenia: Open-Label, Phase 3 Study

Proposal of New Diagnostic Criteria for Primary Immune Thrombocytopenia

The Lack of Tolerable Treatments Options That Can Induce Durable Responses without Fear of Relapse after Discontinuation Represents a Significant Unmet Need for Patients (Pts) with Immune Thrombocytopenia (ITP): Results from the ITP World Impact Survey (I-WISh) 2.0

Long-Term Treatment with Fostamatinib in Japanese Patients with Primary Immune Thrombocytopenia: An Open-Label Extension Study Following a Phase 3 Placebo-Controlled, Double-Blind, Parallel-Group Study

Non-Activating Integrin β3(R734C) Mutation Associated with Macrothrombocytopenia and Impaired Platelet Function

Efficacy and Safety of Long-Term Romiplostim Use for Refractory Aplastic Anemia

Fostamatinib for the Treatment of Japanese Patients with Primary Immune Thrombocytopenia: A Phase 3, Placebo-Controlled, Double-Blind, Parallel-Group Study

Redefining outcomes in immune TTP: an international working group consensus report

ITP World Impact Survey (I-WISh) 2.0: Further Exploration of the Impact of ITP on Patients

The Critical Role of Kindlin-3 in Intiation of Physiological Thrombus Formation ~ Analysis of Kindlin-3 Deficient Patient

Physicians' and Patients' Perspectives on Treatments in ITP - a Multi-Country Perspective: Results from the ITP World Impact Survey (I-WISh)

αIIb(R990W), a Gain-of Function Mutation of αIIbβ3, Knock-in Mice Show Moderately Impaired Thrombopoiesis

Efficacy and Safety of Romiplostim in Patients with Acquired Aplastic Anemia Ineligible or Refractory to Immunosuppressive Therapy: Interim Analysis of Phase 2/3 Clinical Trial

Results from the ITP World IMPACT Survey (I-WISh): Patients with Immune Thrombocytopenia (ITP) Experience Impaired Quality of Life (QoL) Regarding Daily Activities, Social Interactions, Emotional Well-Being and Working Lives

Platelet Integrin αIIbβ3 Activation Kinetics in Inherited Platelet Functional Disorders ∼ the Role of ADP Receptor P2Y12, Caldag-GEFI and Kindlin-3 αIIbβ3 Activation By inside-out Signaling

Patients with Immune Thrombocytopenia (ITP) Frequently Experience Severe Fatigue but Is It Under-Recognized By Physicians: Results from the ITP World Impact Survey (I-WISh)

Addition of Melphalan to Fludarabine/Busulfan (FLU/BU4/MEL) Provides Survival Benefit for Patients with Myeloid Malignancy Following Allogeneic Bone Marrow Transplantation/Peripheral Blood Stem Cell Transplantation

Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation

The Association of PAR4 Polymorphism with Human Platelet Reactivity in Japanese

αIIb(R990W), a Constitutive Activating Mutation of Integrin αIIbβ3, Knock-in Mice Show Macrothrombocytopenia with Impairment of Platelet Function

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