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David R Archer
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Journal Articles

Pharmacological Inhibition of TMPRSS6 Decreases Hemoglobin Concentration and Red Blood Cell (RBC) Hemolysis in a Mouse Model of Sickle Cell Disease

Silvia Giannini, Earl Fields, Jr., Jesse Bueno, Christopher Chambliss, Min Wu, David R Archer
Journal: Blood
Blood (2024) 144 (Supplement 1): 3863.
https://doi.org/10.1182/blood-2024-204708
Published: 2024
Journal Articles

Placental Abnormalities in the Humanized Mouse Model of Sickle Cell Disease

Christopher Chambliss, Elizabeth Manci, Elizabeth Eldeiry, Earl Fields, Jr., Jesse Bueno, Satheesh Chonat, David R Archer
Journal: Blood
Blood (2024) 144 (Supplement 1): 2487.
https://doi.org/10.1182/blood-2024-208162
Published: 2024
Journal Articles

Predictive Biomarker Analysis from the GBT021601 Survival Study in Townes Sickle Mice

Mira Patel Pochron, Jiaxin Sun, Alka A Potdar, Carsten Alt, Francis DeGuzman, Michael W. Connor, Brian Cathers, Kobina Dufu, David R Archer
Journal: Blood
Blood (2023) 142 (Supplement 1): 14.
https://doi.org/10.1182/blood-2023-177776
Published: 2023
Journal Articles

Preliminary Pharmacodynamic Results from a Multicenter Phase 2/3 Study of Next-Generation HbS Polymerization Inhibitor GBT021601 for the Treatment of Patients with Sickle Cell Disease

Mira Patel Pochron, Adeseye Michael Akinsete, Shehu Umar Abdullahi, Foluke A Fasola, Modupe Idowu, Sharon Pennington, William B Ershler, Marshall Patrick Stagg, Earl Fields, Morgan Sterling, Satheesh Chonat, Yuvika Paliwal, Karena Kong, David R Archer, Adeyemi Adenola, Eleanor A Lisbon
Journal: Blood
Blood (2023) 142 (Supplement 1): 1155.
https://doi.org/10.1182/blood-2023-188929
Published: 2023
Journal Articles

Characterizing Pregnancy Outcomes in a Humanized Mouse Model of Sickle Cell Disease

Christopher Chambliss, Elizabeth Manci, Earl Fields, Jesse Bueno, Adeola Michael, Satheesh Chonat, David R Archer
Journal: Blood
Blood (2023) 142 (Supplement 1): 563.
https://doi.org/10.1182/blood-2023-185898
Published: 2023
Journal Articles

Optimization of Lentiviral ß-Globin Vectors in a Forward Orientation to Enhance Therapeutic Effectiveness for Sickle Cell Disease

Jennifer Okalova, Jordan Shields Alexander, Christopher Chambliss, Zhongyu Zhu, Yanping Xie, Matthew Addington-Hall, Oxana Slessareva, Tony Luo, Beatrix Ferencz, Ibeawuchi Oparaocha, Naoya Uchida, John F. Tisdale, Boro Dropulic, H. Trent Spencer, Rimas J Orentas, David R Archer
Journal: Blood
Blood (2023) 142 (Supplement 1): 5002.
https://doi.org/10.1182/blood-2023-187506
Published: 2023
Journal Articles

Development of a Humanized Mouse Model of Cholestatic Sickle Cell Disease

Adeola O Adebayo Michael, Paul Dawson, Saul Karpen, David R. Archer
Journal: Blood
Blood (2022) 140 (Supplement 1): 2506–2507.
https://doi.org/10.1182/blood-2022-169337
Published: 2022
Journal Articles

Complement Drives Acute Chest Syndrome in a Model of Sickle Cell Disease

Satheesh Chonat, Jayre A Jones, Seema R Patel, Patricia E Zerra, Lauren A Jeffers, Ryan Philip Jajosky, Connie M. Arthur, Michael Koval, Clinton H. Joiner, David R. Archer, Sean R. Stowell
Journal: Blood
Blood (2022) 140 (Supplement 1): 8221–8222.
https://doi.org/10.1182/blood-2022-170830
Published: 2022
Journal Articles

Neuroinflammation Underlies the Development of Social Stress Induced Cognitive Deficit in Sickle Cell Disease

Oluwabukola Gbotosho, Kat Propsom, S'Dravious DeVeaux, Sofiya Vyshnya, Edward Botchwey, David R. Archer, Hyacinth I Hyacinth
Journal: Blood
Blood (2022) 140 (Supplement 1): 433–434.
https://doi.org/10.1182/blood-2022-169147
Published: 2022
Journal Articles

Contribution of Vascular Cell Adhesion Molecule to Hemodynamics in Sickle Cell Disease

Noor Mary Abi Rached, David R. Archer, Jayre A Jones, Morgan Sterling, Hyacinth I Hyacinth
Journal: Blood
Blood (2021) 138 (Supplement 1): 958.
https://doi.org/10.1182/blood-2021-153963
Published: 2021
Journal Articles

