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Journal Articles

Predictive Biomarker Analysis from the GBT021601 Survival Study in Townes Sickle Mice

Mira Patel Pochron, Jiaxin Sun, Alka A Potdar, Carsten Alt, Francis DeGuzman, Michael W. Connor, Brian Cathers, Kobina Dufu, David R Archer

Blood (2023) 142 (Supplement 1): 14.

https://doi.org/10.1182/blood-2023-177776

Published: 2023

Journal Articles

Evaluation of GBT021601 As a Therapeutic Agent to Restore Bone Marrow Health and Effective Erythropoiesis in a Sickle Mouse Model

Britney Hernandez, Anupama Priyadarshini, Zachary Kostamo, Yankai Zhang, Ashwin P Patel, Michael A Pendergast, Madhulika Jupelli, Heli Huang, Annie Nguyen Dang, Mira Patel Pochron, Kobina Dufu, Vivien A Sheehan

Blood (2023) 142 (Supplement 1): 16.

https://doi.org/10.1182/blood-2023-175022

Published: 2023

Journal Articles

GBT021601 Prevents Microvascular Dysfunction and Improves Hypoxia-Reoxygenation-Induced Vaso-Occlusion in a Murine Model of Sickle Cell Disease

Kobina Dufu, Donna Oksenberg, Brian E Cathers, Carlos J Munoz, Cynthia R Muller, Pedro Pedro Cabrales

Blood (2022) 140 (Supplement 1): 5377–5378.

https://doi.org/10.1182/blood-2022-167797

Published: 2022

Journal Articles

Increased Hemoglobin Affinity for Oxygen with GBT021601 Reduces Pulmonary Hypertension and Lung Vascular Inflammation in a Murine Model of Sickle Cell Disease

Kobina Dufu, Donna Oksenberg, Brian E Cathers, Carlos J Munoz, Cynthia R Muller, Pedro Pedro Cabrales

Blood (2022) 140 (Supplement 1): 5375–5376.

https://doi.org/10.1182/blood-2022-167954

Published: 2022

Journal Articles

GBT021601 Increases Hemoglobin and Improves Red Blood Cell Deformability without Rebound Hyperviscosity upon Drug Clearance in a Sickle Mouse Model

Celeste K. Kanne, Christina Liu, Britney N. Hernandez, Erica N. Evans, Mira P. Pochron, Kobina Dufu, Vivien A. Sheehan

Blood (2022) 140 (Supplement 1): 5393–5394.

https://doi.org/10.1182/blood-2022-169599

Published: 2022

Journal Articles

Pharmacodynamic Results from Phase 1 Studies of GBT021601, a Next-Generation HbS Polymerization Inhibitor for Treatment of Sickle Cell Disease

Modupe Idowu, Thinh Nguyen, Derek Lewis, Thokozeni Lipato, Erin M. Buckley, Rowan Brothers, Mariam Akbar, Sydney Triplett, Kobina Dufu, Eleanor Lisbon

Blood (2022) 140 (Supplement 1): 24–25.

https://doi.org/10.1182/blood-2022-167997

Published: 2022

Journal Articles

GBT021601 Inhibits HbS Polymerization, Prevents RBC Sickling and Improves the Pathophysiology of Sickle Cell Disease in a Murine Model

Kobina Dufu, PhD, Carsten Alt, MSc, PhD, Steven Strutt, PhD, Tzechiang Tang, Hilary Liao-Zou, Yue Yuan, Brian E Cathers, PhD, Donna Oksenberg, PhD

Blood (2020) 136 (Supplement 1): 7–8.

https://doi.org/10.1182/blood-2020-140539

Published: 2020

Journal Articles

Pharmacological Increase of Hb-O 2 Affinity with a Voxelotor Analog Does Not Decrease Brain Tissue pO 2 or Limit O 2 Extraction in Brain Tissues of Sickle Cell Mice

Kobina Dufu, PhD, Alfredo Lucas, MS, Cynthia Rodrigues Muller, PhD, Alexander T Williams, MS, Xinchun Zhang, MS, Peter Rademacher, PhD, Carsten Alt, MSc, PhD, Donna Oksenberg, PhD, Pedro Cabrales, PhD

Blood (2019) 134 (Supplement_1): 3564.

https://doi.org/10.1182/blood-2019-129282

Published: 2019

Journal Articles

A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease

Jo Howard, Claire Jane Hemmaway, Paul Telfer, D. Mark Layton, John Porter, Moji Awogbade, Timothy Mant, Daniel D. Gretler, Kobina Dufu, Athiwat Hutchaleelaha, Mira Patel, Vincent Siu, Sandra Dixon, Noel Landsman, Margaret Tonda, Joshua Lehrer-Graiwer

Blood (2019) 133 (17): 1865–1875.

https://doi.org/10.1182/blood-2018-08-868893

Published: 2019

Journal Articles

GBT1118 Diminishes Vaso-Occlusion in Sickle Cell Disease Mice

Carsten Alt, PhD, Perry Liu, Chien-Ming Li, PhD, Abel Silva, Peter Rademacher, PhD, Hilary Zou, Mira Patel, PhD, Kobina Dufu, PhD, Donna Oksenberg, PhD, Katalin Kauser, MD PhD

Blood (2017) 130 (Supplement 1): 3516.

https://doi.org/10.1182/blood.V130.Suppl_1.3516.3516

Published: 2017

Journal Articles

Long-Term Dosing in Sickle Cell Disease Subjects with GBT440, a Novel HbS Polymerization Inhibitor

