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Journal Articles

Pharmacological Inhibition of TMPRSS6 Decreases Hemoglobin Concentration and Red Blood Cell (RBC) Hemolysis in a Mouse Model of Sickle Cell Disease

Silvia Giannini, Earl Fields, Jr., Jesse Bueno, Christopher Chambliss, Min Wu, David R Archer

Blood (2024) 144 (Supplement 1): 3863.

https://doi.org/10.1182/blood-2024-204708

Published: 2024

Journal Articles

Placental Abnormalities in the Humanized Mouse Model of Sickle Cell Disease

Christopher Chambliss, Elizabeth Manci, Elizabeth Eldeiry, Earl Fields, Jr., Jesse Bueno, Satheesh Chonat, David R Archer

Blood (2024) 144 (Supplement 1): 2487.

https://doi.org/10.1182/blood-2024-208162

Published: 2024

Journal Articles

Characterizing Pregnancy Outcomes in a Humanized Mouse Model of Sickle Cell Disease

Christopher Chambliss, Elizabeth Manci, Earl Fields, Jesse Bueno, Adeola Michael, Satheesh Chonat, David R Archer

Blood (2023) 142 (Supplement 1): 563.

https://doi.org/10.1182/blood-2023-185898

Published: 2023

Journal Articles

Optimization of Lentiviral ß-Globin Vectors in a Forward Orientation to Enhance Therapeutic Effectiveness for Sickle Cell Disease

Jennifer Okalova, Jordan Shields Alexander, Christopher Chambliss, Zhongyu Zhu, Yanping Xie, Matthew Addington-Hall, Oxana Slessareva, Tony Luo, Beatrix Ferencz, Ibeawuchi Oparaocha, Naoya Uchida, John F. Tisdale, Boro Dropulic, H. Trent Spencer, Rimas J Orentas, David R Archer

Blood (2023) 142 (Supplement 1): 5002.

https://doi.org/10.1182/blood-2023-187506

Published: 2023

Journal Articles

Preliminary Pharmacodynamic Results from a Multicenter Phase 2/3 Study of Next-Generation HbS Polymerization Inhibitor GBT021601 for the Treatment of Patients with Sickle Cell Disease

Mira Patel Pochron, Adeseye Michael Akinsete, Shehu Umar Abdullahi, Foluke A Fasola, Modupe Idowu, Sharon Pennington, William B Ershler, Marshall Patrick Stagg, Earl Fields, Morgan Sterling, Satheesh Chonat, Yuvika Paliwal, Karena Kong, David R Archer, Adeyemi Adenola, Eleanor A Lisbon

Blood (2023) 142 (Supplement 1): 1155.

https://doi.org/10.1182/blood-2023-188929

Published: 2023

Journal Articles

Predictive Biomarker Analysis from the GBT021601 Survival Study in Townes Sickle Mice

Mira Patel Pochron, Jiaxin Sun, Alka A Potdar, Carsten Alt, Francis DeGuzman, Michael W. Connor, Brian Cathers, Kobina Dufu, David R Archer

Blood (2023) 142 (Supplement 1): 14.

https://doi.org/10.1182/blood-2023-177776

Published: 2023

Journal Articles

Development of a Humanized Mouse Model of Cholestatic Sickle Cell Disease

Adeola O Adebayo Michael, Paul Dawson, Saul Karpen, David R. Archer

Blood (2022) 140 (Supplement 1): 2506–2507.

https://doi.org/10.1182/blood-2022-169337

Published: 2022

Journal Articles

Complement Drives Acute Chest Syndrome in a Model of Sickle Cell Disease

Satheesh Chonat, Jayre A Jones, Seema R Patel, Patricia E Zerra, Lauren A Jeffers, Ryan Philip Jajosky, Connie M. Arthur, Michael Koval, Clinton H. Joiner, David R. Archer, Sean R. Stowell

Blood (2022) 140 (Supplement 1): 8221–8222.

https://doi.org/10.1182/blood-2022-170830

Published: 2022

Journal Articles

Neuroinflammation Underlies the Development of Social Stress Induced Cognitive Deficit in Sickle Cell Disease

