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Journal Articles

Evaluation of GBT021601 As a Therapeutic Agent to Restore Bone Marrow Health and Effective Erythropoiesis in a Sickle Mouse Model

Britney Hernandez, Anupama Priyadarshini, Zachary Kostamo, Yankai Zhang, Ashwin P Patel, Michael A Pendergast, Madhulika Jupelli, Heli Huang, Annie Nguyen Dang, Mira Patel Pochron, Kobina Dufu, Vivien A Sheehan

Blood (2023) 142 (Supplement 1): 16.

https://doi.org/10.1182/blood-2023-175022

Published: 2023

Journal Articles

Evaluation of the Impact of a Naturally Occurring Beta Hemoglobin Variant, Hb G-Makassar, on Mature Red Blood Cell Function and Pathology in a Sickle Cell Disease Mouse Model

Zachary Kostamo, Jawa Darazim, Britney Hernandez, Alex Pendergast, Jordan Zgodny, Erica N Evans, Yankai Zhang, Ashwin P Patel, Celeste K. Kanne, Elizabeth Budak, Rebecca Jenkins, Daniel Haupt, Valerie Winton, Bo Yan, Adam Hartigan, Haihua Chu, Giuseppe Ciaramella, Vivien A. Sheehan

Blood (2023) 142 (Supplement 1): 2251.

https://doi.org/10.1182/blood-2023-186237

Published: 2023

Journal Articles

Characterization of Hemoglobin Variants Due to in-Frame Deletions in the β-Globin Gene from CRISPR/Cas9 Gene Correction for Sickle Cell Disease

Alex Alex Pendergast, So Hyun Park, Loren A. Binns, Celeste K. Kanne, Cecile Karsenty, Britney N. Hernandez, Byoungyong Yoo, Yankai Zhang, Gang Bao, Vivien A. Sheehan

Blood (2022) 140 (Supplement 1): 7793–7794.

https://doi.org/10.1182/blood-2022-166931

Published: 2022

Journal Articles

Functionality of a Peripheral Blood Derived Microglia-like Cell System for Drug Discovery to Treat Sickle Cell Related Chronic Pain

Yankai Zhang, Celeste K. Kanne, Britney N. Hernandez, Michael J. Lacagnina, Peter M. Grace, Mark J. Burish, Vivien A. Sheehan

Blood (2022) 140 (Supplement 1): 2498–2499.

https://doi.org/10.1182/blood-2022-169831

Published: 2022

Journal Articles

Development of a High-Throughput Drug Screening System Based on Human Peripheral Blood Derived Microglia-like Cells from Sickle Cell Patients with Chronic Pain

Yankai Zhang, Celeste K. Kanne, Michael J. Lacagnina, Peter M. Grace, Mark J. Burish, Vivien A. Sheehan

Blood (2022) 140 (Supplement 1): 10678–10679.

https://doi.org/10.1182/blood-2022-167510

Published: 2022

Journal Articles

S. Aureus Cas9 Leads to Higher Sickle Mutation Correction Compared to S. Pyogenes Cas9 in Patient Hematopoietic Stem and Progenitor Cells

Byoungyong Yoo, So Hyun Julie Park Park, Yankai Zhang, Vivien A. Sheehan, Gang Bao

Blood (2021) 138 (Supplement 1): 1861.

https://doi.org/10.1182/blood-2021-150830

Published: 2021

Journal Articles

CRISPR/Cas9 Editing Induces High Rates of Unintended Large Gene Modifications in HSPCs from Patients with Sickle Cell Disease

So Hyun Julie Park Park, Mingming Cao, Yankai Zhang, Vivien A. Sheehan, Gang Bao

Blood (2021) 138 (Supplement 1): 3969.

https://doi.org/10.1182/blood-2021-150739

Published: 2021

Journal Articles

Validation of a Peripheral Blood-Derived Microglia-like Cell System

Yankai Zhang, PhD, Celeste K. Kanne, BA, Jennifer N. Tran, DO, Michael J. Lacagnina, PhD, Peter M. Grace, PhD, Mark J. Burish, MD PhD, Vivien A. Sheehan, MDPhD

Blood (2020) 136 (Supplement 1): 12–13.

https://doi.org/10.1182/blood-2020-139888

Published: 2020

Journal Articles

Microglia-like Cells Derived from Hematopoietic Stem and Progenitor Cells Are a Model System to Investigate Chronic Pain in Sickle Cell Disease