Josh Lehrer-Graiwer, MDMPhil, FACC, Jo Howard, MB, BChir, Claire Jane Hemmaway, MD, Moji Awogbade, Paul Telfer, FRCPath,MD, Mark Layton, MB, FRCP, John B. Porter, MD, Timothy Mant, MB, FFPM, FRCP, Kobina Dufu, PhD, Athiwat Hutchaleelaha, PhD, Donna Oksenberg, PhD, Mira Patel, PhD, Margaret Eleanor Tonda, PharmD, Kenneth Bridges, MD, Eleanor Ramos, MD

Blood (2016) 128 (22): 2488.

https://doi.org/10.1182/blood.V128.22.2488.2488

Published: 2016

Journal Articles

GBT440, a Potent Anti-Sickling Hemoglobin Modifier Reduces Hemolysis, Improves Anemia and Nearly Eliminates Sickle Cells in Peripheral Blood of Patients with Sickle Cell Disease

Josh Lehrer-Graiwer, MDMPhil, FACC, Jo Howard, MD, Claire Jane Hemmaway, MD, Moji Awogbade, Paul Telfer, FRCPath,MD, Mark Layton, MB, FRCP, Timothy Mant, MB, FFPM, FRCP, Kobina Dufu, PhD, Athiwat Hutchaleelaha, PhD, Teri Koller, MBA, Donna Oksenberg, PhD, Mira Patel, PhD, Eleanor Ramos, MD

Blood (2015) 126 (23): 542.

https://doi.org/10.1182/blood.V126.23.542.542

Published: 2015

Journal Articles

GTx011, a Potent Allosteric Modifier of Hemoglobin Oxygen Affinity, Prevents RBC Sickling in Whole Blood and Prolongs RBC Half-Life in Vivo in a Murine Model of Sickle Cell Disease

Kobina Dufu, PhD, Donna Oksenberg, PhD, Chengjing Zhou, Athiwat Hutchaleelaha, PhD, David R. Archer, PhD

Blood (2014) 124 (21): 217.

https://doi.org/10.1182/blood.V124.21.217.217

Published: 2014

Journal Articles

GTx011, an Anti-Sickling Compound, Improves SS Blood Rheology By Reduction of HbS polymerization Via Allosteric Modulation of O 2 Affinity

Mira Patel, PhD, Pedro Cabrales, PhD, Kobina Dufu, PhD, Brian Metcalf, PhD, Uma Sinha, PhD

Blood (2014) 124 (21): 1370.

https://doi.org/10.1182/blood.V124.21.1370.1370

Published: 2014

Journal Articles

GTx011, a Potent Allosteric Modifier Of Hemoglobin Oxygen Affinity, Delays Polymerization and Prevents Sickling

Kobina Dufu, PhD, Donna Oksenberg, PhD, Brian Metcalf, PhD, Uma Sinha, PhD

Blood (2013) 122 (21): 316.

https://doi.org/10.1182/blood.V122.21.316.316

Published: 2013

NARROW

Predictive Biomarker Analysis from the GBT021601 Survival Study in Townes Sickle Mice

Evaluation of GBT021601 As a Therapeutic Agent to Restore Bone Marrow Health and Effective Erythropoiesis in a Sickle Mouse Model

GBT021601 Prevents Microvascular Dysfunction and Improves Hypoxia-Reoxygenation-Induced Vaso-Occlusion in a Murine Model of Sickle Cell Disease

Increased Hemoglobin Affinity for Oxygen with GBT021601 Reduces Pulmonary Hypertension and Lung Vascular Inflammation in a Murine Model of Sickle Cell Disease

GBT021601 Increases Hemoglobin and Improves Red Blood Cell Deformability without Rebound Hyperviscosity upon Drug Clearance in a Sickle Mouse Model

Pharmacodynamic Results from Phase 1 Studies of GBT021601, a Next-Generation HbS Polymerization Inhibitor for Treatment of Sickle Cell Disease

GBT021601 Inhibits HbS Polymerization, Prevents RBC Sickling and Improves the Pathophysiology of Sickle Cell Disease in a Murine Model

Pharmacological Increase of Hb-O 2 Affinity with a Voxelotor Analog Does Not Decrease Brain Tissue pO 2 or Limit O 2 Extraction in Brain Tissues of Sickle Cell Mice

A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease

GBT1118 Diminishes Vaso-Occlusion in Sickle Cell Disease Mice

Long-Term Dosing in Sickle Cell Disease Subjects with GBT440, a Novel HbS Polymerization Inhibitor

GBT440, a Potent Anti-Sickling Hemoglobin Modifier Reduces Hemolysis, Improves Anemia and Nearly Eliminates Sickle Cells in Peripheral Blood of Patients with Sickle Cell Disease

GTx011, a Potent Allosteric Modifier of Hemoglobin Oxygen Affinity, Prevents RBC Sickling in Whole Blood and Prolongs RBC Half-Life in Vivo in a Murine Model of Sickle Cell Disease

GTx011, an Anti-Sickling Compound, Improves SS Blood Rheology By Reduction of HbS polymerization Via Allosteric Modulation of O 2 Affinity

GTx011, a Potent Allosteric Modifier Of Hemoglobin Oxygen Affinity, Delays Polymerization and Prevents Sickling

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American Society of Hematology

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American Society of Hematology

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