Oluwabukola Gbotosho, Kat Propsom, S'Dravious DeVeaux, Sofiya Vyshnya, Edward Botchwey, David R. Archer, Hyacinth I Hyacinth

Blood (2022) 140 (Supplement 1): 433–434.

https://doi.org/10.1182/blood-2022-169147

Published: 2022

Journal Articles

Contribution of Vascular Cell Adhesion Molecule to Hemodynamics in Sickle Cell Disease

Noor Mary Abi Rached, David R. Archer, Jayre A Jones, Morgan Sterling, Hyacinth I Hyacinth

Blood (2021) 138 (Supplement 1): 958.

https://doi.org/10.1182/blood-2021-153963

Published: 2021

Journal Articles

Improvement in Red Blood Cell Physiology in Children with Sickle Cell Anemia Receiving Voxelotor

Satheesh Chonat, MD, Earl Fields, Hannah Baratz, Amanda Watt, Mira Pochron, PhD, Sandy Dixon, Margaret Tonda, PharmD, Joshua Lehrer-Graiwer, MD MPhil, FACC, Clark Brown, MD PhD, David R. Archer, PhD

Blood (2019) 134 (Supplement_1): 2281.

https://doi.org/10.1182/blood-2019-129351

Published: 2019

Journal Articles

Aged Neutrophils in Sickle Cell Disease Impede Ischemic Repair

Derick Okwan-Duodu, MD PhD, David R. Archer, PhD, W Robert Taylor, MD PhD

Blood (2018) 132 (Supplement 1): 3688.

https://doi.org/10.1182/blood-2018-99-119384

Published: 2018

Journal Articles

Prophylactic Nrf2 Activation Halts Progression of the Severe Adult Phenotype of Sickle Cell Disease in Transgenic Mice

Samit Ghosh, PhD, Chibueze A. Ihunnah, PhD, Rimi Hazra, PhD, Amma T. Owusu-Ansah, MD, Jason M Hansen, PhD, David R. Archer, PhD, Solomon Fiifi Ofori-Acquah, PhD

Blood (2015) 126 (23): 3394.

https://doi.org/10.1182/blood.V126.23.3394.3394

Published: 2015

Journal Articles

Albuminuria Is Associated with Endothelial Dysfunction in Sickle Cell Disease

Melissa Caughey, PhD, Vimal K. Derebail, MD MPH, Susan K Jones, RN, Jessica Shen, BS, Poulami Maitra, Jianwen Cai, PhD, Alan L. Hinderliter, MD, David R. Archer, PhD, Kenneth I. Ataga, MD

Blood (2015) 126 (23): 2186.

https://doi.org/10.1182/blood.V126.23.2186.2186

Published: 2015

Journal Articles

Endothelin-1 Is Associated with Albuminuria and Measures of Vascular Endothelial Dysfunction in Sickle Cell Anemia

Vimal K. Derebail, MD MPH, Susan K Jones, RN, Jessica Shen, BS, Melissa Caughey, PhD, Alan L. Hinderliter, MD, David M. Pollock, PhD, David R. Archer, PhD, Kenneth I. Ataga, MD

Blood (2015) 126 (23): 983.

https://doi.org/10.1182/blood.V126.23.983.983

Published: 2015

Journal Articles

GTx011, a Potent Allosteric Modifier of Hemoglobin Oxygen Affinity, Prevents RBC Sickling in Whole Blood and Prolongs RBC Half-Life in Vivo in a Murine Model of Sickle Cell Disease

Kobina Dufu, PhD, Donna Oksenberg, PhD, Chengjing Zhou, Athiwat Hutchaleelaha, PhD, David R. Archer, PhD

Blood (2014) 124 (21): 217.

https://doi.org/10.1182/blood.V124.21.217.217

Published: 2014

Journal Articles

Targeted Disruption of Nrf2 in Non-Hematopoietic Tissues Exacerbates Hemolysis and Accelerates Chronic Lung Disease in Transgenic Sickle Cell Anemia Mice