Yankai Zhang, PhD, Celeste K. Kanne, BA, Jennifer N. Tran, DO, Michael J. Lacagnina, PhD, Peter M. Grace, PhD, Vivien A. Sheehan, MD PhD

Blood (2019) 134 (Supplement_1): 3575.

https://doi.org/10.1182/blood-2019-128921

Published: 2019

Journal Articles

Regulation of Fetal Hemoglobin through the Insulin Signaling Pathway

Alireza Paikari, MD, Yankai Zhang, PhD, Alicia Chang, MD, Ankush Goyal, MA, Evadnie Rampersaud, PhD, Jonathan M. Flanagan, PhD, Mitchell J. Weiss, MD, PhD, Vivien A. Sheehan, MD PhD

Blood (2019) 134 (Supplement_1): 811.

https://doi.org/10.1182/blood-2019-131313

Published: 2019

Journal Articles

The Role of Adenosine Monophosphate Activated Protein Kinase Alpha 1 (AMPK) in Gamma-Globin Regulation

Alicia Chang, MD, Yankai Zhang, PhD, Nelda Itzep, MD, Vivien A Sheehan, MD PhD

Blood (2018) 132 (Supplement 1): 413.

https://doi.org/10.1182/blood-2018-99-117092

Published: 2018

Journal Articles

Insulin-like Growth Factor Binding Protein-3 (IGFBP3) Induces Fetal Hemoglobin in Hematopoietic Stem and Progenitor Cells from Patients with Sickle Cell Anemia

Alireza Paikari, MD, Tian Mi, PhD, Yankai Zhang, PhD, Evadnie Rampersaud, PhD, Guolian Kang, PhD, Gang Wu, PhD, Jane S. Hankins, MD MS, Jeremie H. Estepp, MD, Pavel Sumazin, PhD, Mitchell J. Weiss, MD PhD, Vivien A Sheehan, MD PhD

Blood (2018) 132 (Supplement 1): 722.

https://doi.org/10.1182/blood-2018-99-115383

Published: 2018

Journal Articles

Engineered Human Umbilical Cord Derived Erythroid Progenitor Cells (HUDEP2) with Sickle or β-Thalassemia Mutation: An in-Vitro System for Testing Pharmacological Induction of Fetal Hemoglobin

So Hyun Park, BS, Ciaran M Lee, PhD, Yankai Zhang, PhD, Alicia Chang, MD, Vivien A Sheehan, MD PhD, Gang Bao, PhD

Blood (2018) 132 (Supplement 1): 3478.

https://doi.org/10.1182/blood-2018-99-114241

Published: 2018

Journal Articles

Microglia-like Cells Derived from Hematopoietic Stem and Progenitor Cells Are a Model System to Investigate Chronic Pain in Sickle Cell Disease

Yankai Zhang, PhD, Samir K. Ballas, MD, Vivien A Sheehan, MD PhD

Blood (2018) 132 (Supplement 1): 1071.

https://doi.org/10.1182/blood-2018-99-116936

Published: 2018

Journal Articles

Highly Efficient Editing of the Beta-Globin Gene in Patient Derived Hematopoietic Stem and Progenitor Cells to Treat Sickle Cell Disease

So Hyun Park, BS, Ciaran M Lee, PhD, Daniel P. Dever, PhD, Timothy H Davis, BS, Joab Camarena, BS, Yankai Zhang, PhD, Matthew Porteus, MD PhD, Vivian A Sheehan, MD PhD, Gang Bao, PhD

Blood (2018) 132 (Supplement 1): 2192.

https://doi.org/10.1182/blood-2018-99-117371

Published: 2018

Journal Articles

Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells

Yankai Zhang, Alireza Paikari, Pavel Sumazin, Carly C. Ginter Summarell, Jacy R. Crosby, Eric Boerwinkle, Mitchell J. Weiss, Vivien A. Sheehan

Blood (2018) 132 (3): 321–333.

https://doi.org/10.1182/blood-2017-11-814335

Published: 2018

Includes: Supplemental data

Journal Articles

Piceatannol Induces Fetal Hemoglobin in Erythroid Progenitor Cells from Patients with Sickle Cell Disease

