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Journal Articles

An Optimized Human Erythroblast Differentiation System Reveals Cholesterol-Dependency of Robust Production of Cultured Red Blood Cells Ex Vivo

Senquan Liu, Enyu Wang, Xinye Zhang, An Xie, Ding Ma, Linzhao Cheng

Blood (2023) 142 (Supplement 1): 2461.

https://doi.org/10.1182/blood-2023-174639

Published: 2023

Journal Articles

Transcriptional profile of platelets and iPSC-derived megakaryocytes from whole-genome and RNA sequencing

Kai Kammers, Margaret A. Taub, Benjamin Rodriguez, Lisa R. Yanek, Ingo Ruczinski, Joshua Martin, Kanika Kanchan, Alexis Battle, Linzhao Cheng, Zack Z. Wang, Andrew D. Johnson, Jeffrey T. Leek, Nauder Faraday, Lewis C. Becker, Rasika A. Mathias

Blood (2021) 137 (7): 959–968.

https://doi.org/10.1182/blood.2020006115

Published: 2021

Includes: Supplemental data

Journal Articles

Efficient Enucleation and In Vivo Circulation of Differentiated Human Erythroblasts Derived from Peripheral Blood Mononuclear Cells after Extensive Expansion

Senquan Liu, PhD, Mengyao Wu, PhD, Yongxing Gao, MS, Jiusheng Deng, PhD, John D Roback, MD PhD, Tong Chen, MD PhD, Linzhao Cheng, PhD

Blood (2020) 136 (Supplement 1): 23–24.

https://doi.org/10.1182/blood-2020-142226

Published: 2020

Journal Articles

Characteristics of in Vitro Differentiated Erythrocytes Derived from Human Bmi-1 Extensively Expanded Erythroblasts (E3)

Moira M. Lancelot, MD, Natia Saakadze, MSc, Jiusheng Deng, PhD, Sean R. Stowell, MD PhD, Ryan Jajosky, MD, Linzhao Cheng, PhD, Senquan Liu, John D Roback, MD PhD

Blood (2020) 136 (Supplement 1): 30.

https://doi.org/10.1182/blood-2020-142726

Published: 2020

Journal Articles

Effective Erythropoiesis from Human iPSC-Derived RBC in Immunodeficient Mice

Jiusheng Deng, PhD, Moira M. Lancelot, MD, Ryan Jajosky, MD, Kristin Deeb, PhD, Natia Saakadze, MSc, Yongixng Gao, MD, Senquan Liu, PhD, Sean R. Stowell, MD PhD, Linzhao Cheng, PhD, John D Roback, MD PhD

Blood (2020) 136 (Supplement 1): 42.

https://doi.org/10.1182/blood-2020-138606

Published: 2020

Journal Articles

Elucidating an Essential Role of Promoting Endothelial-to-Hematopoietic Transition By a Key EMT-Regulator ZEB2 Using a Human iPSC-Based Model

Mengyao Wu, Senquan Liu, Linzhao Cheng, PhD, Tong Chen, MD

Blood (2019) 134 (Supplement_1): 3716.

https://doi.org/10.1182/blood-2019-126908

Published: 2019

Journal Articles

The VWRPY Domain Is Essential for RUNX1 Function in Hematopoietic Progenitor Cell Maturation and Megakaryocyte Differentiation

Halah Alkadi, BSc, MSc, MT(ASCP), David McKellar, BS, Tao Zhen, PhD, Tatiana Karpova, PhD, Lisa J Garrett, MS, Yongxing Gao, MS, Anfal A Alsadhan, MS, Erika Mijin Kwon, PhD, James J Greene, PhD, David A Ball, PhD, Linzhao Cheng, PhD, April D Sorrell, MD, Paul P Liu, MD PhD

Blood (2018) 132 (Supplement 1): 1319.

https://doi.org/10.1182/blood-2018-99-113400

Published: 2018

Journal Articles

Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation

Yueying Li, Chen Jin, Hao Bai, Yongxing Gao, Shu Sun, Lei Chen, Lei Qin, Paul P. Liu, Linzhao Cheng, Qian-Fei Wang

Blood (2018) 131 (2): 191–201.

https://doi.org/10.1182/blood-2017-04-780379

Published: 2018

Includes: Supplemental data

Journal Articles

A Universal Approach to Correct Various HBB Gene Mutations in Human Stem Cells for Gene Therapy of Beta-Thalassemia and Sickle Cell Disease