Samit Ghosh, PhD, Jason Hansen, PhD, Rimi Hazra, PhD, David R. Archer, PhD, Solomon F. Ofori-Acquah, PhD

Blood (2014) 124 (21): 456.

https://doi.org/10.1182/blood.V124.21.456.456

Published: 2014

Journal Articles

Targeted Treatment Of Acute Chest Syndrome In Transgenic Sickle Mice

Samit Ghosh, PhD, Olufolake Adisa, MD, Prasanthi Chappa, Fang Tan, PhD, Kesmic A Jackson, PhD, David R. Archer, PhD, Solomon F Ofori-Acquah, PhD

Blood (2013) 122 (21): 727.

https://doi.org/10.1182/blood.V122.21.727.727

Published: 2013

Journal Articles

Measuring the Direct Effects of Sickle Cell Vaso-Occlusion on Endothelial Cells Using Microfluidic Technology

David R Myers, PhD, Yumiko Sakurai, MSc, Prasanthi Chappa, Gilda Barabino, PhD, David R. Archer, PhD, Wilbur Lam, MD, PhD

Blood (2011) 118 (21): 897.

https://doi.org/10.1182/blood.V118.21.897.897

Published: 2011

Journal Articles

Bone-Marrow Derived Cells Can Reconstitute GCLM Function in the Sickle Lung

Olufolake Adisa, MD, Samit Ghosh, PhD, Fang Tan, PhD, Prasanthi Chappa, David R. Archer, PhD, Solomon F Ofori-Acquah, PhD

Blood (2011) 118 (21): 4836.

https://doi.org/10.1182/blood.V118.21.4836.4836

Published: 2011

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Pharmacological Inhibition of TMPRSS6 Decreases Hemoglobin Concentration and Red Blood Cell (RBC) Hemolysis in a Mouse Model of Sickle Cell Disease

Placental Abnormalities in the Humanized Mouse Model of Sickle Cell Disease

Characterizing Pregnancy Outcomes in a Humanized Mouse Model of Sickle Cell Disease

Optimization of Lentiviral ß-Globin Vectors in a Forward Orientation to Enhance Therapeutic Effectiveness for Sickle Cell Disease

Preliminary Pharmacodynamic Results from a Multicenter Phase 2/3 Study of Next-Generation HbS Polymerization Inhibitor GBT021601 for the Treatment of Patients with Sickle Cell Disease

Predictive Biomarker Analysis from the GBT021601 Survival Study in Townes Sickle Mice

Development of a Humanized Mouse Model of Cholestatic Sickle Cell Disease

Complement Drives Acute Chest Syndrome in a Model of Sickle Cell Disease

Neuroinflammation Underlies the Development of Social Stress Induced Cognitive Deficit in Sickle Cell Disease

Contribution of Vascular Cell Adhesion Molecule to Hemodynamics in Sickle Cell Disease

Improvement in Red Blood Cell Physiology in Children with Sickle Cell Anemia Receiving Voxelotor

Aged Neutrophils in Sickle Cell Disease Impede Ischemic Repair

Prophylactic Nrf2 Activation Halts Progression of the Severe Adult Phenotype of Sickle Cell Disease in Transgenic Mice

Albuminuria Is Associated with Endothelial Dysfunction in Sickle Cell Disease

Endothelin-1 Is Associated with Albuminuria and Measures of Vascular Endothelial Dysfunction in Sickle Cell Anemia

GTx011, a Potent Allosteric Modifier of Hemoglobin Oxygen Affinity, Prevents RBC Sickling in Whole Blood and Prolongs RBC Half-Life in Vivo in a Murine Model of Sickle Cell Disease

Targeted Disruption of Nrf2 in Non-Hematopoietic Tissues Exacerbates Hemolysis and Accelerates Chronic Lung Disease in Transgenic Sickle Cell Anemia Mice

Targeted Treatment Of Acute Chest Syndrome In Transgenic Sickle Mice

Measuring the Direct Effects of Sickle Cell Vaso-Occlusion on Endothelial Cells Using Microfluidic Technology

Bone-Marrow Derived Cells Can Reconstitute GCLM Function in the Sickle Lung

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