Yankai Zhang, PhD, Alicia Chang, MD, Pavel Sumazin, PhD, Vivien Sheehan, MD PhD

Blood (2017) 130 (Supplement 1): 2221.

https://doi.org/10.1182/blood.V130.Suppl_1.2221.2221

Published: 2017

Journal Articles

Screening Fetal Hemoglobin Inducing Compounds in Human Umbilical Cord Blood-Derived Erythroid Progenitor Cells

Yankai Zhang, PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Vivien Sheehan, MD PhD

Blood (2017) 130 (Supplement 1): 2222.

https://doi.org/10.1182/blood.V130.Suppl_1.2222.2222

Published: 2017

Journal Articles

Metformin Induction of Fetal Hemoglobin

Yankai Zhang, PhD, Alireza Paikari, MD, Pavel Sumazin, PhD, Alex George, MD, PhD, Bogdan Dinu, MD, Carly Summarell, MS, Mitchell J Weiss, MD PhD, Vivien Sheehan, MD PhD

Blood (2017) 130 (Supplement 1): 359.

https://doi.org/10.1182/blood.V130.Suppl_1.359.359

Published: 2017

Journal Articles

Metformin Induces FOXO3-Dependent Fetal Hemoglobin Production in Primary Erythroid Cells

Yankai Zhang, PhD, Mitch Weiss, MD PhD, Pavel Sumazin, PhD, Vivien A. Sheehan, MD PhD

Blood (2016) 128 (22): 322.

https://doi.org/10.1182/blood.V128.22.322.322

Published: 2016

NARROW

Evaluation of GBT021601 As a Therapeutic Agent to Restore Bone Marrow Health and Effective Erythropoiesis in a Sickle Mouse Model

Evaluation of the Impact of a Naturally Occurring Beta Hemoglobin Variant, Hb G-Makassar, on Mature Red Blood Cell Function and Pathology in a Sickle Cell Disease Mouse Model

Characterization of Hemoglobin Variants Due to in-Frame Deletions in the β-Globin Gene from CRISPR/Cas9 Gene Correction for Sickle Cell Disease

Functionality of a Peripheral Blood Derived Microglia-like Cell System for Drug Discovery to Treat Sickle Cell Related Chronic Pain

Development of a High-Throughput Drug Screening System Based on Human Peripheral Blood Derived Microglia-like Cells from Sickle Cell Patients with Chronic Pain

S. Aureus Cas9 Leads to Higher Sickle Mutation Correction Compared to S. Pyogenes Cas9 in Patient Hematopoietic Stem and Progenitor Cells

CRISPR/Cas9 Editing Induces High Rates of Unintended Large Gene Modifications in HSPCs from Patients with Sickle Cell Disease

Validation of a Peripheral Blood-Derived Microglia-like Cell System

Microglia-like Cells Derived from Hematopoietic Stem and Progenitor Cells Are a Model System to Investigate Chronic Pain in Sickle Cell Disease

Regulation of Fetal Hemoglobin through the Insulin Signaling Pathway

The Role of Adenosine Monophosphate Activated Protein Kinase Alpha 1 (AMPK) in Gamma-Globin Regulation

Insulin-like Growth Factor Binding Protein-3 (IGFBP3) Induces Fetal Hemoglobin in Hematopoietic Stem and Progenitor Cells from Patients with Sickle Cell Anemia

Engineered Human Umbilical Cord Derived Erythroid Progenitor Cells (HUDEP2) with Sickle or β-Thalassemia Mutation: An in-Vitro System for Testing Pharmacological Induction of Fetal Hemoglobin

Microglia-like Cells Derived from Hematopoietic Stem and Progenitor Cells Are a Model System to Investigate Chronic Pain in Sickle Cell Disease

Highly Efficient Editing of the Beta-Globin Gene in Patient Derived Hematopoietic Stem and Progenitor Cells to Treat Sickle Cell Disease

Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells

Piceatannol Induces Fetal Hemoglobin in Erythroid Progenitor Cells from Patients with Sickle Cell Disease

Screening Fetal Hemoglobin Inducing Compounds in Human Umbilical Cord Blood-Derived Erythroid Progenitor Cells

Metformin Induction of Fetal Hemoglobin

Metformin Induces FOXO3-Dependent Fetal Hemoglobin Production in Primary Erythroid Cells

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American Society of Hematology

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ASH Publications

American Society of Hematology

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