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Isabelle C. Becker
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Journal Articles

Cytokine Secretion from Megakaryocytes Is Governed By Small GTPASES through Autophagy

Isabelle C Becker, Maria N. Barrachina, Joshua Lykins, Virginia Camacho, Harvey G. Roweth, Kellie R Machlus, Sidney W. Whiteheart, Joseph E. Italiano
Journal: Blood
Blood (2024) 144 (Supplement 1): 819.
https://doi.org/10.1182/blood-2024-201412
Published: 2024
Journal Articles

Bone Marrow Remodeling and Pro-Inflammatory Megakaryocytes in a Murine Model of Chronic Kidney Disease

Estelle Carminita, Virginia Camacho, Isabelle C Becker, Maria Barrachina, Karen Guo, Kellie R. Machlus, Joseph E. Italiano
Journal: Blood
Blood (2024) 144 (Supplement 1): 3930.
https://doi.org/10.1182/blood-2024-203793
Published: 2024
Journal Articles

Priming of Megakaryopoiesis and Platelet Production through DNA Damage Repair Inhibition

Roelof H Bekendam, Andrew Stone, Virginia Camacho, Isabelle C Becker, Clementine Payne, Estelle Carminita, Maria N. Barrachina, Jakub Kaplan, Luis Batista, Sharmista Pal, Joseph E. Italiano, Kellie R Machlus
Journal: Blood
Blood (2024) 144 (Supplement 1): 1173.
https://doi.org/10.1182/blood-2024-207499
Published: 2024
Journal Articles

Acute CCL5 Exposure Promotes Megakaryopoiesis through Non-Canonical Pathways

Maria N. Barrachina, Karen Guo, Daniela Freire, Virginia Camacho, Isabelle C Becker, Emma Nikols, Julia Tilburg, Joseph E. Italiano, Kellie R Machlus
Journal: Blood
Blood (2024) 144 (Supplement 1): 1171.
https://doi.org/10.1182/blood-2024-207027
Published: 2024
Journal Articles

Tet2 Age-Associated Somatic Mutations Impair Megakaryopoiesis and Platelet Function in Clonal Hematopoiesis

Virginia Camacho, Estelle Carminita, Maria Barrachina, Isabelle C Becker, Joseph E. Italiano, Kellie R Machlus
Journal: Blood
Blood (2024) 144 (Supplement 1): 422.
https://doi.org/10.1182/blood-2024-207848
Published: 2024
Journal Articles

The bone marrow is the primary site of thrombopoiesis

Brief Report
Nathan L. Asquith, Estelle Carminita, Virginia Camacho, Antonio Rodriguez-Romera, David Stegner, Daniela Freire, Isabelle C. Becker, Kellie R. Machlus, Abdullah O. Khan, Joseph E. Italiano
Journal: Blood
Blood (2024) 143 (3): 272–278.
https://doi.org/10.1182/blood.2023020895
Published: 2024
Includes: Supplemental data
Journal Articles

TGFβ1 Secretion in Megakaryocytes Is Autophagy-Dependent and Its Inhibition Ameliorates Myelofibrosis in Mice

Isabelle C. Becker, Maria N. Barrachina, Virginia Camacho, Harvey G. Roweth, Julia Tilburg, Bernadette Chua, Zoltan Nagy, Maximilian Englert, Kellie R. Machlus, Robert Signer, Bernhard Nieswandt, Joseph E. Italiano
Journal: Blood
Blood (2023) 142 (Supplement 1): 744.
https://doi.org/10.1182/blood-2023-174409
Published: 2023
Journal Articles

Megakaryocytes Direct CD4 + T Cell Responses Via Major Histocompatibility Complex Class II Antigen Presentation

Virginia Camacho, Karen Guo, Pavel Hanc, Estelle Carminita, Isabelle C. Becker, Em Harrington, Joseph E. Italiano, Kellie R. Machlus
Journal: Blood
Blood (2023) 142 (Supplement 1): 35.
https://doi.org/10.1182/blood-2023-186477
Published: 2023
Journal Articles

The Bone Marrow Is the Primary Site of Thrombopoiesis

Nathan Asquith, Estelle Carminita, Antonio Rodriguez-Romera, Daniela Freire, Virginia Camacho, Isabelle C. Becker, Kellie R. Machlus, Abdullah O Khan, Joseph E. Italiano
Journal: Blood
Blood (2023) 142 (Supplement 1): 5403.
https://doi.org/10.1182/blood-2023-190991
Published: 2023
Journal Articles

Platelet Angiopoietin-1 Protects Against Experimental Lung Metastasis By Limiting Tumor Cell Extravasation

Harvey G. Roweth, Isabelle C. Becker, Michael Malloy, Sophie Munn, Pryia Kumar, Alec A Schmaier, Elisabeth Battinelli
Journal: Blood
Blood (2023) 142 (Supplement 1): 282.
https://doi.org/10.1182/blood-2023-174399
Published: 2023
Journal Articles

Don’t you forget about me(gakaryocytes)

Julia Tilburg, Isabelle C. Becker, Joseph E. Italiano
Journal: Blood
Blood (2022) 139 (22): 3245–3254.
https://doi.org/10.1182/blood.2020009302
Published: 2022
Journal Articles

The triple crown of platelet generation

Isabelle C. Becker, Joseph E. Italiano
Journal: Blood
Blood (2022) 139 (14): 2100–2101.
https://doi.org/10.1182/blood.2021015018
Published: 2022
Journal Articles

Manipulation of Fatty Acid Metabolism Impairs Megakaryocyte Differentiation and Platelet Production

Maria N. Barrachina, Gerard Pernes, Isabelle C Becker, Dafna Groeneveld, James P. Luyendyk, Peter J Meikle, Graeme I Lancaster, Andrew J Murphy, Kellie Machlus
Journal: Blood
Blood (2021) 138 (Supplement 1): 577.
https://doi.org/10.1182/blood-2021-151316
Published: 2021
Journal Articles

CLEC-2 contributes to hemostasis independently of classical hemITAM signaling in mice

Brief Report
Elizabeth J. Haining, Deya Cherpokova, Karen Wolf, Isabelle C. Becker, Sarah Beck, Johannes A. Eble, David Stegner, Steve P. Watson, Bernhard Nieswandt
Journal: Blood
Blood (2017) 130 (20): 2224–2228.
https://doi.org/10.1182/blood-2017-03-771907
Published: 2017
Includes: Multimedia, Supplemental data
Journal Articles

Twinfilin 2a regulates platelet reactivity and turnover in mice

Simon Stritt, Sarah Beck, Isabelle C. Becker, Timo Vögtle, Markku Hakala, Katrin G. Heinze, Xiaoping Du, Markus Bender, Attila Braun, Pekka Lappalainen, Bernhard Nieswandt
Journal: Blood
Blood (2017) 130 (15): 1746–1756.
https://doi.org/10.1182/blood-2017-02-770768
Published: 2017
Includes: Multimedia, Supplemental data