Improvement in Red Blood Cell Physiology in Children with Sickle Cell Anemia Receiving Voxelotor

Satheesh Chonat, MD, Earl Fields, Hannah Baratz, Amanda Watt, Mira Pochron, PhD, Sandy Dixon, Margaret Tonda, PharmD, Joshua Lehrer-Graiwer, MD MPhil, FACC, Clark Brown, MD PhD, David R. Archer, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2281.
https://doi.org/10.1182/blood-2019-129351
Published: 2019
Journal Articles

Aged Neutrophils in Sickle Cell Disease Impede Ischemic Repair

Derick Okwan-Duodu, MD PhD, David R. Archer, PhD, W Robert Taylor, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3688.
https://doi.org/10.1182/blood-2018-99-119384
Published: 2018
Journal Articles

Endothelin-1 Is Associated with Albuminuria and Measures of Vascular Endothelial Dysfunction in Sickle Cell Anemia

Vimal K. Derebail, MD MPH, Susan K Jones, RN, Jessica Shen, BS, Melissa Caughey, PhD, Alan L. Hinderliter, MD, David M. Pollock, PhD, David R. Archer, PhD, Kenneth I. Ataga, MD
Journal: Blood
Blood (2015) 126 (23): 983.
https://doi.org/10.1182/blood.V126.23.983.983
Published: 2015
Journal Articles

Prophylactic Nrf2 Activation Halts Progression of the Severe Adult Phenotype of Sickle Cell Disease in Transgenic Mice

Samit Ghosh, PhD, Chibueze A. Ihunnah, PhD, Rimi Hazra, PhD, Amma T. Owusu-Ansah, MD, Jason M Hansen, PhD, David R. Archer, PhD, Solomon Fiifi Ofori-Acquah, PhD
Journal: Blood
Blood (2015) 126 (23): 3394.
https://doi.org/10.1182/blood.V126.23.3394.3394
Published: 2015
Journal Articles

Albuminuria Is Associated with Endothelial Dysfunction in Sickle Cell Disease

Melissa Caughey, PhD, Vimal K. Derebail, MD MPH, Susan K Jones, RN, Jessica Shen, BS, Poulami Maitra, Jianwen Cai, PhD, Alan L. Hinderliter, MD, David R. Archer, PhD, Kenneth I. Ataga, MD
Journal: Blood
Blood (2015) 126 (23): 2186.
https://doi.org/10.1182/blood.V126.23.2186.2186
Published: 2015
Journal Articles

GTx011, a Potent Allosteric Modifier of Hemoglobin Oxygen Affinity, Prevents RBC Sickling in Whole Blood and Prolongs RBC Half-Life in Vivo in a Murine Model of Sickle Cell Disease

Kobina Dufu, PhD, Donna Oksenberg, PhD, Chengjing Zhou, Athiwat Hutchaleelaha, PhD, David R. Archer, PhD
Journal: Blood
Blood (2014) 124 (21): 217.
https://doi.org/10.1182/blood.V124.21.217.217
Published: 2014
Journal Articles

Targeted Disruption of Nrf2 in Non-Hematopoietic Tissues Exacerbates Hemolysis and Accelerates Chronic Lung Disease in Transgenic Sickle Cell Anemia Mice

Samit Ghosh, PhD, Jason Hansen, PhD, Rimi Hazra, PhD, David R. Archer, PhD, Solomon F. Ofori-Acquah, PhD
Journal: Blood
Blood (2014) 124 (21): 456.
https://doi.org/10.1182/blood.V124.21.456.456
Published: 2014
Journal Articles

Targeted Treatment Of Acute Chest Syndrome In Transgenic Sickle Mice

Samit Ghosh, PhD, Olufolake Adisa, MD, Prasanthi Chappa, Fang Tan, PhD, Kesmic A Jackson, PhD, David R. Archer, PhD, Solomon F Ofori-Acquah, PhD
Journal: Blood
Blood (2013) 122 (21): 727.
https://doi.org/10.1182/blood.V122.21.727.727
Published: 2013
Journal Articles

Measuring the Direct Effects of Sickle Cell Vaso-Occlusion on Endothelial Cells Using Microfluidic Technology

David R Myers, PhD, Yumiko Sakurai, MSc, Prasanthi Chappa, Gilda Barabino, PhD, David R. Archer, PhD, Wilbur Lam, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 897.
https://doi.org/10.1182/blood.V118.21.897.897
Published: 2011
Journal Articles

Bone-Marrow Derived Cells Can Reconstitute GCLM Function in the Sickle Lung

Olufolake Adisa, MD, Samit Ghosh, PhD, Fang Tan, PhD, Prasanthi Chappa, David R. Archer, PhD, Solomon F Ofori-Acquah, PhD
Journal: Blood
Blood (2011) 118 (21): 4836.
https://doi.org/10.1182/blood.V118.21.4836.4836
Published: 2011