Hao Bai, PhD, Liuhong Cai, MD, Vasiliki Machairaki, PhD, Yongxing Gao, Zhaohui Ye, PhD, Linzhao Cheng, PhD

Blood (2017) 130 (Supplement 1): 5564.

https://doi.org/10.1182/blood.V130.Suppl_1.5564.5564

Published: 2017

Journal Articles

Human Hematopoietic Progenitor Cells and Erythrocytes Generated from Human iPSCs Lacking CD55

Mengyao Wu, Senquan Liu, Hao Bai, PhD, Yongxing Gao, Rachel Evans, David Sullivan, Tong Chen, MD, Linzhao Cheng, PhD

Blood (2017) 130 (Supplement 1): 2204.

https://doi.org/10.1182/blood.V130.Suppl_1.2204.2204

Published: 2017

Journal Articles

Human NOTCH4 Is a Key Target of RUNX1 in Megakaryocytic Differentiation

Yueying Li, MD, Chen Jin, Hao Bai, Shu Sun, Paul P. Liu, MD PhD, Linzhao Cheng, PhD, Qianfei Wang, PhD

Blood (2016) 128 (22): 425.

https://doi.org/10.1182/blood.V128.22.425.425

Published: 2016

Journal Articles

Unraveling a Novel Mechanism of RUNX1 Activity in Familial Platelet Disorder with Associated Myeloid Malignancy

Halah I. Alkadi, PhD candidate, Tatiana S. Karpova, PhD, Erika Mijin Kwon, PhD, Lisa J. Garrett, MS, Yongxing Gao, BS, Stephen Wincovitch, Anfal Alsadhan, MS, James J. Greene, PhD, David A. Ball, Linzhao Cheng, PhD, April D. Sorrell, MD, Paul P. Liu, MD PhD

Blood (2016) 128 (22): 2693.

https://doi.org/10.1182/blood.V128.22.2693.2693

Published: 2016

Journal Articles

Generation, Characterization and Genetic Modification of Human iPSCs Containing Calr , MPL and JAK2 Mutations Found in MPN Patients

Liu Senquan, BS, Donna Marie Williams, PhD, Alison R. Moliterno, MD, Jerry L. Spivak, MD, He Huang, MD PhD, Yongxing Gao, BS, Zhaohui Ye, PhD, Linzhao Cheng, PhD

Blood (2016) 128 (22): 3139.

https://doi.org/10.1182/blood.V128.22.3139.3139

Published: 2016

Journal Articles

The Roles of RUNX1 in Human Hematopoiesis and Megakaryopoiesis Revealed By Genome-Targeted Human iPSCs and an Improved Hematopoietic Differentiation Model

Bin-Kuan Chou, PhD, Hao Bai, PhD, Yongxing Gao, Ying Wang, Zhaohui Ye, PhD, Erika Mijin Kwon, PhD, Pu Paul Liu, MD PhD, Alan D. Friedman, MD, Zack Z. Wang, PhD, Linzhao Cheng, PhD

Blood (2015) 126 (23): 1167.

https://doi.org/10.1182/blood.V126.23.1167.1167

Published: 2015

Journal Articles

A Germline Mutation in ERBB3 Predisposes to Inherited Erythroid Myelodysplasia/Erythroleukemia

Evan M. Braunstein, MD PhD, Ruijuan Li, Nara Sobreira, MD, Christopher Gocke, MD, Robert A. Brodsky, MD, David Valle, MD, Linzhao Cheng, PhD

Blood (2015) 126 (23): 4105.

https://doi.org/10.1182/blood.V126.23.4105.4105

Published: 2015

Journal Articles

Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects

Jon P. Connelly, Erika M. Kwon, Yongxing Gao, Niraj S. Trivedi, Abdel G. Elkahloun, Marshall S. Horwitz, Linzhao Cheng, P. Paul Liu

Blood (2014) 124 (12): 1926–1930.

https://doi.org/10.1182/blood-2014-01-550525

Published: 2014

Includes: Supplemental data

Journal Articles

FDA-Approved Pharmacological Agents, Romiplostium and Oprelvekin, Synergistically Promote Megakaryocytic Differentiation From Human iPSCs In a Chemically Defined System

Yanfeng Liu, Ph.D., Yongxing Gao, BS, Sid Shah, MS, Lewis Becker, MD, Linzhao Cheng, PhD, Zack Z Wang, PhD

Blood (2013) 122 (21): 1208.

https://doi.org/10.1182/blood.V122.21.1208.1208

Published: 2013

Journal Articles

Targeted correction Of RUNX1 Mutation In The FPD Patient-Specific Induced Pluripotent Stem Cells Restores Megakaryocytic Differentiation

Erika Mijin Kwon, PhD, Jon P Connelly, PhD, Yongxing Gao, BS, Marshall Horwitz, MD, PhD, Linzhao Cheng, PhD, Pu Paul Liu, MD, PhD

Blood (2013) 122 (21): 738.

https://doi.org/10.1182/blood.V122.21.738.738

Published: 2013

Journal Articles

Response: the role of RUNX1 isoforms in hematopoietic commitment of human pluripotent stem cells

Dan Ran, Kentson Lam, Wei-Jong Shia, Miao-Chia Lo, Jun-Bao Fan, David A. Knorr, Patrick I. Ferrell, Zhaohui Ye, Ming Yan, Linzhao Cheng, Dan S. Kaufman, Dong-Er Zhang

Blood (2013) 121 (26): 5252–5253.

https://doi.org/10.1182/blood-2013-04-494914

Published: 2013

Journal Articles

RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells

Dan Ran, Wei-Jong Shia, Miao-Chia Lo, Jun-Bao Fan, David A. Knorr, Patrick I. Ferrell, Zhaohui Ye, Ming Yan, Linzhao Cheng, Dan S. Kaufman, Dong-Er Zhang

Blood (2013) 121 (15): 2882–2890.

https://doi.org/10.1182/blood-2012-08-451641

Published: 2013

Includes: Supplemental data

NARROW

An Optimized Human Erythroblast Differentiation System Reveals Cholesterol-Dependency of Robust Production of Cultured Red Blood Cells Ex Vivo

Transcriptional profile of platelets and iPSC-derived megakaryocytes from whole-genome and RNA sequencing

Efficient Enucleation and In Vivo Circulation of Differentiated Human Erythroblasts Derived from Peripheral Blood Mononuclear Cells after Extensive Expansion

Characteristics of in Vitro Differentiated Erythrocytes Derived from Human Bmi-1 Extensively Expanded Erythroblasts (E3)

Effective Erythropoiesis from Human iPSC-Derived RBC in Immunodeficient Mice

Elucidating an Essential Role of Promoting Endothelial-to-Hematopoietic Transition By a Key EMT-Regulator ZEB2 Using a Human iPSC-Based Model

The VWRPY Domain Is Essential for RUNX1 Function in Hematopoietic Progenitor Cell Maturation and Megakaryocyte Differentiation

Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation

A Universal Approach to Correct Various HBB Gene Mutations in Human Stem Cells for Gene Therapy of Beta-Thalassemia and Sickle Cell Disease

Human Hematopoietic Progenitor Cells and Erythrocytes Generated from Human iPSCs Lacking CD55

Human NOTCH4 Is a Key Target of RUNX1 in Megakaryocytic Differentiation

Unraveling a Novel Mechanism of RUNX1 Activity in Familial Platelet Disorder with Associated Myeloid Malignancy

Generation, Characterization and Genetic Modification of Human iPSCs Containing Calr , MPL and JAK2 Mutations Found in MPN Patients

The Roles of RUNX1 in Human Hematopoiesis and Megakaryopoiesis Revealed By Genome-Targeted Human iPSCs and an Improved Hematopoietic Differentiation Model

A Germline Mutation in ERBB3 Predisposes to Inherited Erythroid Myelodysplasia/Erythroleukemia

Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects

FDA-Approved Pharmacological Agents, Romiplostium and Oprelvekin, Synergistically Promote Megakaryocytic Differentiation From Human iPSCs In a Chemically Defined System

Targeted correction Of RUNX1 Mutation In The FPD Patient-Specific Induced Pluripotent Stem Cells Restores Megakaryocytic Differentiation

Response: the role of RUNX1 isoforms in hematopoietic commitment of human pluripotent stem cells

RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells

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American Society of Hematology

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American Society of Hematology

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